Detection Chip Design for Uniform Temperature Control
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Summary
Problems
Existing digital PCR detection chips face challenges with poor thermal conductivity, uneven heat dissipation, and increased chip size due to the need for large-area blank regions for temperature uniformity, which limits the number of micro-reaction chambers and complicates production.
Innovation solutions
The detection chip incorporates a heating electrode with multiple sub-electrodes of varying resistance values and widths, allowing for differential heating control. This design ensures uniform temperature distribution across the chip, reducing the edge low-temperature region, and enabling a smaller chip size with more micro-reaction chambers.
TRIZ Analysis
Specific contradictions:
General conflict description:
Principle concept:
If a conventional heating electrode is used, then the chip structure is simple, but the temperature distribution is uneven and the chip size increases due to large-area blank regions
Why choose this principle:
The heating electrode is divided into multiple sub-electrodes (first sub-electrode, second sub-electrode, third sub-electrode) with different resistance values. This segmentation allows independent control of heating in different regions, enabling uniform temperature distribution across the chip without requiring large blank regions, thus reducing overall chip size while improving temperature uniformity.
Principle concept:
If a conventional heating electrode is used, then the chip structure is simple, but the temperature distribution is uneven and the chip size increases due to large-area blank regions
Why choose this principle:
Different sub-electrodes are designed with different resistance values (R1, R2, R3) to provide localized heating characteristics. The first sub-electrode has lower resistance for higher heating power in regions requiring more heat, while the third sub-electrode has higher resistance for lower heating power. This local quality differentiation achieves uniform temperature distribution without increasing chip area.
Application Domain
Data Source
AI summary:
The detection chip incorporates a heating electrode with multiple sub-electrodes of varying resistance values and widths, allowing for differential heating control. This design ensures uniform temperature distribution across the chip, reducing the edge low-temperature region, and enabling a smaller chip size with more micro-reaction chambers.
Abstract
A detection chip, a method of using a detection chip and a reaction system are provided. The detection chip includes a first substrate, a micro-chamber definition layer and a heating electrode. The micro-chamber definition layer is located on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is located on the first substrate and closer to the first substrate than the micro-chamber definition layer, and configured to release heat after being energized. The heating electrode includes a plurality of sub-electrodes, orthographic projections of the plurality of micro-reaction chambers on the first substrate overlap with orthographic projections of at least two of the plurality of sub-electrodes on the first substrate, and the at least two of the plurality of sub-electrodes have different heating values per unit time after being energized.