29 results about "Stimulus response" patented technology

The invention discloses a motor cortex excitability evaluation method based on threshold tracking magnetic stimulation, and relates to the technical field of biomedical engineering. The motor cortex excitability assessment method based on threshold tracking magnetic stimulation comprises the following steps: performing electrical stimulation on median nerves of a wrist of a subject, recording on an abductor politics brevis (APB), recording a stimuli-response curve, determining a stimuli-response (SR) curve of cortex stimulation by increasing the magnetic stimulation intensity to the following level, and determining the stimuli-response (SR) curve of cortex stimulation according to the stimuli-response (SR) curve. And calculating statistical parameters of the average value and the standard deviation of the excitability threshold values, and judging the dynamic trend of cortical excitability. According to the method, the stimulation-reaction curve of cortex stimulation is determined by improving the magnetic stimulation intensity to the following level, the central movement conduction time is calculated through the F-wave method based on the stimulation-reaction curve, initial stimulation and threshold determination are completed, subsequent threshold tracking is carried out on the technology, and the accuracy and the reliability of the system are improved. And an efficient and accurate brain motor cortex function detection means is provided for diagnosis of nervous system diseases.

The invention relates to a dual-stimulus-responsive hydrogel with programmable reversible shape movement (namely bidirectional shape memory) and pH (Potential of Hydrogen). The invention belongs to the field of organic polymer materials. According to the method, stearyl acrylate, acrylic acid and N-isopropylacrylamide are copolymerized through free radical copolymerization, the method is wide in raw material source, simple to operate and easy for industrial production, and the dual-stimulus-responsive hydrogel prepared by the method is a brand new material which is never reported and has wide application prospects. The shape memory characteristic is good, the pH sensitivity is high (the whole period of pH softening / enhancing only needs 5 minutes), and the pH range is wide (1-14). The hydrogel with dual effects (good shape memory characteristic and high pH sensitivity) has wide positive effects on drug delivery, control and release in the biomedical field.

The invention discloses a robot lacrimation control method and a microfluid lacrimation execution device for a robot, and relates to the technical field of bionic robot emotional interaction.The robot lacrimation control method comprises the steps that multi-modal sensing data of the robot is obtained, determining a first code used for judging an emotional state and a second code used for judging a physical stimulation response of the robot according to the multi-modal sensing data; and according to the first code and / or the second code, determining an emotion code of the robot, and according to the emotion code, determining a tear instruction for controlling the operation of a microfluid tear execution device of the robot, so that the robot tears. The emotional codes are generated through an emotional state and physical stimulation double-path mechanism, the simulated lacrimation effect matched with the human emotional state can be achieved, the purpose of rich physiological feedback is achieved, and the lacrimation performance is improved through a liquid storage device, a lacrimation channel, a lacrimation outlet and a miniature pressure pump of the lacrimation execution device. And the robot can realize accurate tear control on the basis of emotion perception of physiological feedback.

Provided are an optical measurement device, an optical measurement method, a data processing device, and a program, capable of generating data that is a stimulus value that takes into account the time response of an eye and suppresses waveform distortion, capable of performing good flicker measurement, and also capable of coping with a measurement target object having a non-periodic light emission waveform. A stimulus value acquisition unit (20) receives light from a measurement target object to continuously acquire intensities corresponding to stimulus values at constant time intervals; a response characteristic acquisition unit (32) acquires a pulse response characteristic from a storage unit (31) that stores a pulse response characteristic corresponding to a visual stimulus response; and a digital filter processing unit (32) performs digital filter processing on continuous data of the acquired stimulus value intensities using the acquired pulse response characteristic to generate data on which a visual stimulus response is superimposed.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

The invention relates to a stimulus-responsive CRISPR-Cas12a (clustered regularly interspaced short palindromic repeats-associated 12a) system and application thereof, and belongs to the technical field of biology. The CRISPR-Cas12a (clustered regularly interspaced short palindromic repeats-CRISPR-Cas12a) system with the stimulation response comprises a DNA (deoxyribonucleic acid) tetrahedron-stimulation response factor aptamer compound and a CRISPR-Cas12a reaction system, the DNA tetrahedron-stimulus response factor aptamer compound is formed by hybridizing a DNA tetrahedron and a stimulus response factor aptamer; the DNA tetrahedron is formed by self-assembly of TH1, TH2, TH3 and a target chain TS of a CRISPR-Cas12a reaction system, and the stimuli response factor aptamer and the TS are hybridized so that the stimuli response factor and the stimuli response factor aptamer are combined to expose the TS under the action of the stimuli response factor, and then the CRISPR-Cas12a reaction system is activated. The H1 / H3 treated by the CRISPR-Cas12a with stimulation response can effectively inhibit the phosphorylation level of c-Met and the phosphorylation level of downstream protein of the c-Met, and inhibit the proliferation, migration and invasion ability of cells. The invention realizes specific control of membrane receptor dimerization and corresponding cell behaviors in a customizable manner.

The present application provides a transcranial magnetic sham stimulation device and related products. When a subject is subjected to transcranial magnetic sham stimulation, the current detection module of the device detects the magnitude of the stimulation current output by the stimulation generating device; the current attenuator attenuates the stimulation current to obtain an attenuated current; the current converter converts the attenuated current to provide a power supply current for a waveform modulator; the waveform modulator provides a first input current to a sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current. The present application is conducive to improving the authenticity of transcranial magnetic sham stimulation and reducing the impact of the subject's psychological effects on the experimental results.

Arrangements are described for monitoring cochlear implantation surgery. During surgical insertion of a cochlear implant electrode array into a patient cochlea, at least one measurement difference value is determined for at least one electrode contact currently located at a given insertion depth into the patient cochlea based on comparing current stimulus response data for the at least one electrode contact to prior stimulus response data for at least one prior electrode contact previously located at the given insertion depth. A potential trauma response is identified when the at least one measurement difference value exceeds a defined difference value.

The invention relates to the technical field of brain-computer signal classification, in particular to a brain-computer interface signal classification method, electronic equipment and system, and the method comprises the steps: collecting brain-computer interface signals and the acceleration of a user, dividing a stimulation reaction time period and a result time period, and determining local maximum stimulation; the partial maximum stimulation deviation amplitude in the stimulation reaction time period and the deviation amplitude evaluation and value of the stimulation reaction time period and the result time period are determined, and the partial maximum stimulation collected in the pulse collection time period is updated according to the deviation amplitude evaluation and value of the stimulation reaction time period and the result time period; and acquiring a fitting curve of the brain-computer interface signals in the acquisition time period according to the brain-computer interface signals and the accelerations at the beginning moment and the last acquisition moment of the acquisition time period and the updating result of the local maximum stimulation. The information in the brain activity signal can be accurately extracted, and the intention of the user can be accurately recognized.

The present disclosure provides an occluder and a preparation method thereof, wherein the occluder includes a bending area and a straight area, wherein the bending area includes a convex bending area and a concave bending area, the straight area is composed of a material of a monofilament, and the bending area is composed of a material with stimulus-responsive properties or a material with an expansion coefficient different from that of the monofilament. The preparation method includes selecting a biodegradable polymer material to prepare a block copolymer and extruding a monofilament, weaving the monofilament after adjusting the shape by a combination of temperature stimulation and mechanical force; or weaving in layers with materials of different expansion coefficients and then storing the same. The occluder disclosed in the present disclosure can restore the designed shape within the body temperature range, simplifying the locking structure and the locking steps during the implantation of the occluder. The preparation process does not require high-temperature shaping, which reduces energy consumption.

The present application discloses a pathological network connection method, device, equipment and storage medium for processing cortico-cortical evoked potentials. The method includes obtaining the original cortico-cortical evoked potential data, superimposing and averaging the electroencephalogram signals obtained from multiple repeated stimulations of the same evoked stimulus, performing false discovery rate verification on the thresholds obtained from all evoked stimuli, obtaining the connection relationship between the evoked electrode and the current electrode according to the verification, constructing a stimulus-response matrix diagram and constructing a connection relationship diagram between all brain electrode sites; the above solution provided by the present application obtains the position of the electrode site in the brain region through the CT and magnetic resonance imaging registration method, aggregates the stimulus responses of the electrode sites between the same brain regions together, obtains the connection relationship between the cerebral cortex brain regions, and thus can abstractly analyze the higher-level brain connection relationship, which helps to assist the surgical treatment that requires evoked stimulation and improves work efficiency.

The application provides a preparation method and application of a dual-indocyanine green diagnosis and treatment integrated compound with a stimulus response, provides a micro-nano structure formed by self-assembly of a compound with a structure shown in formula (I) or an isomer, a pharmaceutically acceptable salt, a hydrate or a solvate thereof in an aqueous solution, and preparation of a pharmaceutical composition and application thereof in preparation of a fluorescent probe, a phototherapy drug, a drug for diagnosis and / or treatment of cancer, and stimulus-responsive drug release. The compound provided by the application can accumulate at a tumor site, and can realize aggregation structure conversion and optical performance regulation by responding to a unique redox stimulus of a tumor microenvironment, realize precise photothermal / photodynamic combined treatment of the tumor in an aggregated state under irradiation of a specific excitation wavelength, and realize long-acting fluorescence imaging of a low background at the tumor after disaggregation of the aggregation. The tumor treatment effect is good, the trauma is small, the fluorescence imaging precision is high, the time is long, the biological safety is excellent, and diagnosis and treatment integration at the tumor site is realized.

Systems and methods for inverted binocular stimulation may include a device that determines a target frequency of a stimulation response. The device may output a first visual stimulus of a first frequency and a first phase to a first eye. The device may output a second visual stimulus of a second frequency and a second phase to a second eye. The first visual stimulus and the second visual stimulus together may produce a stimulus response at a target frequency.

The invention discloses a fish stimulus response behavior tracking and monitoring device and method.The device comprises an observation box and an animal behavior trajectory tracking system in communication connection with the observation box, the observation box comprises a box body with one hollow side, a supporting frame is arranged in the box body, a bearing plate is attached to the top of the supporting frame, and the bearing plate is connected with the observation box in a sliding mode; a perforated plate is inserted into the bearing plate, a stimulation mechanism for stimulating fishes in the perforated plate is arranged in the supporting frame, an infrared camera is arranged on the inner wall of the box body above the supporting frame, and the bearing plate is movably arranged in the box body through a driving mechanism; an auxiliary mechanism is arranged on the inner wall of the top of the box body and located on the outer side of the infrared camera. The auxiliary mechanism is arranged, after tracking and monitoring work is finished, the auxiliary mechanism can replace manual work to transfer juvenile zebrafish located in the perforated plate into the containing container, time is saved, and meanwhile the manual labor intensity is greatly reduced.

Provided herein are methods for the automated testing of a sample response to one or more chemical stimuli. The provided methods are particularly useful for the automated analysis of allergic responses. Also provided are computer systems and instructions for implementing the provided methods.

The invention discloses a sensory / motor neuron differentiated neural restoration catheter based on controllable release of metal ions triggered by ultrasound. The SF / metal ion neural restoration conduit with an ultrasonic piezoelectric and directional topological structure is developed by combining a one-pot method with an electrostatic spinning process. Wherein the oriented structure of the SF spinning membrane can promote the directional migration of cells and the directional extension of axons while being physically guided; and the material can also be used as a stimulation response platform to generate piezoelectricity under the ultrasonic action, so that the controllable release of metal ions is realized. The released metal ions (such as Zn2, Cu2, K, Mg2 and the like) can accurately program cell behaviors by activating intracellular signal transduction pathways in sensory / motor neurons in the neural restoration process. Expression of neurotrophic factors and receptors of the neurotrophic factors can be differentially up-regulated or inhibited, and other possibilities are provided for differentiated regeneration of sensory / motor neurons.

To provide an intellectual tissue classifier for bone and soft tissue.SOLUTION: A method for an intraoperative state analysis and classification of a joint tissue includes: a step for sensing data of the joint tissue via a plurality of sensors installed in proximity to the joint tissue so as to detect a response to a stimulus; a step for determining a state analysis and classification information through collation means; a step for processing the sensed data in a format adapted so as to be assessed against a comparator; a step for using a history data set of the processed information and generating means that predicts the state analysis and classification; and a step for using the generated means to perform the state analysis and classification on the basis of processing of a stimulus response acquired during the operation.SELECTED DRAWING: None

A method for analyzing a user's reaction to a stimulus is described which includes providing a user stimulus and a stimulation parameter through a sensory stimulator, measuring a biological response and acquiring a biosignal which indicates a neurophysiological reaction provides neurophysiological reaction data which generates sensory metadata indicative of the user's response to the corresponding stimulus. The sensory metadata is archived to obtain a plurality of sensory metadata associated with the user. Each piece of stored sensory metadata is processed according to input information, generating an output information including a reaction index to the stimulus as a function of the input information, and modifying a stimulation parameter according to the reaction index.

A system and method for anti-phased binocular stimulation may include a device for determining a target frequency for the stimulus response. The device may output a first visual stimulus to the first eye at a first frequency and a first phase. The device may output a second visual stimulus to the second eye at a second frequency and a second phase. Both the first and second visual stimuli may produce a stimulus response at a target frequency. The first frequency may be half of the target frequency, and the second frequency may be half of the target frequency.

An optical measuring device includes: a stimulus value acquirer that receives light from a measurement target and continuously acquires intensity corresponding to a stimulus value at a regular time interval; a response characteristic acquirer that acquires an impulse response characteristic from a storage that stores the impulse response characteristic corresponding to a luminous stimulus response; and a hardware processor that performs digital filter processing on continuous data of stimulus value intensity acquired by the stimulus value acquirer by the impulse response characteristic acquired by the response characteristic acquirer to generate data on which the luminous stimulus response is superimposed.

The invention discloses an anthropomorphic robot facial expression control method, device and equipment, a medium and a product, and relates to the technical field of anthropomorphic humans. The method comprises the following steps: firstly, receiving an external expression trigger instruction, then planning a corresponding facial expression action sequence, specifically, when each facial expression action in the sequence is planned, actively inserting a silence delay before executing the action, the duration of the silence delay being the duration from instruction receiving to action execution starting, and the duration of the silence delay being the duration from instruction receiving to action execution starting. The ratio of the stimulation-reaction delay to the execution duration of the corresponding action is controlled within a preset interval, and finally the robot face execution mechanism is driven based on the sequence to complete the expression, so that the mechanical and abrupt feeling caused by transient response in the prior art is overcome by actively introducing and quantitatively controlling the proportion of the stimulation-reaction delay to the action duration, and the safety of the robot is improved. And the natural cognitive processing rhythm of human is simulated, so that the facial organ movement of the robot better conforms to the movement mode and reaction rule of human, and the expression naturalness and life feeling are remarkably improved.

A method for aligning neural signals from unhealthy states with those from healthy states. Based on factors such as the target's behavioral health, stimulus response, body temperature, and cross-functional noise cells, the method adjusts the neural signal's response time, corrects the waveform amplitude and width, and removes noise. This method aligns the quality of neural signals from unhealthy states with that from healthy states and cleans up noise. This method addresses the current problem of inaccurate neural signal acquisition when an organism is in an unhealthy state, as neural signals are not collected based on the target's health status.

The present invention discloses a device and method for tracking and monitoring fish stimulus-response behavior, comprising an observation box and an animal behavior trajectory tracking system communicatively connected to the observation box. The observation box comprises a hollow box body on one side, a support frame disposed within the box body, a carrier plate attached to the top of the support frame, a porous plate inserted into the carrier plate, a stimulation mechanism disposed within the support frame for stimulating fish within the porous plate, an infrared camera disposed on the inner wall of the box body above the support frame, the carrier plate movable within the box body via a drive mechanism, and an auxiliary mechanism disposed on the inner wall of the top of the box body, located outside the infrared camera. The present invention provides an auxiliary mechanism, which, after the tracking and monitoring work is completed, can replace manual labor to transfer zebrafish juveniles within the porous plate to a storage container, thereby saving time and significantly reducing labor intensity.

This invention discloses a method for assessing motor cortical excitability based on threshold-tracking magnetic stimulation, relating to the field of biomedical engineering technology. The method includes the following steps: electrical stimulation of the median nerve in the subject's wrist; recording on the abductor pollicis brevis (APB) muscle; recording the stimulus-response curve; determining the cortical stimulus-response (SR) curve by increasing the magnetic stimulation intensity to the specified levels; calculating the statistical parameters of the mean and standard deviation of the excitability threshold; and determining the dynamic trend of cortical excitability. This invention determines the cortical stimulus-response curve by increasing the magnetic stimulation intensity to the specified levels, and calculates the central motor conduction time based on the stimulus-response curve using the F-wave method, thus completing the initial stimulus and threshold determination. Subsequent threshold tracking is then performed based on this technique, providing an efficient and accurate means of detecting motor cortical function for the diagnosis of neurological diseases.

The embodiment of the present invention discloses a wakefulness state detection system and method. The system includes: a physiological index detection device for generating physiological detection results of physiological indexes; a body posture detection device for generating posture detection results of body postures; a motor ability detection device for generating motor ability detection results of motion information; a stimulus response detection device for generating stimulus response detection results of target stimulus signals; an emotional response detection device for generating emotional response detection results of emotional behavior representations; a behavior pattern detection device for generating behavior pattern detection results of behavioral phenotypes and an awakening state evaluation device for determining and displaying the awakening state of the target detection object based on physiological detection results, posture detection results, motor ability detection results, stimulus response detection results, behavior pattern detection results and emotional response detection results, and realizing accurate analysis of the awakening state through multi-dimensional information detection.

The invention discloses a cognitive function evaluation method, device, equipment and system, and relates to the technical field of man-machine interaction, and the method comprises the steps: obtaining stimulation response data of a tested object; wherein the stimulation response data is data acquired in the process of presenting the visual stimulation material to the tested object, and the stimulation response data comprises facial image data, eye movement tracking data and stimulation judgment data of the tested object; determining a multi-dimensional cognitive feature index according to the stimulation response data; wherein the multi-dimensional cognitive feature indexes comprise a face reaction index, a sight line index and a judgment accuracy index; according to the multi-dimensional cognitive feature index and a preset reference feature index, determining a cognitive function evaluation result of the tested object; according to the method, the eye movement behavior, the face reaction and the quantitative characteristic index of the judgment accuracy degree of the tested object in the visual stimulation material recognition process can be synthesized, the cognitive function of the tested object can be rapidly and accurately evaluated, and automatic objective evaluation of the cognitive disorder risk is achieved.

The present invention relates to a non-contact operation device for a vehicle and a vehicle, and aims to improve the operation device for the vehicle. The non-contact operation device (40) of the vehicle (1) comprises: a projection device (43) that projects an image onto the vehicle interior (3) of the vehicle (1); a generation unit (51) that generates and updates the image projected by the projection device (43); a stimulus response output unit (53) that outputs tactile stimulation caused by an ultrasonic field as a response to the operation of the operating part of the occupant who operates the image projected on the vehicle interior (3); and a detection device (44) that detects the operating part of the occupant who performs non-contact operation on the image projected on the space of the vehicle interior (3). The generation unit (51) and the stimulus response output unit (53) update the output of the image and the tactile stimulation based on the operation information of the operating part of the occupant detected by the detection device (44).

A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.