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A surgical severing and stapling instrument, suitable for laparoscopic and endoscopic clinical procedures, clamps tissue within an end effector of an elongate channel pivotally opposed by an anvil. An E-beam firing bar moves distally through the clamped end effector to sever tissue and to drive staples on each side of the cut. The E-beam firing bar affirmatively spaces the anvil from the elongate channel to assure properly formed closed staples, especially when an amount of tissue is clamped that is inadequate to space the end effector. In particular, an upper pin of the firing bar longitudinally moves through an anvil slot and a channel slot is captured between a lower cap and a middle pin of the firing bar to assure a minimum spacing. Forming the E-beam from a thickened distal portion and a thinned proximal strip enhances manufacturability and facilitates use in such articulating surgical instruments.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A surgical buttress-dispensing assembly configured for releasably engaging a surgical stapling device. The surgical buttress-dispensing assembly comprises an one-piece cartridge for receiving and engaging therein an elongate buttress strip, and a carrier configured to slidingly receive, engage, and discharge the cartridge. The cartridge comprises a cylindrical end portion from which extends a pair of opposed elongate semi-circular sleeves. The cylindrical end portion is configured to slidingly received therethrough the closed closed jaws of a surgical stapler. The semi-circular sleeves are configured such that each sleeve slidingly communicates and cooperates with one of the stapler's jaws. The elongate edges of the sleeves are configured to engage and retain therewith the elongate edges of a surgical buttress strip. The carrier is engaged with a cartridge having a buttress strip installed onto the opposed sleeves, and is manipulated to slide and mount the cartridge onto the jaws of a surgical stapler.

An apparatus for use with a surgical stapler to provide a reinforced surgical staple line. The apparatus includes an applicator that carries a first and second bioimplantable material connected by a hinge. An applicator clip may be provided to releasably secure the first and second bioimplantable material onto the applicator.

A surgical severing and stapling instrument, suitable for laparoscopic and endoscopic clinical procedures, clamps tissue within an end effector of an elongate channel pivotally opposed by an anvil. An E-beam firing bar moves distally through the clamped end effector to sever tissue and to drive staples on each side of the cut. The E-beam firing bar affirmatively spaces the anvil from the elongate channel to assure properly formed closed staples, especially when an amount of tissue is clamped that is inadequate to space the end effector. In particular, an upper pin of the firing bar longitudinally moves through an anvil slot and a channel slot is captured between a lower cap and a middle pin of the firing bar to assure a minimum spacing. Forming the E-beam from a thickened distal portion and a thinned proximal strip enhances manufacturability and facilitates use in such articulating surgical instruments.

A novel system for performing a heart valve annuloplasty. The system involves the use of a plication band. In one embodiment, the annulus of the valve is reduced by constriction of the plication band itself. More particularly, each plication band enters the tissue at two or more points which are spaced from one other by a distance which is dictated by the geometry of the plication band. Subsequent constriction of the plication band causes these points to move toward each other, thereby constricting the tissue trapped between these points and thus reducing the overall circumference of the valve annulus. In a second embodiment, the annulus of the valve is reduced by linking multiple plication bands to one other, using a linkage construct, and then using a shortening of the length of the linkage construct between each plication band so as to gather the tissue between each plication band, whereby to reduce the overall circumference of the valve annulus.

An apparatus for supplying surgical buttress material to a surgical stapler is provided. The apparatus has a pivotable area for attaching surgical buttress material. The apparatus may also have an adhesive and a release liner disposed over the buttress material.

An efficient method for breaking source data into smaller data subsets and storing those subsets along with coded information about some of the other data subsets on different storage nodes such that the original data can be recreated from a portion of those data subsets in an efficient manner.

A two-component fluid dispenser which can accurately mix two liquids of varying viscosity and then precisely deliver the mixture formed in discrete amounts. The mixture of the two components is delivered from a single delivery tube in a manner such that none of the mixture remains within the delivery tube at the completion of each mixing and delivery cycle. In one form of the apparatus, the single delivery tube of the apparatus is operably coupled with conventional hypodermic syringes of various sizes so that different fluids can be mixed in different ratios.

An elongated plate for coupling severed bone regions comprising at least one bridge region, the at least one bridge region terminating in at least two bone fixation regions. The at least two bone fixation regions each contain at least one aperture for receiving a suitable fastening device for securing the elongated plate to the bone regions to be coupled. The bridge region may be configured so as to be easily severed by a suitable severing device such as surgical scissors. The elongated plate and fastening device may be formed from a bio-compatible or bio-resorbable material.

A wound dressing includes a first layer located adjacent the wound and which comprises a material that is bioabsorbable, porous and adapted for serving as a scaffold for cell attachment and proliferation; and a second layer which is in contact with the first layer and which comprises an absorbent, gel forming material adapted for serving as a barrier to cell adhesion and penetration. A method of treating a wound with the dressing is also disclosed.

Systems and apparatuses include devices, biosensors, environmental sensors, security related sensors, networked products, communications processors and components, alert and information components, processors, and software to support: 1) facilitating medication regimen and patient / user health administration, dosage control, tracking, compliance, information inquiry and presentation, reminder and notification; 2) providing monitoring, information, ordering, and intervention; 3) presenting the option of leveraging the preventative care, alert and notification components with other components to facilitate user or occupant well being, along with living, work area and dwelling environmental or security safety; and 4) enhancing the dwelling, living or work area with products that may be networked to support the widespread acceptance of these systems and apparatuses. The systems include a) processing, centralizing and communicating device commands and / or programs, e.g. a multifunctional device controller; b) device administration; c) patient / user information; d) dwelling environmental safety; e) security breach information; f) centralized and remote apparatus and system activations through primary component or at least one backup.

An apparatus for supplying surgical buttress material to a surgical stapler is provided. The apparatus has a pivotable area for attaching surgical buttress material. The apparatus may also have an adhesive and a release liner disposed over the buttress material.

A device for dispensing an individual plastic fastener from a supply of fastener stock to couple together two or more objects. The supply of fastener stock includes a plurality of equidistantly spaced cross links which are coupled at one end to a continuous side rail. The fastener dispensing device includes a hollowed sharpened needle shaped to define a longitudinal bore and a feed mechanism for advancing the continuous side rail of the fastener stock into direct axial alignment behind the longitudinal bore of the hollowed needle. The feed mechanism includes a rotatably mounted feed shaft, a pair of feed wheels fixedly mounted on the feed shaft, each feed wheel comprising a plurality of sprockets which are sized and shaped to engage the supply of fastener stock, and first and second clutch wheels which are releasably matingly engageable with one another, the first clutch wheel being fixedly mounted on the feed shaft and the second clutch wheel being rotatably mounted on the feed shaft, each of the first and second clutch wheels including a plurality of ratchets. As a feature of the invention, the number of ratchets on each clutch wheel is at most equal to the number of sprockets on each feed wheel.

The invention relates to an instrument for surgery, in particular minimally invasive surgery. The instrument includes means for feeding back a force which is exerted on the working element of the instrument to the operating element. These means include at least a first force sensor for measuring the force which is exerted on the working element, a control unit and a first actuator. On the basis of a signal which originates from the first force sensor, the control unit controls at least the first actuator in order to control the operating element. Furthermore, the means preferably include a first position sensor for measuring a position of the working element with respect to the frame. The control unit advantageously determines an impedance which the working element is subject to as a result of the presence of a tissue or the like, on the basis of which impedance the control unit controls at least the first actuator.

A mobile payment platform and service provides a fast, easy way to make payments by users of mobile devices. The platform also interfaces with nonmobile channels and devices such as e-mail, instant messenger, and Web. In an implementation, funds are accessed from an account holder's mobile device such as a mobile phone or a personal digital assistant to make or receive payments. Financial transactions can be conducted on a person-to-person (P2P) or person-to-merchant (P2M) basis where each party is identified by a unique indicator such as a telephone number or bar code. Transactions can be requested through any number of means including SMS messaging, Web, e-mail, instant messenger, a mobile client application, an instant messaging plug-in application or “widget.” The mobile client application, resident on the mobile device, simplifies access and performing financial transactions in a fast, secure manner.

A business methodology for optimizing energy procurement energy demand (usage) and energy supply for a facility or complex. After ascertaining a baseline model, energy consumption is monitored and adjusted to reflect dynamic economic factors of operations. With the accumulation of data, contract negotiations with energy suppliers may provide further energy savings. Over time and patterns of usage determined further savings and optimization in energy, equipment, staffing and other operational areas are obtained. Remote access provides efficient monitoring of established systems.

An aerosol electronic cigarette includes a battery assembly, an atomizer assembly and a cigarette bottle assembly and also includes a shell (a) which is hollow and integrally formed. Said battery assembly connects with said atomizer assembly and both are located in said shell (a). Said cigarette bottle assembly is located in one end of the shell (a), which is detachable. Said cigarette bottle assembly fits with said atomizer assembly. Said shell (a) has through-air-inlets (a1).

This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.

An integrated multimedia, entertainment, communications and control system. The system is based on a general purpose computer and is capable of interfacing with, controlling or managing a wide variety of audio, video, telecommunications, data communications or other devices. The system includes a programming environment for creating services or user experiences that may incorporate features or functionalities of several devices that are conventionally operated as separate, standalone devices.

An energy distribution may include a server and one or more databases. The system may communicate with an energy provider to receive energy provider data, at least one information collector to receive information collector data such as individualized energy usage data, customer preferences, and customer or location characteristics, and the one or more databases for receiving data for optimization. The system may calculate a cost of service or avoided cost using at least one of the individualized energy usage data and a system generation cost at a nearest bus. The system may also forecast individualized demand by end-use, individualized demand by location, energy prices, or energy costs. The system may optimize energy distribution, energy use, cost of service, or avoided cost using the forecasted individualized demand by end-use, the forecasted individualized demand by location, the forecasted energy prices, and the forecasted energy costs.