3764 results about "Acyl group" patented technology

The present application provides tricyclic triazolo compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.

The invention relates to a construction method of a multi-class lipid retention time general prediction model and a prediction system. The method comprises the following steps: by taking experimental retention time tRE of a lipid compound in a training set as a dependent variable and characteristic structure parameters of the lipid compound as an independent variable, carrying out quantitative processing on the independent variable and then carrying out regression modeling analysis, the characteristic structure parameters comprise the total carbon number c and the total carbon-carbon double bond number d of a fatty acyl chain, an ether chain, an alkenyl ether chain or / and a sphingosine skeleton, the types of skeletons contained in the lipid compound and the number of corresponding skeletons, and the types of characteristic groups and residues in the lipid compound and the number of corresponding residues; carrying out numerical quantization on parameters according to the number of skeletons, characteristic groups or residues of the corresponding types; the QSRR general prediction model of the retention time of the multi-class lipid compounds is obtained by adopting regression modeling, a more accurate MRM data acquisition window can be set for the lipid compounds, and the sensitivity, stability and coverage can be improved.

The invention discloses a crosslinked polyethylene reinforced high-strength insulating aerial cable, and belongs to the technical field of crosslinked polyethylene cable materials.The crosslinked polyethylene reinforced high-strength insulating aerial cable is prepared by the steps that hydroxyl is introduced to nano boron nitride powder, then amino is grafted through KH-550, nano alpha-Al2O3 powder is modified through gamma-glycidyl ether oxypropyl trimethoxy silane, and the cross-linked polyethylene reinforced high-strength insulating aerial cable is obtained; the preparation method comprises the following steps: preparing low-density polyethylene, compounding the low-density polyethylene with aminated nano boron nitride powder to form nano composite powder, improving the interface bonding force between the low-density polyethylene and the nano composite powder, carrying out melt blending on the low-density polyethylene and the nano composite powder to improve the dispersity of the nano composite powder in the low-density polyethylene, and carrying out nucleophilic acyl substitution reaction to obtain a fluorine-containing modified monomer. The nano boron nitride powder and the nano alpha-Al2O3 powder are subjected to a cross-linking reaction under the initiation action of an initiator and then coat the exterior of the thermal insulation layer, and the nano boron nitride powder and the nano alpha-Al2O3 powder are bridged through siloxane bonds to form a three-dimensional heat-conducting network, so that the heat resistance of the outer insulating layer is improved.

The invention discloses a graphene nanometer heavy anti-corrosion coating and a preparation method thereof, and belongs to the technical field of anti-corrosion coatings. The coating is prepared from the following components in parts by mass: 50 to 70 parts of diallyl bisphenol A type epoxy resin, 8 to 15 parts of histidine modifier, 12 to 20 parts of graphene nano composite modified filler, 5 to 10 parts of curing agent, 0.5 to 2 parts of flatting agent and 0.3 to 1 part of defoaming agent. The preparation method of the histidine modifier comprises the following steps: carrying out a Schiff base reaction on 1-palmitoyl-2-oleoyl ethanolamine and N-formyl-L-histidine to generate an intermediate A; reacting with a spiro quaternization reagent to form a quaternary ammonium salt intermediate B; and then compounding with aminopropyltriethoxysilane and silicotungstic heteropoly acid salt to obtain the product. The graphene nano-composite modified filler is prepared by modifying the surface of a graphene oxide / bentonite mutual intercalation layer structure through allyl trimethoxy silane. The graphene nano heavy anti-corrosion coating prepared by the invention forms a high-density cross-linked network, and has excellent barrier property, strong adhesive force, impact resistance and long-acting anti-corrosion performance.

The invention belongs to the field of enzymatic preparation of structural phospholipids, and particularly relates to a method for preparing phosphatidylserine through interfacial enzyme catalysis. A series of high-activity immobilized phospholipase are prepared by innovatively adopting bifunctional group modified hollow mesoporous silica microspheres as a carrier and adsorbing immobilized phospholipase D. The catalyst has the functions of a catalyst and an emulsifier, and a Pickering emulsion interfacial enzyme catalysis system can be efficiently constructed. In the system, the phosphatidylcholine and the serine are efficiently converted into the phosphatidylserine through a phosphatidyl transfer reaction, the conversion rate of the phosphatidylserine within 20 minutes can reach 85%-95%, and the catalytic efficiency reaches up to 372 mmol / (g.h). In addition, after the catalyst is recycled for 10 times, the conversion rate is still kept at 70.9%, and the catalyst shows excellent stability and reusability. The method has the remarkable advantages of being mild in reaction condition, high in catalytic efficiency, capable of being repeatedly used and the like, and a new technical approach is provided for industrial production of phosphatidylserine.

The invention relates to a bionic exosome for anti-inflammation and repair as well as a preparation method and application thereof, and belongs to the field of cosmetics. The bionic exosome provided by the invention comprises a membrane structure and an internal load phase, the membrane structure comprises a phospholipid bilayer, a stabilizer and a targeting ligand; the internal load phase comprises a solvent and an active component; the phospholipid bilayer is composed of phospholipid compounds; preferably, at least one of the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and the 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine is adopted as the phospholipid compound, and at least one of the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and the 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine is adopted as the phospholipid compound; at least one of cholesterol, phytosphingosine and sodium stearoyl glutamate is preferably adopted as a stabilizer, so that the stabilizer of the obtained bionic exosome is improved, and the bionic exosome has the advantages of high encapsulation efficiency, good encapsulation efficiency stability, simplicity in operation, excellent anti-inflammatory and repairing effects and the like.

The invention is applicable to the technical field of intelligent response materials, and provides a three-dimensional azobenzene functionalized covalent organic framework intelligent response material and a preparation method thereof. The three-dimensional azobenzene functionalized covalent organic framework intelligent response material is prepared by uniformly grinding 3, 3 ', 5'-tetra [(3 ', 5'-diformylphenyl)]-hexamethyl biphenyl and azobenzene-4, 4 '-diaminotriphenylamine, adding an organic solvent, adding a catalyst acetic acid aqueous solution, quickly freezing, emptying air, sealing with flame, heating after recovering to room temperature, and obtaining the three-dimensional azobenzene functionalized covalent organic framework intelligent response material. According to the invention, the azobenzene functionalized covalent organic framework material with a bcu topological structure is synthesized; the material has excellent photostimulation response CO2 adsorption performance; reversible control of CO2 adsorption capacity can be realized through ultraviolet light and heating conditions, at least five times of circulation can be maintained, and good circulation stability is achieved.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The invention discloses an all-solid-state composite dry conductive agent and a preparation method thereof, and belongs to the technical field of batteries. The all-solid-state composite dry conductive agent is prepared by the following steps: uniformly mixing carbon nanotubes, high-dispersion carbon black and graphene to obtain a primary mixture; then preparing a uniformly dispersed glue solution from the composite dispersant and water; and then adding the primary mixture into the glue solution, uniformly mixing, sanding, homogenizing, drying and crushing to obtain the product, the high-dispersion carbon black is obtained by oxidizing carbon black to form active groups such as carboxyl and hydroxyl on the surface of the carbon black, halogenating acyl and then reacting with lithium 2, 5-diaminobenzene sulfonate. The preparation method comprises the following steps: grafting histidine ester into carboxymethyl cellulose by using propylene glycol diglycidyl ester as a cross-linking agent, then introducing allyl-1, 3-sultone, then copolymerizing with lithium 2-acrylamido-2-methylpropanesulfonate and 3-aminobenzoic acid allyl ester protected by fluorenylmethoxycarbonyl, and then deprotecting to obtain the composite dispersant.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The invention discloses an implantable absorbable PLA composite material and a preparation method thereof, and relates to the technical field of medical materials. The implantable absorbable PLA composite material is prepared from the following raw materials in parts by weight: 60 to 70 parts of PLA, 5 to 10 parts of poly (lactic-co-glycolic acid), 8 to 12 parts of polycaprolactone, 5 to 8 parts of modified hydroxyapatite, 2 to 3 parts of a toughening agent and 0.2 to 0.6 part of an antioxidant, the toughening agent is prepared by the following steps: reacting hydroxyethyl methylacrylate with ethylenediamine to prepare a four-arm compound, reacting the four-arm compound with 1-chloro-4-isocyanatobutane to prepare an isocyanate compound, and finally reacting the isocyanate compound with polyethylene glycol. The implantable absorbable PLA composite material prepared by the invention has excellent tensile property and impact resistance, and can meet the application requirements of clinical medical treatment.

The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

The invention discloses a heat dissipation type anti-corrosion coating and a preparation method thereof, and belongs to the technical field of anti-corrosion coatings. The heat dissipation type anticorrosive paint comprises a component A and a component B, wherein the component A comprises the following components in parts by mass: 100 parts of heat-conducting water-borne epoxy resin, 4-6 parts of graphene, 0.3-0.5 part of an antioxidant, 0.2-0.4 part of a defoaming agent, 0.2-0.4 part of a flatting agent and 10 parts of first deionized water; the component B comprises the following components in parts by mass: 10-20 parts of a curing agent, 40-60 parts of a toughening agent, 4-6 parts of functionalized boron nitride microspheres and 30-50 parts of second deionized water; the heat-conducting water-borne epoxy resin is 1, 5-naphthalene diphenol modified water-borne epoxy resin; the curing agent is an aromatic amine curing agent; the toughening agent is obtained by carrying out copolymerization on acrylamide, N-(4-aminophenyl) acrylamide, 1, 3, 5-triacryloyl-s-triazine and 3-dimethylamino allyl phosphoric acid; the functionalized boron nitride microspheres are boron nitride microspheres modified by 4-aminobenzoic acid.

A cosmetic containing (A) an alkali metal salt of an alkanoyl N-methyltaurine having an alkanoyl group having 8-20 carbon atoms, (B) a plant extract, (C) one or more compounds selected from the group consisting of compounds represented by general formula (1) and pharmacologically acceptable salts thereof, and (D) water (in general formula (1), R1, R3, R4 and R6 are each independently an alkyl group having 1-3 carbon atoms, R2 is an alkyl group having 1-3 carbon atoms, and R3 is an alkyl group having 1-3 carbon atoms; and R2 and R5 each independently represent a hydrogen atom or an alkyl group having 1-3 carbon atoms. ). # imgabs0 #

The invention discloses a preparation method of an optical OCA (Optical Clear Adhesive) and application of the optical OCA in a mobile phone folding screen, and relates to the technical field of optical cement, the optical OCA is prepared from the following raw materials in parts by weight: 50 parts of acrylate prepolymers, 2-4 parts of 3-allyl-2-mercapto-3H-quinazoline-4-ketone, 1-3 parts of diallyl disulfide, 1-3 parts of 3-[N, N-dimethyl formamide], 1-3 parts of 2, 3, 5-trimethyl-1, 3-pentanediol monoisobutyronitrile, 1-3 parts of 2, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3 The preparation method comprises the following steps: adding 3-5 parts of N, N-dimethyl-[2-(2-methylpropane-2-enoyloxy) ethyl] ammonium] propane-1-sulfonic acid inner salt, 1-3 parts of allyl succinimido carbonate, 2-4 parts of dicyclopentene methacrylate, 1-3 parts of 1, 3, 5-triacryloyl hexahydro-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5- The invention relates to a graphene quantum dot photoinitiator which is prepared from the following components in parts by weight: 1-3 parts of 1, 3, 5-triazine, 0.8-1.2 parts of a photoinitiator, 1-3 parts of an aziridine cross-linking agent, 1-3 parts of graphene quantum dots, 0.8-1.2 parts of a coupling agent and 40-50 parts of a diluent. The optical OCA adhesive is high in light transmittance and bonding strength, good in weather resistance and excellent in folding resistance.

The invention discloses a preparation method of a grafted and substituted thiophene polymer material, which comprises the following steps: mixing poly (3-hexylthiophene), a grafting monomer, a catalyst and an auxiliary agent, and heating for reaction to obtain the grafted and substituted thiophene polymer material, the structural formula of the grafting monomer is as shown in formula (I); wherein B is fluorine, chlorine, bromine or iodine, A is a carbon atom or a nitrogen atom, and R is cyano, formyl, methoxycarbonyl or; according to the method, pre-synthesis of complex functional monomers is avoided, the main chain of the poly (3-hexylthiophene) can be directly modified without using an expensive catalyst or ligand, the polymerization reaction of the poly (3-hexylthiophene) is not interfered, and meanwhile, the method has the advantages of simplified steps and low cost.

The invention relates to alkali-soluble light-cured resin and a preparation method thereof, a light-cured resin composition, a photosensitive dry film and a semiconductor device. The structural formula of the alkali-soluble light-cured resin is shown as a formula (I) or a formula (II), wherein in the formula (I), R1 is selected from one of a single bond, an oxygen atom, a sulfonyl group and an organic group with 1-30 carbon atoms; in the formula (I) and the formula (II), n is a natural number greater than or equal to 0; r2 is selected from organic groups with 1-50 carbon atoms; r3 is selected from an aromatic organic group or an aliphatic organic group; r4 is selected from organic groups containing unsaturated carbon-carbon double bonds; and R5 is selected from carboxyl-containing organic groups. A molecular chain of the alkali-soluble light-cured resin contains a photosensitive group, an imide structure and an alkali-soluble group, on one hand, the thermal mechanical property of the alkali-soluble light-cured resin can be enhanced, and on the other hand, the alkali-soluble light-cured resin can form a uniform and stable resin glue solution in a solvent, so that the comprehensive performance of the alkali-soluble light-cured resin is improved.

The invention relates to the technical field of biomedical materials, and discloses a thrombectomy stent support material and a preparation process thereof, the thrombectomy stent support material comprises the following components by mass: 60-70% of a polysebacic diglyceride prepolymer; 25-35% of a dynamic covalent bond cross-linking agent; 5%-10% of carboxylated nano-diamond; 3 to 5 percent of temperature-sensitive and photo-thermal dual-response microspheres; the dynamic covalent bond cross-linking agent is composed of 4-formyl phenylboronic acid and hexamethylenediamine according to a molar ratio of 1: (1-3); the microsphere is prepared from poly (N-isopropylacrylamide), a gold nanorod and a recombinant tissue type plasminogen activating agent, and by combining a low-temperature 3D printing technology, the material can form a complex bionic structure, the mechanical strength is dynamically adjusted along with the physiological environment after implantation, and the material is safely degraded after functions are completed. The material is suitable for the scenes of cardiovascular and cerebrovascular stents, bone repair instruments and the like, has treatment accuracy, manufacturing suitability and clinical safety, and solves the problems of non-degradability, sudden drug release, mechanical mismatch and the like of traditional implants.

A photoinitiator including 2 to 6 monoacyl phosphine oxide moieties characterized in that the monoacyl phosphine oxide moieties are linked to each other via their acyl group and that at least 2 monoacyl phosphine oxide moieties have a chemical structure differing in the phosphine oxide part.

The invention discloses a recombinant halomonas for producing polyhydroxyalkanoate as well as a construction method and application of the recombinant halomonas. The recombinant halomonas comprises an exogenous gene, the exogenous gene comprises a combination of an aldD gene, a dhaT gene and an orfz gene, and the recombinant halomonas weakens the expression of an endogenous prpc gene. According to the invention, a P34HB synthesis route is successfully constructed through a synthesis route of exogenous introduction from 1, 4-butanediol (BDO) to 4-hydroxybutyryl coenzyme A, the proportion of each monomer in the copolymer can be effectively regulated and controlled, especially after exogenous addition of short-chain fatty acids (such as formic acid, acetic acid, propionic acid, butyric acid and the like), the synthesis of copolymers such as PHB, PHBV, P34HB, P34HB3HV and the like can be further improved, and the synthesis efficiency of the copolymer is improved. And the proportion of different monomers is adjusted, so that the diversity and yield of the copolymer are enhanced.

The invention discloses a fluorescent covalent organic framework material for hydrogen sulfide detection as well as a preparation method and application thereof, relates to a covalent organic framework material as well as a preparation method and application thereof, and aims to solve the technical problems that an existing porous material for H2S detection is few in structure type, unstable in COFs (Covalent Organic Frameworks) structure, high in detection limit and harsh in detection environment. The periodic structure fragment of the fluorescent covalent organic framework material for hydrogen sulfide detection is shown in the specification. 3-(5, 10-diamino-1H-phenanthrene) [9, 10-d] imidazole-2-yl) phenol and 2, 4, 6-tri (4-formylphenoxy)-1, 3, 5-triazine are subjected to a reaction to obtain a hydroxyl intermediate, the hydroxyl intermediate is modified with 2, 4-dinitrofluorobenzene, and the fluorescent material is used for qualitative detection of H2S. The method is not interfered by amino acids and anions in the environment, and is not influenced by an acid-base environment. The method can be used in the field of H2S detection.

The invention discloses a perovskite precursor solution containing substituted aromatic ring group sulfonic acid, which comprises a perovskite material, an additive and an organic solvent, the additive is aromatic ring group sulfonic acid with a substituent group or a salt thereof, the aromatic ring is a benzene ring, a naphthalene ring or a pyrene ring, and the substituent group is one or more of H, halogen, C1-C4 alkenyl and C1-C4 alkyl. Polycyclic aromatic hydrocarbon (such as benzene, naphthalene and pyrene) is used as a framework, one sulfonic acid group instead of a sulfonyl group is introduced, and uncoordinated type defect passivation is realized through bonding with Pb < 2 + >; meanwhile, the electron push-pull characteristic of the substituent group is utilized, the Lewis acid-base amphoteric property is exerted, passivation of various types of defects is achieved, anchoring and passivation of multiple sites are achieved, the defects of the perovskite active layer can be remarkably reduced, non-radiative recombination can be reduced, and the performance and stability of the prepared perovskite solar cell in the large-scale preparation process are further improved.

The invention belongs to the field of functional composite materials, and particularly relates to low-viscosity and high-dispersity aluminum oxide slurry and a preparation method thereof.The low-viscosity and high-dispersity aluminum oxide slurry is prepared from a newly-designed phosphono-carboxyl block copolymer and biquaternary ammonium salt polyether silane as composite modifiers; and efficient anchoring and stable dispersion of the surfaces of alumina particles are realized through the synergistic effect of molecular structures. The phosphono-carboxyl block copolymer is prepared through controllable polymerization and deprotection reaction, and strong chemical bonding is formed between a phosphono group and the surface of aluminum oxide; the biquaternary ammonium salt polyether silane is subjected to click chemical synthesis, and electrostatic adsorption of quaternary ammonium salt and the steric hindrance effect of a polyether chain are combined. When the slurry is prepared, the two modifiers are sequentially added into water, the aluminum oxide powder is added after the pH value is adjusted, finally, the isobutylene maleic anhydride copolymer and the defoaming agent are introduced, and the slurry is obtained through vacuum defoaming and filtering. The slurry prepared by the method has the characteristics of high solid content, low viscosity and good dispersion stability.

The invention discloses a low-temperature-resistant working electrolyte for a liquid capacitor and a preparation method of the low-temperature-resistant working electrolyte, and relates to the technical field of electrolytes for capacitors. The low-temperature-resistant working electrolyte is prepared from the following raw materials: ethylene glycol, an auxiliary solvent, a solute, ammonium hypophosphite, a synergist, a stabilizer, 1-ethyl-3-methylimidazolium bis (trifluoromethylsulfonyl) imine, boron nitride nanosheets and 2, 2, 2-trifluoroethyl acrylate. According to the invention, while the auxiliary solvent with a specific proportion is added, the synergist capable of improving the conductivity, the cycle life, the low-temperature ion mobility and the low-temperature power density and the 2, 2, 2-trifluoroethyl acrylate capable of further improving the electrochemical performance stability at the low temperature are also introduced, so that the low-temperature electrochemical performance of the lithium ion battery is improved. And a specific preparation method capable of preventing agglomeration and improving the smoothness of an ion conduction path is combined. Therefore, the electrolyte is more excellent in chemical performance at low temperature and wider in application prospect.

A composite membrane for desalination includes a polyethylene terephthalate (PET) nonwoven layer having a fibrous structure, and has an average thickness of about 30 to 200 micrometers (μm). A polysulfone (PS) layer having an average thickness of about 30 to 100 μm is disposed on a surface of the PET nonwoven layer. Further, a polyamide layer is disposed on a surface of the PS layer including reacted units of an acyl compound, a phenylenediamine monomer, and a poly-(DADMAC-co-DADA). The polyamide layer has a rough surface including a plurality of irregular-sized ridge-and-valley structures of polyamide. The poly-(DADMAC-co-DADA) has a formula (I), and n is a positive integer.

The present invention discloses a naphthalimide guanidine derivative, a preparation method thereof and an application thereof. The structural formula of the naphthalimide acyl guanidine compound is shown as formula (I), denoted as CAUZL-C; in formula (I), R is halogen, hydrogen, piperidyl or dimethylamino; n is 1, 2, 3 or 4. The naphthalimide guanidine derivative or a pharmaceutically acceptable salt thereof according to the present invention has good target enzyme inhibitory activity and insecticidal activity.

A photocurable resin composition for nails or artificial nails, contains the following components (A) to (D): a component (A): a urethane (meth)acrylate oligomer, a component (B): a monomer selected from the group consisting of a (meth)acrylate monomer, a (meth)acrylamide monomer, and (meth)acrylic acid (excluding the component (A)), a component (C): polyglycerol having no (meth)acryloyl group and / or a compound having a polyglyceryl ether skeleton having no (meth)acryloyl group, a component (D): a photoinitiator. A molecular weight of the component (C) is 200 or more.

A composition comprising an expanded population of cells can be used in therapy, wherein the cells have been expanded by a method comprising: i) obtaining an isolated population of HSPCs; ii) culturing the isolated population of HSPCs in the presence of a histone deacetylase inhibitor (HDAC inhibitor) to form a cultured population; iii) adding to the cultured HSPC population an aminothiol compound having the formula RNH (CnH2n) NH (CnH2n) SX wherein R is hydrogen, an aryl group, an acyl group or an alkyl group containing from 1 to 7 carbon atoms, each n having a value of from 2 to 6, and X is H or PO3H2 to form expanded cells; or a pharmaceutically acceptable salt thereof.

The invention discloses a preparation method and application of a sulfonylurea structure thermosensitive color developing agent, and relates to the technical field of color developing agents. The core of the thermosensitive color developing agent is a # imgabs0 # compound in a formula 1 containing a sulfonylurea structure. The preparation method comprises the following three steps: synthesizing an intermediate 1 through esterification of raw materials, obtaining an intermediate 2 through boric acidification, and synthesizing a target compound through Suzuki reaction. Through the synergistic effect of sulfonyl and ureido, hydrogen bond network regulation and electron transfer efficiency optimization are realized, and the technical bottlenecks of high-temperature activation requirements and insufficient color development stability of a traditional thermosensitive color developing agent are solved.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 3-sulfamoyl benzamide compound as well as a preparation method and application thereof. The 3-sulfamoyl benzamide compound has a structure as shown in a formula I. In the formula I, X is chlorine or trifluoromethyl; r1 and R2 are independently C1-4 alkyl or R1, R2 and N atoms connected with R1 and R2 jointly form a heterocyclic group, and the heterocyclic group is a substituted or unsubstituted five-membered or six-membered heterocyclic group; and when the heterocyclic group is a substituted heterocyclic group, the substituent group in the substituted heterocyclic group is one or more of C1-4 alkyl, phenyl and acetyl. The 3-sulfamoyl benzamide compound disclosed by the invention has a remarkable proliferation inhibition effect on HCT116 colon cancer cells, HeLa human cervical cancer cells, MDA-MB-231 human breast cancer cells and A375 human malignant melanoma cells.