Yttrium Silicon Oxynitride Bone Prosthetic for Biocompatibility
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Solution Overview
Problem
Existing biocompatible ceramic materials, such as silicon nitride, do not adequately address biocompatibility issues in biological materials and bone prosthetics.
Innovation Solution
A composite compound comprising yttrium, oxygen, and silicon, with specific compounds like Si 3 N 4 -SiO 2 -Y 2 O 3 -based materials, is used to create a biological material with enhanced biocompatibility, including a bone prosthetic material, by controlling phase composition, surface area, and pH to improve cell compatibility and antibacterial properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If silicon nitride is used as a ceramic material in biological materials, then antibacterial properties are provided, but biocompatibility is not adequate
Solution Approach 1:
The patent applies composite materials by combining silicon nitride particles with a glass matrix containing specific oxides (Bi2O3, B2O3, SiO2, P2O5) to create a composite biological material. This composite structure allows the silicon nitride to provide antibacterial properties while the glass matrix enhances biocompatibility through controlled ion release and surface characteristics, thus resolving the contradiction between antibacterial function and biocompatibility.
Solution Approach 2:
The patent changes the chemical composition parameters of the material by incorporating specific oxide ratios (Bi2O3: 20-40 wt%, B2O3: 10-30 wt%, SiO2: 20-40 wt%, P2O5: 5-20 wt%) and controlling the particle size distribution of silicon nitride (D50: 3-10 μm). These parameter changes optimize both the antibacterial activity and biocompatibility, allowing the material to satisfy both requirements simultaneously.
2Strength
If silicon nitride is fired with oxide to generate composite oxide, then material properties are enhanced, but grain boundary composite oxide formation may affect biocompatibility
Solution Approach 1:
The patent changes the chemical composition parameters by incorporating specific oxide ratios (Bi2O3: 20-40 wt%, B2O3: 10-30 wt%, SiO2: 20-40 wt%, P2O5: 5-20 wt%) and controlling the particle size distribution of silicon nitride (D50: 3-10 μm). These parameter changes optimize both the antibacterial activity and biocompatibility, allowing the material to satisfy both requirements simultaneously.
Solution Approach 2:
The patent utilizes a glass matrix structure that can be considered a porous or amorphous phase surrounding silicon nitride particles. This glass matrix provides a controlled environment for ion release and creates a surface structure that enhances biocompatibility while maintaining the structural integrity provided by the fired composite oxide, thus resolving the contradiction between material strength and biocompatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite compound exhibits excellent biocompatibility, reduces cell cytotoxicity, promotes osteoblast differentiation, and enhances antibacterial performance against Gram-positive bacteria, making it suitable for bone prosthetics and implants.
Implementation Method 1
promotes osteoblast differentiation
Implementation Method 2
enhances antibacterial performance against Gram-positive bacteria
Data Source
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AI summary
A biological material according to the present disclosure includes as a main component, a composite compound having yttrium, oxygen, silicon, and nitrogen as constituent elements. A powder composition according to the present disclosure includes, as a main component, a composite compound having yttrium, oxygen, silicon, and nitrogen as constituent elements, the powder composition having a BET specific surface area of 0.3 m2/g or more. A bone prosthetic material according to the present disclosure includes the biological material described above. A method for using a composition containing a composite compound as a main component as a biological material according to the present disclosure uses, as a biological material, a composition containing, as a main component, a composite compound having yttrium, oxygen, silicon, and nitrogen as constituent elements.