2 results about "Adaptive response" patented technology

In the present invention, cyclic dinucleotides or their compositions are used as biological response modifiers to enhance the immune response of subjects with deficient immune systems, with a low or absent response to vaccine antigens, or with a deficient immune response to pathogens. The formulations of the present invention are capable of modifying the biological response in such a way as to eliminate the lack of response, resulting in the development of a high-avid immune response that prevents disease caused by infectious agents, particularly viruses with the ability to evade immune surveillance mechanisms and, consequently, suppress the induction of an effective, high-avid adaptive response.The present invention also comprises cyclic dinucleotide formulations, which can be administered alone, in combination with other biological response modifiers, or in vaccine formulations with antigens. The proposed invention further includes a method for preventing or treating acute respiratory infections, preventing disease severity, and blocking transmission by inducing an immune response at the point of entry (nasopharyngeal mucosa), preventing or reducing person-to-person transmission of pathogens / viruses in preventive vaccine formulations, as well as in formulations used for prophylaxis before and after exposure to acute respiratory infections.

The application relates to the technical field of industrial equipment monitoring and defect diagnosis, and particularly discloses a data-adaptive equipment production process defect identification method and system. A multi-dimensional delay dynamic benchmark is constructed, and a joint decision based on a delay gradient and fluctuation entropy is adopted to realize intelligent classification and rapid routing of sudden failures, environmental disturbances and composite hidden dangers. The system adopts a three-layer nested diagnosis mechanism of abnormal dimension screening, cause-effect chain tracing and defect mode matching to accurately locate the root cause and drive a three-order adaptive response closed loop of instantaneous inhibition, parameter compensation and model correction to minimize production interruption. Meanwhile, the system periodically calculates a production line health index to realize self-evaluation and collaborative optimization of key parameters, so that the monitoring model can continuously evolve with changes in the equipment state and the environment, and finally form an integration of real-time sensing, intelligent diagnosis and adaptive optimization, thereby significantly improving the defect identification accuracy, system stability and overall operation efficiency.