6 results about "Adaptive response" patented technology

In the present invention, cyclic dinucleotides or their compositions are used as biological response modifiers to enhance the immune response of subjects with deficient immune systems, with a low or absent response to vaccine antigens, or with a deficient immune response to pathogens. The formulations of the present invention are capable of modifying the biological response in such a way as to eliminate the lack of response, resulting in the development of a high-avid immune response that prevents disease caused by infectious agents, particularly viruses with the ability to evade immune surveillance mechanisms and, consequently, suppress the induction of an effective, high-avid adaptive response.The present invention also comprises cyclic dinucleotide formulations, which can be administered alone, in combination with other biological response modifiers, or in vaccine formulations with antigens. The proposed invention further includes a method for preventing or treating acute respiratory infections, preventing disease severity, and blocking transmission by inducing an immune response at the point of entry (nasopharyngeal mucosa), preventing or reducing person-to-person transmission of pathogens / viruses in preventive vaccine formulations, as well as in formulations used for prophylaxis before and after exposure to acute respiratory infections.

The application discloses a micro-nano dual-phase structure scaffold for shoulder rotator cuff tissue regeneration, a preparation method and application. The micro-nano dual-phase structure scaffold comprises an oriented nanofiber membrane in an upper layer and a porous micrometer fiber scaffold in a lower layer of the oriented nanofiber membrane; the oriented nanofiber membrane comprises a first high-molecular polymer-small-molecule drug; the porous micrometer fiber scaffold comprises a second high-molecular polymer, and the porous micrometer fiber scaffold is loaded with one or more of a small-molecule compound, an inorganic mineral and a bioactive ion. The micro-nano dual-phase structure scaffold is particularly suitable for tissue regeneration and repair under a complex interface environment at a rotator cuff insertion. Through the synergistic effect of a biomimetic hierarchical design and biochemical regulation, the micro-nano dual-phase structure scaffold can realize the gradient heterogeneity regulation of an immune microenvironment and induce a biomechanics-biology adaptive response while realizing the differentiation repair function of a tendon and a bone, and finally realizes the biomimetic reconstruction of a rotator cuff injury.

In the present invention, a cyclic dinucleotide or a composition thereof is used as a biological response modulator to improve an immune response in a subject having a low immune system function, a low / no response to a vaccine antigen, or a poor immune response to a pathogen. The formulations of the present invention are able to alter biological responses in a manner that eliminates non-responsiveness, thereby producing a high affinity immune response to prevent diseases caused by infectious agents, in particular viruses, which have the ability to evade the immune surveillance mechanism and thus inhibit the induction of high affinity and efficient adaptive responses. The invention also includes formulations of cyclic dinucleotides that can be administered alone, in combination with other biological response modulators, or in antigen-containing vaccine formulations. The proposed invention also includes methods of preventing or treating acute respiratory infections, preventing disease severity and blocking propagation by inducing an immune response at the entry site (nasopharyngeal mucosa), whether in a prophylactic vaccine formulation or in a formulation for prophylaxis before / after exposure of acute respiratory infections, and pathogen / virus transmission between people can be prevented or reduced.

The application relates to the technical field of industrial equipment monitoring and defect diagnosis, and particularly discloses a data-adaptive equipment production process defect identification method and system. A multi-dimensional delay dynamic benchmark is constructed, and a joint decision based on a delay gradient and fluctuation entropy is adopted to realize intelligent classification and rapid routing of sudden failures, environmental disturbances and composite hidden dangers. The system adopts a three-layer nested diagnosis mechanism of abnormal dimension screening, cause-effect chain tracing and defect mode matching to accurately locate the root cause and drive a three-order adaptive response closed loop of instantaneous inhibition, parameter compensation and model correction to minimize production interruption. Meanwhile, the system periodically calculates a production line health index to realize self-evaluation and collaborative optimization of key parameters, so that the monitoring model can continuously evolve with changes in the equipment state and the environment, and finally form an integration of real-time sensing, intelligent diagnosis and adaptive optimization, thereby significantly improving the defect identification accuracy, system stability and overall operation efficiency.

The invention relates to the technical field of biological fermentation, and discloses a fermentation system for preventing and controlling contamination, which comprises a fermentation tank body, an online monitoring system, a microbial Raman spectrum fingerprint database, a dynamic purification system and a self-adaptive response control system, and the online monitoring system collects Raman spectrum data in the fermentation process in real time. The self-adaptive response control system compares the real-time spectral data with a fingerprint database, quickly identifies the contamination condition, the pollution type and the pollution source, and intelligently selects and activates corresponding subsystems in the dynamic purification system to perform targeted removal according to an analysis result; if so, activating a plasma gas purification subsystem; and activating the acoustic cavitation fixed-point removal subsystem if the fermentation liquid or the wall surface is infected with bacteria. According to the method, real-time early warning, accurate identification and dynamic response type purification of pollution in the fermentation process are realized, the bacterial contamination risk is remarkably reduced, and the stability and the product yield of the fermentation process are improved.

In cancers such as prostate cancer, the combination of PTEN loss and activation of Myc activates an adaptive stress response that enables tumor cells to escape the stress of massively upregulated protein synthesis. This pro-survival response is mediated by the PERK-phosphorylated eIF2α axis of the UPR adaptive response. Agents that disrupt PERK-eIF2α pathways disrupt the adaptive response and lead to cancer cell death from uncontrolled growth. For example, ISRIB and derivatives may be employed as therapeutic agents to disrupt PERK-mediated adaptive mechanisms. Additionally PTEN loss and activation of Myc provides a diagnostic marker that enables better prognosis and the selection of amenable treatments.