The invention belongs to the food drying and processing technical field, and particularly relates to a manufacturing method of a nostoc flagelliforme product. The manufacturing method comprises eight steps of culturing nostoc flagelliforme cells, scalding and blanching, beating to obtain a nostoc flagelliforme cell filtrate, blending, homogenizing, concentrating, sterilizing, and spray-drying. A culture medium added with a soil extraction liquid and a strontium solution with the mass concentration of 2 mg/L is inoculated with the nostoc flagelliforme cells, so that the absorption of the nostoc flagelliforme cells on strontium is greatly promoted, and besides, effects of prevention and treatment of cardiovascular diseases and promotion of human body health are played. With adopting of the spray drying method, the manufacturing method has the advantages of large evaporation area, fast drying speed, low material temperature, and easy continuous production; based on reservation of the material original nutritional organization composition and flavor to a greatest degree, the drying efficiency is greatly improved; and moreover, with utilization of the spray drying method, a nostoc flagelliforme cell slurry can be quickly dried into a powder, the powder collecting rate is high, the damage rate of the composition of the nostoc flagelliforme cells is reduced, and the original nutrients and flavor of the nostoc flagelliforme cells are relatively well maintained.