Zn-Complexed Brain Protein Hydrolysate Bioavailability
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Solution Overview
Problem
Current mammalian brain protein hydrolysate products, while effective in treating neurological conditions, lack extension into nutritional supplements and have limited neural system effects, particularly on cerebral endothelial integrity and age-associated memory impairment.
Innovation Solution
A method involving the production of a mammalian brain protein hydrolysate composition by adding Zn ions, preferably as zinc gluconate, to form a complex with the hydrolysate, optimizing pH and concentration for enhanced bioavailability and effectiveness as a nutritional supplement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Zn ions are added to form a complex with brain protein hydrolysate, then bioavailability and neural system effects are improved, but product complexity and manufacturing steps increase
Solution Approach 1:
The patent creates a composite material by forming a complex between Zn ions and brain protein hydrolysate. This composite structure enhances the bioavailability and neural system effects of the hydrolysate while maintaining it as a single integrated product entity, resolving the contradiction between improved reliability and increased complexity.
Solution Approach 2:
The patent optimizes specific parameters including Zn ion concentration (0.1-10 mM), pH range (5.0-7.5), and temperature (20-37°C) to maximize complex formation efficiency. By controlling these parameters, the patent achieves high bioavailability while keeping the manufacturing process manageable and not excessively complex.
2Reliability
If Zn ions are added to form a complex with brain protein hydrolysate, then endothelial permeability and anti-inflammatory effects are enhanced, but manufacturing precision and process control requirements increase
Solution Approach 1:
The patent specifies optimal parameter ranges for complex formation: Zn ion concentration of 0.1-10 mM, pH of 5.0-7.5, and temperature of 20-37°C. These well-defined parameter ranges enable consistent manufacturing with controlled precision while achieving enhanced neural system effects, resolving the contradiction between reliability and manufacturing precision requirements.
3Adaptability or versatility
If the patent extends brain protein hydrolysate application to nutritional supplements, then product versatility and market applicability increase, but regulatory requirements and safety standards become more stringent
Solution Approach 1:
The patent develops a multi-functional product that serves both pharmaceutical and nutritional supplement applications. The Zn-complexed brain protein hydrolysate can be used for treating neurological conditions while also functioning as a cognitive health supplement, thereby increasing product versatility. The standardized manufacturing process and defined composition help meet varying regulatory requirements across different application domains.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Zn-complexed mammalian brain protein hydrolysate exhibits improved neural system effects, including enhanced endothelial permeability and reduced pro-inflammatory proteins, offering potential for both therapeutic and preventive applications in neurological conditions and age-related cognitive decline.
Implementation Method 1
adding Zn ions to the mammalian brain protein hydrolysate to form a complex comprising the Zn ions and the protein hydrolysate
Data Source
AI summary
A method for producing a mammalian brain protein hydrolysate composition, by providing a mammalian brain protein hydrolysate, adding Zn ions to the mammalian brain protein hydrolysate to form a complex with the Zn ions and the mammalian brain protein hydrolysate, and obtaining the complex with the Zn ions and the mammalian brain protein hydrolysate in a mammalian brain protein hydrolysate composition. A composition with a mammalian brain protein hydrolysate. A nutritional supplement with a mammalian brain protein hydrolysate. A pharmaceutical composition with a mammalian brain protein hydrolysate.