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75 results about "Adaptive response" patented technology

The adaptive response is a form of direct DNA repair in E. coli that protects DNA from damage by external agents or by errors during replication. It is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E. coli can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective. This mechanism has four related genes, also known as “SOS genes”: ada, alkA, alkB, and aidB, each one working in specific residues, all regulated by Ada protein.

System and apparatus for providing diagnosis and personalized abnormalities alerts and for providing adaptive responses in clinical trials

A personalized real-time automated cardiovascular monitoring system monitors abnormalities in a patient's cardiovascular activity data through the use of individually adjusted electrocardiogram Holter apparatus (Holter/ECG device) that provides an automatic medical diagnosis of cardiac abnormalities and generates abnormality alert signals representative of certain abnormalities in patient's cardiac activities. The signals are transmitted using a wireless network through a bi-directional wireless protocol to a medical dispatcher center. A response is generated according to the abnormality detected. Individual parameters indicative of patient's cardio activities are personalized to allow for adjustments of chronic patients. A base Holter/ECG unit, includes the wireless/electric electrodes and their respective wireless/electric connections, and a Holter/ECG recording unit affixed to the base unit. The Holter/ECG apparatus can be integrated as a chip into a wireless device, such device being in a wireless phone network. Automatic real-time medical response may be provided to detection of risks of adverse effects resulting from use of at least one medication, based on automatic cardiac abnormality alert detection from the Holter/ECG data.
Owner:MAKOR ISSUES & RIGHTS

Body optimization design method of light-weight large-stiffness fine blanking press machine

The invention belongs to the technical field of fine blanking press machines, and particularly relates to a body optimization design method of a light-weight large-stiffness fine blanking press machine. The body optimization design method is characterized by comprising the following steps: (1) coarsely designing the body of the fine blanking press machine to obtain a coarse CAD (computer aided design) model; (2) determining whether the coarse CAD model of the step (1) can be optimized according to the strain cloud picture and the stress cloud picture of the coarse-designed body, and carrying out the next step if the coarse CAD model can be optimized; (3) optimizing the stiffness and the natural frequency of the coarse-designed body to find the optimization space of the stiffness and the natural frequency; (4) optimizing a plurality of targets of the coarse-designed body by a compromise programming method; (5) optimizing the size of the machine body optimized by topology; and (6) optimizing the size of the body model of the step (5) by an adaptive response surface method to obtain the optimized body model of the fine blanking press machine. The method can ensure reliable dynamic indexes and static indexes, and can lower the cost maximally.
Owner:WUHAN UNIV OF TECH
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