38 results about "Solvation" patented technology

The present invention relates to processes for the preparation of reslitrast and intermediate compounds thereof. In particular, the present invention relates to a process for the synthesis of reslitrast, key intermediates for the synthesis of reslitrast, solvates thereof and a process for the hydrolysis of reslitrast under basic conditions.

The present invention relates to a method for purifying (PU) at least one aqueous medium based on at least one C-glycoside derivative corresponding to formula (I) (preferably corresponding to formula (I') or (I''), and optical or geometric isomers thereof, and / or solvates (e.g., hydrates) thereof, and at least one salt, comprising at least one step of electrodialysis (PU1) of the aqueous medium. The present invention also relates to a method for preparing (PR) at least one C-glycoside derivative as described herein, comprising at least one step of electrodialysis (PU) of at least one aqueous medium containing at least the C-glycoside derivative and at least one salt. JPEG2026518301000030.jpg41170

The present invention relates to a prodrug and drug having a controllable drug release rate. Specifically provided are a prodrug or a stereoisomer, deuterated substance, solvate, polymorph or pharmaceutically acceptable salt thereof. The prodrug contains a drug and a linker, wherein the drug is linked to the linker, and the linker contains a structure as represented by formula (1). The prodrug has a long half-life, does not require an enzymatic or redox environment, can controllably and spontaneously release the drug under physiological conditions, and exhibits a high drug delivery efficiency. The released drug exhibits a complete activity and is not affected by the linker or a macromolecular carrier.

The application discloses a preparation and purification method of high-purity radioiodine-labeled antigen. The method comprises the following steps: pre-activating carrier-free sodium iodine[125I] solution in an orthogonal solvation sensitization buffer containing lithium sulfate, 18-crown-6 and beta-cyclodextrin; adding antigen and chloramine-T for a labeling reaction; and performing magnetic separation and purification by using a suspension containing adamantane-modified magnetic microspheres and quaternary ammonium salt-modified strong anion exchange magnetic microspheres after the reaction. The orthogonal solvation effect is used to enhance the nucleophilic activity of iodine ions, and the amount of oxidizing agent is reduced to reduce protein damage; impurities are quickly removed through the double mechanisms of electrostatic adsorption and host-guest recognition. The application has the advantages of high labeling efficiency, high radiochemical purity of the product and complete retention of biological activity.

An apparatus and method are provided for optimizing the use of gas hydrate inhibitors by combining real-time "dew point" measurement with quantum-chemical phase-change analysis. A gas hydrate inhibitor reduces gas moisture; by measuring gas humidity and identifying the "dew type" using two chilled-mirror sensors each equipped with an imaging camera, a "dew coefficient" (0–1) is calculated via quantum chemistry analysis of inhibitor solvation. This mesoscale coefficient is used to monitor fluid phase changes. A general relationship for the water / hydrocarbon "dew coefficient" is derived as a function of changes in Gibbs free energy of dew evaporation (inhibitor solvation), gas temperature and pressure, and gas / liquid density. By combining measured "dew point" and "dew type" with quantum chemistry data of phase transformations "dew coefficient", the optimal inhibitor injection rate is determined, minimizing inhibitor consumption while preventing hydrate formation.

This invention relates to the fields of biomass oil processing and liquid hydrocarbon refining technology, and discloses a method for refining crude oil from pyrolysis of Ulva prolifera based on multi-stage membrane separation. The method includes: mixing crude oil from pyrolysis of Ulva prolifera with a n-alkane solvent to perform solvation reconstruction; inducing the precipitation of large-molecule polar impurities by utilizing differences in solubility parameters and performing solid-liquid separation; introducing the resulting degummed hydrocarbon oil into a multi-stage membrane separation system; performing component screening using a modified polytetrafluoroethylene membrane; and applying periodic pressure pulses to the permeate side. This invention utilizes the negative pressure difference generated during the pressure drop phase to drive a reverse flushing action, stripping adsorbates from the membrane interface, maintaining the distribution of hydrophobic components at the interface, and in principle avoiding thermally excited free radical polymerization reactions. This effectively solves the technical obstacle of difficult separation of polar components and hydrocarbon molecules, achieving membrane interface maintenance without downtime, and ensuring the thermodynamic stability of the refined hydrocarbon oil product.

Provided is a compound of Formula (I) or a salt, solvate, or isomer thereof: wherein R 1 is selected from H, optionally substituted alkyl and optionally substituted alkoxy; R 2 is selected from optionally substituted alkyl and optionally substituted alkenyl; R 3 is selected from H, oxo and optionally substituted alkyl; R 4 is selected from optionally substituted aryl and optionally substituted heteroaryl; R 5 and R 6 are independently selected from H and optionally substituted alkyl; wherein when R 1 is optionally substituted alkoxy, R 3 is H or optionally substituted alkyl; wherein when R 3 is oxo, R 1 is H or optionally substituted alkyl; or R 4 and R 5 are linked to form optionally substituted aryl or optionally substituted heteroaryl; n is an integer selected from 1 to 5.

This invention discloses a method for removing metallic impurities from polyolefins using supercritical CO2 and a composite solvent, belonging to the field of polyolefin material preparation technology. The method involves dispersing the polyolefin in a composite solvent containing a dispersant, a polar solvent, and a chelating agent, and performing deashing under supercritical CO2 conditions. After depressurization, solid-liquid separation, washing, and drying are performed to obtain high-purity polyolefin. This invention utilizes the plasticizing effect of supercritical CO2 to carry the composite solvent into the interior of the polyolefin, where it undergoes solvation and chelation reactions with metallic impurities such as Mg, Al, Ti, and Zn, achieving highly efficient removal. The total metal content can be reduced to below 20 ppm using this method, with a metal removal rate exceeding 85%. When using the novel chelating agent F7-AA, the removal rate can reach 94.90%, reducing the metal content to below 5 ppm. This invention is a mild, low-cost, and environmentally friendly process, suitable for the preparation of high-purity polyolefins required in the electronic information field.

The present invention relates to a method for producing (S)-amlodipine succinate comprising reacting (S)-amlodipine (D)-hemitartrate or a solvate thereof with a first base in the presence of a two-phase solvent system comprising a first non-polar organic solvent and water to produce (S)-amlodipine base, removing the water layer, and reacting (S)-amlodipine base with succinic acid to produce (S)-amlodipine succinate. The present invention also relates to a formulation comprising (S)-amlodipine succinate.

This invention belongs to the field of lithium metal battery technology, specifically relating to an isocyanate-containing in-situ gel electrolyte, its preparation method, and its application. The in-situ gel electrolyte uses methacrylate compounds containing coordinating functional groups as monomers and lithium salts containing carbonate solvents as electrolytes. After mixing, the mixture undergoes in-situ polymerization under the action of a crosslinking agent to form a composite gel system. The methacrylate compounds contain isocyanate groups, or the methacrylate compounds undergo crosslinking polymerization to form isocyanate-derived structures. This invention uses methacrylate compounds to undergo in-situ polymerization to form strongly coordinated polymers, which serve as a continuous backbone to selectively anchor Li at the molecular scale with strong coordination sites. + Carbonate-based solvents reduce the binding of anions and strong solvents at the solvation level, thereby forming a synergistic effect of "strong coordination framework + weak coordination solvent", resulting in a gel electrolyte with high lithium-ion mobility, stable interface and high voltage adaptability.

This solid dispersion comprises: a component (1) which is one or more selected from the group consisting of a compound represented by formula (I), a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable solvate thereof; and a component (2) which is one or more polymers selected from the group consisting of hydroxypropyl methylcellulose and a derivative thereof, wherein the total content of the component (2) per 1 part by mass of the total content of the component (1) is more than 0.1 parts by mass and less than 1.0 part by mass. This composition comprises said solid dispersion and an alkyl sulfate.

Provided are a salt of an arylaminoquinazoline-containing compound as shown in formula 2, a solvate or hydrate thereof, a preparation method therefor and the use thereof. The prepared salt has good crystallinity, and compared to a compound in a free form, the water solubility is significantly improved, and preferably, the salt form and crystal form can stably exist. Therefore, compared to a compound in a free form or other salts, the salt has better druggability.

The invention relates to a composition comprising N,N-dicarboxymethyl glutamic acid, babassu oil, at least one alkali metal, and at least one oxidizing dye. The invention also relates to a composition comprising at least one compound selected from N,N-dicarboxymethyl glutamic acid, one of its salts, solvates and / or solvates of its salts, babassu oil, at least one alkali metal, and at least one oxidizing dye.

A process for modifying a surface chemistry of a cathode active material includes providing a powder of the cathode active material, wetting the powder of cathode active material with an efficient amount of a solution to form a mixture, and baking the mixture to obtain a surface modified cathode active material, wherein: the cathode active material has a formula of LiNixMnyCo1-x-yO2, wherein 0≤x≤1, 0≤y≤1, and 0≤x+y≤1; the solution comprises a solvate and a solvent; and the solvate comprises H3BO3, H3PO4, a phosphate salt, a hydrogenphosphate salt, a dihydrogenphosphate salt, or a combination of any two or more thereof.

Disclosed herein are various solid forms of Compound A, including crystalline and amorphous forms of Compound A free base, as well as salt forms, cocrystals, and solvates thereof. Also disclosed are methods of making the salt, cocrystal, and solvate forms, and methods of treating diseases and disorders with the salt, cocrystal, and solvate forms (Compound A).

The present invention provides a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein: Y is selected from C or N; X is O; bond a is a single or double bond; x is 1 when a is a single bond and x is 0 when a is a double bond; R1 is selected from hydrogen and methyl; R2 (when present) is selected from hydrogen and methyl; R3 is selected from hydrogen, (1-6C)alkyl and (1-6C)alkyl-phenyl, wherein said phenyl is optionally substituted by one or more (for example 1 to 3) substituents each independently selected from hydroxy, (1-6C)alkoxy, (1-6C)alkyl and halo (such as chloro and fluoro).

The application discloses a preparation method of a dispersant for ceramics and belongs to the technical field of ceramic dispersants. The method uses 4-carboxyl-4'-bromoterphenyl, 4-formylphenylboronic acid, dopamine and amino-terminated polyethylene glycol monomethyl ether as raw materials, and the target dispersant is prepared through three-step reactions of Suzuki coupling, reductive amination and amidation. The prepared dispersant has an accurate structure of "dopamine double-site anchoring-terphenyl rigid skeleton-pure polyether hydrophilic end", is firmly anchored on the ceramic surface through synergistic adsorption of coordination bonds and double hydrogen bonds, and realizes spontaneous vertical orientation adsorption of molecules by relying on the solvation pulling force of the polyether chain and the leverage effect of the rigid skeleton. The dispersant can significantly reduce the viscosity of ceramic slurry, improve the storage stability and green strength, and has low high-temperature residual ash content, and is suitable for various ceramic systems. The synthesis process is simple and easy for industrial production.

The present invention relates to a process for preparing one or more C-glycoside derivatives corresponding to formula (I), preferably formula (I'), and solvates such as optical isomers, geometric isomers, and / or hydrates thereof, comprising at least one purification step carried out in an aqueous medium. The present invention also relates to a process for preparing one or more C-glycoside derivatives corresponding to formula (I'B), comprising a reduction step of at least one compound of formula (I), preferably a compound of formula (I'), carried out in an aqueous medium. JPEG2026521213000031.jpg77170

The application discloses a local high-concentration electrolyte based on synergistic regulation of cationic electrostatic shielding and molecular dipole and application thereof. The electrolyte comprises a sodium salt, an ether solvent, a fluorinated ether diluent and an additive combination composed of an electrostatic shielding additive and a dipole flattening additive. The electrostatic shielding additive comprises a metal cation salt with a metal cation reduction potential a less than or equal to -2.75 V, and the dipole flattening additive comprises a heterocyclic compound with a lactam structure. The electrostatic shielding additive is preferentially adsorbed on the negative electrode surface tip to form an electrostatic shielding layer by using cations, thereby repelling sodium ion deposition. The dipole flattening additive is adsorbed on the defect site by using a high dipole moment, thereby inducing uniform nucleation and lateral growth of metal ions. The application induces the formation of an SEI film by the dual regulation of electrostatic shielding and dipole flattening, in combination with a specific local high-concentration solvation structure, thereby effectively inhibiting sodium dendrite growth and significantly widening the low-temperature and high-pressure working window of the battery.

The invention discloses the crystal form, preparation method and application of an alkynyl compound, its salt and solvent compound. The invention specifically discloses 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide crystal form I and 3-((1H-pyrazolo [3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide fumarate crystal form II. The crystal form of the invention has good stability and has important value for drug optimization and development.

The application relates to a liquid metal thermal interface material and a preparation method thereof, and relates to the field of interface materials. The liquid metal thermal interface material comprises liquid metal and an ionic liquid; an anion part of the ionic liquid contains a multi-dentate electron-donating coordination group. The application forms a dense solvation protective film on the surface of a liquid metal droplet in situ through the strong multi-point coordination and chemical adsorption between the anion part of the ionic liquid containing the multi-dentate electron-donating coordination group and the surface of the liquid metal, which significantly improves the dispersion stability and oxidation resistance of the liquid metal thermal interface material, and makes up for the defects of the prior art.

The present disclosure provides a transparent composition comprising: a. 5-methyl-5 2-(propan-2-yl)phenol, and / or the derivatives, salts and solvates thereof; b. Curcuma zedoaria oil; c. at least one non-ionic surfactant; and d. at least one anionic surfactant having HLB value ≥ 10. The present disclosure also provides method for treating a keratin material, preferably the skin, and use thereof.

The present invention discloses the prodrugs of hexahydro-β-acid compounds, feed composition and use thereof, and a prodrug of hexahydro-β-acid compound of formula (I), or solvates thereof, or feed-acceptable salts thereof, wherein R1 is selected from a substituted or unsubstituted C1-C2 alkyl, and each of R2 and R3 is independently selected from H and a linear or branched C2-C4 carbonyl, wherein the C2-C4 carbonyl is substituted or unsubstituted. Disclosed herein is that the prodrug of a hexahydro-β-acid compound from esterification by aliphatic acid exhibits excellent stability at high temperature to overcome the problem resulting from the degradation of hexahydro-β-acid compound in a high-temperature pelleting process. Furthermore, disclosed herein is that, both propionate and butyrate, the prodrugs of a hexahydro-β-acid compound from esterification by aliphatic acid, and feed-acceptable salt thereof and solvate thereof, are stable in high-temperature feed processing and achieve effects substantially equal to the hexahydro-β-acid compound in farm breeding.

Use of a merocyanin for photostabilizing resveratrol and / or one of its derivatives. The invention therefore relates to the use of (i) one or more merocyanins of the following formula (3) and their isomeric geometric forms E / E or E / Z, and their tautomers, salts, and solvates such as hydrates: [Formula 3] Formula 3 wherein: A is –O- or –NH; R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alcinyl group, a C3-C22 cycloalkyl group, or a C3-C22 cycloalkenyl group, said groups being able to be interrupted by one or more O groups, for (photo)stabilizing (ii) resveratrol, one of its derivatives, and their isomeric geometric forms, salts, and solvates such as hydrates or their mixtures.

The application relates to the technical field of lithium metal batteries, and discloses an electrolyte suitable for extreme working conditions, a lithium metal battery and application of the electrolyte. The electrolyte suitable for extreme working conditions is composed of a lithium salt, a main solvent and a fluorinated ether diluent, the main solvent is an ether solvent with a side chain methyl, the molar concentration of the lithium salt is 0.8-1.5 mol / L, and the volume ratio of the main solvent to the fluorinated ether diluent is 1:0.5-2. ‑1 The electrolyte system disclosed by the application not only reduces the direct chemical corrosion of the fluorinated diluent TTE on lithium metal, but also significantly inhibits the oxidative decomposition of solvent molecules on the positive electrode surface under high pressure through the weak solvation characteristics and moderate anion coordination of DMP; the electrolyte system realizes the synergistic regulation of the solvation structure of lithium ions, the interface film forming behavior and the ion transport kinetics, in-situ constructs a SEI / CEI interface film layer rich in inorganic components and mechanically stable on the surface of a lithium metal negative electrode and a high-nickel positive electrode, and fundamentally inhibits the growth of lithium dendrites, slows down the degradation of the positive electrode structure and reduces the interface side reaction rate.

This invention provides a polymer electrolyte, its preparation method, and its application. The raw materials of the polymer electrolyte, by mass, include the following components: 8-12 parts of an olefin polymer, 4-8 parts of a sodium salt, 0.4-1.2 parts of hydrophobic fumed silica (SiO2), 7-30 parts of a fluorinated small-molecule plasticizer, and 35-85 parts of a solvent. The polymer electrolyte of this invention uses a fluorinated small-molecule plasticizer with weak solvation ability as the plasticizer in the electrolyte, which improves the mechanical properties of the electrolyte membrane. Simultaneously, it forms a competitive coordination effect with the residual solvent with strong solvation ability, which is beneficial for inhibiting the corrosion effect of sodium salt on the current collector. The hydrophobic fumed silica filler reduces the crystallinity of the polymer matrix and enhances the mobility of the polymer matrix segments, thereby improving the ionic conductivity.

A 4-carbonylamino isoindolin-1-one compound represented by formula (I), or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate (e.g. hydrate) thereof, or a clathrate thereof, or a racemate thereof, or an isotopically-labeled material thereof, or a nitroxide thereof; and pharmaceutical compositions and uses thereof. The compound has good anti-multiple myeloma activity, and can effectively treat and / or prevent the growth and reproduction of multiple myeloma.

The application belongs to the technical field of hydrogen production by water electrolysis, and particularly relates to a composite dispersant, a preparation method and application thereof, and a structure formula of the composite dispersant is as follows. The beneficial effects of the application include that the composite dispersant can make the mixing of high-molecular organic matter and inorganic nano-particle slurry more uniform and stable; the bisphenol A derivative in the composition of the composite dispersant can form a strong pi-pi electron interaction with inorganic nano-material to play an anchoring role, the bisphenol A derivative has similar structural units with a diaphragm base material to improve the affinity of diaphragm slurry and the diaphragm base material support layer, the hydroxyl functional groups in the structure anchor the dispersant on the particle surface through hydrogen bonds and van der waals forces to increase the dispersing performance, the polyether as a strong polar solvation chain has good compatibility with a dispersion medium, and the particles are more stably dispersed in the slurry through a steric hindrance effect.

An electrochemical cell electrolyte is described, where the electrolyte includes a solvating solvent comprising a linear ester, a cyclic ester, or a combination thereof; a non-solvating solvent; and an alkali metal salt.

This invention discloses a method for synthesizing and applying a nested carborane B-N coupling derivative with optical properties. The specific synthesis process is as follows: under anhydrous and oxygen-free conditions, nonborane (CH3)3N·B9H is synthesized... 13 Nested carboranes were prepared by reflux reaction of alkynes in toluene, followed by further reaction of the intermediate with alkali metal hydroxide (MOH) and purification. The nested carboranes were then subjected to a Brønsted-N coupling reaction with 8-aminoisoquinoline, and the crude product was purified to obtain the target product, the nested carborane Brønsted-N coupling derivative. This invention features a simple, safe, and high-yield synthetic process, avoiding the use of expensive ortho-carboranes as raw materials, thus significantly reducing the synthesis cost of nested carboranes. The synthesized nested carborane derivatives exhibit a significant positive solvation colorimetric effect, providing a new synthetic strategy for the design of boron cluster-based functional molecules and the development of luminescent materials.