29310results about "Organic compound preparation" patented technology

The invention relates to a preparation method of phenylmethylamine. The technical scheme adopted by the invention for mainly solving the problems of high catalyst loss, low production efficiency and high intermittent operation labor intensity is as follows: the preparation method of the phenylmethylamine comprises the following steps: mixing the raw material of cyanobenzene with a solvent material or at least one of one part of product materials in a mixing unit, introducing the mixture into a fixed bed hydrogenation reactor to be in contact with hydrogen and a catalyst and carry out multi-phase continuous hydrogenation reaction to obtain a product material containing phenylmethylamine, separating the product material to obtain a phenylmethylamine product, wherein the catalyst is a metal loaded catalyst; and the metal is selected from at least one of Pd, Pt, Cu, Ni, Mo and Fe. The preparation method can be used for preparing phenylmethylamine.

This invention discloses a fluorene-based organic small molecule hole transport material and its applications. The general structural formula of the fluorene-based organic small molecule hole transport material is as follows: where n = 1-4, and R represents the hole transport capacity. This fluorene-based organic small molecule hole transport material is used as an undoped hole transport material in perovskite solar cell devices. By introducing dicarboxylic acid groups onto the fluorene-based organic small molecule hole transport material, when used in an inverted perovskite solar cell device, it can form chemical bonds with the hydroxyl groups of the glass conductive substrate, forming a directionally aligned self-assembled layer on the surface of the glass conductive substrate. This effectively improves the charge transport capability at the interface and increases the photoelectric conversion efficiency of the perovskite solar cell device. Furthermore, since this perovskite solar cell device does not contain lithium salts, it exhibits high water and oxygen stability. In addition, the synthesis process of this fluorene-based organic small molecule hole transport material is simple, and the raw materials are inexpensive and readily available, making it highly valuable for practical applications.

The invention discloses a green preparation process of a microwave-assisted synthesized perovskite semiconductor material, which aims at solving the problems of long reaction period, large reagent dosage, heavy pollution and the like of the traditional perovskite preparation process, adopts a novel organic-inorganic hybrid precursor and green solvent system, and accelerates the reaction by microwave radiation. The rapid and environment-friendly synthesis of the material is realized by accurately regulating and controlling microwave parameters and combining multiple processes such as intermittent and collaborative ultrasonic processes. Novel compounds such as nitrogen-containing heterocyclic borate and organic phosphonate are introduced to optimize the performance of the material. The process significantly shortens the preparation period, reduces reagent consumption, improves photoelectric properties, and enhances material stability.

The invention discloses a catalyst used for preparing acrylic acid and butyl ester by the dehydration of butyl lactate and a preparation method thereof. The catalyst is a composite catalyst, comprising a main catalyst A and auxiliary catalysts B, C, D and E, wherein, A is calcium sulphate, B is sulphuric acid, C is phosphate, D is alkaline matter and E is promoter. The preparation method comprises the steps as follows: five compositions A, B, C, D and E are sufficiently mixed, baked for 2-10 hours at the temperature of 200-800DEG C and formed for standby. The catalyst has high catalytic activation; under the catalysis of the catalyst, the molar yield reaches 75.1 percent and the molar selectivity of the acrylic acid and butyl ester reaches 71.5 percent. The preparation method has the advantages that the crystal structure of the main catalyst can be improved so as to be beneficial for carrying out the reaction; and the introduction of different auxiliary catalysts and quantities is helpful to improve the conversion ratio of the raw material and the product selectivity and is beneficial for improving the strength of the catalyst.

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

Disclosed are compositions of lipid nanoparticles (LNP) comprising an ionizable cationic lipid, a phospholipid, a sterol, and a PEG-lipid (non-functionalized and optionally functionalized). The functionalized PEG-lipid can be conjugated with a binding moiety to create a targeted LNP (tLNP). The disclosed tLNP preferentially deliver a nucleic acid molecule or other negatively charged payload to cells expressing a cell surface antigen recognized by the binding moiety of the tLNP, and are better tolerated, as compared to LNPs and tLNPs comprising ionizable cationic lipids found in marketed pharmaceuticals comprising LNPs.

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

Disclosed are compositions of lipid nanoparticles (LNP) comprising an ionizable cationic lipid, a phospholipid, a sterol, and a PEG-lipid (non-functionalized and optionally functionalized). The functionalized PEG-lipid can be conjugated with a binding moiety to create a targeted LNP (tLNP). The disclosed tLNP preferentially deliver a nucleic acid molecule or other negatively charged payload to cells expressing a cell surface antigen recognized by the binding moiety of the tLNP, and are better tolerated, as compared to LNPs and tLNPs comprising ionizable cationic lipids found in marketed pharmaceuticals comprising LNPs.

The invention relates to the technical field of scintillator materials and X-ray detection, in particular to a rare earth organic-inorganic hybrid complex scintillator and a preparation method and application thereof. The general formula of the rare earth organic-inorganic hybrid complex scintillator is [RE (L) 4] <->. [A] < + >, wherein RE is selected from Eu, Tb, Sm or Dy; l is a beta-diketone ligand; [A] < + > is selected from long-chain hydrophobic quaternary ammonium salt cations or heterocyclic quaternary ammonium cations which have the carbon atom number of C8-C20 and do not contain active functional groups. The rare earth organic-inorganic hybrid complex scintillator provided by the invention has good solubility and molecular-level dispersion capability. The scintillator film based on the rare earth organic-inorganic hybrid complex prepared by using the rare earth organic-inorganic hybrid complex has the characteristic of compatibility of high scintillator load and high light transmission, overcomes the problems of low scintillator load rate, poor transparency and limited imaging resolution of the traditional scintillator film, and has excellent practical value and popularization prospect.

The invention belongs to the field of pesticide preparations, and particularly relates to an oil suspending agent containing pleuromutilin and a preparation method of the oil suspending agent. According to the invention, by optimizing the formula, the obtained oil suspending agent can effectively prevent and treat bacterial diseases, the dosage form of the oil suspending agent is more beneficial to application to spraying method pesticide application, and the embodiment verifies that the prevention and treatment effect on the bacterial diseases can reach 90% or above under the condition that the concentration of pleuromutilin is 200PPM. In addition, according to a traditional method, an active compound is obtained through fermentation, and then the active compound is mixed with a corresponding solvent and an auxiliary agent to be processed into a dosage form, so that the cost is high, and great pollution is brought. The method provided by the invention not only meets the control requirements on bacterial diseases, but also saves the energy and power cost from the aspect of process, reduces the use of solvents, is more beneficial to environmental protection, and thus has great economic benefits, environmental benefits and ecological benefits.

The invention relates to the technical field of food, in particular to diglyceride for reducing triglyceride, cholesterol and uric acid as well as a biological enzyme preparation method and application of the diglyceride. The preparation method comprises the following steps: (1) adding water and glycerol into vegetable oil, and then adding immobilized lipase to react to obtain a reactant; (2) centrifuging reactants, collecting a light-phase product, carrying out molecular distillation, and collecting a heavy-phase product to obtain diglyceride; the immobilized lipase comprises lipase and a carrier, the carrier comprises loofah sponge, soybean meal and bentonite, and the mass ratio of the loofah sponge to the soybean meal to the bentonite is 1: (2-4): (3-6). The method has the advantages that the effects of reducing triglyceride, total cholesterol and uric acid are relatively good, and the yield and the purity are relatively high.

The invention belongs to the technical field of oilfield chemistry, and discloses a cross-linking agent for degradable gel and a preparation method and application thereof.The preparation method comprises the steps that a compound A is dissolved in an organic solvent and stirred to be uniform, and a first solution is obtained; adding a polymerization inhibitor and a compound B into the first solution, and uniformly stirring at room temperature to obtain a second solution; the second solution is sequentially subjected to heating stirring, diethyl ether washing, ethanol recrystallization, suction filtration and drying, and the cross-linking agent for gel is obtained. According to the invention, a non-conjugated aromatic system is added into a cross-linking agent structure, so that the prepared gel can be automatically degraded under a certain temperature condition; ammonium ions and halide ions are added into a cross-linking agent structure, so that the anti-pollution performance of the gel is enhanced, and the problems that existing gel is difficult to degrade and poor in anti-pollution performance are solved.

The invention relates to a method for purifying a monomer bis (2-hydroxyethyl) terephthalate (BHET) obtained by depolymerizing waste polyester through ethylene glycol (EG), and belongs to the technical field of polyester recycling. The BHET microwave radiation induced film evaporation separation and molecular distillation refining continuous process provided by the invention solves the problems of long process flow, poor continuity, more side reactions and low purity and yield in the direct separation and refining process of BHET in alcoholysis liquid based on a gas-liquid equilibrium separation method at present. The whole technological parameter requirement is mild, the process is short, continuity is good, the BHET purity of the product is larger than or equal to 99.0 wt%, the hue is good, and the BHET yield is larger than or equal to 80.0%. And meanwhile, the method has the advantages that EG is conveniently recycled in a system, the production process is cleaner and more environment-friendly, and the comprehensive efficiency advantage is obvious.

A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of 3, 4 '-diaminodiphenyl ether.The preparation method comprises the steps that S1, under inert gas and in a first solvent, m-dinitrobenzene and p-acetamidophenol are subjected to a heating reaction under the condition of a weak base catalyst, and 3-nitro-4-acetamido diphenyl ether is prepared; s2, in a second solvent, the 3-nitro-4-acetamido diphenyl ether is subjected to a hydrogenation reduction reaction, and 3-amino-4-acetamido diphenyl ether is prepared; and S3, dissolving the 3-amino-4-acetaminodiphenyl ether in an alcohol solvent system, adding an aqueous solution of alkali, controlling the reaction temperature, carrying out a hydrolysis reaction, and after the reaction is finished, carrying out post-treatment to obtain the 3, 4 '-diaminodiphenyl ether. The preparation method provided by the invention has the advantages of easily available raw materials, low price, good selectivity and high product yield, and is more suitable for industrial production by comprehensively considering economical efficiency and safety.

The invention relates to application of a metal ion doped graphene oxide membrane catalytic material to efficiently and rapidly catalyze thioether to oxidize and synthesize sulfone at room temperature. Metal ions are added into dispersion liquid of graphene oxide, so that the graphene oxide interacts with the metal ions, the metal ions are doped, and then the dispersion liquid of the graphene oxide doped with the metal ions is prepared into the metal ion doped graphene oxide membrane catalytic material by using a vacuum filtration method. And the content of metal ions in the metal ion doped graphene oxide membrane catalytic material is continuously adjustable. Compared with a traditional catalytic method, the method has the advantages that a thioether substrate and an oxidizing agent react in a two-dimensional interlayer confinement channel of the metal ion doped graphene oxide membrane catalytic material in a continuous mobile phase reaction mode, and a product flows out along with a mobile phase; the catalytic method can achieve the purposes of high conversion rate (90-100%), high selectivity (60-100%) and high speed (1-60 s) of thioether oxidation reaction at room temperature.

The invention belongs to the technical field of novel fluorescent materials, and particularly discloses application of a mechanical color change pyrenyl derivative in latent fingerprint fluorescence imaging and extraction. The mechanical color-changing pyrenyl derivative can be selectively combined with fingerprint residual substances under the excitation of ultraviolet light through the unique fluorescence response characteristic, so that potential fingerprints form high-contrast fluorescence imaging on smooth or rough surfaces (such as glass, metal, plastic and the like), and the mechanical color-changing pyrenyl derivative is compatible with conventional camera equipment to realize rapid acquisition. The compound design is based on a modular synthesis route, and has the advantages of simple and convenient synthesis process, controllable raw material cost, high reaction yield and the like. The product has excellent thermal stability and chemical stability, can be stored at normal temperature and does not need special treatment, and the practical application threshold is greatly reduced. Compared with a traditional fingerprint developing technology, the method has remarkable breakthroughs in the aspects of sensitivity, substrate adaptability and operation convenience, and an efficient, economical and environment-friendly novel solution is provided for the fields of criminal investigation, forensic identification and the like.

The invention discloses a photocatalytic preparation method of a deuterated acetamide compound, and belongs to the technical field of synthesis of deuterated acetamide compounds. According to the technical scheme, the method is characterized in that a dichloroacetamide compound is used as a raw material, D2O is used as a deuterium source, and the dideuterated acetamide compound is synthesized through reaction under the room-temperature nitrogen illumination condition; according to the method, dichloroacetamide compounds are taken as raw materials, D2O is taken as a deuterium source, deuterated dichloroacetamide compounds are synthesized through room-temperature reaction, and monodeuterated or trideuterated acetamide compounds are respectively obtained through photocatalytic reaction according to different solvents (H2O or D2O) added into a system. The preparation method provided by the invention has the advantages of simple and safe operation, mild reaction conditions, no transition metal participation, cheap and easily available deuterium source, high deuteration rate, controllable number and the like.

The invention provides a method for recovering a BHET monomer from a waste polyester textile alcoholysis solution, and is characterized in that the recovery method comprises the following steps: (1) filtering: mixing the waste polyester textile alcoholysis solution with water under a stirring condition, and filtering at 55-70 DEG C; and (2) cooling crystallization: under a stirring condition, carrying out primary cooling on the filtrate obtained by filtering in the step (1) from 55-70 DEG C to 45-55 DEG C, then adding a BHET seed crystal, then carrying out secondary cooling to 5-15 DEG C, and maintaining the temperature for 20-60 min to obtain the BHET monomer. The mixed solution cooling crystallization method is developed on the basis of complexity of components of the waste polyester textile fabric, the problems that in the conventional production process, a BHET crystal product is low in quality, prone to scaling, difficult to filter and dry and the like are solved, and the obtained BHET product is large in particle size, narrow in particle size distribution, high in purity, good in fluidity and high in stability.

Provided in the present invention is a polyester polymer containing a cyclic imide structure. A cyclic imide side group or side chain is introduced into a polyester polymer by means of a diacid monomer or a diol monomer, thereby overcoming the defects of the polyester polymer being hard and brittle, improving the comprehensive mechanical properties of toughness, etc., thereof, and improving the heat resistance of the polyester polymer.

The invention provides a preparation method and application of a cobalt-based catalyst, and relates to the technical field of chemical production. The cobalt-based catalyst includes cobalt, a transition metal element, and a Group IIIA element other than aluminum. Transition metal elements and IIIA group elements except aluminum are introduced into the cobalt-based catalyst, and the electronic structure and active sites of the cobalt-based catalyst are changed. The method not only can cooperate with catalytic reaction and promote the formation and conversion of intermediates, but also can enhance the adsorption and activation capability on substrates, reduce the reaction activation energy and guide the reaction to be carried out along a specific path. Finally, the effect of efficiently harvesting the 2-methyl pentamethylene diamine and the 3-methylpiperidine at the same time is achieved.

The invention provides a novel method for synthesizing a fluoroalkyl substituted 4, 4 '-diaminodiphenylmethane compound, which comprises the following steps: under the action of a catalyst, reacting an amine compound with a fluorine-containing aldehyde compound in an organic solvent, and after the reaction is finished, carrying out post-treatment to obtain the fluoroalkyl substituted 4, 4'-diaminodiphenylmethane compound. The method has the advantages of mild reaction conditions, simple operation, high reaction efficiency, cheap and easily available raw materials, good atom economy, no generation of wastes, and large-scale application prospects. In addition, the fluoroalcohol solvent is recycled through simple distillation operation, the cost of a large amount of solvent is effectively saved, the process safety is improved, and efficient and green industrial production is facilitated.

The invention discloses a preparation method of magnesium threonate. The preparation method comprises the following steps: S1, preparing a stable glucose-magnesium six-membered ring compound; s2, concentrating the reaction liquid, crystallizing, and drying in vacuum to obtain a glucose-magnesium six-membered ring compound; s3, dissolving the compound in water, and adding Fe < 2 + > to adjust the pH value to 2.5-3.0; s4, the solution obtained in S3 is heated, H2O2 is dropwise added, Fe < 2 + > in the solution catalyzes H2O2 to generate hydroxyl radicals, the glucose-magnesium compound is selectively cracked, and magnesium threonate is generated; s5, adding Na2S2O3 to terminate the reaction, and filtering to remove Fe (OH) 3 precipitate; concentrating the filtrate under reduced pressure until the filtrate is sticky, standing at low temperature, and separating out a magnesium threonate crude product; according to the method, the glucose-magnesium six-membered ring compound is used as a raw material and is converted into magnesium threonate through Fenton reaction oxidative cracking, and the purified magnesium threonate is high in purity, low in Fe residue, mild in process condition and suitable for large-scale production.

The invention relates to the technical field of methanol production, and discloses an efficient gas-liquid distribution device for a methanol synthesis reaction tower. The liquid distribution assembly is used for distributing a catalyst; the filler assembly is used for promoting gas-liquid contact; when the liquid distribution assembly runs, the liquid distribution assembly drives the atomization assembly to atomize the catalyst flowing on the inner wall of the tank body; the liquid distribution assembly comprises a rotating shaft, the rotating shaft is rotationally installed in the tank body, a wind wheel is fixedly connected to the rotating shaft, a liquid disc is fixedly connected to the top end of the rotating shaft, a plurality of first spray heads are hinged to the liquid disc, and hoses are arranged between the first spray heads and the liquid disc. Through the arrangement of the liquid distribution assembly, the multiple first spray heads can swing in a reciprocating mode in the rotating process, so that the spraying range of the first spray heads is expanded, the situation that spraying blind areas occur in the tank body is avoided, catalysts in the tank body are distributed more evenly, and the gas-liquid contact efficiency is improved.

The invention discloses a large-aperture aluminum oxide loaded copper-based catalyst as well as preparation and application thereof. The large-aperture alumina-loaded copper-based catalyst comprises a large-aperture alumina carrier, and copper oxide and lanthanum oxide loaded on the surface of the large-aperture alumina carrier, the large-aperture alumina-loaded copper-based catalyst is granular, the specific surface area is 250-500 m < 2 > / g, the pore volume is 1.0-2.0 cm < 3 > / g, the average aperture is 16-30 nm, and the pore diameter of the large-aperture alumina-loaded copper-based catalyst is 20-30 nm. The large-aperture alumina supported copper-based catalyst comprises the following components in percentage by mass: 79%-98.9% of a large-aperture alumina carrier, 0.1%-6% of copper oxide and 1%-15% of lanthanum oxide. The large-aperture aluminum oxide loaded copper-based catalyst disclosed by the invention shows relatively high catalytic activity and higher alcohol selectivity in a reaction for preparing higher alcohol from ethanol, and particularly has relatively high C6-C10 fatty alcohol selectivity.

The invention discloses a method for chemically synthesizing berberine hydrochloride. The method comprises the following steps: firstly, synthesizing a methyl substance; synthesizing a condensation compound; then, berberine hydrochloride is synthesized; the synthesis method has the advantages of cheap and easily available raw materials, less generated three wastes, environmental protection, no use of a heavy metal catalyst, no drug safety risk caused by excessive heavy metals in the finished product, no high-temperature and high-pressure reaction, mild reaction conditions, simple required equipment, convenient operation and good controllability, and is suitable for large-scale industrial production; the purity of berberine hydrochloride produced through the method can reach 99.8% or above, the single impurity content is smaller than 0.1%, and the medicine safety and effectiveness are greatly guaranteed.

The invention relates to a preparation method and application of a porous material for preparing methanol through carbon dioxide adsorption and conversion. When the material is prepared, firstly, 4, 4 '4' '-(1, 3, 5-triazine-2, 4, 6-trimethylene) triphenylamine and 1, 2-acenaphthequinone are treated in a mixed solvent containing dioxane / acetonitrile / 6M acetic acid, and AT-COF is obtained; further synthesizing by adopting an impregnation method to obtain IrRu-COF; and finally, uniformly mixing the active gamma-aluminum oxide and the IrRu-COF material to form a carrier dispersion liquid, and then carrying out PEI loading, vacuum impregnation, washing and drying to obtain the PEI functionalized gamma-Al2O3 / COF composite catalyst. The technical closed loop from low-concentration CO2 capture to solar driven conversion is realized, the process flow is simple, and the energy consumption is low.

The invention provides a metal organic sulfonic acid-based solid acid catalyst applied to nylon 6 recovery and depolymerization and a preparation method thereof, and realizes upgrading and recovery of waste nylon 6. The main contents are as follows: (1) a structural design and a preparation method of the metal organic framework sulfonic acid-based solid acid catalyst; and (2) the solid acid is used for catalytic depolymerization of nylon 6. The problems that equipment corrosion is aggravated by inorganic acid in the nylon 6 recovery process and a liquid-phase catalyst is difficult to separate and recover are solved, and the application prospect is good.

The invention relates to an ammonia distillation-polymerization carbonization one-step preparation method and application of a carbon-modified copper-silicon catalyst. According to the method, carbon is introduced through aldol condensation on the basis of an ammonia distillation method Cu / SiO2 catalyst, and a carbon modified Cu / Si C-x catalyst is prepared; the proper carbon content can promote dispersion of copper on the surface, increase the proportion of Cu < + > / (Cu < + > + Cu0) and remarkably increase the number of Cu < + > sites on the surface of the catalyst, so that the catalytic performance of the catalyst is improved. According to the method, the purpose of carbon modification is achieved without any template agent or acid-base etching agent, a good methyl laurate hydrogenation effect is achieved, and meanwhile the catalyst preparation process is environmentally friendly.