Yeast Parietal Polysaccharide Composition for Specific Immune Stimulation
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Solution Overview
Problem
Current yeast-based products for stimulating immune responses lack specificity and consistency in composition and outcome, failing to effectively enhance animal or human immune responses.
Innovation Solution
A composition comprising parietal polysaccharides from at least one Candida species combined with parietal polysaccharides from at least one different yeast species, which when combined, enhance immune responses even at low inclusion rates, with specific ratios and species such as Candida utilis and Saccharomyces cerevisiae being used.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If unspecific inactive yeast-based products are used to stimulate immune responses, then immune activation is claimed to occur through β-glucan/Dectin 1 pathways, but the products lack specificity and consistency in composition and outcome
Solution Approach 1:
The patent segments the immune stimulation function by identifying and isolating specific parietal polysaccharide components from yeast cell walls that selectively activate the β-glucan/Dectin 1 pathway, rather than relying on unspecific whole yeast products. This segmentation enables consistent and specific immune response activation.
Solution Approach 2:
The patent applies parameter changes by defining specific compositional parameters of parietal polysaccharides (such as β-glucan content, molecular weight, and structural characteristics) that determine their ability to consistently activate Dectin 1 receptors, thereby transforming unspecific yeast products into specific immune stimulants with reliable outcomes.
2Reliability
If higher inclusion rates of yeast-based products are used to enhance immune stimulation, then stronger immune activation may be achieved, but the cost and complexity of the formulation increases
Solution Approach 1:
The patent extracts the active immunostimulatory parietal polysaccharide components from whole yeast cells, concentrating the beneficial effects into a purified form that requires lower inclusion rates in formulations. This extraction eliminates the need for complex whole yeast formulations while maintaining or enhancing immune stimulation effectiveness.
Solution Approach 2:
The patent creates a composite material consisting of purified parietal polysaccharides with defined compositional characteristics that combine multiple beneficial properties (specificity, consistency, potency) into a single formulation component, simplifying the overall formulation while improving reliability of immune response.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of parietal polysaccharides from different yeast species significantly stimulates animal or human immune responses, as demonstrated by increased production of reactive oxygen species and improved resistance to pathogens, enhancing intestinal health and immune gene expression.
Implementation Method 1
activation of anti-fungal immune responses initiated in the intestinal mucosal surface, primarily through Dectin 1 and β-glucan pathways, or via direct binding with undesirable bacteria
Implementation Method 2
increased production of reactive oxygen species
Data Source
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AI summary
There is providedacomposition comprising parietal polysaccharides from at least one Candida species and parietal polysaccharides from at least one different yeast species. The composition can be used in modulating and/or stimulating immune responses in animal or human.