Feed Additive Formulation with Xylanase and Bacillus Strains

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Solution Overview

Problem

Current enzyme and probiotic products used in animal feeds are costly and unstable, leading to inconsistent results in improving animal production performance, especially after the removal of antibiotic growth promoters from animal production.

Innovation Solution

A feed additive formulation comprising an isolated xylanase enzyme and biologically pure cultures of Bacillus licheniformis strain PWD-1 and Bacillus amyloliquefaciens strain Ba-BPD1, which are added to animal feeds to enhance animal performance and health.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antibiotic growth promoters are removed from animal production, then animal health and productivity can be improved through alternative feed additives, but the efficacy and stability of these alternatives are inconsistent

Engineering Contradiction:
Improveefficacy consistencyVSAvoidalternative feed additive options
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent combines multiple functional components into a single feed additive formulation: xylanase enzyme for carbohydrate digestion, Bacillus licheniformis for protein supplementation and pathogen inhibition, and Bacillus amyloliquefaciens for additional enzymatic activity. This merging of components creates a synergistic effect that provides consistent and reliable animal performance improvement, addressing the inconsistency problem of individual additives.

Inventive Principle:
Principle #5Merging (Combining)

2Productivity

If enzyme and probiotic products are used in animal feeds, then animal production performance can be improved, but the products are costly and unstable

Engineering Contradiction:
Improveanimal production performanceVSAvoidproduct stability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent employs encapsulation technology to pre-protect the enzyme and probiotic components before they are exposed to feed processing conditions. The encapsulated form allows the additives to withstand heat, moisture, and mechanical stress during feed manufacturing and storage, ensuring stability is maintained until the additives reach the animal's digestive system where they then become active.

Inventive Principle:
Principle #10Preliminary action

3Productivity

If multiple feed additives are combined to improve animal performance, then productivity can be enhanced, but the formulation complexity and manufacturing difficulty increase

Engineering Contradiction:
Improveanimal growth performanceVSAvoidformulation manufacturing
Core Design Contradiction:
ProductivityVSEase of manufacture

Solution Approach 1:

The patent optimizes the formulation by controlling key parameters including the ratio of different bacterial strains, encapsulation material composition, particle size distribution, and moisture content. By precisely controlling these parameters during manufacturing, the patent achieves consistent product quality and stable animal performance improvements while maintaining manufacturability through standardized production processes.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of xylanase and the bacterial strains significantly improves animal growth, feed conversion rates, reduces intestinal lesions, and decreases pathogen incidence, showing synergistic benefits over using either component alone.

Implementation Method 1

an isolated xylanase enzyme

Methodology Applied
Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 2

a biologically pure culture of Bacillus licheniformis strain PWD-1

Methodology Applied
Scientific EffectProbiotic action: Fermentation

Implementation Method 3

a biologically pure culture of Bacillus amyloliquefaciens strain Ba-BPD1

Methodology Applied
Scientific EffectProbiotic action: Fermentation

Data Source

PatentUS11260084B2Feed additive formulation and methods of making and using the same
Publication Date: 2022.03.01 BIORESOURCE INTERNATIONAL INC
  • US11260084B2 patent drawing
  • US11260084B2 patent drawing
  • US11260084B2 patent drawing

AI summary

The presently disclosed subject matter relates to feed additive formulations for monogastric animal feed. Particularly, the disclosed formulations comprise an isolated xylanase enzyme and a B. licheniformis strain PWD-1. The feed additive formulations may further include B. amyloliquefaciens strain Ba-BPD1. The disclosed formulations are useful for addition to feeds for monogastric animals to synergistically improve the performance of the animals.