Transdermal Tape Vaccine Delivery for WT1 Peptide Administration
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Solution Overview
Problem
Current cancer vaccine administration methods, particularly injections, are invasive, painful, and generate medical waste, while transdermal creams face issues with drug stability and application control.
Innovation Solution
A cancer vaccine tape preparation containing a WT1 peptide and/or modified WT1 peptide, combined with cellular immunity induction promoters like TLR ligands and cyclic dinucleotides, applied transdermally using an adhesive layer on a support to induce strong cellular immunity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If injection method is used for cancer vaccine administration, then the vaccine can be delivered to the body, but it causes pain and generates medical waste
Solution Approach 1:
The patent replaces the mechanical injection system with a transdermal tape preparation system. The vaccine composition is incorporated into a tape formulation that delivers the antigen through the skin via adhesive application, eliminating the need for needles and mechanical injection while maintaining vaccine delivery effectiveness and reducing pain and medical waste
Solution Approach 2:
The patent introduces a transdermal tape preparation as an intermediary delivery system between the vaccine composition and the body. The tape formulation acts as a mediator that facilitates vaccine delivery through the skin barrier, avoiding direct injection while ensuring effective antigen presentation to the immune system
2Object-affected harmful factors
If transdermal cream is used for cancer vaccine administration, then it avoids injection pain, but it has issues with drug stability and application control
Solution Approach 1:
The patent uses a tape preparation with a flexible adhesive layer and support structure to deliver the vaccine composition. The tape formulation provides a stable carrier system that maintains drug stability while allowing controlled application through the adhesive mechanism, improving upon cream-based transdermal delivery
Solution Approach 2:
The patent changes the physical form of the vaccine delivery system from liquid cream to solid tape preparation. This parameter change improves drug stability by providing a more stable matrix and enhances application control through the adhesive tape mechanism, while maintaining the benefit of pain-free transdermal administration
3Reliability
If conventional injection methods are used, then cancer vaccine can be administered, but it causes trauma and requires medical professional intervention
Solution Approach 1:
The patent enables self-service vaccine administration through the transdermal tape preparation. The adhesive tape formulation can be applied by patients or caregivers without requiring medical professionals or causing trauma, allowing self-administration while maintaining effective vaccine delivery
Solution Approach 2:
The patent replaces the mechanical injection system requiring professional intervention with a transdermal adhesive tape system. This substitution eliminates the need for medical professionals to perform injections and removes the trauma associated with needle insertion, enabling patient self-administration
Data Source
AI summary
The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising:a support,an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of:(i) a WT1 peptide and/or a modified WT1 peptide; and(ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.