The invention relates to a slow-release formulation containing 
sarafloxacin as antibiotic, which is slow-released injection or slow-released 
implant; the injection is composed of a slow-released 
microsphere and dissolvent; the slow-released 
microsphere contains a slow-released 
adjuvant and the antibiotic; the dissolvent is a special dissolvent containing suspending agent such as 
sodium carboxymethylcellulose, etc. and the 
viscosity of the dissolvent is 100cp-3000cp (at the temperature of 20 DEG C-30 DEC C); the slow-released 
adjuvant is selected from EVAc, polifeprosan, PLA, 
PLGA, 
sebacic acid copolymer, albumen glue, 
gelatin, etc.; the slow-released 
implant is prepared with the slow-released 
microsphere or by other methods. The slow-released 
implant can be partially placed or injected in a bacterial focus to release 
medicine on a partial 
disease focus for more than 10 days slowly; valid 
medicine concentration on the partial focus is obtained and maintained effectively, at the same time 
toxicity of an entire body is remarkably reduced. The slow-release formulation containing the 
sarafloxacin as the antibiotic has remarkable and special 
treatment effect on infection caused by 
staphylococcus, 
streptococcus, 
peptostreptococcus, 
propionibacterium acnes, 
enterobacter, 
tubercle bacillus, gonococci and meningococcus, etc., and particularly the partial focus such as 
chronic osteomyelitis, severe bedsore, 
refractory skin ulcer, 
diabetic foot, 
femoral head necrosis and various abscesses, etc..