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3937results about "Transmissivity measurements" patented technology

Low-noise optical probes for reducing ambient noise

An optical probe, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip, measures characteristics of the material. A neonatal and adult disposable embodiment of the probe include adhesive coated surfaces to securely affix the probe onto the patient. In addition, the surface of the probe is specially constructed to reduce the effect of ambient noise.
Owner:JPMORGAN CHASE BANK NA

Sample element qualification

A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
Owner:OPTISCAN BIOMEDICAL

High-Accuracy Mid-IR Laser-Based Gas Sensor

A gas sensor system is provided, comprising: a gas cell operable so as to receive a sample gas; a vacuum system fluidically coupled to the gas cell operable to maintain the sample gas within the gas cell at a sub-ambient pressure; a pressure sensor operable to sense a pressure of the sample gas; a thermally insulated enclosure having the gas cell therein; a heat source or heat exchanger operable to influence an interior temperature of the thermally insulated enclosure; a light source within the thermally insulated enclosure operable to provide a mid-infrared (mid-IR) light into and through the gas cell; a photodetector within the thermally insulated enclosure operable to receive the attenuated mid-IR; and a control system electronically coupled to the vacuum system and to the pressure sensor operable to maintain the sample gas within the gas cell at the predetermined pressure to within one torr (1 Torr).
Owner:THERMO FISHER SCI BREMEN

Methods And Apparatus For Ascertaining Interferents And Physical Dimensions In Liquid Samples And Containers To Be Analyzed By A Clinical Analyzer

A method of inspecting a clinical specimen for a presence of one or more interferents, such as those that might be found within clinical analytical blood specimens by subjecting the specimen to centrifugation to separate the specimen into a red blood cell portion and a blood serum or plasma portion is provided. Subsequent to the centrifuging procedure, the serum or plasma portion of the clinical analytical specimen may be tested for the presence of one or more interferents such as hemolysis, icterus, lipemia, or liquid nonuniformities therein. Additionally, physical dimensional characteristics of the sample container and / or specimen may be determined. Apparatus for carrying out the method are described, as are other aspects.
Owner:SIEMENS HEALTHCARE DIAGNOSTICS INC

Method for reducing effect of hematocrit on measurement of an analyte in whole blood

A method for determining the presence and / or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the hematocrit by reducing the size of the red blood cells. In optical detection systems, the smaller red blood cells create greater scatter, which allows a more accurate correction to be applied in a dual-wavelength detection system. In electrochemical detection systems, as well as in optical detection systems, the smaller red blood cells provide less obstruction to the diffusion of analyte and reagents in the sample, to facilitate the reactions thereof.
Owner:ASCENSIA DIABETES CARE HLDG AG

System and Method for Photoacoustic Guided Diffuse Optical Imaging

A system and method for photoacoustic guided diffuse optical imaging of a sample include at least one light source configured to deliver light to the sample, at least one ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light by the sample, and at least one optical detector for receiving optical signals generated due to light scattered by the sample. A control system is provided in communication with the at least one light source, the ultrasonic transducer, and the optical detector for reconstructing photoacoustic images of the sample from the received photoacoustic signals and reconstructing optical images of the sample from the received optical signals. The priori anatomical information and spatially distributed optical parameters of biological tissues from the photoacoustic images employed in diffuse optical imaging may improve the accuracy of measurements and the reconstruction speed.
Owner:RGT UNIV OF MICHIGAN

Method and apparatus for laser-based remote methane leak detection

A method and apparatus for remote laser-based detection of gas at levels exceeding natural background levels preferably utilizing wavelength modulated tunable diode laser absorption spectroscopy. In a preferred embodiment, background gas and noise are estimated using statistical moving average and variance calculations. Gas concentration length measurements resulting from the spectroscopy are preferably compared in real-time or near-real-time to the sum of the background and noise estimates and an alarm limit to detect gas presence of concern. Gas levels exceeding this detection threshold are preferably indicated by a prolonged output tone with a pitch indicative of the magnitude of the gas measurement, and gas levels below the detection threshold are preferably indicated by silence.
Owner:HEATH CONSULTANTS

Method and apparatus for transmittance measurements of large articles

Methods and apparatus for measuring light intensity are disclosed. The methods and apparatus can be used to verify an article, such as a reaction chamber. Exemplary apparatus include a first arm, a light source coupled to the first arm, a second arm, and a sensor coupled to the second arm. The sensor can receive light from the light source that is transmitted through at least a portion of the article.
Owner:ASM IP HLDG BV

Method of making high performance optical edge and notch filters and resulting products

High performance optical edge and notch filters and methods of making the same are disclosed. The multi-layer, thin-film optical edge filters have an edge steepness greater than about 0.8% as measured by dividing (a) the edge width from the 50% transmission wavelength to the optical density 6 (“OD6”) wavelength by (b) the 50% transmission wavelength. The optical edge filters also have an average transmission above about 95%. The notch filters exhibit a blocking of OD>6, very high transmission (>90%) outside the notch(es), and a narrow notch bandwidth comparable to that of holographic notch filters. The methods for making such filters accurately determine when deposition of each layer of the filter should terminate.
Owner:IDEX HEALTH & SCI

Quartz-enhanced photoacoustic spectroscopy

Methods and apparatus for detecting photoacoustic signals in fluid media are described. The present invention differs from conventional photoacoustic spectroscopy in that rather than accumulating the absorbed energy in the fluid of a sample cell, the absorbed energy is accumulated in an acoustic detector or sensitive element. In a preferred embodiment, the acoustic detector comprises piezoelectric crystal quartz. The quartz is preferably in the shape of a tuning fork.
Owner:RICE UNIV

Microfluidic device and surface decoration process for solid phase affinity binding assays

This invention provides a microfluidic device for use in the detection of one or more analytes in a fluid using solid-phase affinity binding assays. The device offers a practical, easy-to-use, portable, inexpensive, robust analytical system for the parallel and quantitative detection of multiple analytes. In addition, this invention provides methods and devices for the formation of concentration gradients of capture molecules immobilized on a solid phase.
Owner:UNIV OF WASHINGTON

Spectral imaging for downhole fluid characterization

The present invention contemplates implementation of transitory downhole video imaging and / or spectral imaging for the characterization of formation fluid samples in situ, as well as during flow through production tubing, including subsea flow lines, for permanent and / or long term installations. The present invention contemplates various methods and apparatus that facilitate one-time or ongoing downhole fluid characterization by video analysis in real time. The methods and systems may be particularly well suited to permanent and periodic intervention-based operations.
Owner:SCHLUMBERGER TECH CORP

Method and a system for determination of particles in a liquid sample

The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
Owner:CHEMOMETEC AS

Multiple sensing system and device

The present invention provides a distributed sensing system in a networked environment for identifying an analyte, including a first sensor array connected to the network comprising sensors capable of producing a first response in the presence of a chemical stimulus; a second sensor array connected to the network comprising sensors capable of producing a second response in the presence of a physical stimulus; and a computer comprising a resident algorithm. The algorithm indicates or selects the most relevant sensor in the network to identify the analyte. The sensors can be separated over large spatial areas, wherein the sensor arrays are networked. Suitable networks include a computer local area network, an intranet or the Internet.
Owner:SMITHS DETECTION

Radiation probe and detecting tooth decay

A probe assembly for examining a sample, the assembly including a probe, a fiber optic cable for communicating signals to and / or from the probe, an emitter for emitting radiation to irradiate the sample and an electro-magnetic radiation detector for detecting radiation which is transmitted or reflected from the sample. The emitter includes a frequency conversion member which emits radiation in response to being irradiated with input radiation which has a different frequency to that of the emitted radiation. At least one of the emitter or detector is located in the probe. The probe is particularly for use as an endoscope or for imaging teeth. The invention also extends to a method of imaging teeth, and apparatus for imaging diseased teeth, for example, teeth with caries or suffering from periodontal disease.
Owner:TERAVIEW

Infrared radiation sources, sensors and source combinations, and methods of manufacture

A blackbody radiation device (110) includes a planar filament emission element (102) and a planar detector (104) for respectively producing and detecting radiation having width dl / 1 less than about 0.1 to test a sample gas, where 1 is the wavelength of the radiation; a reflector (108); a window (W); an electrical control (118); and a data output element (116).
Owner:FLIR SURVEILLANCE

Disposable sensor for use in measuring an analyte in a gaseous sample

The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.
Owner:CIRCASSIA AB

Method for performing a blood count and determining the morphology of a blood smear

A method for counting blood cells in a sample of whole blood. The method comprises the steps of:(a) providing a sample of whole blood;(b) depositing the sample of whole blood onto a slide, e.g., a microscope slide;(c) employing a spreader to create a blood smear;(d) allowing the blood smear to dry on the slide;(e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide;(f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and(g) collecting, analyzing, and storing data from the magnified two-dimensional digital image.Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
Owner:ABBOTT LAB INC

Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer

A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and height of fluid above the gel in blood samples, where appropriate, for the purposes of positioning the specimen for determination of interferents. Such interferents include hemoglobin (Hb), total bilirubin and lipids. These interferents are determined by measurement of absorption of different wavelengths of light in serum or plasma, or other specimens, which are then compared with values obtained through calibration using reference measurements for the respective interferents in serum or plasma or other type of specimen. Determinations of temperature of the specimen, as well as specimen type, for example whether the specimen is urine or plasma or serum, may also be carried out.
Owner:NELLCOR PURITAN BENNETT LLC

Ultraviolet Water Disinfection System

A solution for treating a fluid, such as water, is provided. An ultraviolet transparency of a fluid can be determined before or as the fluid enters a disinfection chamber. In the disinfection chamber, the fluid can be irradiated by ultraviolet radiation to harm microorganisms that may be present in the fluid. One or more attributes of the disinfection chamber, fluid flow, and / or ultraviolet radiation can be adjusted based on the transparency to provide more efficient irradiation and / or higher disinfection rates. In addition, various attributes of the disinfection chamber, such as the position of the inlet(s) and outlet(s), the shape of the disinfection chamber, and other attributes of the disinfection chamber can be utilized to create a turbulent flow of the fluid within the disinfection chamber to promote mixing and improve uniform ultraviolet exposure.
Owner:SENSOR ELECTRONICS TECH

Optical sensors for monitoring biopharmaceutical solutions in single-use containers

Disposable, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. The sensor comprises a disposable fluid conduit or reactor bag and a reusable sensor assembly. An optical bench or inset optical component is integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.
Owner:PARKER INTANGIBLES LLC

Improved stability for optical computing system

The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. Temperature within the analysis system is monitored and the output signals of the optical detectors are compensated or corrections are made within the analysis calculations to compensate or correct for the system temperature. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.
Owner:HALLIBURTON ENERGY SERVICES INC

Pulsed laser linescanner for a backscatter absorption gas imaging system

An active (laser-illuminated) imaging system is described that is suitable for use in backscatter absorption gas imaging (BAGI). A BAGI imager operates by imaging a scene as it is illuminated with radiation that is absorbed by the gas to be detected. Gases become "visible" in the image when they attenuate the illumination creating a shadow in the image. This disclosure describes a BAGI imager that operates in a linescanned manner using a high repetition rate pulsed laser as its illumination source. The format of this system allows differential imaging, in which the scene is illuminated with light at least 2 wavelengths-one or more absorbed by the gas and one or more not absorbed. The system is designed to accomplish imaging in a manner that is insensitive to motion of the camera, so that it can be held in the hand of an operator or operated from a moving vehicle.
Owner:SANDIA NAT LAB

Method of determining analyte concentration in a sample using infrared transmission data

A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
Owner:OPTISCAN BIOMEDICAL
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