Superficial Wound Cell Delivery for Skin Regeneration
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Solution Overview
Problem
Current cell delivery techniques often fail to maintain the morphology of cells during delivery, which is crucial for their health and differentiation state, and are ineffective in treating conditions like skin ulcers and scars without causing scarring or bleeding.
Innovation Solution
A method involving making shallow superficial wounds on the skin with a sharp instrument and placing skin forming cells, such as dermal or epidermal cells, into the wound to allow them to form new skin structures like hair follicles or skin layers without causing bleeding, using a suitable dressing to aid in healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If current cell delivery techniques are used, then cells can be delivered to the skin, but the morphology of the cells is not maintained
Solution Approach 1:
The method creates superficial wounds in advance before cell delivery, preparing the skin surface to receive cells in a controlled manner. This preliminary action allows cells to be delivered to a pre-prepared site, ensuring proper morphology maintenance and reducing damage during the delivery process.
2Length of moving object
If deep wounds are made to deliver cells, then cells can be delivered deeper into the skin, but bleeding occurs
Solution Approach 1:
The method creates wounds with specific local characteristics - superficial depth that is sufficient for cell delivery but not deep enough to reach blood vessels. This localized control of wound depth ensures cells are delivered to the appropriate skin layer without causing bleeding or excessive trauma.
3Ease of manufacture
If traditional cell delivery methods are used, then cells can be applied to the skin, but scarring occurs
Solution Approach 1:
The method uses superficial wounds that are partial in depth - enough to facilitate cell delivery and initiation of healing, but not excessive deepness that would lead to scarring. This partial action approach achieves the therapeutic goal while minimizing harmful outcomes.
Data Source
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AI summary
The present invention is a method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed from the hair follicle progenitor cells. The present invention is also a method of forming new skin comprising making a wound in the skin and placing skin forming cells on the wound, wherein new skin is formed from the skin forming cells.