Aminodihydrothiazine derivatives substituted with cyclic groups
By developing compounds with BACE-1 inhibitory activity and inhibiting the activity of the BACE-1 enzyme, the problem of amyloid beta production and deposition is solved, providing a potential solution for the treatment of diseases such as Alzheimer's disease.
CN101687827AInactive Publication Date: 2010-03-31SHIONOGI & CO LTD
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Patent Information
- Application Number
- CN200880021335.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2007-11-08
- Filing Date
- 2008-04-23
- Publication Date
- 2010-03-31
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Existing technology is difficult to effectively inhibit the production and deposition of amyloid beta, which leads to the occurrence of diseases such as Alzheimer's disease.
Method used
A compound with BACE-1 inhibitory activity is provided to reduce the production and deposition of amyloid beta by inhibiting the activity of BACE-1 enzyme.
Benefits of technology
Effectively inhibits the production and deposition of amyloid beta and can potentially be used to treat diseases such as Alzheimer's disease.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides compounds represented by the general formula (I) which are useful as remedies for diseases induced by the production, secretion, or deposition of amyloid ss protein. Compounds represented by the general formula (I); pharmaceutically acceptable salts thereof; or solvates of both: (I) wherein A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R<1> is optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted lower alkynyl; R<2a> and R<2b> are each independently hydrogen, optionally substituted lower alkyl, or optionally substituted acyl; and R<3a>, R<3b>, R<3c> and R<3d> are each independently hydrogen, halogeno, hydroxy, optionally substituted lower alkyl, or the like.
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