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842 results about "Solvation" patented technology

Solvation describes the interaction of solvent with dissolved molecules. Ionized and uncharged molecules interact strongly with solvent, and the strength and nature of this interaction influence many properties of the solute, including solubility, reactivity, and color, as well as influencing the properties of the solvent such as the viscosity and density. In the process of solvation, ions are surrounded by a concentric shell of solvent. Solvation is the process of reorganizing solvent and solute molecules into solvation complexes. Solvation involves bond formation, hydrogen bonding, and van der Waals forces. Solvation of a solute by water is called hydration.

Gel suitable for implantation and delivery system

InactiveUS20050186240A1Readily and quickly rehydratableFacilitates cellular ingrowthPowder deliveryProsthesisHigh concentrationSolvation
The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce solvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.
Owner:KENSEY NASH CORP

11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines

The present inventors have developed a key intermediate for the production of C2 substituted PBDs, which has a leaving group at the C2 position, a carbamate protecting group at the N10 position and a protected hydroxy group at the C11 position. In a first aspect, the present invention comprises a compound with a the formula (I), wherein: R10 is a carbamate-based nitrogen protecting group; R11 is an oxygen protecting group; and R2 is a labile leaving group. In a further aspect, the present invention comprises a method of synthesising a compound of formula (III), or a solvate thereof, from a compound of formula (I) as defined in the first aspect, R16 is either O—R11, wherein R11 is as defined in the first aspect, or OH, or R10 and R16 together form a double bond between N10 and C11; and R15 is R. The other substituents are defined in the claims. Further aspects of the present invention relate to compounds of formula (III) (including solvates thereof when R10 and R16 form a double bond between N10 and C11, and pharmaceutical salts thereof), pharmaceutical compositions comprising these, and their use in the manufacture of a medicament for the treatment of a proliferative disease.
Owner:MEDIMMUNE LTD

Electronic Cigarette Assembly

The present invention provides improved devices, components, and conduit assemblies for delivery of a breathable / inhalable fluid stream containing a solvation-enhancing atomized liquid, the fluid stream carrying a functional liquid component. In one aspect, devices of the invention incorporate an exchangeable fluid-permeable body, such as a cartridge comprising a fluid-permeable packing material, containing the functional liquid. In another aspect, devices of the invention incorporate an electronic control system configured to detect and store physical states, settings, modes / configurations, and / or usage of the device over time. Optionally, the detected states may be exported to a separate electronic device via a Wi-Fi or other suitable remote connection. In other embodiments, the electronic control system provides passcode authorization for actuating an atomizing element and / or toggling the device between locked and unlocked states.
Owner:VOODOO SCI

Palladium-silver bimetallic hydrogenation catalyst

The invention relates to a palladium-silver bimetallic hydrogenation catalyst, a carrier of which mainly contains Al2O3 and which is characterized by comprising, based on 100% of the catalyst weight, 0.01-0.4% of Pd, 0.02-0.2% of Ag, and has a specific surface area of 1-100m<2> / g. The catalyst is obtained through three steps of: first, preparing a functionalized-high-molecular / Al2O3 precursor, then preparing a Pd-Ag-high-molecular / Al2O3 precursor, and lastly roasting the precursors at 380-550 DEG C for 2-6h. The preparation method overcomes the influences of dipping liquid surface tensionand solvation effect on palladium-silver disperseness, and the prepared catalyst has excellent selectivity. The catalyst of the invention can be applied to selective hydrogenation process of fractions such as C2 and C3, and has a good hydrogenation activity, excellent selectivity and good hydrogenation stability.
Owner:PETROCHINA CO LTD

Use of lignocellulosics solvated in ionic liquids for production of biofuels

The present invention provides a method for converting lignocellulosic material into biofuel. In particular embodiments, the method comprises pre-treating lignocellulosic material by dissolving the material in ionic liquids. The pretreated lignocellulosic material can be isolated, such as by precipitation with a regenerating solvent (e.g., water), and be used directly in the formation of biofuel, including undergoing hydrolysis to form sugar and fermentation to form fuel, such as bioethanol. The ionic liquid can be recycled for further use, such as by evaporation of the water introduced during precipitation, and the recycling provides a route to a hemicellulose rich fraction and an ionic liquid of consistent quality and wood dissolution characteristics. The recovered hemicelluloses are of significant utilization potential toward commodity and specialty applications.
Owner:NORTH CAROLINA STATE UNIV

Method and apparatus for embedded heater for desorption and ionization of analytes

A heated DESI spray device provides improved resolution or control of analyte desorption at a target locus on a sample. Heating controls spot size and enhances resolution in an imaging mode without impairing signal level. Additionally or alternatively the heated DESI spray may control desorption kinetics of a target analyte or otherwise control analyte discrimination in detection mode. One embodiment of the DESI spray is heated by heating nebulizing gas that accompanies the electrosprayed solvent. Another embodiment heats a separate gas stream that transports or directs desorbed material to the ion aperture of an analysis instrument. Heating may reduce size of primary droplets, alter the impact dynamics or the energy delivered by the spray to the surface, reduce size of secondary droplets and / or assure desolvation, improve species selectivity or otherwise affect sampling and enhance the ion signal level.
Owner:WATERS TECH CORP

Surfaces which are self-cleaning by hydrophobic structures, and a process for their production

A process for producing self-cleaning surfaces, in which an at least partially hydrophobic, surface structure is formed by securing particles on a polymer surface, which comprises applying, to the polymer surface, at least one solvent which comprises the particles and which solvates the polymer surface, and securing at least part of the particles to the polymer surface by removing the solvent; self-cleaning surfaces obtained by the process; and objects containing self-cleaning surfaces obtained by the process.
Owner:CREAVIS GES FUER TECH

Thermochromic responsive elastic polymer substrate

A material composition including a flexible, polymeric matrix and a reverse-thermochromic colorant is described. When subjected to a heat source, the polymeric material can change color from a pale or neutral color to a darker or more vibrant color of a Delta E (ΔE) change of >3. The reverse-thermochromic colorant exhibits a color change when exposed to a heat source within a period of about 30 seconds, and is observable by an unaided human eye under either natural daylight or ambient artificial normal lighting conditions. One or more different reverse-thermochromic colorants in combination may be incorporated. The polymeric matrix surrounds or encapsulates a solvatochromic dye molecule with a phenolate betaine structure. The polymeric matrix includes a dipole orientating agent that induces said solvatochromic dye to express locally when subjected to a temperature change. Various uses for the composition and articles that incorporate the composition are also described, in addition to a method of indicating the temperature of an object or environmental condition.
Owner:KIMBERLY-CLARK WORLDWIDE INC

Hydrogen release from complex metal hydrides by solvation in ionic liquids

A hydrogen release material includes a complex metal hydride and an ionic liquid wherein the hydrogen release material has a lower hydrogen release temperature in comparison to the complex metal hydride alone. Also disclosed is a process of releasing hydrogen from a storage material including the steps of: providing a complex metal hydride; combining the metal hydride with an ionic liquid in a desired amount forming a mixture; and heating the mixture to a temperature releasing hydrogen wherein the temperature is lower in comparison to the complex metal hydride alone.
Owner:TOYOTA JIDOSHA KK

Pyrimidine compound and medicinal composition thereof

A compound having excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action, of the following formula, a salt thereof or a solvate of them:wherein, R1 and R2, same or different, each represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an aromatic hydrocarbon cyclic group, an acyl group or an alkylsulfonyl group, which groups may be substituted (except the hydrogen atom); R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon cyclic group, a nitrogen atom, an oxygen atom or a sulfur atom, which groups may be substituted (except the hydrogen atom, the halogen atom and the cyano group); R4 represents an aromatic hydrocarbon cyclic group which may be substituted, and R5 represents an aromatic hydrocarbon cyclic group which may be substituted.
Owner:EISIA R&D MANAGEMENT CO LTD

Methods for adsorption and retention of solvated compounds and ions

A solid phase mixed solvent polymer, compositions and methods for removing and retaining solvated organic compounds and inorganic ions from water, wastewater, superficial and ground water, soil and other environmental sources, a soil amendment and method resulting from adhesively coating the polymer onto sand along with at least one ion exchange material, and methods for the containment, reduction, and prevention of organic leaching from soils, agricultural, industrial, and commercial environments, and in particular, sports and athletic turf facilities such as golf courses where pesticides are frequently applied.
Owner:ECO VERDE TECH

Multimicroparticulate pharmaceutical forms for oral administration

The object of the present invention is to minimize the risks of dose dumping associated with the concomitant consumption of alcohol and certain modified-release pharmaceutical or dietetic forms. The invention relates to an oral form comprising microparticles of the reservoir type for the modified release of at least one active principle (AP), characterized in that it is resistant to immediate dumping of the dose of AP in the presence of alcohol. In particular, the oral form according to the invention is characterized in that the time taken to release 50% of the AP in an alcoholic solution is not reduced more than 3-fold relative to the time taken to release 50% of the AP in an alcohol-free aqueous medium. The form comprises an agent D, which is a pharmaceutically acceptable compound whose hydration or solvation rate or capacity is greater in an alcohol-free aqueous medium than in alcoholic solution
Owner:FLAMEL IRELAND

Means and method for multiplexing sprays in an electrospray ionization source

A means and method are disclosed for multiplexing a plurality of samples from multiple sprayer devices to be efficiently transferred to a mass analyzer for subsequent analysis. Sample sprays are formed from a plurality of sprayers, which are desolvated to form the sample ions. The sample ions are then selected from one of the sprayers for transportation into a mass analyzer. To accomplish this, the apparatus of the invention comprises a multi-part capillary wherein a first section thereof is connected to a motor which is able to move this first section from one sprayer to the next. This first section may be a flexible tube-like structure loosely mounted in an aperture of a cone-shaped end of a motor which rotates such that the sampling orifice may be aligned with different sprayers at different times to sequentially and repetitively sample ions produced by each of the plurality of sprayers.
Owner:BRUKER SCI LLC

Process for preparing vegetable oil fractions rich in non-tocolic, high-melting, unsaponifiable matter

A vegetable oil fraction rich in non-tocolic, high-melting, unsaponifiable matter is prepared by the following steps: A vegetable oil having a slip melting point of not more thatn 30° C. and a content of unsaponifiable matter of at least 0.5% by weight is hydrogenated to fully saturate the fatty acids of the glycerides and to reach a slip melting point of at least 57° C. To the hydrogenated oil is added from 1 to 75% by weight of the unhydrogenated starting oil or another oil having a slip melting point of not more than 30° C. in order to act as a carrier and vehicle for the unsaponifiable matter. Then, a solvent is added to the oil mixture in a ratio between oil and solvent from 1:2 to 1:20, and the mixture is heated to transparency. The oil / -solvent-mixture is cooled in one or more steps to a final temperature in the range from −35 to +30° C., and the precipitated high-melting fraction(s) is (are) filtered off. The filtrate is desolventised, leaving a fraction rich in unsaponifiable matter. By this process very high concentrations of in particular the non-tocolic, higher melting unsaponifiables can be achieved, and the composition of the glyceridic part of the enriched fraction can betailored to specific applications. Also, a novel blood cholesterol-lowering effect of the unsaponifiable constituents from shea butter has been found.
Owner:AAK DENMARK

Atmospheric pressure charged particle discriminator for mass spectrometry

An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.
Owner:MDS SCIEX

Microspray liquid-liquid extractive ionization device

InactiveUS20080179511A1Increased effective productionImprove long-term stabilityIon sources/gunsIsotope separationAnalyteSprayer
A device enables direct, continual analysis by mass spectrometry of one or more analytes in a complex liquid sample. A first sprayer nebulizes the liquid sample, forming sample droplets. A second sprayer provides multiple charged droplets of a liquid solvent or solution. The first sprayer forms a first angle (β) relative to the second sprayer such that the analytes are transferred to the charged droplets and are desolvated to generate free gas phase ions in an interface of a mass spectrometer (MS).
Owner:PURDUE RES FOUND INC

Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease

A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from —H, —OH, =0, ═CH2, —CN, —R, OR, halo, ═CH—R, O—SO2—R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR′, nitro, Me3Sn and halo, where R and R′ are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and R is H or C1-7 alkyl or H and SOxM, where x is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and RE is C1-4 alkyl. The compound is useful for the treatment of proliferative diseases.
Owner:MEDIMMUNE LTD

Industrial process for the synthesis of 17a-acetoxy-11ss-[4-(n,n-dimethyl-amino)- phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.
Owner:RICHTER GEDEON NYRT

Method and device for detecting freshness of fish based on olfaction visualization

The invention discloses a method and a device for detecting the freshness of fish based on olfaction visualization, which is characterized in that a computer is connected with a constant temperature control room and a scanner; a visual gas sensor array, the scanner, a reaction room and a sample room are arranged inside the constant temperature control room; detected gas diffused from a detected fish sample is in contact with the visual gas sensor array; the detected gas reacts with a porphyrins sensor, a pH indicator sensor or a solvation chromotropic dye sensor arranged in the visual gas sensor array; images before and after the reaction are collected by the scanner and input into the computer; and the freshness of the detected fish sample is determined according to the correlation between the color change of the three sensors and the variety and the concentration of the detected gas. The invention can ensure that the extraction quantity of characteristic values is reduced by determining the selection of the sensor type and the characteristic values; the synthesis course is simple, and the use quantity of the sensors is less; the gas can be fully contact with the sensors; the detection by human eyes can be utilized; and the use of the device is simple and convenient; the detection time only needs 3 to 5 minutes.
Owner:JIANGSU UNIV

Detection of microbe contamination on elastomeric articles

An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
Owner:O&M HALYARD INC

Paclitaxel solvates

Biologically active crystalline solvates of paclitaxel are precipitated using polar, aprotic, organic solvents. A pharmaceutical composition is also disclosed, as well as the preparation of the novel solvates and their uses as anti-tumor agents.
Owner:BRISTOL MYERS SQUIBB CO

Breathable Fluid Delivery System Including Exchangeable Fluid Permeable Cartridge

InactiveUS20150258288A1Easy to shipFacilitate extended storageRespiratorsTobacco devicesSolvationPropylene glycol
The present invention provides improved apparatus, systems, and methods of delivering a breathable fluid stream carrying an atomized or vaporized functional liquid. In particular, a fluid-permeable exchangeable cartridge is provided for containing the functional liquid to be introduced into a fluid stream comprising a breathable base fluid flowing through the cartridge. Preferably, the breathable base fluid includes a solvation enhancer such as atomized or vaporized propylene glycol or glycerin. In another aspect, a throttling valve system is provided for adjusting the ratio of flow from a breathable base fluid source through the cartridge or around the cartridge via a bypass channel, to vary the concentration of the functional liquid component mixed with the breathable base fluid.
Owner:VOODOO SCI

Means and method for multiplexing sprays in an electrospray ionization source

A means and method are disclosed for multiplexing a plurality of samples from multiple sprayer devices to be efficiently transferred to a mass analyzer for subsequent analysis. Sample sprays are formed from a plurality of sprayers, which are desolvated to form the sample ions. The sample ions are then selected from one of the sprayers for transportation into a mass analyzer. To accomplish this, the apparatus of the invention comprises a multi-part capillary wherein a first section thereof is connected to a motor which is able to move this first section from one sprayer to the next. This first section may be a flexible tube-like structure loosely mounted in an aperture of a cone-shaped end of a motor which rotates such that the sampling orifice may be aligned with different sprayers at different times to sequentially and repetitively sample ions produced by each of the plurality of sprayers.
Owner:BRUKER SCI LLC

Compositions comprising a solvated metal

A method of solvating metal ions in an aromatic organic liquid. The method includes adding an ammonium salt having an organic acid reagent to the aromatic organic liquid. The organic acid reagent comprises a carboxylate having eight (8) or less carbon atoms. Thereafter, an aqueous solution comprising a metal salt is added to the aromatic organic liquid comprising the ammonium salt and the organic acid reagent. As a result, at least 10% by weight of metal ions is solvated in the aromatic organic liquid.
Owner:LUCENT TECH INC

Method for destroying energetic materials

InactiveUS6121506AAffect environmentSafely, simply and economicallyAmmunitionHalogenated hydrocarbon separation/purificationChemical reactionSolvation
Energetic materials, such as nitrocellulose, TNT, RDX, and combinations thereof, optionally in combination with chemical warfare agents, such as mustard gas, Lewisite, Tabun, Sarin, Toman, VX, and combinations thereof, are destroyed when chemically reacted according to the method of the invention. The method comprises reacting the energetic materials and chemical warfare agents, of present, with solvated electrons which are preferably produced by dissolving an active metal such as sodium in a nitrogenous base such as anhydrous liquid ammonia.
Owner:MILFORD CAPITAL & MANAGEMENT

Methods and compositions for reducing body fat and adipocytes

Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR1, —SR2, or —NR3R4, and R1, R2, R3, and R4 are as defined herein.
Owner:TOPOKINE THERAPEUTICS
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