720 results about "Carboxylate" patented technology

The present disclosure relates to novel lamotrigine salts, co-crystals, and compositions. In some embodiments, the lamotrigine salt is a lamotrigine dicarboxylic acid salt or hydrate or solvate thereof. In some embodiments, the lamotrigine co-crystal is a co-crystal of lamotrigine and a dicarboxylic acid, or a hydrate or solvate thereof. In some embodiments, the compositions comprise lamotrigine or a salt or co-crystal thereof, or a hydrate or solvate thereof. In some embodiments, the composition is in the form of a powder. In some embodiments, the composition is in the form of a liquid. The present disclosure also relates to methods of preparation and use in medical therapy, for example, for the treatment of a subject with epilepsy or bipolar disorder.

The invention discloses a compatible molybdenum-aluminum mixed acid etching solution which comprises the following components in percentage by mass: 4%-7% of nitric acid, 55%-65% of phosphoric acid, 17%-28% of acetic acid, 0.5%-3% of an oxidizing additive, 0.05%-5% of a metal corrosion inhibitor and 10%-20% of deionized water, and the oxidizing additive is ceric nitrate and at least one selected from sodium nitrate, potassium nitrate and ammonium nitrate; the etching liquid does not contain other organic components except for organic carboxylic acid and organic carboxylate. According to the compatible molybdenum-aluminum mixed acid etching solution, on the basis that ceric nitrate is introduced, the content of nitric acid is reduced, the nitrate ion concentration is increased by adding nitrate, the overall oxidation performance of an etching solution system is improved, the etching rate ratio of different metals is adjusted, CD-Bias is reduced, the etching dip angles of a molybdenum single layer and a molybdenum-aluminum laminated layer are controlled to be kept at 20-50 degrees, and the problem of aluminum thorns is solved. The invention further discloses a molybdenum-aluminum etching method based on the compatible molybdenum-aluminum mixed acid etching solution.

Described herein are pharmaceutical formulations of a farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, and methods of using such pharmaceutical formulations in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.

The invention discloses a preparation method of a photo-thermal conversion-phase change heat storage polyurethane flexible film, and relates to the technical field of polyurethane phase change materials. According to the invention, polyethylene glycol is used as a polymeric monomer and a phase change heat storage substrate, diisocyanate and dimethylolbutyric acid are used as reaction monomers, any one of 3, 3-dithio-bis-propionyl hydrazide or (R, R)-3, 3 '-diseleno-bis (2-aminopropionic acid) is used as a cross-linking agent, and transition metal carboxylate and a nano photo-thermal conversion agent are introduced to prepare the phase change heat storage material. And the polyurethane flexible film with photo-thermal conversion-phase change heat storage is prepared. A hydrazide group at the tail end of a cross-linking agent and an isocyanate group are subjected to nucleophilic addition reaction to generate a hydrazide-urea structure of which the main chain contains disulfide bonds and constructs multiple hydrogen bonds, and meanwhile, a metal carboxylate coordination bond is introduced, so that the film is endowed with an excellent mechanical response effect in a wide temperature range; the nano photo-thermal conversion agent is added into the system, so that the system has good photo-thermal conversion performance.

The invention discloses a high-voltage-resistant brominated flame-retardant polyamide composition and a preparation method thereof, and belongs to the technical field of flame-retardant materials. The composition comprises the following components in percentage by mass: 30-80 wt% of aliphatic polyamide, 10-30 wt% of a brominated flame retardant, 0.5-10 wt% of an antimony-based synergist, 0.5-10 wt% of aromatic zinc carboxylate, 0.5-5 wt% of hydroxyapatite, 0.1-50 wt% of a reinforcing agent and 0-5 wt% of other auxiliaries, the sum of the contents of all the components is 100 wt%, and the raw material components are subjected to melt blending processing through a single-screw or double-screw extruder. The invention provides the high-voltage-resistant brominated flame-retardant polyamide composition, the relative tracking index (CTI) of the high-voltage-resistant brominated flame-retardant polyamide composition is greater than 400V, and the high-voltage-resistant brominated flame-retardant polyamide composition has high-level flame retardance and cost effect.

The invention discloses a film quality optimization method based on perovskite precursor solution deprotonation inhibition, and relates to the field of perovskite solar cells, and the method comprises the steps: preparing a perovskite precursor solution; adding a carboxylic ester-containing compound into the perovskite precursor solution as a deprotonation inhibitor to obtain a mixed solution; and preparing the mixed solution into a thin film through a spin-coating process, and then carrying out annealing treatment to form the perovskite thin film. The compound containing carboxylic ester is adopted as the deprotonation inhibitor, the deprotonation inhibitor can effectively inhibit the deprotonation reaction of the precursor solution, meanwhile, competitive proton exchange caused by excessive carboxyl deprotonation inhibitor can be avoided, the halogen defect in the film can be passivated, and the quality of the perovskite film is remarkably improved. The perovskite solar cell prepared based on the technology shows excellent photoelectric conversion efficiency and stability, and a new technical path is provided for industrialization of perovskite photovoltaic devices.

The application relates to the technical field of adhesives, and discloses a low-VOC flame-retardant double-faced adhesive for automobile interiors and a preparation method thereof. In the application, tetramethyl ethylene (epoxy propyl ammonium chloride) and bis (4-aminophenyl) -phenyl phosphate are reacted to obtain a cationic flame retardant, which is then added into a water-based acrylic resin emulsion to obtain a flame-retardant water-based acrylic resin adhesive and a flame-retardant double-faced adhesive. The cationic groups in the cationic flame retardant and the sodium carboxylate anions in the water-based acrylic resin form electrostatic force, the crosslinking degree between acrylic resin molecular chains is improved, the cohesion is increased, and the bonding performance and tensile shear strength of the adhesive are improved. The cationic flame retardant contains a triphenyl phosphate flame-retardant structure, has condensed-phase flame-retardant effect, improves the limiting oxygen index and the flame-retardant performance of the adhesive, and has good practical application in adhesives for new energy vehicles, double-faced adhesives and the like.

Described herein is the farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.

The invention relates to the technical field of flash fire lifting agents, and discloses a flash fire lifting agent of an electrolyte of a boron-free aluminum electrolytic capacitor and a preparation method of the flash fire lifting agent, and the flash fire lifting agent comprises the following components in percentage by mass: 10-30% of organic ammonium carboxylate; 5%-15% of a nitro compound; 3%-10% of a phosphate ester compound; 2%-8% of a polyethylene glycol derivative; 0.5%-3% of organic siloxane; and the balance of deionized water. Through the synergistic effect of the organic ammonium carboxylate, the nitro compound, the phosphate ester substance and the organosiloxane in a specific proportion, the sparking voltage of the electrolyte is remarkably improved, and the negative effects of boron elements on the environment and the performance of a capacitor are avoided; a nitro compound is used as an electron acceptor to inhibit hydrogen precipitation, and cooperates with phosphate to fill oxide film micropores and block current concentration; the organic siloxane forms a hydrophobic barrier on an electrode interface, electrolyte decomposition is delayed, the organic carboxylic acid ammonium salt accurately controls the free acid concentration, and the conductivity rise caused by hydrogen ion migration is avoided.

The invention discloses a method for preparing a porous carbon material by using petroleum coke and biomass as raw materials, which comprises the following steps: respectively crushing and drying a biomass raw material and a petroleum coke raw material, adding a dry biomass fine powder material and a dry petroleum coke fine powder material into urotropine, melamine, alcohol ether carboxylate and water according to a ratio, adding the materials into a reactor, stirring, mixing and reacting; the cured product is fed into a tubular furnace to be subjected to heat treatment in the nitrogen atmosphere, and a carbonized product is obtained; and activating the carbonized product in a carbon dioxide atmosphere to obtain the porous carbon material with the specific surface area of 1510-2090 m < 2 > / g, the total pore volume of 0.72-0.99 cm < 3 > / g and the average pore size of 1.71-2.29 nm. The raw material proportion, the mixing aid dosage and the carbonization activation condition can be adjusted according to different biomass types, the pore distribution of the product can be flexibly adjusted, and the method can be applied to different scenes. The method is low in cost, environment-friendly, controllable in product stability and suitable for large-scale production and application.

The invention relates to a high-hydrophilicity CMP hard polishing pad, a preparation method and application thereof, the polishing pad comprises a polishing layer, a fitting layer and a buffer layer, the polishing layer is formed by mixing and pouring a component A and a component B, the component A comprises polyisocyanate, polyol, a foaming agent and a hydrophilic modifier, and the component B is an amine curing agent. The carboxylate is added into the polishing layer to serve as a hydrophilic modifier, and after dissociation, the carboxylate is combined with polar groups in a polyurethane molecular chain through coordinate bonds or ionic bonds to form a stable bonding structure, so that the carboxylate is attached to a main chain of the polyurethane molecular chain, and the overall hydrophilicity of the polyurethane structure is improved. According to the method, the surface energy and surface characteristics of the polishing pad can be changed fundamentally, the introduced hydrophilic auxiliary agent cannot reduce the mechanical property of an original formula, and the constant hydrophilicity is maintained during the polishing service life of the polishing pad.

The preparation method comprises the following steps: S1, hydrophilic-hydrophobic bi-component modification reaction: dissolving a styrene-maleic anhydride copolymer, hydrophilic polyethylene glycol monomethyl ether and hydrophobic long-chain alkyl alcohol in butanone according to a ratio, adding a catalyst, stirring, reacting, filtering, washing, and drying to obtain the dispersing agent for the lithium battery diaphragm based on the modified benzyl resin micelle. Performing ester exchange reaction on anhydride bonds of the styrene-maleic anhydride copolymer and polyether hydroxyl and alkyl alcohol hydroxyl respectively to obtain a modified intermediate; s2, neutralization reaction: dropwise adding organic alkali into the modified intermediate, and adjusting the pH value to obtain a modified SMA solution containing carboxylate groups; s3, preparing nano-micelles: dropwise adding the modified SMA solution into deionized water, and stirring to enable the modified SMA solution to be self-assembled to form the nano-micelles, so as to obtain nano-micelle dispersion liquid; and S4, dispersing agent forming: stirring the nano-micelle dispersion liquid to remove butanone so as to obtain the water-based dispersing agent.

It has been unexpectedly found that certain neodymium catalyst systems can be used to copolymerize isoprene and 1,3-butadiene to produce random isoprene-butadiene copolymer rubbers which are not tapered. These random isoprene-butadiene copolymer rubbers have properties which are beneficial for use in rubber formulations for manufacturing a wide variety of rubber products, such as tires, hoses, conveyor belts, power transmission belts, and shoe soles. These random isoprene-butadiene rubbers are synthesized by copolymerizing (a) isoprene monomer or a substituted isoprene monomer and (b) 1,3-butadiene monomer in the presence of a neodymium catalyst system, wherein the neodymium catalyst system is prepared by (1) reacting a neodymium carboxylate with an organoaluminum compound in the presence of a conjugated diolefin monomer to produce neodymium-aluminum catalyst component, and (2) subsequently reacting the neodymium-aluminum catalyst component with an alkyl aluminum chloride to produce the neodymium catalyst system.

This invention discloses an analytical method for benzothiazole contaminants, comprising the following steps: detection by high performance liquid chromatography (HPLC), with the following chromatographic conditions: a phenylhexyl column as the stationary phase, mobile phase A being water, mobile phase B being acetonitrile, and gradient elution; wherein the benzothiazole contaminants are at least one of 2-aminobenzothiazole, 2-hydroxybenzothiazole, benzothiazole, 2-methylbenzothiazole, 2-mercaptobenzothiazole, 2,5-dimethylbenzothiazole, 2-cyanobenzothiazole, ethyl 2-carboxylate benzothiazole, 2-chlorobenzothiazole, 2-bromobenzothiazole, 2-methylthiobenzothiazole, phenylthiocyanate, N-tert-butyl-2-benzothiazole sulfenamide, 2-(2-hydroxyphenyl)-benzothiazole, N-cyclohexyl-2-benzothiazole sulfinamide, dibenzothiazole disulfide, and N,N-dicyclohexyl-2-benzothiazole sulfonamide.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

The invention relates to a difunctional organic lithium salt, a preparation method thereof and application of the difunctional organic lithium salt in regeneration of waste lithium iron phosphate. Firstly, benzene-containing organic molecules, inorganic lithium salt, an organic solvent and the like are used as raw materials, difunctional organic lithium salt with a lithium carboxylate (COO-Li +) and lithium phenolate (Ph-O-Li +) composite structure is prepared, then the waste lithium iron phosphate positive electrode material and the difunctional organic lithium salt are evenly mixed according to a certain proportion, the obtained mixture is heated to 650-800 DEG C to be subjected to high-temperature calcination, and the waste lithium iron phosphate positive electrode material is obtained. And repeatedly cleaning with absolute ethyl alcohol and deionized water, and drying to finally obtain the regenerated lithium iron phosphate which has a crystal structure equivalent to that of the original lithium iron phosphate and has high specific capacity, excellent rate capability and good cycle stability. In the regeneration process of the waste lithium iron phosphate, the difunctional organic lithium salt can supplement lithium vacancies and realize carbon coating, so that the defects of the waste lithium iron phosphate are repaired, the regenerated lithium iron phosphate can be directly used for manufacturing battery positive electrodes and lithium batteries, and an important support is provided for sustainable development of the lithium battery industry.

The invention discloses an anti-counterfeiting flexible packaging film material and a preparation process thereof, belongs to the technical field of packaging material preparation, and aims to solve the technical problem that the anti-counterfeiting performance and the mechanical property of a packaging material in the prior art need to be further improved. Modified polyurethane, zinc-carboxylate cluster polyester and phosphorus-containing polysiloxane are synergistically compounded to construct a multi-scale structure with a flexible matrix, physical crosslinking and an inorganic skeleton, and the prepared anti-counterfeiting flexible package film has high strength and high ductility in mechanical properties and still keeps excellent stability after thermal aging; a phosphorus-silicon synergistic gas phase flame suppression and condensed phase vitrification barrier is formed in the aspect of flame retardance; the anti-counterfeiting packaging film has stable optical fingerprints under ultraviolet light in anti-counterfeiting performance and has reversible color change characteristics under the action of tensile stress, static and dynamic dual verification is realized, and the overall performance of the anti-counterfeiting packaging film is obviously superior to that of a conventional packaging film.

The present invention relates to a novel polymorph of (1R,2R,3aS,3bR,10aS,10bR,11S,12aS)-5,10b-difluoro-1-(((fluoromethyl)thio)carbonyl)-11-hydroxyl-2,10a,12a-trimethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecylhydrocyclapenta[5,6]napththo[1,2-F]indazole-1-furan-2-carboxylate ester as shown in formula (I), a preparation method therefor, and a use thereof. The crystal form of the present invention has characteristics such as a significant pharmaceutical effect, good stability, high yield, and high purity, and is beneficial for the selection and design of a drug administration route and the determination of a drug preparation process parameter, thereby improving drug production quality.

A water-based rust inhibiting agent according to the present disclosure contains a carboxylate, a sorbitan-based surfactant, a silane coupling agent having an epoxy group or a glycol group, and an aqueous medium.

This invention relates to a polyamide composite material, its preparation method, and its applications. The polyamide composite material comprises the following components by weight: 55-75 parts polyamide resin, 15-35 parts glass fiber, 7-17 parts halogen-free flame retardant, 0.1-1 parts nucleating agent, 0.1-0.7 parts colorant, and 0.1-0.6 parts lubricant. The nucleating agent comprises a linear saturated sodium carboxylate with a carbon chain length of C28-C32. The polyamide composite material provided by this invention exhibits high blackness, enables high-contrast ultraviolet laser marking, and possesses excellent mechanical and flame-retardant properties, making it suitable for ultraviolet laser marking in the electronics and electrical appliance fields.

The invention discloses preparation of a polymer conductive binder and application of the polymer conductive binder in a lithium ion battery, and belongs to the field of lithium ion batteries. A main chain of the high-molecular conductive binder is of a conjugated structure, and a side chain or the main chain contains functional groups such as lithium phenolate, lithium carboxylate, furanone and lactone; the preparation method comprises the following steps: carrying out heat treatment on a specific polymeric monomer and an initiator in an inert atmosphere and a solvent in the presence of a lithium source, and carrying out post-treatment to obtain a target product. The polymer conductive binder can effectively fill pores of active substances, buffer volume expansion and prevent the active substances from falling off. The polymer conductive binder has higher intrinsic conductivity (greater than or equal to 102S / cm), stronger electrode bonding strength (greater than or equal to 1.5 N / cm) and considerable lithium ion storage capacity (specific capacity greater than or equal to 200mAh / g), can remarkably improve the capacity and cycling stability of the battery, and has a wide market application prospect.

The application discloses a heat-insulating and light-shielding curtain and a preparation method thereof, and relates to the field of curtains. The graphene oxide is first prepared into a hydrogel, and modified carbon black is added to improve the light-shielding performance of the curtain; then, silver carboxylate is generated by the reaction between silver oxide and the carboxyl in the hydrogel, so that the antibacterial effect of the curtain is improved; the hydrogel is then frozen and spun, and is woven to obtain an aerogel fabric layer; bamboo charcoal microsphere particles are added to a bottom glue layer, and form spherical protrusions with tin foil, so that the light can be reflected, and the light-shielding effect is improved; the main raw material of a surface glue layer is titanium dioxide modified polyurethane, which is rolled on the surface of the tin foil to further improve the light-shielding, heat-insulating and antibacterial performances; finally, electrostatic flocking is performed to obtain the curtain with the heat-insulating and light-shielding effects.

The present disclosure relates to a method of forming electrical signal sensor. The method includes the following operations. An oxidoreductase and an amphiphilic molecule are dissolved into a solvent to form a solution, in which the amphiphilic molecule includes alkyl sulfuric acid, alkyl sulfate, alkyl sulfonic acid, alkyl sulfonate, alkyl ammonium, alkyl ammonium salt, alkyl phosphoric acid, alkyl phosphate, alkyl carboxylic acid, alkyl carboxylate, alkylboronic acid, alkylborate, or combinations thereof. The solution is coated on an electrode layer. The solution is dried.

To improve the adhesion of the coating film to the resin and the resistance of the coating films to blocking each other. [Solution] The polyurethane aqueous dispersion according to the embodiment comprises a polyurethane resin (A) containing a polyester polyol as a constituent component dispersed in an aqueous dispersion medium, and includes a carbodiimide group-containing compound (B) and a salt (C) of an acid and an alkali metal. The polyurethane resin (A) has carboxyl groups, and the salt (C) is at least one selected from the group consisting of bicarbonates, carbonates, monocarboxylates, dicarboxylates, tricarboxylates, and phosphates, and the salt (C) exists in an ionized state in the aqueous dispersion medium.

This invention provides anhydrous ethyl carboxylate compound-coated taste-masking granules. The anhydrous taste-masking granules comprise ethyl carboxylate compound-coated microcapsules and a flavoring material. The ethyl carboxylate compound-coated microcapsules are formed by sequentially coating a blank core with a drug-loaded layer, an isolation layer, and a taste-masking layer. The drug-loaded layer includes an active pharmaceutical ingredient, a coating material, an anti-adhesion agent, and an antistatic agent. The isolation layer includes a coating material, an anti-adhesion agent, and an antistatic agent. The taste-masking layer includes a coating material, a plasticizer, an anti-adhesion agent, and an antistatic agent. The active pharmaceutical ingredient is an ethyl carboxylate compound or a pharmaceutically acceptable salt thereof. The structure of the ethyl carboxylate compound is shown below. By using a smaller-sized blank core, a specific amount of talc, and Eutec E100 / EPO as the coating material for the taste-masking layer, smaller-sized coated microcapsules with fewer static electricity and adhesion problems, and anhydrous ethyl carboxylate compound-coated taste-masking granules with a better taste, are obtained.

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

The present application relates to the field of frother, in particular to a kind of copper flotation collector frother and preparation method thereof, by weight parts, including the following raw materials: N,N-dibutyl dithiocarbamic acid propyl cyanurate 100-120 parts, O-butyl-N-isobutyl thiopropyl carbamate 12-18 parts, xanthate 12-18 parts, phosphate ester polypropylene glycol ether 15-20 parts, modified betaine 5-8 parts, alcohol ether 3-5 parts, slime inhibitor 1-3 parts, alcohol ether carboxylate 2-5 parts, sorbitan monooleate 0.8-1.2 parts. Through the synergies of each raw material, the collector capacity, selectivity in copper flotation process can be effectively improved, and the reagent stability is good.

The application belongs to the technical field of metal surface treatment, and particularly relates to a passivation agent for a conversion film of die-cast aluminum and aluminum alloy and a preparation method thereof, which comprises gamma-aminopropyl triethoxysilane, cyclopentadienyl dibutoxy titanium chloride, fatty alcohol polyoxyethylene ether sodium carboxylate, zirconium isooctoate, aluminum coupling agent AL-M and water. The passivation agent for the conversion film of the die-cast aluminum provided by the application does not contain strong acid, strong base and phosphorus components, is friendly to the environment, is safe to operate in production and use, has a simple operation process, does not have obvious corrosion or discoloration on a metal substrate, and can reach 120 hours in neutral salt spray.

The invention belongs to the technical field of drug synthesis, and particularly relates to an improved preparation method of a fenerenone intermediate 2-cyanoethyl 4-(4-cyano-2-methoxybenzyl)-2, 8-dimethyl-5-oxo-1, 4, 5, 6-tetrahydro-1, 6-naphthyridine-3-carboxylate, which comprises the following three steps: S1, preparing an intermediate I; s2, preparing an intermediate II; and S3, preparing an intermediate V, namely, the fenerenone intermediate, namely, 2-cyanoethyl 4-(4-cyano-2-methoxybenzyl)-2, 8-dimethyl-5-oxo-1, 4, 5, 6-tetrahydro-1, 6-naphthyridine-3-carboxylate. The preparation method of the fenerenone intermediate comprises the following steps of: 1, preparing an intermediate A, and 2, 4-dimethyl-5-oxo-1, 4, 5, 6-tetrahydro-1, 6-naphthyridine-3-carboxylate. The method has the advantages of short reaction flow and few operation steps, is favorable for improving the production efficiency, effectively reduces the possibility of material loss and side reaction increase caused by tedious steps, reduces the safety risk in the production process, reduces the potential pollution to the environment, also improves the continuity and stability of the production process, and reduces the production cost. The industrial large-scale production is convenient to realize, the large demand of the market on the fenerenone intermediate is met, and the method has a good industrial application prospect.