A personalized real-time automated 
cardiovascular monitoring system monitors abnormalities in a patient's cardiovascular activity data through the use of individually adjusted electrocardiogram Holter apparatus (Holter / ECG device) that provides an automatic 
medical diagnosis of cardiac abnormalities and generates 
abnormality alert signals representative of certain abnormalities 
in patient's cardiac activities. The signals are transmitted using a 
wireless network through a bi-directional 
wireless protocol to a medical dispatcher center. A response is generated according to the 
abnormality detected. Individual parameters indicative of patient's cardio activities are personalized to allow for adjustments of chronic patients. A base Holter / ECG unit, includes the 
wireless / electric electrodes and their respective wireless / electric connections, and a Holter / ECG recording unit affixed to the base unit. The Holter / ECG apparatus can be integrated as a 
chip into a wireless device, such device being in a wireless phone network. Automatic real-time medical response may be provided to detection of risks of adverse effects resulting from use of at least one medication, based on automatic cardiac 
abnormality alert detection from the Holter / ECG data.