Yan-Sheng-Yin Herbal Extract for Hyperlipidemia and Obesity

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Solution Overview

Problem

Current treatments for obesity and hyperlipidemia often come with risks of cardiovascular disease and severe side effects, necessitating an alternative therapy that effectively addresses adipocyte differentiation and lipid metabolism.

Innovation Solution

A water extract of Yan-Sheng-Yin (YSY), comprising wood ear, shiitake, hawthorn fruit, roselle, celery, and Chinese plum, which activates AMPK, suppresses PPAR-γ and C/EBPs, and increases adiponectin secretion to inhibit adipocyte differentiation and promote lipid metabolism, thereby treating and preventing hyperlipidemia, atherogenesis, and obesity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Weight of moving object

If weight-loss drugs are used to reduce body weight and adipose tissue, then obesity is treated, but the risk of cardiovascular diseases increases

Engineering Contradiction:

Improvebody weightVSAvoidcardiovascular safety

Core Design Contradiction:

Weight of moving objectVSReliability

Solution Approach 1:

The patent uses a composite herbal formulation containing multiple natural ingredients (Hibiscus sabdariffa, Lentinus edodes, Crataegus pinnatifida, Apium graveolens, Prunus mume, and Auricularia auricular) working synergistically to reduce adipose tissue while maintaining cardiovascular safety, avoiding the harmful effects of synthetic weight-loss drugs

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If statins are used to lower cholesterol, then hyperlipidemia is treated, but mild to severe side effects occur

Engineering Contradiction:

Improvecholesterol levelVSAvoidside effects

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent replaces expensive statin drugs with natural, readily available herbal ingredients that achieve similar cholesterol-lowering effects without the severe side effects, using plant-based compounds like polysaccharides and phenolic acids from common foods

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Use of energy by moving object

If adipocyte differentiation is promoted for metabolic regulation, then energy metabolism is modulated, but adipogenesis increases leading to obesity

Engineering Contradiction:

Improveenergy metabolismVSAvoidadipose tissue mass

Core Design Contradiction:

Use of energy by moving objectVSWeight of moving object

Solution Approach 1:

The patent selectively modulates adipocyte function by enhancing lipogenic activity in brown adipose tissue (beneficial for energy expenditure) while suppressing adipogenesis in white adipose tissue (preventing obesity), achieving localized metabolic regulation with different effects in different tissue types

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS10238701B2Composition of wood ear, shiitake, hawthorn fruit, roselle, celery and fruit of chinese plum for treatment and/or prevention of hyperlipidemia, atherogenesis and obesity

Publication Date: 2019.03.26 TAIPEI MEDICAL UNIV

AI summary

The invention provides a water extract of Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement for treatment and/or prevention of hyperlipidemia, atherogenesis and obesity, comprised entirely of natural foods and a preparation comprising the same.