88 results about "Sulfamide" patented technology

The invention discloses a low-temperature zinc ion battery high-entropy eutectic electrolyte and a preparation method and application thereof, and relates to the field of batteries, the electrolyte comprises a hydrogen bond donor, a hydrogen bond acceptor and a solvent; the hydrogen bond donor is at least one of methyl sulfonamide, thioformamide, butyramide, asparagine, tert-butylamine, dimethyl propane diamine, oxalyl diamine, benzamide, sulfamide and ethyl sulfonamide; the hydrogen bond receptor is at least one of aspartic acid, glutamic acid, methionine, zinc chloride, zinc perchlorate, zinc fluoborate and zinc acetate; the preparation method comprises the following steps: mixing a hydrogen bond donor and a hydrogen bond acceptor, and heating to convert a solid into a liquid phase; and adding a solvent, and uniformly mixing to obtain the product. The invention also provides a zinc ion battery containing the electrolyte. The high-entropy eutectic electrolyte has the beneficial effects that-NH2 and halogen or carboxyl form hydrogen bonds to perform eutectic reaction, the freezing point of the eutectic solution is lower than that of a reactant, and the solvent is added to improve the confusion degree of the electrolyte, so that the high-entropy eutectic electrolyte is prepared.

The present invention (named: a class of aminonaphthoquinone derivatives and their preparation and sterilization, weeding and algae killing uses) relates to 33 2-chloro-3-aminonaphthoquinone formate, urea, amide and sulfonamide derivatives and their preparation methods, as well as their uses in sterilization, weeding and algae killing. The 33 2-chloro-3-aminonaphthoquinone formate, urea, amide and sulfonamide derivatives are generated by reacting 2,3-dichloronaphthoquinone with potassium cyanate, substituted alcohol or amine, or with sulfonamide; or by reacting 2-chloro-3-aminonaphthoquinone with different amides. These compounds can be used as fungicides to control tomato gray mold, or as herbicides to control weeds such as Amaranthus retroflexus and Crabgrass, or as algaecides to control algae.

The invention provides a sodium ion battery without a negative electrode, which adopts sodium ferric phosphate as a positive electrode active material and does not contain a negative electrode active material. According to the negative-electrode-free sodium ion battery, the electrochemical performance, the cycling stability and the safety of the battery are remarkably improved, and the conductivity and the charge transmission efficiency of the positive electrode material are improved. The surface of the negative electrode current collector is roughened, so that the surface area and active sites are increased, and the deposition efficiency and stability of sodium ions are improved. Additives such as sulfamide-grafted nano-diamond are added into the electrolyte, so that the conductivity and the electrochemical stability of the electrolyte are optimized. Meanwhile, by adjusting the concentration of the sodium hexafluorophosphate sodium salt electrolyte, the proportion of the cyclic organic ether solvent and the mass ratio of the small organic molecule additive to the inorganic sodium salt additive, the electrochemical performance and the thermal stability of the battery are improved.

The invention provides a method of reducing dinitrogen to produce ammonia, the method comprising: contacting a cathode of an electrochemical cell with an electrolyte comprising: (i) a metal cation selected from the group consisting of lithium, magnesium, calcium, strontium, barium, zinc, aluminium, vanadium and combinations thereof, wherein the metal cation is present at a concentration of greater than 0.5 mol / L in the electrolyte, (ii) one or more anions comprising at least one negative ion selected from the group consisting of fluorinated sulfonyl imides, fluorinated sulfonyl methides and combinations thereof, (iii) a proton carrier; and (iv) optionally, at least one phosphonium cation, wherein the combined amount of the metal cation and the optional at least one phosphonium cation is greater than 1 mol / L in the electrolyte; supplying dinitrogen to the electrochemical cell for cathodic reduction; and applying a potential at the cathode sufficient to reduce the dinitrogen, thereby producing ammonia.

Mcl-1 selective inhibitors, Bcl-2 selective inhibitors, and Mcl-1 / Bcl-2 dual inhibitors and methods of using the same for the treatment of disease are disclosed.

An endocyclic thiamidoamide-arylamide compound and a pharmaceutical composition comprising said compound are described, as well as the use of the same or of the pharmaceutical composition in the treatment of hepatitis B. In particular, a compound that can be used as an inhibitor of HBV replication and that has the structure shown in chemical formula (L), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, is described.

The invention belongs to the field of organic synthesis, and relates to a method for synthesizing beta-sulfamide. According to the method, primary amine and alkenyl sulfonyl fluoride are used as raw materials, silica gel is used as a catalyst, and a reaction is carried out in a solvent to generate the beta-sulfamide compound. Compared with a traditional method for synthesizing beta-sulfamide through a multi-step reaction, the beta-sulfamide synthesis method is easy and convenient to operate, mild in condition, low in reagent cost, easy to obtain, high in reaction yield and wide in substrate application range. The invention also discloses an application of beta-sulfamide compounds synthesized from primary amine and alkenyl sulfonyl fluoride under a silica gel catalysis condition in drug modification.

The invention discloses a pyrimidine derivative containing a thiosemicarbazide structure and application of the pyrimidine derivative, and relates to the technical field of medicines, the compound has good oxidation resistance and alpha-glucosidase resistance activity, and the compound is 2-(4, 4 '-difluorophenyl)-2-(4, 4'-difluorophenyl)-2-(4, 4 '-difluorophenyl)-2-(4, 4' The IC50 values of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on DPPH (1, 1-diphenyl-2-picrylhydrazyl) scavenging activity and ABTS (2, 2, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide are 3.96 mu g / mL and 2.01 mu g / mL respectively, the IC50 value of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on alpha-glucosidase inhibitory activity is 38.62 mu g / mL, the effect is best, and the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1 The pyrimidine derivative containing the thiosemicarbazide structure has a general formula shown in the specification, and is superior to control medicaments such as vitamin C, vitamin E and acarbose.

The invention discloses an industrial production method of a quinoline mercaptoacetic acid sulfonamide compound, which comprises the following steps: carrying out condensation reaction on an intermediate D-3 and methyl sulfonamide under the action of a condensing agent, concentrating under reduced pressure until no liquid flows out after the reaction is finished, adding acid, separating out a large amount of solid, filtering, pulping a filter cake with purified water, filtering and drying to obtain the quinoline mercaptoacetic acid sulfonamide compound. A compound D is obtained. The problems that in the prior art, the reaction yield is low, starting material impurities are contained, and the process is complex are solved, and the prepared compound D is low in cost, simple in process operation, high in yield, stable in quality and suitable for large-scale industrial production.

This invention discloses 2'-hydroxy-4,4',6'-trimethoxychalcone and 5,7,4'-trimethoxyflavanone sulfonamide derivatives, their synthesis methods and applications, belonging to the field of pharmaceutical technology, and involving two series of compounds: 3-sulfonamido-2'-hydroxy-4,4',6'-trimethoxychalcone and 8,3'-disulfonamido-5,7,4'-trimethoxyflavanone, and their preparation methods. Starting with 2-hydroxy-4,6-dimethoxyacetophenone and p-anisaldehyde or 4-methoxy-3-nitrobenzaldehyde, 2'-hydroxy-4,4',6'-trimethoxychalcone or 3-amino-2'-hydroxy-4,4',6'-trimethoxychalcone intermediates were synthesized via the Claisen-Schmidt reaction. Then, through sulfonation and intramolecular Michael addition reactions, 2'-hydroxy-4,4',6'-trimethoxychalcone and 5,7,4'-trimethoxyflavanone sulfonamide derivatives were synthesized. The preparation method is simple, mild, and yields high results. In vitro and in vivo activity tests show that the derivatives disclosed in this invention have significant in vitro inhibitory activity against gastric cancer, esophageal cancer, colorectal cancer, and lung cancer cell lines, acting as inhibitors of the protein YBX1 / RPN1. Clinically, they can be applied to targeted therapy for cancers such as gastric cancer, esophageal cancer, colorectal cancer, and lung cancer.

The invention relates to an internal sulfonamide compound and a preparation method thereof. The invention relates to a preparation method of a sulfamide compound, which comprises the following steps: mixing an aminomalonic acid diethyl ester compound or an N-benzyl malonic acid monomethyl ester monoamide compound, a beta-aryl vinyl sulfonyl fluoride compound and MS, adding a solvent and a base catalyst, reacting at room temperature for 12-24 hours, separating and purifying to obtain the amide compound. The sulfamide compound and the preparation method thereof have the advantages of being simple in method, free of transition metal catalysis, wide in substrate range, mild in reaction condition, good in universality and the like.

Disclosed is a pharmaceutical composition for treatment of Parkinson's disease comprising N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide represented by formula (1) or a pharmaceutically acceptable salt thereof.

Compounds of formula I, that modulate DCAF15 and induce RBM139 protein degradation, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with RBM39 protein activity and DCAF15 modulation are described herein.

The present invention discloses a sulfur-containing amide type organic molybdenum compound and its preparation method and application, which belongs to the technical field of lubricating additives. The structural formula is as follows: #imgabs0# wherein R1 is a C2-C3 straight chain or branched alkyl group, R2 is a C8-C 26 Straight-chain or branched alkyl; a sulfur-amide-type organic molybdenum compound prepared by the present invention can be used as a lubricating grease additive, has good tribological properties, and can significantly improve the friction-reducing and anti-wear properties of lubricating grease.

The application provides a preparation method of a pyrimidine sulfamide compound, and the method overcomes the defects of the prior art, such as the need of using an excessive strong base, low conversion efficiency, and more by-products, and the like, and the method is characterized in that the pyrimidine sulfamide is generated through the reaction of the combined action of a molecular sieve and a catalyst, the reaction condition is mild, the step is economical, the environment is friendly, the comprehensive production cost is low, the raw material is easy to obtain, the environment is friendly and economical, and the method is beneficial to the industrialized production of the pyrimidine sulfamide compound.

The invention relates to application of a sulfonamide compound or a pharmaceutical composition containing the sulfonamide compound in preparation of a medicine for treating pulmonary edema. The medicine has a prominent curative effect on pulmonary edema by inhibiting NKCC1 targets of lungs and is high in safety, so that adverse effects such as electrolyte disorder caused by potent diuretics are reduced, and the medicine is a better new medicine for clinically treating pulmonary edema.

The invention discloses a modified nylon composite flame retardant and a preparation method thereof, and the preparation method comprises the following steps: mixing agmatine and sulfuric acid according to a ratio of 1: 1, adding ethanol, heating and stirring, and carrying out rotary evaporation to remove a solvent to obtain agmatine sulfate; then, 4, 4 '-diaminodiphenyl sulfone and phenylphosphoryl dichloride are dissolved in acetonitrile, and after a reaction, a phosphorus-sulfur composite flame retardant is obtained; then mixing brominated polystyrene and antimony trioxide according to a ratio of 3: 1, adding a dimethyl sulfoxide solvent, and stirring to obtain a bromine-antimony composite flame retardant; and finally, mixing all the components with the long glass fiber, performing high-speed stirring and twin-screw extrusion melt blending, and performing cooling and pelletizing molding. The agmatine sulfate can provide gas-phase flame retardance, the phosphorus-sulfur composite flame retardant generates a carbon layer to enhance solid-phase flame retardance, and the bromine-antimony composite flame retardant synergistically delays flame propagation, so that the flame retardance stability and durability of the nylon composite flame retardant are improved, and the long-term use safety in a high-temperature environment is ensured.

The invention discloses a low-dielectric-loss chemical silver plating solution and a preparation method thereof. Each liter of the chemical silver plating solution comprises the following components: 0.2-10 g of soluble silver salt, 15-35 g of a complexing agent, 0.1-2 g of soluble nickel salt, 5-25 g of a reducing agent, 0.5-3 g of a stabilizer, 0.5-3 g of a brightener and the balance of water and a pH regulator. The complexing agent comprises at least one of carboxyl polyethylene glycol sulfamide and sodium 2, 3-dimercaptopropanesulfonate. The pH value of the prepared low-dielectric-loss chemical silver plating solution is weak acidity, the low-dielectric-loss chemical silver plating solution is good in compatibility and high in stability, very high stability can be kept after multi-period plating, and meanwhile a prepared silver plating layer is flat and uniform, has good thickness and white and bright metal luster and has high hardness and good wear resistance.

The invention relates to the field of chemical engineering, in particular to a detergent for lubricating oil and a preparation method of the detergent. The clearing agent for the lubricating oil is prepared from the following raw material components in parts by weight: 35 to 45 parts of lubricating oil base oil, 15 to 25 parts of a composite purification dispersant, 2 to 6 parts of a clearing agent, 10 to 20 parts of diluent oil, 3 to 7 parts of a copolyamide compound and 2 to 8 parts of ethylene glycol monobutyl ether, the composite purification dispersant is prepared by compounding a modified amide auxiliary agent and modified sulfamide in a mass ratio of (1-1.5): 1. The prepared copolyamide compound, the modified amide auxiliary agent and the modified sulfamide have excellent dispersing capacity on components generated in the process of oxidizing the lubricating oil into sludge, solid particles and other pollutants, and can particularly disperse the solid particles in the lubricating oil and prevent the solid particles from gathering and precipitating; meanwhile, acid-base balance of the lubricating oil can be maintained, and a good cleaning effect is achieved.

The application discloses a sulfonamide compound, a preparation method and application thereof. The compound can selectively antagonize a human and mouse NOD1 signal path, can inhibit secretion of inflammatory cytokines, and can be used for treating inflammatory diseases, in particular, gastritis caused by helicobacter pylori infection.

The present invention concerns the compound aprocitentan, {5-(4-bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-sulfamide:and its use as endothelin receptor antagonist, in combination with an SGLT-2 inhibitor. The invention further relates to pharmaceutical compositions comprising aprocitentan in combination with said SGLT-2 inhibitor. The invention further relates to such pharmaceutical compositions comprising crystalline forms of aprocitentan.

The application discloses a preparation method of cyclohexyl sulfonamide and belongs to the technical field of pharmaceutical chemical synthesis. The method comprises the following steps: bromocyclohexane and potassium thioacetate are added into a solvent, and a thioesterification reaction is carried out under stirring and heating in nitrogen protection, then cooling and diluting with water, and then extracting with ethyl acetate, and drying and concentrating to obtain cyclohexyl thioacetate; the cyclohexyl thioacetate, water and KCl are added into a reactor, and Oxone is added in batches, and the mixture is uniformly stirred to carry out an oxidation reaction, and then extracted with dichloromethane, and then dried and distilled to obtain cyclohexyl sulfonyl chloride; the cyclohexyl sulfonyl chloride is subjected to an amination reaction in an ammonia / THF system, and then recrystallized in a solvent to obtain cyclohexyl sulfonamide. The process has the advantages of easy availability of starting materials, mild conditions, high selectivity, and product HPLC purity of greater than or equal to 99.5%, and is suitable for laboratory research and development. The cyclohexyl sulfonamide prepared by the method can be used as a key intermediate of KRAS G12C inhibitor, and is used for laboratory synthesis and structure-activity relationship research of an antitumor targeted drug.

To provide a method for controlling harmful arthropods.SOLUTION: For example, a compound represented by the formula in the figure or its N-oxide is used for controlling harmful arthropods.SELECTED DRAWING: None

The present invention provides novel fluorinated cyclic derivatives of sulfonamides and sulfones useful in the treatment of various diseases and disorders associated with TRPML activity, such as neurodegenerative diseases, lysosomal storage diseases, muscular dystrophy, age-related common neurodegenerative diseases, oxidative stress or reactive oxygen substance (ROS)-related diseases, aging, etc. The invention also relates to a composition, a preparation method and application thereof.

The application belongs to the field of carbon dioxide photocatalytic materials, and relates to a spin catalytic material for promoting CO2 photocatalysis and a preparation method thereof. The material is a high-activity metal grid supramolecule obtained by a volatilization method from a ligand 2,2'-pyrazine dihydrazine methanesulfamide (pbd) and a metal salt. As a photocatalyst, the material can adjust multiple spin states on a single Fe site in the metal grid supramolecule to effectively promote a visible light driven CO2 reduction reaction (CO2RR). After 1h of irradiation, the CO2 to CO yield can reach 6.26mmol g ‑1 , which shows an effective strategy of designing spin-based photocatalysts through supramolecular assembly to promote artificial photosynthesis.

To provide a method for controlling harmful arthropods.SOLUTION: A compound represented by Formula (I) can control harmful arthropods. In the formula, Q represents a group represented by Formula Q1 (# represents the site of bonding to a sulfur atom, and the solid circle represents the site of bonding to Het) or the like, and Het represents a group represented by Formula Het1 or the like.SELECTED DRAWING: None

The invention discloses a battery cell, a lithium ion battery containing the same and electronic equipment. Electrolyte is injected into the battery cell by adopting a one-two injection scheme, the electrolyte comprises a one-injection electrolyte and a two-injection electrolyte, the two-injection electrolyte comprises bis (trifluoromethylsulfonyl) lithium imide and / or difluorosulfamide lithium, the content of bis (trifluoromethylsulfonyl) lithium imide and / or difluorosulfamide lithium is 1-10%, and the content of bis (trifluoromethylsulfonyl) lithium imide and / or difluorosulfamide lithium is 1-10%. The percentage is the mass percentage of the secondary injection electrolyte; and the positive electrode material layer of the positive plate of the battery cell comprises lithium iron phosphate and an overcharge-proof material. The battery cell is relatively good in safety performance and excellent in cycle performance.

The application discloses a 1, 2, 3-triazole sulfamide derivative, a preparation method and application thereof. The compound has a general formula (A). The synthesis method is as follows: sulfamide is used as a starting material, diazotization, azidation, and then coupling with ethyl acetoacetate to complete the docking of the triazole ring and the sulfamide, and an amide bond is introduced into the structure, and then a series of novel 1, 2, 3-triazole sulfamide derivatives are synthesized. The compounds have excellent bacteriostatic, insecticidal and fungicidal functions on escherichia coli, pseudomonas aeruginosa, salmonella typhi, staphylococcus aureus, bacillus subtilis, and fungi such as candida albicans and aspergillus niger, pests and plant pathogenic bacteria in forestry and other fields.