Zeolite NaY Filter for IMS Breath Analysis

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Solution Overview

Problem

Existing systems for measuring substance concentrations in exhaled breath, such as those using gas chromatography ion mobility spectrometry (GC-IMS), face challenges in achieving accurate measurements due to interference from contaminants and the need for frequent filter regeneration or replacement.

Innovation Solution

The use of a molecular sieve filter with zeolite NaY as the filter material, which effectively removes substances like Propofol and water from gas streams, allowing for prolonged filter use and reducing contamination-related measurement errors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional filters are used in GC-IMS systems, then measurement accuracy is compromised due to contamination, but filter regeneration or replacement requires frequent intervention

Engineering Contradiction:
Improvesubstance concentration measurement accuracyVSAvoidfilter regeneration or replacement frequency
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent changes the chemical composition parameter of the filter material from conventional activated carbon to zeolite NaY, which has different adsorption properties. This parameter change enables the filter to selectively adsorb water and certain contaminants while allowing anesthetic agents to pass through, thereby improving measurement accuracy and extending filter usage time before regeneration is needed

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs zeolite NaY as a composite filter material that combines crystalline structure with specific pore sizes and adsorption characteristics. This composite material provides both high water capacity and selective adsorption properties, resolving the contradiction between measurement precision and filter maintenance frequency

Inventive Principle:
Principle #40Composite materials

2Duration of action of stationary object

If filters with high adsorption capacity are used, then filter lifespan is extended, but measurement accuracy may be compromised due to selective adsorption of target substances

Engineering Contradiction:
Improvefilter time-of-useVSAvoidanesthetic agent concentration measurement
Core Design Contradiction:
Duration of action of stationary objectVSMeasurement precision

Solution Approach 1:

The patent applies the concept of local quality by designing the zeolite NaY filter with specific local adsorption properties - it has high affinity for water molecules in certain pore regions while allowing anesthetic agent molecules to pass through other pathways. This localized selective adsorption extends filter lifespan without compromising measurement accuracy of the target anesthetic substances

Inventive Principle:
Principle #3Local quality

3Measurement precision

If frequent filter regeneration is performed, then measurement accuracy is maintained, but system downtime and operational complexity increase

Engineering Contradiction:
Improvesubstance concentration accuracyVSAvoidfilter maintenance procedure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent adopts a disposable filter cartridge design made of zeolite NaY that is optimized for extended single-use operation. Instead of implementing complex regeneration systems, the filter is designed to maintain high measurement precision throughout its extended service life and then be replaced as a complete unit, simplifying the overall system while maintaining accuracy

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The NaY filter material provides a high dynamic adsorption capacity for water, enabling a filter with a long time-of-use and ensuring accurate concentration measurements by minimizing interference from contaminants.

Implementation Method 1

The filter material comprises the zeolite NaY... provides a high dynamic adsorption capacity for water... effectively removes substances like Propofol and water from gas streams

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 2

components of a gas sample are ionized by means of an ion molecule reaction... applying a substantial electrical field strength... the ionized components are driven towards a detector

Methodology Applied
Scientific EffectIonization: Ionisation

Data Source

PatentUS12295721B2System and method for identifying and/or measuring a substance concentration in the exhaled breath of a patient
Publication Date: 2025.05.13 FRESENIUS VIAL
  • US12295721B2 patent drawing
  • US12295721B2 patent drawing
  • US12295721B2 patent drawing

AI summary

A system for identifying and/or measuring a substance concentration in the exhaled breath of a patient (4), comprises a measurement apparatus (20) for performing an ion mobility spectrometry measurement of a sampling gas stream (A) obtained from the exhaled breath of the patient (4), the measurement apparatus (20) comprising a drift detector (22) and at least one gas circuit (23, 24) connected to the drift detector (22) for guiding an analytic gas stream (B), into which a sample of the sampling gas stream (A) is injectable, towards an inlet end (220) of the drift detector (22) and/or a drift gas stream (C) towards an outlet end (221) of the drift detector (22), wherein the at least one gas circuit (23, 24) comprises a molecular sieve filter (233, 241) comprising a filter material (26) for filtering the analytic gas stream (B) and/or the drift gas stream (C). Herein, the filter material (26) comprises the zeolite NaY. In this way a system for measuring a substance concentration in the exhaled breath of a patient is provided which allows for accurate measurements using the ion mobility spectrometry (IMS).