Yeast Particle Delivery for Controlled Cannabinoid Release
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Solution Overview
Problem
Current methods for delivering cannabinoids lack precision and control, failing to provide consistent and controlled doses to cells and organisms.
Innovation Solution
A yeast particle delivery system is developed, which encapsulates hydrophobic payloads like cannabinoids within a hollow internal space, using adjuvants, release agents, and sequestering agents to facilitate controlled release, including self-emulsifying drug delivery systems and specific solvents to manage the release timing and duration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional delivery methods (inhalation, ingestion, intraoral delivery) are used for cannabinoids, then delivery to cells and organisms is achieved, but precise and controlled dosing cannot be delivered
Solution Approach 1:
The delivery system segments the cannabinoid formulation into discrete yeast particle units, each containing a specific hydrophobic payload. This segmentation enables precise dosing control while maintaining a relatively simple administration process, as each particle acts as an independent dosing unit that can be administered orally or parenterally without complex delivery devices
Solution Approach 2:
The system controls the release of cannabinoids by changing the physical-chemical parameters of the yeast particle matrix in response to physiological conditions. The controlled release is achieved through modification of particle permeability, dissolution rate, or structural integrity in response to pH, enzymes, or other biological triggers, enabling precise dosing without complex mechanical delivery systems
2Stability of the object's composition
If hydrophobic payloads are encapsulated in yeast particles with hollow internal space, then storage stability is enhanced, but controlled and sustained release mechanism is required
Solution Approach 1:
The yeast particle matrix is pre-formulated with controlled porosity and structural characteristics during manufacturing. This preliminary structuring of the particle matrix enables both stable encapsulation of hydrophobic payloads during storage and controlled release upon administration, without requiring complex real-time control mechanisms. The matrix composition and pore structure are optimized in advance to provide both stability and sustained release
Solution Approach 2:
The yeast particle matrix utilizes its inherent porous structure to achieve both stable encapsulation and controlled release. The porous matrix provides protection and stability during storage while allowing gradual diffusion and sustained release of the hydrophobic payload over time. The pore size, distribution, and connectivity are controlled during particle formation to regulate release duration and rate
3Reliability
If self-emulsifying drug delivery system (SEDDS) solvents are used, then bioavailability is improved, but formulation complexity increases
Solution Approach 1:
The system merges the SEDDS emulsification mechanism with the yeast particle encapsulation approach. The yeast particles are formulated with SEDDS components integrated into their matrix structure, combining the benefits of physical encapsulation with self-emulsifying properties. This integration improves bioavailability through enhanced solubilization and absorption while avoiding the complexity of separate SEDDS formulation and administration systems
Solution Approach 2:
The yeast particle formulation incorporates self-emulsifying properties that enable it to automatically form emulsions in the gastrointestinal tract without requiring external emulsification devices or complex administration procedures. The particle matrix contains lipophilic and hydrophilic components that self-assemble into emulsion structures upon contact with gastrointestinal fluids, enhancing bioavailability through a self-service mechanism that simplifies the overall formulation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves controlled and sustained release of cannabinoids, enhancing storage stability and bioavailability, allowing for precise delivery and improved therapeutic efficacy.
Implementation Method 1
an adjuvant, wherein the adjuvant comprises a self-emulsifying delivery system (SEDDS) solvent
Implementation Method 2
a release agent encapsulated within the hollow internal space of the YP along with the hydrophobic payload
Implementation Method 3
a sequestering agent encapsulated within the hollow internal space of the YP along with the payload
Data Source
AI summary
The present disclosure provides a yeast particle delivery system for controlled release of cannabinoids and other hydrophobic payloads. The disclosure further provides methods of making and methods of using the yeast particle delivery system.