5439results about "Milk preparation" patented technology

The invention relates to application of breast milk oligosaccharides to improvement of intestinal flora of mothers and infants, in particular to application of 2 '-fucosyllactose to preparation of food which is taken by a mother and contributes to regulation of intestinal flora of the mother and offspring thereof, and the mother is in a gestation period and / or a lactation period. The invention is provided through a large amount of research; when a mother supplements a certain amount of 2 '-fucosyllactose in a gestation period and / or a lactation period, the abundance of beneficial bacteria in intestinal tracts of the mother can be remarkably improved, the content of harmful bacteria is reduced, meanwhile, the abundance of beneficial bacteria in intestinal tracts of filial generations of the mother is remarkably improved, and the content of harmful bacteria is reduced; particularly, the abundance of some beneficial bacteria which cannot be directly eaten in the intestinal tracts of the mother and the offspring can be adjusted.

The invention discloses a plant lactobacillus with a bacteriostatic effect and application of the plant lactobacillus. The lactobacillus plantarum is named as lactobacillus plantarum C07, the preservation number is CCTCC NO: M20242086, the preservation unit is China Center for Type Culture Collection, the preservation time is September 26, 2024, and the preservation address is Wuhan University, Wuhan University, No. 299, eight road, Wuchang District, Wuhan City, Hubei Province. The strain can produce lactic acid and indole-3-lactic acid at high yield, has a very strong antibacterial effect on multiple putrefying and pathogenic microorganisms such as staphylococcus aureus, escherichia coli, listeria monocytogenes, pseudomonas aeruginosa, salmonella and mould, and is a broad-spectrum antibacterial microorganism.

The invention relates to lactobacillus rhamnosus CBBM005 and application thereof in products for balancing intestinal flora, improving immunity and improving oral cavity, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus CBBM005 is separated from human intestinal secretion, the lactobacillus rhamnosus CBBM005 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation time is March 20, 2025, and the preservation number is CGMCC NO.33904. The lactobacillus rhamnosus CBBM005 has the characteristics of balancing intestinal flora, improving immunity and improving oral cavity.

The invention provides a yoghurt viscosity control method and device based on reinforcement learning, the method is applied to a control device comprising a data acquisition module and an edge processing unit, and the method specifically comprises the following steps: establishing a digital twinborn model of a demulsification process; environment parameters in the demulsification process are collected in real time, and a time sequence data set is constructed in combination with simulation parameters output by the digital twin model; based on a reinforcement learning algorithm, correcting the digital twinborn model according to the time sequence data set; based on the corrected digital twinborn model, generating a stirring control strategy in combination with a preset viscosity value; and adjusting stirring parameters in the demulsification process according to the stirring control strategy. On the basis of realizing efficient control of the yogurt viscosity through the digital twinborn model, the reinforcement learning algorithm is further introduced, so that the digital twinborn model is closer to reality, the accuracy of the output control strategy is guaranteed, and the control efficiency and accuracy of yogurt viscosity control are both considered.

A synergistic composition for improving the bioaccessibility of minerals comprises lutein, a casein phosphopeptide, or a 1, 3-dioleoyl-2-palmitic acid triglyceride, preferably in combination with one or more non-digestible oligosaccharides. These compositions are useful for the prevention and / or treatment of mineral deficiency and related conditions, preferably anemia, said minerals comprising iron and / or calcium.

The present invention relates to a nutritional composition, food and pharmaceutical products comprising the nutritional composition, and uses thereof. The nutritional composition comprises medium and long chain fatty acid triglycerides and breast milk oligosaccharides, and the weight ratio of the medium and long chain fatty acid triglycerides to the breast milk oligosaccharides is 1: 1 to 9: 1. The nutritional composition disclosed by the invention can play a role in synergistically promoting skeletal development and particularly improving bone mineral density.

The invention relates to the technical field of microorganisms, in particular to application of lactobacillus rhamnosus KF7 in improving intestinal barrier injury and regulating intestinal flora and functional food containing the lactobacillus rhamnosus KF7. The invention provides application of lactobacillus rhamnosus KF7 in preparation of a product for improving intestinal barrier injury and / or regulating intestinal flora. The preservation number of the lactobacillus rhamnosus KF7 is CGMCC (China General Microbiological Culture Collection Center) NO.6430. The invention further provides application of the lactobacillus rhamnosus KF7 in preparation of a product for improving intestinal barrier injury and / or regulating intestinal flora. The invention discloses the novel application of the caseus rhamnosus KF7 in the aspects of improving the normal intestinal epithelial barrier function, protecting the normal intestinal epithelial barrier from lipopolysaccharide induced barrier injury, recovering animal intestinal barrier injury caused by rhythm disorder, regulating intestinal flora disorder and improving growth, development and metabolic states for the first time. The method can be used for producing functional food products such as fermented milk, lactic acid bacteria beverages, probiotic powder, viable bacteria water, milk powder and cheese.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum 9A-2 and application thereof in preparation of products for regulating intestinal tracts and protecting eyes. A probiotic product is successfully researched and developed on the basis of the lactobacillus plantarum, and verification shows that the lactobacillus plantarum can continuously provide endophytic essential isorhamnetin, chromium and vitamin H in the intestinal reproduction and growth process while regulating intestinal flora balance and promoting digestion, and also has the effect of relieving visual fatigue; particularly, visual fatigue caused by eye related diseases is relieved. The endophytic essential quantity of isorhamnetin, chromium and vitamin H can be continuously provided in the intestinal reproduction and growth process by feeding 3 billion strains and 200 milligrams of metabolites of the strain every day, visual fatigue caused by eye related diseases can be prevented and relieved, and the body health can be kept.

The invention relates to the technical field of microorganisms, in particular to a lactobacillus kefir-producing subsp. Kefir W182 and application thereof. The preservation number of the lactobacillus kefir-producing subspecies is CGMCC No.27058, the preservation time is April 11, 2023, and the lactobacillus kefir-producing subspecies can survive for a long time in intestinal tracts, has a strong adhesion characteristic, can produce exopolysaccharides at high yield, can be used for fermenting dairy products, fruit juice, fruit puree, soybean milk and the like, and can also be used for preparing leavening agents and natural thickening agents. Especially when applied to fermented milk products, the fermented milk products can have rich flavor and very good viscosity without adding any existing thickening agent and emulsifying agent, can remarkably reduce separation of whey, can be stored for a long time, and have wide application in the field of food.

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

The invention relates to a nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and nervonic acid in a mass ratio of (3: 1)-(1500: 1), and has a synergistic effect in the aspects of preventing or relieving diarrhea, inhibiting staphylococcus aureus in vivo or in vitro and / or preventing or treating inflammation. The invention also relates to a food product comprising said nutritional composition. The invention also relates to application of the nutritional composition in preparation of products with one or more purposes selected from 1) to 3): 1) preventing or relieving diarrhea; 2) inhibiting staphylococcus aureus in vivo or in vitro; and 3) preventing or treating inflammation.

The present invention relates to the technical field of microorganisms. Disclosed are lacticaseibacillus paracasei and a postbiotic product prepared therefrom, and a use of both. The present invention provides lacticaseibacillus paracasei (Latin name) YJS05199, which has the preservation number of GDMCC No.63668, and was preserved in Guangdong Microbial Culture Collection Center on 19 July 2023. The present invention further provides a postbiotic prepared by applying the lacticaseibacillus paracasei. The lacticaseibacillus paracasei and the postbiotic prepared therefrom have a bacteriostatic effect, can inhibit the weight gain of a mouse fed with high-fat diets, reduce the adipose tissue weight and the blood glucose concentration, and can remarkably reduce the levels of TG, TC, and LDL-C in serum of the mouse. Thus, the lacticaseibacillus paracasei and the postbiotic prepared therefrom have great application prospects in preparation of products for preventing or treating obesity and related diseases or in preparation of bacteriostatic products.

The invention relates to milk capable of promoting calcium absorption and a preparation method thereof, and the preparation method comprises the following steps: (1) degreasing raw milk to obtain skimmed milk and single cream; (2) performing membrane treatment on the skimmed milk obtained in the step (1) to obtain membrane-treated milk; (3) mixing the membrane-treated milk obtained in the step (2) with the single cream obtained in the step (1) to obtain fat backfill milk; (4) mixing the sodium hyaluronate and the calcium beta-hydroxy-beta-methyl butyrate to obtain a premix; and mixing the premix with the fat backfill milk obtained in the step (3), and then performing homogenization treatment and sterilization treatment to obtain the milk capable of promoting calcium absorption. According to the preparation method provided by the invention, the technical effects of improving the stability of the milk and improving the mouth feel under the condition of not containing any food thickening agent and edible essence are realized, and the obtained milk has the functional effects of promoting calcium absorption and improving the bone mineral density at the same time.

The invention provides a genetically engineered bacterium for producing lactose-N-neotetraose as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium meets the following conditions: (1) exogenous expression of an MFS transport protein, beta-1, 3-N-acetylglucosamine transferase and beta-1, 4-galactosyl transferase is carried out; (2) carrying out overexpression on galactoside permease and UDP-galactose-4-epimerase (UDP-galactose-4-epimerase); and (3) not expressing or weakening the expression of the setA transporter. Through research, the applicant of the application finds that MFS transporter, beta-1, 3-N-acetylglucosamine transferase and beta-1, 4-galactosyl transferase are exogenously introduced into genetically engineered bacteria, so that the expression quantity of galactosidase and UDP-galactose-4-epimerase in a genome is enhanced, the expression quantity of setA transporter is reduced, and the expression quantity of setA transporter is reduced. The residual quantity of the LNT II in the LNnT synthesis route can be effectively reduced, and the fermentation yield of the LNnT is increased.

The invention provides a nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and a milk fat globule membrane in a mass ratio of (2: 1)-(97: 1), and the medium-chain and long-chain fatty acid triglyceride and the milk fat globule membrane have a synergistic effect in the aspects of promoting skeletal development, especially increasing bone mineral density and / or preventing or treating osteogenesis insufficiency and / or osteoporosis.

A breast milk-derived Limosilactobacillus fermentum MSJK0025 capable of improving the intestinal flora condition and the use thereof. The breast milk-derived Limosilactobacillus fermentum MSJK0025 is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No. 26426. The breast milk-derived Limosilactobacillus fermentum is a new strain isolated from breast milk of healthy puerperae, and is referred to as Limosilactobacillus fermentum MSJK0025. The strain has a good antibiotic sensitivity and stable inheritance of traits, has a good tolerance to acid, bile salts and artificial gastric / intestinal fluid, and has a fast growth rate and good safety. Furthermore, the strain has a strong intestinal colonization capability and can effectively inhibit intestinal pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Candida albicans, but has no inhibitory effects on intestinal probiotics such as Lactobacillus and Bifidobacterium.

Provided is a Bifidobacterium lactis. The Bifidobacterium lactis is Bifidobacterium animalis subsp. lactis BL-11, and the preservation number of the Bifidobacterium animalis subsp. lactis BL-11 is CGMCC No. 20847. The provided Bifidobacterium animalis subsp. Lactis can improve intestine metabolism disorder and normalize the composition of intestine microbiome so as to improve height, suppresses obesity, promote infant and youth physical development and mental development, and prevent and treat mental disorders, said mental disorders including anxiety, depression, attention-deficit / hyperactivity disorder, autism, schizophrenia, hepatic encephalopathy, anorexia, Tourette syndrome, and Asperger syndrome.

The invention discloses a nutritional composition. The nutritional composition comprises vitamin D, basic protein and lysine, wherein in the nutritional composition, the mass ratio of the vitamin D to the basic protein to the lysine is (0.005 to 0.020) to (70 to 200) to (1000 to 3000). The invention also discloses an application of the nutritional composition and a formula food containing the nutritional composition. According to the nutritional composition disclosed by the invention, the vitamin D, the basic protein and the lysine can be matched with one another, so that linear growth of bones of children and teenagers can be effectively promoted, bone health and bone strength can be enhanced, and height development can be promoted.

The invention relates to an optimization regulation and control technology for goat milk powder production process parameters, in particular to a self-optimization regulation and control method and system for the goat milk powder production process parameters. The historical production data comprises characteristic data of raw milk of historical batches, technological parameter data which are adopted for the characteristic data of the raw milk of the historical batches and cover key procedures of goat milk powder production, and retention level data of specific thermosensitive functional components in a final product produced by adopting the technological parameter data; the goat milk powder production key working procedures at least comprise a sterilization working procedure, a concentration working procedure and a drying working procedure. By recording the historical production data, obtaining the current raw material characteristics and determining the optimal historical batch based on similarity comparison and target screening, the problem that it is difficult to optimize and adjust process parameters according to raw material fluctuation and inter-process influence to improve the retention level of specific thermosensitive functional components in the prior art is effectively solved.

The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and / or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

The present invention relates to a whey protein product and a preparation method therefor. The product is derived from a whey protein-based protein composition, and the protein composition comprises at least a portion of whey protein degradation components, wherein protein components in the protein composition have a molecular weight distribution of: (i) the content of the protein component having a molecular weight of less than 5000 Da is 80-96% by mass; (ii) the content of the protein component having a molecular weight of 5000 Da to 10,000 Da is 0.5-10% by mass; and (iii) the content of protein component having a molecular weight of greater than 10,000 Da is 0-10% by mass, the content being the content of each of the three protein components in the total protein components based on dry weight.

The invention relates to the field of microorganisms, and discloses an aspergillus cristatus strain and application thereof. The preservation number of the aspergillus cristatus provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No.41727. The aspergillus cristatus provided by the invention can produce chymosin at high yield, has excellent curding activity and relatively low proteolytic activity, and can reduce the bitter taste of dairy products and improve the yield; the aspergillus cristatus provided by the invention not only can shorten the fermentation time of the dairy product, improve the cream flavor of the dairy product, reduce the peculiar smell of the dairy product, balance the sourness and sweetness of the dairy product and improve the cinnamon flavor, but also has intestinal colonization ability, and has the potential of improving the flavor level of the dairy product and becoming intestinal probiotics.

The invention relates to the technical field of dairy products, and particularly discloses a desalted whey product as well as a preparation method and application thereof. The method for preparing the desalted whey product comprises the following steps: (1) carrying out nanofiltration by taking natural whey or degreased sweet whey as a raw material to obtain nanofiltration trapped fluid with the dry matter content of 18-32 g / 100g; the pore diameter of the nanofiltration membrane is 200 Da to 1000 Da; (2) adjusting the pH value of the nanofiltration trapped fluid to 8-9 to obtain whey fluid after pH adjustment; and (3) performing electrodialysis on the whey liquid subjected to pH regulation to obtain desalted whey liquid. According to the preparation method disclosed by the invention, the loss rate of active protein in the raw materials can be reduced, so that the utilization rate of the raw materials is improved, and the obtained product is low in furosine content, high in proportion of undenatured protein and good in bioavailability.

The invention discloses bifidobacterium breve and application thereof in relieving Alzheimer's disease, and belongs to the technical field of probiotics. The preparation method comprises the following steps: separating 18 bifidobacterium strains from feces of children aged 0-3 years old, analyzing and identifying the 18 bifidobacterium strains including bifidobacterium longum, bifidobacterium breve and bifidobacterium animalis, and screening out the bifidobacterium breve LE4 with potential Alzheimer's disease relieving capacity through in-vitro oxidation resistance and LPS (Lipopolysaccharide) removal capacity. The method comprises the steps of behavioral experiments (nesting experiments, open field experiments and water maze experiments), histopathologic analysis, molecular biological detection and the like. The multi-target AD intervention effects of improving the cognitive function, reducing A beta deposition and tau protein phosphorylation, relieving neuroinflammation, enhancing synaptic plasticity, repairing intestinal barriers, adjusting intestinal flora and metabolites and the like of the LE4 strain are comprehensively evaluated, and a new strategy is provided for promoting AD micro-ecological treatment.

The invention belongs to the technical field of health-care food, and provides a composition containing ergothioneine and having sleep-aiding, whitening, anti-aging and anti-inflammatory effects and application thereof. The ergothioneine composition disclosed by the invention is prepared from ergothioneine, collagen peptide, carnosine, nicotinamide, an olive leaf extract and a chamomile extract. The components in the composition are matched for use, the synergistic effect is obvious, the whitening, anti-aging and anti-inflammatory effects are obviously improved, meanwhile, the composition also has a sleep-aiding effect, and the comprehensive performance is excellent.

The invention discloses horizontal rotary fermentation equipment for food processing and a fermentation method, and relates to the technical field of food processing ferment.The horizontal rotary fermentation equipment comprises a tank body, a feeding hopper, a discharging pipe, a barometer, an exhaust pipe and a pressure relief valve, the circumferential outer wall of the tank body is fixedly connected with a fixing frame, and a supporting frame is arranged below the tank body; the fixing frame is fixedly connected with the supporting frame, and a first stirring assembly and a second stirring assembly which are used for fully fermenting materials are arranged in the tank body. According to the invention, through the arrangement of the first stirring assembly and the second stirring assembly, under the synergistic effect of the driving force provided by the power assembly and the stirring direction changed by the reversing assembly, efficient stirring of materials is realized, and good conditions are created for fermentation; the defoaming assembly is arranged, so that the problem that the fermentation quality is influenced by excessive bubbles during stirring of traditional horizontal fermentation equipment is effectively solved, and the stability and high efficiency of the food processing and fermentation process are guaranteed on the whole.

The invention discloses application of Lactobacillus reuteri CCFM1289 with high yield of indoleacetic acid in relieving anxiety and depression, and belongs to the technical field of microorganisms. The Lactobacillus reuteri CCFM1289 can produce heteroauxin at high yield in vivo and in vitro, promote the yield of heteroauxin in fecal flora, relieve anxiety-like and depression-like behaviors of depression mice, relieve HPA hyperfunction, improve the level of brain-derived neurotrophic factor BDNF in hippocampus, promote secretion of 5-HTP and 5-HT in brain, improve the content of heteroauxin in colon, serum and brain, and improve the content of heteroauxin in colon, serum and brain. The compound can be used for improving intestinal flora metabolism imbalance, improving mRNA levels of hippocampal neurogenin-2, synapsin and post-synaptic dense protein 95, maintaining neuronal synaptic function stability, activating AHR signal channels, improving bicortin DCX expression and promoting neurogenesis so as to relieve depression mood, and can be used for drugs, health care products or healthy food for preventing and treating depression.

The invention discloses lactobacillus reuteri CCFM1288 for relieving depressive mood and application of the lactobacillus reuteri CCFM1288, and belongs to the technical field of microorganisms. The lactobacillus reuteri CCFM1288 has the tryptophan metabolism capability, and can survive for 7 days in the intestinal tract; after the lactobacillus reuteri CCFM1288 intervenes a depressive mouse, anxiety-like and depression-like behaviors of the mouse can be obviously relieved, flora alpha-diversity is improved, intestinal symbiotic bacteria are promoted to secrete indole substances, intestinal homeostasis is maintained, hypothalamic-pituitary-adrenal axis hyperfunction is relieved, dopamine and serotonin neurotransmitter nervous system functions are improved, and the effect of preventing and treating depression is achieved. The neurotransmitter release is promoted, and the anti-depression effect is achieved. In clinical tests, intervention of Lactobacillus reuteri CCFM1288 can significantly improve the depressive symptom of MDD patients, and a new safe alleviation approach is provided for depression treatment.

The invention discloses bifidobacterium longum subsp. Longum IMAU12449 and application thereof, belongs to the technical field of microorganisms, and provides the bifidobacterium longum subsp. Longum IMAU12449, the bifidobacterium longum subsp. Longum IMAU12449 is preserved in the China General Microbiological Culture Collection Center on July 8, 2024, the preservation address is No. 3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO. The preservation number is CGMCC (China General Microbiological Culture Collection Center) The invention provides application of the bifidobacterium longum subsp. Longum IMAU12449 in preparation of fermented cow milk and / or soybean milk. The bifidobacterium longum subsp. Longum IMAU12449 is used as a potential probiotic to prepare cow milk and soybean milk, and the prepared fermented milk is stable in viable count, moderate in acidity and free of whey precipitation.

The invention provides ACE (Angiotensin Converting Enzyme) inhibitory peptide, middle-aged and elderly formula goat milk powder and a preparation method thereof, goat milk is taken as a raw material, the goat milk is sterilized and cooled, compound protease consisting of three proteases is inoculated for constant-temperature enzymolysis, and the ACE inhibitory peptide is obtained through ultrafiltration, preparative chromatographic separation and freeze drying. And uniformly mixing the active peptide with a nutrition enhancer and goat milk powder required by the middle-aged and elderly people to obtain the active peptide goat milk powder for the middle-aged and elderly people. Or after the goat milk is subjected to enzymolysis by compound protease, directly adding a nutrition enhancer required by the middle-aged and elderly people, and then concentrating and spray-drying to obtain the formula goat milk powder for the middle-aged and elderly people. The ACE inhibitory peptide prepared by the invention can be used as a food functional factor, and the prepared formula goat milk powder for middle-aged and elderly people contains the ACE inhibitory peptide and has the function of assisting in lowering blood pressure.