Zwitterionic Copolymer Tooth Coating Bacterial Resistance

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Solution Overview

Problem

Conventional dental care products often have reduced efficacy due to the presence of surfactants and may contain ingredients that are not safe for human use, failing to effectively prevent bacterial attachment and tooth decay.

Innovation Solution

A dental care product incorporating a bacterial resistance copolymer with a zwitterionic block and an anchoring block that binds to tooth surfaces via electrostatic attraction, reducing bacterial attachment, and optionally using a two-part formulation with opposite electric charges for enhanced resistance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional dental care products use surfactants and essential oils, then they can solubilize active ingredients and provide antimicrobial effects, but the efficacy of active ingredients is reduced and safety concerns arise

Engineering Contradiction:
Improveantimicrobial efficacyVSAvoidreduced efficacy and safety issues
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent removes harmful surfactants and essential oils from the formulation, extracting only the necessary functional components. The copolymer is applied alone without adjuvants, eliminating the harmful interactions that reduce efficacy and raise safety concerns while maintaining antimicrobial effectiveness.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention changes the chemical parameters of the active ingredient by designing a specific copolymer structure with zwitterionic blocks and anchoring blocks having opposite electric charges. This structural parameter change enables the material to function effectively without requiring surfactants or essential oils, thereby improving both efficacy and safety.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If dental care products use traditional antimicrobial agents, then they can kill bacteria, but they may contain ingredients that are not safe for human use

Engineering Contradiction:
Improvebacterial resistanceVSAvoidsafety for human use
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses a composite copolymer structure combining zwitterionic blocks with anchoring blocks of opposite electric charges. This composite material achieves bacterial resistance through electrostatic interactions and physical adsorption mechanisms that are inherently safer than traditional antimicrobial agents, eliminating the need for potentially harmful chemicals while maintaining effective bacterial resistance.

Inventive Principle:
Principle #40Composite materials

3Reliability

If copolymer concentration is increased to improve bacterial resistance, then bacterial attachment is reduced, but product complexity and formulation challenges increase

Engineering Contradiction:
Improvebacterial resistanceVSAvoidformulation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The copolymer is segmented into distinct functional blocks: zwitterionic blocks that provide bacterial resistance and anchoring blocks with opposite electric charges that bind to tooth surfaces. This segmentation allows each block to perform its specific function independently, achieving effective bacterial resistance at lower overall concentrations and simplifying the formulation process.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The product achieves high bacterial resistance without the need for essential oils or antimicrobial agents, providing safety and effectiveness comparable to or superior to commercial products like Listerine®, while being safe for human use.

Implementation Method 1

the anchoring block binds to tooth surfaces by electrostatic attraction

Methodology Applied
Scientific EffectElectrostatic attraction: Electrostatics

Implementation Method 2

the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces

Methodology Applied
Scientific EffectSteric hindrance:

Data Source

PatentUS9254255B2Dental care product with two-part formulations and utility thereof
Publication Date: 2016.02.09 CHUNG YUAN CHRISTIAN UNIVERSITY
  • US9254255B2 patent drawing
  • US9254255B2 patent drawing
  • US9254255B2 patent drawing

AI summary

A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.