Anti-viral cnidarins
Cnidarin proteins from the soft coral Synthecium sp. inhibit HIV viral fusion, addressing the limitations of current microbicides and PrEP agents by offering a novel, effective prevention mechanism against HIV infection.
CA2935123CActive Publication Date: 2026-09-22THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
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Patent Information
- Application Number
- CA2935123
- Authority / Receiving Office
- CA · CA
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2014-01-09
- Filing Date
- 2015-01-09
- Publication Date
- 2026-09-22
- Estimated Expiration
- 2035-01-09
AI Technical Summary
Technical Problem
Current microbicides and pre-exposure prophylaxis (PrEP) agents for preventing HIV infection face challenges such as emergence of resistant viruses, poor compliance, and ineffective vaginal tissue penetration, necessitating the development of novel, non-ARV anti-HIV microbicides and PrEP agents.
Method used
Isolation and use of cnidarin proteins from the soft coral Synthecium sp., which inhibit HIV viral fusion but not attachment, as a polypeptide, fusion protein, or conjugate, offering a novel approach to prevent HIV infection.
Benefits of technology
Cnidarin proteins demonstrate low-to-sub-nanomolar activity against HIV-1, providing a potential barrier to viral entry and reducing the risk of HIV infection effectively.
✦ Generated by Eureka AI based on patent content.
Abstract
An anti-viral polypeptide comprising SEQ ID NO: 1, 2, or 3, or comprising SEQ ID NO: 1, 2 or 3 with a C-terminal truncation of from 1-60 amino acids, wherein the polypeptide exhibits antiviral activity against HIV-1, as well as a conjugate comprising such polypeptide an at least one effector component, a nucleic acid encoding such polypeptide, a cell comprising the nucleic acid molecule, an antibody that specifically binds the polypeptide of SEQ ID NO: 1, 2, or 3, compositions and production methods and uses of the same.
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