18 results about "Stimulus response" patented technology

The invention discloses a robot lacrimation control method and a microfluid lacrimation execution device for a robot, and relates to the technical field of bionic robot emotional interaction.The robot lacrimation control method comprises the steps that multi-modal sensing data of the robot is obtained, determining a first code used for judging an emotional state and a second code used for judging a physical stimulation response of the robot according to the multi-modal sensing data; and according to the first code and / or the second code, determining an emotion code of the robot, and according to the emotion code, determining a tear instruction for controlling the operation of a microfluid tear execution device of the robot, so that the robot tears. The emotional codes are generated through an emotional state and physical stimulation double-path mechanism, the simulated lacrimation effect matched with the human emotional state can be achieved, the purpose of rich physiological feedback is achieved, and the lacrimation performance is improved through a liquid storage device, a lacrimation channel, a lacrimation outlet and a miniature pressure pump of the lacrimation execution device. And the robot can realize accurate tear control on the basis of emotion perception of physiological feedback.

Provided are an optical measurement device, an optical measurement method, a data processing device, and a program, capable of generating data that is a stimulus value that takes into account the time response of an eye and suppresses waveform distortion, capable of performing good flicker measurement, and also capable of coping with a measurement target object having a non-periodic light emission waveform. A stimulus value acquisition unit (20) receives light from a measurement target object to continuously acquire intensities corresponding to stimulus values at constant time intervals; a response characteristic acquisition unit (32) acquires a pulse response characteristic from a storage unit (31) that stores a pulse response characteristic corresponding to a visual stimulus response; and a digital filter processing unit (32) performs digital filter processing on continuous data of the acquired stimulus value intensities using the acquired pulse response characteristic to generate data on which a visual stimulus response is superimposed.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

The invention relates to a stimulus-responsive CRISPR-Cas12a (clustered regularly interspaced short palindromic repeats-associated 12a) system and application thereof, and belongs to the technical field of biology. The CRISPR-Cas12a (clustered regularly interspaced short palindromic repeats-CRISPR-Cas12a) system with the stimulation response comprises a DNA (deoxyribonucleic acid) tetrahedron-stimulation response factor aptamer compound and a CRISPR-Cas12a reaction system, the DNA tetrahedron-stimulus response factor aptamer compound is formed by hybridizing a DNA tetrahedron and a stimulus response factor aptamer; the DNA tetrahedron is formed by self-assembly of TH1, TH2, TH3 and a target chain TS of a CRISPR-Cas12a reaction system, and the stimuli response factor aptamer and the TS are hybridized so that the stimuli response factor and the stimuli response factor aptamer are combined to expose the TS under the action of the stimuli response factor, and then the CRISPR-Cas12a reaction system is activated. The H1 / H3 treated by the CRISPR-Cas12a with stimulation response can effectively inhibit the phosphorylation level of c-Met and the phosphorylation level of downstream protein of the c-Met, and inhibit the proliferation, migration and invasion ability of cells. The invention realizes specific control of membrane receptor dimerization and corresponding cell behaviors in a customizable manner.

The invention relates to the technical field of brain-computer signal classification, in particular to a brain-computer interface signal classification method, electronic equipment and system, and the method comprises the steps: collecting brain-computer interface signals and the acceleration of a user, dividing a stimulation reaction time period and a result time period, and determining local maximum stimulation; the partial maximum stimulation deviation amplitude in the stimulation reaction time period and the deviation amplitude evaluation and value of the stimulation reaction time period and the result time period are determined, and the partial maximum stimulation collected in the pulse collection time period is updated according to the deviation amplitude evaluation and value of the stimulation reaction time period and the result time period; and acquiring a fitting curve of the brain-computer interface signals in the acquisition time period according to the brain-computer interface signals and the accelerations at the beginning moment and the last acquisition moment of the acquisition time period and the updating result of the local maximum stimulation. The information in the brain activity signal can be accurately extracted, and the intention of the user can be accurately recognized.

The application provides a preparation method and application of a dual-indocyanine green diagnosis and treatment integrated compound with a stimulus response, provides a micro-nano structure formed by self-assembly of a compound with a structure shown in formula (I) or an isomer, a pharmaceutically acceptable salt, a hydrate or a solvate thereof in an aqueous solution, and preparation of a pharmaceutical composition and application thereof in preparation of a fluorescent probe, a phototherapy drug, a drug for diagnosis and / or treatment of cancer, and stimulus-responsive drug release. The compound provided by the application can accumulate at a tumor site, and can realize aggregation structure conversion and optical performance regulation by responding to a unique redox stimulus of a tumor microenvironment, realize precise photothermal / photodynamic combined treatment of the tumor in an aggregated state under irradiation of a specific excitation wavelength, and realize long-acting fluorescence imaging of a low background at the tumor after disaggregation of the aggregation. The tumor treatment effect is good, the trauma is small, the fluorescence imaging precision is high, the time is long, the biological safety is excellent, and diagnosis and treatment integration at the tumor site is realized.

Systems and methods for inverted binocular stimulation may include a device that determines a target frequency of a stimulation response. The device may output a first visual stimulus of a first frequency and a first phase to a first eye. The device may output a second visual stimulus of a second frequency and a second phase to a second eye. The first visual stimulus and the second visual stimulus together may produce a stimulus response at a target frequency.

Provided herein are methods for the automated testing of a sample response to one or more chemical stimuli. The provided methods are particularly useful for the automated analysis of allergic responses. Also provided are computer systems and instructions for implementing the provided methods.

The invention discloses a sensory / motor neuron differentiated neural restoration catheter based on controllable release of metal ions triggered by ultrasound. The SF / metal ion neural restoration conduit with an ultrasonic piezoelectric and directional topological structure is developed by combining a one-pot method with an electrostatic spinning process. Wherein the oriented structure of the SF spinning membrane can promote the directional migration of cells and the directional extension of axons while being physically guided; and the material can also be used as a stimulation response platform to generate piezoelectricity under the ultrasonic action, so that the controllable release of metal ions is realized. The released metal ions (such as Zn2, Cu2, K, Mg2 and the like) can accurately program cell behaviors by activating intracellular signal transduction pathways in sensory / motor neurons in the neural restoration process. Expression of neurotrophic factors and receptors of the neurotrophic factors can be differentially up-regulated or inhibited, and other possibilities are provided for differentiated regeneration of sensory / motor neurons.

A method for analyzing a user's reaction to a stimulus is described which includes providing a user stimulus and a stimulation parameter through a sensory stimulator, measuring a biological response and acquiring a biosignal which indicates a neurophysiological reaction provides neurophysiological reaction data which generates sensory metadata indicative of the user's response to the corresponding stimulus. The sensory metadata is archived to obtain a plurality of sensory metadata associated with the user. Each piece of stored sensory metadata is processed according to input information, generating an output information including a reaction index to the stimulus as a function of the input information, and modifying a stimulation parameter according to the reaction index.

A system and method for anti-phased binocular stimulation may include a device for determining a target frequency for the stimulus response. The device may output a first visual stimulus to the first eye at a first frequency and a first phase. The device may output a second visual stimulus to the second eye at a second frequency and a second phase. Both the first and second visual stimuli may produce a stimulus response at a target frequency. The first frequency may be half of the target frequency, and the second frequency may be half of the target frequency.

The invention discloses an anthropomorphic robot facial expression control method, device and equipment, a medium and a product, and relates to the technical field of anthropomorphic humans. The method comprises the following steps: firstly, receiving an external expression trigger instruction, then planning a corresponding facial expression action sequence, specifically, when each facial expression action in the sequence is planned, actively inserting a silence delay before executing the action, the duration of the silence delay being the duration from instruction receiving to action execution starting, and the duration of the silence delay being the duration from instruction receiving to action execution starting. The ratio of the stimulation-reaction delay to the execution duration of the corresponding action is controlled within a preset interval, and finally the robot face execution mechanism is driven based on the sequence to complete the expression, so that the mechanical and abrupt feeling caused by transient response in the prior art is overcome by actively introducing and quantitatively controlling the proportion of the stimulation-reaction delay to the action duration, and the safety of the robot is improved. And the natural cognitive processing rhythm of human is simulated, so that the facial organ movement of the robot better conforms to the movement mode and reaction rule of human, and the expression naturalness and life feeling are remarkably improved.

A method for aligning neural signals from unhealthy states with those from healthy states. Based on factors such as the target's behavioral health, stimulus response, body temperature, and cross-functional noise cells, the method adjusts the neural signal's response time, corrects the waveform amplitude and width, and removes noise. This method aligns the quality of neural signals from unhealthy states with that from healthy states and cleans up noise. This method addresses the current problem of inaccurate neural signal acquisition when an organism is in an unhealthy state, as neural signals are not collected based on the target's health status.

The present invention discloses a device and method for tracking and monitoring fish stimulus-response behavior, comprising an observation box and an animal behavior trajectory tracking system communicatively connected to the observation box. The observation box comprises a hollow box body on one side, a support frame disposed within the box body, a carrier plate attached to the top of the support frame, a porous plate inserted into the carrier plate, a stimulation mechanism disposed within the support frame for stimulating fish within the porous plate, an infrared camera disposed on the inner wall of the box body above the support frame, the carrier plate movable within the box body via a drive mechanism, and an auxiliary mechanism disposed on the inner wall of the top of the box body, located outside the infrared camera. The present invention provides an auxiliary mechanism, which, after the tracking and monitoring work is completed, can replace manual labor to transfer zebrafish juveniles within the porous plate to a storage container, thereby saving time and significantly reducing labor intensity.

This invention discloses a method for assessing motor cortical excitability based on threshold-tracking magnetic stimulation, relating to the field of biomedical engineering technology. The method includes the following steps: electrical stimulation of the median nerve in the subject's wrist; recording on the abductor pollicis brevis (APB) muscle; recording the stimulus-response curve; determining the cortical stimulus-response (SR) curve by increasing the magnetic stimulation intensity to the specified levels; calculating the statistical parameters of the mean and standard deviation of the excitability threshold; and determining the dynamic trend of cortical excitability. This invention determines the cortical stimulus-response curve by increasing the magnetic stimulation intensity to the specified levels, and calculates the central motor conduction time based on the stimulus-response curve using the F-wave method, thus completing the initial stimulus and threshold determination. Subsequent threshold tracking is then performed based on this technique, providing an efficient and accurate means of detecting motor cortical function for the diagnosis of neurological diseases.

The invention discloses a cognitive function evaluation method, device, equipment and system, and relates to the technical field of man-machine interaction, and the method comprises the steps: obtaining stimulation response data of a tested object; wherein the stimulation response data is data acquired in the process of presenting the visual stimulation material to the tested object, and the stimulation response data comprises facial image data, eye movement tracking data and stimulation judgment data of the tested object; determining a multi-dimensional cognitive feature index according to the stimulation response data; wherein the multi-dimensional cognitive feature indexes comprise a face reaction index, a sight line index and a judgment accuracy index; according to the multi-dimensional cognitive feature index and a preset reference feature index, determining a cognitive function evaluation result of the tested object; according to the method, the eye movement behavior, the face reaction and the quantitative characteristic index of the judgment accuracy degree of the tested object in the visual stimulation material recognition process can be synthesized, the cognitive function of the tested object can be rapidly and accurately evaluated, and automatic objective evaluation of the cognitive disorder risk is achieved.

A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.