213 results about "Solvation" patented technology

The invention belongs to the technical field of membranes, and discloses a monovalent / divalent cation selective separation membrane based on an intrinsic microporous polymer, and the preparation route of the membrane is as follows: taking an ether-free polymer synthesized by super acid catalysis as a precursor, introducing an ion exchange site into the polymer by utilizing grafting of a sulfonated monomer, and preparing the monovalent / divalent cation selective separation membrane based on the intrinsic microporous polymer. And improving the separation performance of monovalent ions / divalent ions by using an alkoxy chain graft with specific interaction on the monovalent ions, and greatly improving the mechanical strength of the membrane by using the interaction of hydrogen bonds between main and side chains, thereby finally obtaining the monovalent / divalent cation selective separation membrane. According to the present invention, the industrial production difficulty is significantly reduced by the full solvation reaction membrane synthesis route, the selectivity of the prepared membrane material is superior to the selectivity of the commercial membrane of the same type, the extremely high mechanical strength is maintained, and the large-scale production and application potential is provided.

The invention discloses a triphenyl phosphate standard substance structure identification method, and relates to the technical field of fluorine-containing gas emission reduction, and the method comprises the following steps: obtaining a standardized analysis sample through fluorine-containing matrix separation, target substance enrichment and solvation treatment; a multi-dimensional chromatographic system and a heart cutting technology are adopted, and temperature programming optimization is combined to realize separation and purification of a sample; carrying out multi-dimensional structure analysis and confirmation by using gas chromatography-mass spectrometry, infrared spectroscopy and nuclear magnetic resonance technologies; a five-stage progressive identification algorithm is constructed, and systematic identification is realized by combining a confidence evaluation system and a fluorine-containing interference correction technology; establishing a structural integrity verification and purity quantitative evaluation standard, and outputting a standardized identification report; a method applicability database is established through multi-type fluorine-containing environment verification and process condition adaptability testing. The method effectively solves the problem of accurate identification of triphenyl phosphate in a complex fluorine-containing matrix, and realizes effective removal of interference components such as light gas, hydrofluorocarbon, perfluorinated compounds and the like.

The invention belongs to the technical field of electrochemical energy storage, and discloses a weak-solvation non-aqueous electrolyte as well as a preparation method and application thereof. According to the weak solvation non-aqueous electrolyte, 1-methylimidazole is used as a solvent, and zinc bis (trifluoromethane sulfonimide) is used as a soluble salt. Zn < 2 + > forms a solvation structure of Zn (EMI) 4.99 (TFSI) 1.01 in the electrolyte. Along with the progress of an electrochemical reaction process, TFSIanions are preferentially reduced and decomposed, and an organic-inorganic hybrid double-layer SEI film rich in inorganic components such as ZnF2, ZnS and ZnNx is formed on the surface of a zinc negative electrode, so that the problems of hydrogen evolution side reaction and zinc dendrite existing in an aqueous electrolyte are effectively avoided, and efficient and reversible deposition / stripping of Zn < 2 + > is realized. The zinc ion battery using the electrolyte shows ultra-long cycle life, ultra-low overpotential, high coulombic efficiency and wide temperature adaptability, and a new solution is provided for practical application of the zinc ion battery.

The solvated metal particle-coating system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and / or hexamethylphosphoramide. The metal additive may include an alkali metal and / or an alkaline earth metal. The solvated metal additive within the polar outer-sphere electron transferring solvent may be used to coat a metal particle and / or a metalloid particle as a layer. As the polar outer-sphere electron transferring solvent evaporates, the solvated metal additive is coupled to the metal particle and / or the metalloid particle.

The present application relates to the technical field of gas purification and separation, and discloses a selective separation material for carbon dioxide and hydrogen sulfide, which is prepared from 15-25 parts of a hindered hydrazine salt active component, 5-15 parts of a dielectric regulation dissociation agent, 1-5 parts of a proton transfer agent and 55-79 parts of an inert poor water solvent, and preparation is performed by using a step-by-step strategy of pre-solvent activation, dissolution assistance and homogeneous complexing. The present application solves the problems of low solubility of a high-concentration hindered hydrazine salt in a poor water organic solvent and shielding of active sites by introducing a high-dielectric-constant regulating agent to construct a solvent separation ion pair environment. By using the synergistic effect of the large steric hindrance effect of a hindered hydrazine group and a poor water environment, carbon dioxide chemical absorption is strongly inhibited in thermodynamics and kinetics, while the high-efficiency proton transfer and capture capacity for hydrogen sulfide is retained. The material has a very high selectivity factor, excellent hydrogen sulfide absorption capacity and low regeneration energy consumption.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

1. A compound of formula (I): [MCL-1 ligand site]-[linker]-[ligase ligand site] (I), or a salt, solvate, hydrate, isomer, or prodrug thereof, wherein [MCL-1 ligand site] is a compound of formula (A), or [MCL-1 ligand site] is a compound of formula (A1), (A2), (A3), or (A4), and use thereof in the treatment of cancer. [Formula 1] JPEG2025540970000791.jpg126170

To provide a detection reagent hardly causing noise due to generation of nonspecific fluorescence, and capable of detecting sialidase with higher accuracy.SOLUTION: The present invention relates to a compound represented by formula (I) or a salt thereof, or a solvate thereof. In the formula (I), R1 represents a halogen atom, and R2 represents an alkyl group having 5 to 11 carbon atoms or a hydrocarbyl group having 5 to 11 carbon atoms and having one or more unsaturated bonds. ] SELECTED DRAWING: None

The present invention relates to processes for the preparation of reslitrast and intermediate compounds thereof. In particular, the present invention relates to a process for the synthesis of reslitrast, key intermediates for the synthesis of reslitrast, solvates thereof and a process for the hydrolysis of reslitrast under basic conditions.

The present invention relates to a method for purifying (PU) at least one aqueous medium based on at least one C-glycoside derivative corresponding to formula (I) (preferably corresponding to formula (I') or (I''), and optical or geometric isomers thereof, and / or solvates (e.g., hydrates) thereof, and at least one salt, comprising at least one step of electrodialysis (PU1) of the aqueous medium. The present invention also relates to a method for preparing (PR) at least one C-glycoside derivative as described herein, comprising at least one step of electrodialysis (PU) of at least one aqueous medium containing at least the C-glycoside derivative and at least one salt. JPEG2026518301000030.jpg41170

The solvated metal particle-coating system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and / or hexamethylphosphoramide. The metal additive may include an alkali metal and / or an alkaline earth metal. The solvated metal additive within the polar outer-sphere electron transferring solvent may be used to coat a metal particle and / or a metalloid particle as a layer. As the polar outer-sphere electron transferring solvent evaporates, the solvated metal additive is coupled to the metal particle and / or the metalloid particle.

In order to solve the problems that the high-temperature cycle life and the low-temperature cycle life of the battery are short due to the fact that an electrolyte used by an existing lithium metal battery contains a strong-strong solvent pair or a strong-anti-solvent pair in LHCE, the invention provides a high and low temperature resistant electrolyte and a lithium metal battery. The high and low temperature resistant electrolyte comprises an organic solvent, the organic solvent comprises a strong solvating solvent and a weak solvating solvent, the weak solvating solvent is 4-methyl-1, 3-dioxane, and the strong solvating solvent is ethylene glycol dimethyl ether. At low temperature, due to the dipole interaction of MeDX-DME, a layered solvation structure is formed, and the interaction of Li < + >-DME is weakened, so that the Li < + > desolvation energy is reduced, the Li < + > transmission kinetics is increased, and the low-temperature cycle life of the battery is prolonged; and at high temperature, due to the dipole interaction of MeDX-DME, a layered solvation structure is formed, so that the ring-opening reaction of MeDX is slowed down, the generation of side reactions is reduced, the high-temperature stability of the electrolyte is improved, and the high-temperature cycle life of the battery is prolonged.

The invention relates to the technical field of chemical synthesis of medicines, in particular to a pleuromutilin derivative, a preparation method thereof and an antibacterial active composition. The structural formula of the pleuromutilin derivative is a compound with a structure as shown in a formula I, or pharmaceutically and / or veterinarily acceptable salt, a solvent compound, an optical isomer and a polymorphic compound of the pleuromutilin derivative, wherein R is selected from any one of a group consisting of R and R. According to the scheme provided by the invention, the compound has good antibacterial activity and is suitable for being used as a novel antibacterial drug for preventing and treating human or animal bacterial infectious diseases.

Disclosed is an electrolyte comprising: a first salt, wherein the first salt is an active material salt; a second salt; and a solvent, wherein the first salt and the second salt are dissolved in the solvent, such that the dissolved first salt has a solvation structure; wherein a solubility of the first salt in the solvent is greater than about 2 M; wherein the second salt is different from the first salt and has a solubility in the solvent lower than about 2 M; wherein the second salt behaves as a diluent and is at least partially incorporated into the solvation structure; such that the solvation structure is substantially dominated by a plurality of solvent-separated pairs, contact-ion pairs, aggregates or a combination thereof. Also disclosed are electrochemical cells comprising such electrolytes. Also disclosed are methods of making the disclosed herein electrolytes and electrochemical cells.

The invention relates to the technical field of crystal structure prediction, and discloses a quantum algorithm-based energetic CxNyOz crystal structure prediction method, which comprises the following steps of: calculating an evaporation and diffusion dimensionless number and capillary pressure by obtaining surface tension, a contact angle, a geometric feature scale, temperature, partial pressure, a diffusion coefficient and an evaporation rate; establishing a residual solvent mole fraction and solvent chemical potential sequence; constructing a binary layer occupancy model Hamiltonian containing layer occupancy energy, adjacent layer action energy, a capillary pressure volume term and a molecular polarity action term, and obtaining a hierarchical occupancy number by using a quantum approximation optimization algorithm; calculating interlayer respiration and shear frequency and mode volume sensitivity based on a quantum variation algorithm; and finally, the lattice spacing and the prediction result are obtained through cost functional minimization, and accurate prediction and quantitative analysis of the structure of the energetic crystal under the unbalanced desolvation condition are realized.

To provide a new compound having inhibitory activity against MYT1, its salts or their solvates.SOLUTION: Wherein, R4 is selected from optionally substituted C6 - C10 aryl and the like; R5 and R6 are taken together with the atoms to which they are attached to form an optionally substituted D ring; D ring is selected from 3 - to 10-membered mono-alicyclic ring and the like; any two adjacent substituents on D ring may be taken together with the atoms to which they are attached to form an optionally substituted E ring. Or a salt thereof, or a solvate thereof.SELECTED DRAWING: None

The present invention relates to a prodrug and drug having a controllable drug release rate. Specifically provided are a prodrug or a stereoisomer, deuterated substance, solvate, polymorph or pharmaceutically acceptable salt thereof. The prodrug contains a drug and a linker, wherein the drug is linked to the linker, and the linker contains a structure as represented by formula (1). The prodrug has a long half-life, does not require an enzymatic or redox environment, can controllably and spontaneously release the drug under physiological conditions, and exhibits a high drug delivery efficiency. The released drug exhibits a complete activity and is not affected by the linker or a macromolecular carrier.

One aspect of the present invention relates to a method for producing a salt of an amino acid or a salt of a peptide compound or a solvate thereof, comprising the following steps (A) and (B): step (A); a step of contacting a lithium-containing substance with a mixture to be purified which is a mixture of the following purification target (i) and the following impurities (ii): (i) the amino acid having a protective group at the N terminus or the peptide compound having a protective group at the N terminus, and (ii) compounds other than the purification target, and step (B); a step of precipitating a lithium salt of the purification target.

The invention relates to the field of medicine and pharmacology, in particular to a deuterated balosavir precursor compound as well as a preparation method, a pharmaceutical composition and application of the deuterated balosavir precursor compound. The deuterated balosavir precursor compound is a compound as shown in a formula I, or a tautomer, a stereoisomer, a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof, in the formula, R is the following groups: in the formula, R1, R2, R3, R4 and R5 are respectively and independently hydrogen or deuterium and at least contain one deuterium atom or are all deuterium. The compound and the composition have good cap-dependent endonuclease activity and better pharmacokinetic properties, have better safety to normal cells and better in-vitro antiviral effect, and can be used for preparing medicines for treating and / or preventing symptoms caused by influenza virus infection.

A battery includes an electrolyte comprised of a solvating solvent, diluent, and a lithium salt. The electrolyte is a solution having a saturation point, the lithium salt being at least 5 times more soluble in the solvating solvent than in the diluent. The diluent and the solvating solvent are immiscible at a molar ratio of diluent / solvating solvent of 2 or more, and the solvating solvent and diluent are present in the electrolyte at a diluent / solvating solvent molar ratio of 0.1 to less than 2.

The invention relates to a crystal of (R)-2-amino-3-phenylpropyl carbamate hydrochloride, a composition of the crystal and application of the (R)-2-amino-3-phenylpropyl carbamate hydrochloride. The present invention relates to newly discovered solvate forms of (R)-2-amino-3-phenylpropylcarbamate (APC) hydrochloride, methods of making APC hydrochloride, and methods of using the same in the treatment of disorders. The invention also relates to a method for preparing APC hydrochloride with improved purity.

The invention discloses a preparation method of high-dispersity pigment carbon black, which comprises the following steps: S1, carrying out heat treatment on original carbon black under the protection of inert gas to obtain surface-activated carbon black; s2, carrying out heating reaction on the carbon black and grafting molecules to obtain functional carbon black of which the surface is grafted with specific active groups after the reaction; s3, dispersing the carbon black in an organic solvent, firstly adding an olefin pyridine monomer to carry out substitution reaction, then adding a functional monomer containing a dynamic covalent bond to carry out polymerization reaction, and forming a polymer brush on the surface of the carbon black; and S4, carrying out post-treatment to obtain the high-dispersity pigment carbon black. According to the preparation method, high steric hindrance and solvation rejection are given to the carbon black through a covalent anchoring-polymer brush structure, the sedimentation rate of an alcohol ester system is smaller than 5%, and long-term thermal aging stability is maintained by virtue of a stress relaxation mechanism of a dynamic disulfide bond; the harsh requirements of high-end printing ink, high-solid-content coatings and polymer master batches on high blackness, low sedimentation and durability can be met.

One aspect of the present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein X is NH, Y is CO, and ring C is a 6-membered heteroaryl or aryl group, or a 6-membered partially or fully unsaturated heterocyclic group containing at least one N and optionally at least one CO group, wherein said aryl, heteroaryl, or heterocyclic group is selected from the group consisting of alkyl, haloalkyl, alkoxy, haloalkoxy, halo, cyano, NRSO2R 11 , NR9COR 12 , N.R. 13 R 14 , OH, CO2R 15 , SO2NR 16 R 17 ,CONR 18 R 19 , cycloalkyl and (CH2) q -heterocycloalkyl; Ring A is a phenyl group or a 6-membered heteroaryl group, or Ring A is a 5-membered heteroaryl group; in each case, the wavy lines indicate the points of attachment to Y and Ring C, respectively; Ring B is a phenyl group or a 6-membered heteroaryl group; R2 is (CR 33 R 34 ) m COOH; each R6 is alkyl, halo, haloalkyl, alkoxy, haloalkoxy, cyano, NR 10 COR 20 , N.R. 10 SO2R 21 , (CH2) q SR 22 , (CH2) q SOR 23 , (CH2) q SO2R 24 , SO2NR 25 R 26 , (CH2) q OH, (CH2) q OR 27 , N.R. 28 R 29 ,CONR 30 R 31 , cycloalkyl and (CH2) q-heterocycloalkyl; each R is independently selected from alkyl, halo, haloalkyl, alkoxy, haloalkoxy, cyano, NR 10 COR 20 , N.R. 10 SO2R 21 , (CH2) q SR 22 , (CH2) q SOR 23 , (CH2) q SO2R 24 , SO2NR 25 R 26 , (CH2) q OH, (CH2) q OR 27 , N.R. 28 R 29 ,CONR 30 R 31 , cycloalkyl and (CH2) q -heterocycloalkyl; R7 is selected from H and alkyl; each R9 is independently selected from H and alkyl; and each R 10 is independently selected from H and alkyl; R 11 ~R 31 are each independently selected from H, alkyl, haloalkyl, aralkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, and cycloalkyl; m, n, and p are each independently an integer from 0 to 4; each q is independently an integer from 0 to 4; L is a direct bond or -SO2-, -O-SO2-, -SO2-O-, -O-, -NR 32 -SO2-, -NR 32 -SO2-alkylene, -SO2-NR 32 -, -SO2-NR 32-a group selected from alkylene, alkylene, heteroalkylene, cycloalkylene, heterocycloalkylene, alkylene-cycloalkylene, alkylene-SO2-, -SO2-alkylene, alkylene-SO-, -SO-alkylene, alkylene-SO2-alkylene, alkylene-SO-alkylene, cycloalkylene-alkylene, alkylene-heterocycloalkylene, heterocycloalkylene-alkylene, heteroalkylene-heterocycloalkylene, heterocycloalkylene-heteroalkylene, heteroalkylene-cycloalkylene, cycloalkylene-heteroalkylene, wherein the alkylene moiety in the group is optionally substituted by one or more substituents selected from halo, alkyl, haloalkyl, and cycloalkyl; R 32 , R 33 and R 34 are each independently selected from H and alkyl; Z is a group selected from alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl, each of which is optionally further substituted by one or more groups selected from CN, halo, alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, and haloalkoxy. Further aspects of the present invention relate to pharmaceutical compositions comprising compounds of formula (I) and the use of said compounds in the treatment of various GPR35-related disorders. [Formula 1] JPEG2026503167000340.jpg121170

The invention discloses a difunctional aqueous zinc ion battery high-voltage electrolyte and a preparation method and application thereof, and belongs to the technical field of aqueous zinc ion batteries. The electrolyte is prepared from the additive with the structural general formula that R groups are hydroxyl, carboxyl, acetyl and methoxyl, and the additive contains oxygen atom-containing functional groups capable of serving as hydrogen bond acceptors, so that the water-phase solubility of molecules can be remarkably improved, the electrolyte ion concentration can be adjusted through specific interaction with solvent molecules, and the service life of the electrolyte is prolonged. The solvation sheath structure of zinc ions is regulated and controlled by reducing the number of solvent molecules. Meanwhile, the functional group containing the oxygen atom serving as the hydrogen bond acceptor is a strong electron withdrawing group and can interact with water molecules to form intermolecular hydrogen bonds, the oxygen atom can serve as an electron donor, and the hydrogen atom of water serves as a proton donor to destroy the original hydrogen bonds and tetrahedral structures of the water molecules, so that the water molecules can be absorbed. And the formation of a hydrogen bond network of water molecules is blocked, so that the corrosion side reaction and hydrogen evolution behavior caused by water are effectively inhibited.

The application discloses a kind of electrolyte for lithium metal battery and lithium metal battery, it is related to lithium battery technical field.The electrolyte provided in the application contains lithium salt, weak solvation solvent, active diluent, weak solvation solvent includes fluorinated cyclic carbonate and other weak solvation solvent, by optimizing the raw material selection and proportioning of each component, weak solvation solvent, active diluent and anion cooperate synergistically, regulate the coordination environment of Li + Anion-dominated solvation structure is realized, and anion-derived inorganic matter such as LiF-rich SEI / CEI is generated on the surface of lithium metal and the surface of positive and negative electrode materials during charging and discharging, so that the lithium metal battery has higher coulomb efficiency, cycle stability, better rate performance and high voltage performance.

This solid dispersion comprises: a component (1) which is one or more selected from the group consisting of a compound represented by formula (I), a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable solvate thereof; and a component (2) which is one or more polymers selected from the group consisting of hydroxypropyl methylcellulose and a derivative thereof, wherein the total content of the component (2) per 1 part by mass of the total content of the component (1) is more than 0.1 parts by mass and less than 1.0 part by mass. This composition comprises said solid dispersion and an alkyl sulfate.

The invention relates to a quantitative analysis method for determining trace dimethyl sulfide impurities in a dimethyl disulfide product, a high performance liquid chromatograph-variable wavelength detector is adopted for analysis, and the specific analysis method comprises the following steps: preparing a standard solution and a sample to be detected; and detecting the components of the sample to be detected by adopting a liquid chromatography system-variable wavelength detector (VWD). Wherein the detection conditions are as follows: a C18 chromatographic column, a quaternary pump and an automatic sampling system are adopted, a mobile phase A is ultrapure water, a mobile phase B is acetonitrile, the flow velocity is 0.8-1.2 mL / min, and the column temperature is 30-40 DEG C. According to the present invention, the strong ultraviolet response of DMDS is inhibited by using the high water phase environment, and the retention behavior and the peak shape of DMS are improved by using the solvation effect of the synergist so as to achieve the efficient separation of the main component and the trace impurity; in actual sample determination, the method successfully detects the residual trace DMS in the industrial grade disulfide, the result is stable and reliable, and the method is suitable for product quality control and process optimization.

The application discloses a preparation and purification method of high-purity radioiodine-labeled antigen. The method comprises the following steps: pre-activating carrier-free sodium iodine[125I] solution in an orthogonal solvation sensitization buffer containing lithium sulfate, 18-crown-6 and beta-cyclodextrin; adding antigen and chloramine-T for a labeling reaction; and performing magnetic separation and purification by using a suspension containing adamantane-modified magnetic microspheres and quaternary ammonium salt-modified strong anion exchange magnetic microspheres after the reaction. The orthogonal solvation effect is used to enhance the nucleophilic activity of iodine ions, and the amount of oxidizing agent is reduced to reduce protein damage; impurities are quickly removed through the double mechanisms of electrostatic adsorption and host-guest recognition. The application has the advantages of high labeling efficiency, high radiochemical purity of the product and complete retention of biological activity.

The embodiment of the invention discloses an electrolyte, a battery and an electric device. The electrolyte includes an aprotic organic solvent and an alkali metal salt dissolved therein, the aprotic organic solvent including: a cyclic ester that imparts excellent thermal stability and chemical stability with low ring tension and a stable conjugated structure; straight-chain ether is used for reducing the viscosity of the system and promoting ion transmission; and the weak coordination characteristic of the low-donor-number solvent (DN is less than or equal to 18) promotes more anions to enter a first solvation sheath of Li < + >, so that an anion-dominated solvation structure is formed, the desolvation energy barrier of lithium ions on an electrode interface is reduced, charge transfer is accelerated, and electrochemical polarization is reduced. The solvated structure induces to form a compact and stable SEI film rich in LiF and other high-ionic-conductivity inorganic components at the same time, side reaction is inhibited, deposition / dissolution kinetics of vanadium ions is synergistically improved, and lagging voltage reduction and overall electrochemical stability improvement are finally achieved by synergistically reducing interface impedance in the battery discharging process.