10 results about "Peptostreptococcus" patented technology

The invention discloses an osthole derivative shown in a general formula 3 in the technical field of organic chemistry. The substituent group R of # imgabs0 is nitroimidazole, substituted nitroimidazole, nitrobenzimidazole or nitrotriazole; and n is 3 or 4. The invention further relates to application of the compound shown in the general formula 3 to preparation of antibacterial drugs independently or in combination with antibacterial active ingredients, and bacteria comprise any one of bacteroides fragilis, anaerobic peptostreptococcus, staphylococcus aureus and escherichia coli.

This invention belongs to the fields of bioinformatics and medical testing technology, specifically relating to a combination of biomarkers related to the postoperative prognosis of colorectal cancer and their application and prediction system. This invention, through 16S rRNA gene sequencing of tumor mucosal samples from colorectal cancer patients, combined with long-term postoperative follow-up data and screening, found that *Peptostreptococcus*, *Fusobacterium*, *Bacteroides*, *Porphyromonas*, and *Prevotella* are closely related to postoperative recurrence of colorectal cancer, with an AUC of 0.81 for assessing postoperative recurrence. Based on this, this invention conducts non-targeted metabolomics analysis, finding that combining alanine glutamate, putrescine, arginine, histidine, and sebacic acid with the above microbial biomarkers can improve the AUC to 0.91, significantly enhancing accuracy, specificity, and precision. This enables prognostic stratification of recurrence-free survival in colorectal cancer patients, demonstrating higher predictive efficacy and stability.

The application belongs to the technical field of biological detection, and particularly relates to a biomarker for idiopathic hyperaldosteronism and application thereof. The biomarker for idiopathic hyperaldosteronism is human intestinal microorganisms, and the human intestinal microorganisms include one or more combinations of Desulfovibrionales, Peptostreptococcaceae, Ruminococcus or Prevotellaceae. A diagnostic model constructed based on the biomarker (two or more of Desulfovibrionales, Peptostreptococcus, Ruminococcus or Prevotella) provided by the application can be used for auxiliary diagnosis of idiopathic hyperaldosteronism, and has high accuracy, excellent sensitivity and good specificity.

This invention belongs to the field of biomedical and analytical technology and provides an early screening model for esophageal cancer based on oral microorganisms and a method for constructing the same. [Solution] The early screening model uses the oral microbiome, including Prevotella, Granulicatella, Rothia, Prevotellamassilia, Blautia, Abiotrophia, Peptostreptococcus, Actinomyces, Burkholderia, Akkermansia, Fudania, Kineothrix, Bacillus, Duncanella, and Eisenbergiella, as markers. By identifying non-invasive biomarkers, asymptomatic esophageal cancer patients can be detected early.

The invention discloses a cervical cancer plasma circulating microbial marker combination, a reagent, a kit, a risk assessment model and application thereof, and belongs to the cross technical field of liquid biopsy and microbiomics. The cervical cancer plasma circulating microbial marker combination disclosed by the invention is prepared from prevotella, stenosiella, chlamydia trachomatis, peptostreptococcus, fusobacterium, campylobacter and haemophilus. Cervical cancer patients and healthy people are verified by using the cervical cancer plasma circulating microbial marker combination disclosed by the invention, the AUC value is 0.939, the sensitivity is 81.58%, the specificity is 90.00%, the accuracy is 85.29%, the positive predictive value is 91.18%, and the negative predictive value is 79.41%, so that the cervical cancer plasma circulating microbial marker combination disclosed by the invention can be used for effectively distinguishing the cervical cancer patients from the healthy people; the method is suitable for early screening of cervical cancer and has remarkable clinical screening application value.

The application discloses a cervical cancer plasma circulating microbial marker combination, a reagent, a kit, a risk assessment model and application thereof, and belongs to the technical field of liquid biopsy and microbiome. The cervical cancer plasma circulating microbial marker combination comprises Prevotella, Sneathia, Chlamydia trachomatis, Peptostreptococcus, Fusobacterium, Campylobacter and Haemophilus. The cervical cancer plasma circulating microbial marker combination is used for verifying cervical cancer patients and healthy people, and the AUC value is 0.939, the sensitivity is 81.58%, the specificity is 90.00%, the accuracy is 85.29%, the positive predictive value is 91.18%, and the negative predictive value is 79.41%, which indicates that the cervical cancer plasma circulating microbial marker combination can effectively distinguish cervical cancer patients from healthy people, is suitable for early screening of cervical cancer, and has significant clinical screening application value.

The invention belongs to the technical field of biological detection, and particularly relates to an idiopathic aldosteronism biomarker and application thereof. The idiopathic aldosteronism biomarker is a human body intestinal microorganism, and the human body intestinal microorganism comprises one or a combination of more of desulfurization vibrio, peptostreptococcaceae, ruminococcus and prevotella. A diagnostic model constructed on the basis of the biomarkers (two or more of devulcanivibrio, peptostreptococcus, ruminococcus or prevotella) provided by the invention can be used for auxiliary diagnosis of idiopathic aldosteronism, and is high in accuracy, excellent in sensitivity and good in specificity.

The invention belongs to the technical field of biological medicine and analysis, and provides an esophageal cancer early screening model based on oral microorganisms combined with oral health related behavior variables and a construction method thereof. The model is the following oral cavity microbial flora and oral cavity health related behavior variables: Prevotella, Granulicalala, Rothia, Prevotella, Blauria, Abiotrophia, Peptostreptococcus, Actinomyces, Burkholderia, Akkermansia, Fudania, Kineothrix, Bacillus, Duncaniella, Eisenbergiella, and a tooth brushing frequency, and the oral cavity health related behavior variables are selected from the group consisting of the following oral cavity microbial flora and oral cavity health related behavior variables. By identifying non-invasive biomarkers in combination with oral health related behavior variables, esophageal cancer patients without symptoms in the early stage can be found.

Existing studies have found various strains of bacteria that produce multiple tryptophan metabolites through various metabolic pathways. These strains include: Clostridium, Peptostreptococcus, Lactobacillus, and Bacteroides. However, the bacteria in the prior art for metabolizing tryptophan to produce indole derivatives have a single function. The present invention provides a Bacillus coagulans that can decompose sugars and produce indole derivatives, which can produce multiple tryptophan metabolites and be applied as probiotics in microecological preparations. The Bacillus coagulans was deposited at the General Microbiology Center of the China Microbial Culture Collection Center on June 21, 2022, with the deposit number: CGMCC NO. 25145.

To provide a novel biomarker of prostate cancer and a method for use thereof.SOLUTION: A method for testing prostate cancer includes the step (1) of detecting at least one biomarker selected from the group consisting of Alistipes, Rikenellaceae, Lachnospira, Aeromonas, Eggerthella, Kytococcus, Phascolarctobacterium, p-75-a5, Raoultella, Roseomonas, Syntrophococcus, Acidaminococcus, Anaerofilum, Atopobium, Blautia, Kocuria, Moryella, Peptostreptococcus, Propionispora, and Sebaldella in an enteric bacteria-containing sample taken from a subject.SELECTED DRAWING: None