X-Ray Bone Marrow Edema Estimation Without MRI

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Solution Overview

Problem

Current diagnostic methods for bone marrow edema in rheumatoid arthritis, such as MRI, are costly and inaccessible to many patients, hindering early diagnosis and treatment.

Innovation Solution

A machine learning-based system using X-ray images and deep learning algorithms to estimate the presence of bone marrow edema without the need for an MRI machine.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If MRI is used to diagnose bone marrow edema, then diagnostic accuracy is improved, but cost and accessibility worsen

Engineering Contradiction:
Improvediagnostic accuracyVSAvoidcost and accessibility
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent uses X-ray images as a cheaper copy or alternative representation of the joint structure, attempting to capture bone marrow edema information without requiring the expensive MRI scan. The deep learning model learns to extract BME features from this simpler X-ray representation, effectively copying the diagnostic capability of MRI at lower cost.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The patent replaces the expensive, complex MRI machine with a more economical X-ray system combined with a software-based deep learning model. This substitution uses cheaper hardware (X-ray machine) and computational resources (training data and models) to achieve comparable diagnostic accuracy for bone marrow edema detection.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Device complexity

If deep learning model is trained using X-ray images, then cost-effectiveness is improved, but measurement precision may worsen

Engineering Contradiction:
Improvecost-effectivenessVSAvoidestimation accuracy
Core Design Contradiction:
Device complexityVSMeasurement precision

Solution Approach 1:

The patent changes the input parameter from MRI images to X-ray images for training the deep learning model. By adjusting the training data source and learning parameters, the model adapts to extract bone marrow edema features from X-ray images, achieving cost-effective diagnosis while maintaining acceptable precision through optimized training procedures.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs feedback mechanisms during model training where the deep learning model continuously refines its estimates based on training data and validation results. This feedback loop allows the model to improve its accuracy in estimating bone marrow edema from X-ray images, ensuring that cost-effectiveness does not come at the expense of diagnostic precision.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS12493961B2Estimation device, estimation method, program, and generation method
Publication Date: 2025.12.09 MEDICAL CORP KATAYAMA ORTHOPEDIC RHEUMATOLOGY CLINIC
  • US12493961B2 patent drawing
  • US12493961B2 patent drawing
  • US12493961B2 patent drawing

AI summary

A purpose of the present invention is to make it possible, when diagnosing bone marrow edema, to estimate whether bone marrow edema is present in a body part of a subject without using MRI testing using a high-cost MRI device. The present invention is an estimation device that includes a learner that is trained using X-ray images in which the body part is photographed, and learning data including information about whether the body part photographed in the X-ray image has bone marrow edema, the X-ray image in which the body part of the subject is photographed being inputted into the learner, and an estimation result being outputted that relates to the presence of bone marrow edema in the body part photographed in the inputted X-ray image.