Zwitterionic Solubilizing Agent for Low-Viscosity Aqueous Solutions
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Solution Overview
Problem
Existing methods for solubilizing hardly water-soluble substances, such as liposoluble vitamins and steroids, often result in increased solution viscosity and handling issues due to the use of high molecular weight polymers, and require labor-intensive surfactant selection to avoid protein denaturation.
Innovation Solution
A solubilizing agent represented by the compound formula (1), with a hydrogen or methyl group (X) and an integer n of 5 to 15, is used to enhance solubility and reduce viscosity, comprising a mixture with water to form a solubilizing solution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If high molecular weight polymers (2-methacryloyloxyethyl phosphorylcholine polymers) are used as solubilizing agents, then solubility of hardly water-soluble substances is improved, but solution viscosity increases and handling property deteriorates
Solution Approach 1:
The patent applies parameter changes by transitioning from high molecular weight polymers to low molecular weight compounds (specifically compounds of formula (1) with n=5-15). This molecular weight parameter change enables effective solubilization of hardly water-soluble substances while preventing excessive viscosity increase, thus maintaining good handling properties. The specific parameter range (n=5-15) was optimized to balance solubilizing capability with solution flow characteristics.
2Quantity of substance
If conventional surfactants are used to increase solubility of hardly water-soluble substances, then solubility is improved, but protein denaturation occurs which decreases activity of antibodies and enzymes
Solution Approach 1:
The patent changes the chemical structure parameter from conventional surfactants to zwitterionic compounds of formula (1), which possess both positive and negative charges. This structural parameter change provides effective solubilization while maintaining biocompatibility, preventing protein denaturation and preserving the activity of antibodies and enzymes required for immune response measurements.
3Quantity of substance
If multiple types of surfactants are investigated and combined to dissolve hardly water-soluble substances, then solubility is improved, but the investigation becomes very complicated and requires a lot of labor
Solution Approach 1:
The patent applies universality by developing a single compound type (formula (1) with n=5-15) that can effectively solubilize various hardly water-soluble substances including liposoluble vitamins, fatty acids, and steroids. This universal solubilizing agent eliminates the need for complicated investigations of multiple surfactant combinations, providing a simplified one-size-fits-all solution for diverse analytical applications.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compound (1) effectively improves the solubility of hardly water-soluble substances like liposoluble vitamins and steroids in water while maintaining solution clarity and handling properties.
Implementation Method 1
a solubilizing agent capable of dissolving hardly water-soluble substances such as liposoluble vitamin, fatty acid, and the like in water or an aqueous solution
Data Source
AI summary
The present invention provides a solubilizing agent for hardly water-soluble substances, which contains a compound represented by the formula (1):wherein the symbols in the above formula are as defined in the specification.