Woven Aspiration Thrombectomy Structure for Gentle Clot Removal

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Solution Overview

Problem

Existing thrombectomy devices are not gentle on fragile blood vessels, require multiple devices for clot removal, and lack visibility and flexibility in tortuous vessels, leading to inefficiencies in capturing and removing thrombi.

Innovation Solution

A textile structure-based mechanical thrombectomy device with self-expanding bulbs and a hypotube, featuring varying slit patterns and radiopaque wires for visibility and flexibility, allowing for torsional rasping and distal emboli filtration without a separate embolic protection member.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If existing thrombectomy devices are used, then clot removal function is provided, but vessel wall damage occurs and vessels are not gentle on

Engineering Contradiction:

Improvevessel wall damageVSAvoidclot removal effectiveness

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The device employs a flexible textile structure with interwoven radiopaque and shape memory wires that can conform to tortuous vessel geometries while maintaining mechanical strength for effective thrombus capture and removal, thereby reducing vessel wall damage

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

The shape memory wires enable the device to change its physical state and configuration in response to temperature changes, allowing it to adapt to different vessel diameters and maintain gentle contact with the vessel wall while effectively capturing clots

Inventive Principle:

Principle #35Parameter changes

2Adaptability or versatility

If multiple devices are used for clot removal, then comprehensive treatment is achieved, but device complexity increases

Engineering Contradiction:

Improvetreatment capabilityVSAvoidnumber of devices

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The device integrates multiple functions into a single system: the textile structure captures thrombi through its filtering action, the radiopaque wires provide imaging visibility, the shape memory wires enable adaptation to vessel geometry, and the integrated embolic protection filters distal emboli, eliminating the need for separate devices

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Ease of operation

If traditional devices are used, then basic thrombectomy is performed, but visibility and flexibility in tortuous vessels are lacking

Engineering Contradiction:

Improvenavigability in tortuous vesselsVSAvoiddevice visibility

Core Design Contradiction:

Ease of operationVSDifficulty of detecting and measuring

Solution Approach 1:

The flexible textile structure allows the device to navigate tortuous vessel paths while maintaining its structural integrity and filtering function

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

The radiopaque wires embedded in the textile structure provide enhanced visibility under fluoroscopic imaging, allowing operators to track device position and function in real-time during the procedure

Inventive Principle:

Principle #32Color changes

4Reliability

If embolic protection member is added, then distal emboli filtration is improved, but device complexity increases

Engineering Contradiction:

Improveemboli filtrationVSAvoidstructure components

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The device merges the embolic protection function with the main thrombectomy structure by integrating filtering capabilities directly into the textile structure, eliminating the need for a separate embolic protection member while maintaining comprehensive emboli filtration

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device effectively captures and removes thrombi across varying vessel diameters with minimal vessel damage, providing enhanced visibility and flexibility, and filters distal emboli without impeding blood flow, thus improving treatment efficacy.

Implementation Method 1

The plurality of wires includes shape memory wires

Methodology Applied

Scientific EffectShape memory: Shape Memory Alloy

Data Source

PatentUS12478390B2Methods of treating a vessel using an aspiration pattern

Publication Date: 2025.11.25 INSERA THERAPEUTICS INC

AI summary

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measureable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.