183 results about "Stimulus response" patented technology

A system and method for sequential decision-making for customer relationship management includes providing customer data including stimulus-response history data, and automatically generating actionable rules based on the customer data. Further, automatically generating actionable rules may include estimating a value function using reinforcement learning.

The ACSSECR invention is a biometric access control system and methodology that measures cognitive, psychophysiological responses to stimuli to confirm the identity of an individual. As an alternative to “Logging in” with a user ID and password, this cognitive biometric authentication system is used for “Cogging in” to a system with user ID and user-selected “Cogkey”. ACSSECR is designed for strict access control scenarios where significant authentication confidence is required to gain access to controlled information, facilities, systems, vehicles, or devices. The system takes advantage of a behavioral and physiological characteristic of humans that is an unconscious response to a stimulus. The Event Related Potential (ERP) response (specifically the P3 ERP) involuntarily occurs when an individual perceives and reacts to an unexpected, task-relevant event. The task is for the user to recognize their Cogkey which is presented infrequently amidst more frequent non-target stimuli. There is no requirement for extensive enrollment by users, only the recognition of their Cogkey. The basic system does not store biometric data for comparison, but rather measures the user's Cogkey recognition responses in comparison to non-Cogkey stimulus responses. An individual can have multiple personas with different Cog keys.

The present invention relates to a mental balance or imbalance estimation system (100) and method for estimating a level of mental balance or imbalance of a user (1). The system comprises a skin conductance sensor (20) for sensing the skin conductance of the user (1), the skin conductance over time forming a skin conductance trace (22). The system further comprises a processing unit (10) for receiving and processing the skin conductance trace (22), the processing unit configured to determine at least one stimulus response (24) in the skin conductance trace (22), to determine an estimated cortisol level trace (28) of the user (1) based on the determined at least one stimulus response (24), and to determine the estimated level of mental balance or imbalance of the user (1) based on the estimated cortisol level trace (28).

This method of determining an intracochlea tissue impedance comprises using at least two stimulating electrodes to apply an electrical stimulus to intracochlea tissue. A voltage caused by the stimulus is measured between two measuring electrodes distinct from the stimulating electrodes. From the voltage a stimulus-response characteristic of tissue between the two measuring electrodes is determined. This allows the tissue / electrode interface impedance and potential and the tissue impedance and potential to be uniquely determined. In turn, modiolus currents can be estimated in monopolar stimulation mode. Also provided is automated initiation of re-mapping of the device when tissue characteristics change

A testing system and various methods involving testing of a device under test (DUT) use a device model to model a stimulus-response behavior of a the DUT. The testing system includes a device model of the DUT that is fitted to the stimulus-response behavior of the DUT and a measurement projector connected to an output of the device model. The device model includes a block diagram model and a difference model. Test metrics for the DUT are produced by the measurement projector from an output of the fitted device model.

A method and system of a software development using visual action elements is disclosed. In one embodiment, the method includes providing a user interface with action elements, and providing a mechanism for specification and review of the action elements using the user interface. For example, providing a user interface includes providing a prototype of the user interface in a web browser and providing a mechanism for specification and review includes providing a toolbar with functionality to record user comments regarding the action elements. The method may also include providing a user interface to document the user interface. The method may further include providing an animated view of stimulus response behavior of the action elements.

The invention relates to carrier materials of medicament sustained controlled release, a process for preparing the carrier materials and usage, in particular relating to carrier materials of double shell medicament sustained controlled release of a hollow silicon dioxde micro-balloon coated by pluralities layers f polyelectrolyte membranes, and the making method and usage of the carrier materials of double shell medicament sustained controlled release. The materials are prepared by the hollow silicon dioxde micro-balloon and the compatible polyelectrolyte. An inner shell of the carrier material of double shell medicament sustained controlled release is the hollow silicon dioxde micro-balloon, and an outer shell is composed of polarities layers of the polyelectrolyte membranes. A cavity of the hollow silicon dioxde micro-balloon can be a container for carrying medicament, and the polarities layers of the polyelectrolyte membranes of the outer shell can control the release rate of medicament molecules under different external environments. The carrier materials of double shell medicament sustained controlled release of the invention have high medicament-carrying capacity, and have certain targeting function, and environmental stimulus response of the medicament is release-controllable.

A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli. The response curves show how the phenotype of one or more cells changes in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype or signature for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The signatures are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. To facilitate the comparison of stimuli, distances between points on the response curves are calculated. First, the response curves may be aligned on a coordinate representing a separate distance, r, from a common point of negative control (e.g., the point where no stimulus is applied). Integration on r may be used to compute the distance between two response curves. The distance between response curves is used to classify stimuli.

The invention belongs to the field of synthesis of drug carrier base materials and provides a nano particle-polymer injectable composite hydrogel double drug loading system and a preparation method thereof. The double drug loading system is loaded with not only an anti-cancer drug I of which polymer nano particles are synthesized through a disulfide bond cross-linking agent by taking acrylic acidand 4-vinylphenylboric acid as monomers, but also an anti-cancer drug II of which injectable hydrogel is synthesized through Michael addition reaction between a macromolecular cross-linking agent witha sulfhydryl functional group and a polymer containing a catechol functional group aiming at the drug loading capacity, the action time, the treatment effect and other demands. The bi-stimulus response is pH stimulus response and reducing stimulus response of glutathione to the disulfide bond cross-linking agent in a tumor cell environment respectively, the interaction between the nano particlesand the drug I as well as the degradation process of the nano particle can be affected, and the long-term delivery of the drug I is realized. The nano particle-polymer injectable composite hydrogel double drug loading system provided by the invention realizes the effects of local long-time administration, step-by-step osmotic treatment and combined treatment of a variety of drugs.

The invention relates to a method and an apparatus for stimulating and / or measuring visceral pain in a bodily hollow system of a human being or an animal. The method and apparatus is especially well suited for multi-modal stimulation and measuring, where different stimulus modalities are integrated into one stimulus device. The stimuli may be any one or more of the stimuli: mechanical stimulus, thermal stimulus, chemical stimulus and electric stimulus. The stimuli may activate superficial and deeper layers of the hollow system. Distinct responses to the individual stimuli and robust stimulus-response relations are obtained and result in the possibility of comparative studies of different visceral sensations.

An apparatus and method for distributed, non-invasive assessment of the functional state and state of adaptive response of a subject under test. The functional state tests may include heart rate variability, differential ECG, omega brain wave, jump and stimulus response tests. A plurality of data collection (and result display) units are provided, and collected data is propagated over the internet or another network to a centralized processing computer that performs the functional state assessments and returns the results.

The invention relates to a new compound-stilbene nitrile derivatives (I) with reversible stimulus-response discoloring performance, a preparation method thereof, and application as a reversible stimulus-response discoloring material. The compound synthesis method is simple, and can be used for conveniently preparing devices; the pressure-sensitive devices prepared from organic micromolecules discolor under pressure, and can recover easily; and thus, the invention is applicable to the fields of sensors, anti-counterfeiting, storage, display and the like. The invention has blue-green reversible piezallochromy performance, and can implement quick reversion in a heating or organic solvent atmosphere. The preparation process is simple and convenient; and the invention can be widely used in the fields of sensors, anti-counterfeiting, storage, display and the like.

The invention provides a field effect transistor device by taking graphene as an electrode and a preparation method thereof. In the device, the material of a source region and a drain region is graphene; the materials of a channel region are various small organic molecules, high polymers and semiconducting polymer materials, such as polythiophene, pentacene, polycyclic aromatic hydrocarbon, perylene imide and the like; and the material of a gate region is highly doped conductive silicone. The device further comprises a gate dielectric layer the material of which is silicon dioxide, silicon nitride and various high-K dielectrics. The nano field effect transistor device can be n-typed, p-typed or amphoteric type, and the device realizes all functions of a macroscopic field effect transistor device at the nanometer level. The transistor device has very high application value in terms of ultrasensitive environmental stimuli response devices, ultrasensitive solar stimuli response devices and the like. In addition, in the fields of molecular electronics and nanometer, the transistor device plays an essential role of promoting the development of ultramicro photoelectric devices with various dimensions at molecular level.

The invention belongs to the field of environmental-stimulus-response-type medicines, and particularly relates to a sol system used for preparing pH-sensitive double-network hydrogel, the hydrogel andapplication. The sol system is prepared from gelatin methacryloyl, oxidized alginate, a photoinitiator, gentamicin and mesoporous silica nano particles loaded with phenamil medicinal molecules, the sol system is transformed from sol to gel fast under ultraviolet irradiation, thus the pH-sensitive double-network hydrogel can be obtained, and the hydrogel is excellent in physical and chemical property and good in biocompatibility, can effectively control release of an antibacterial medicine GS and an osteogenic differentiation promoting medicine phenamil, prevent early infection of a graft, induce C2C12 cell osteogenic differentiation, and promote endogenous bone generation. Based on the character that the sol system is transformed from the sol to the gel fast under ultraviolet irradiation,in practical application, in-situ gelation can be conducted by means of minimally-invasive injection, and the requirements of complex orbital bone defect repair can be met, so that the sol system used for preparing the pH-sensitive double-network hydrogel has important values in orbit repair and reconstruction.

A composite emulsifier with double stimulus-response performance belongs to the field of colloid and interface chemistry. The emulsifier comprises the non-modified commercial nano-silica particles and a double stimulus-response surfactant. The nano-silica particles have primary particle diameter of 20-200nm, usage concentration of 0.1%-3.0% (with water phase as the reference). An emulsion stabilized by the emulsifier belongs to a Pickering emulsion; introduction of N2 or air into the emulsion at 50-70 DEG C leads to inactivation of the emulsifier and demulsification of the emulsion; but introduction of CO2 into the system at room temperature restores activity of the emulsifier, and the stable Pickering emulsion can be obtained after homogenization of the system; and under irradiation of UV of higher than 300nm, the emulsion droplets have larger diameter, so that the composite emulsifier has a double stimulus-response performance.

The invention discloses an oil water separation nanofiber membrane with CO2 stimulus response as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing a random copolymer and a solvent to obtain spinning solution, wherein the random copolymer is polymethyl methacrylate-2-Diethylaminoethyl Methacrylate; (2) performing electrostatic spinning on the spinning solution to obtain nanofibers, and interweaving and arranging the nanofibers to obtain the nanofiber membrane. The oil water separation nanofiber membrane is applied to oil water separation. The nanofiber membrane prepared by utilizing an electrostatic spinning technology has a CO2 stimulus response function, can selectively perform oil water separation, is low in cost, simple and convenient to operate, clean and environment-friendly, and has better separation effects for various oil-water mixed systems.

The invention provides gel-in-oil-in-water emulsion as well as a preparation method and an application thereof. The gel-in-oil-in-water emulsion comprises an internal gel phase, an oil phase and an external water phase, wherein the internal gel phase is coated with the oil phase which is coated with the external water phase. The gel-in-oil-in-water emulsion can be used as a delivery carrier for human or animals, the internal gel phase has good biocompatibility, can be prepared under mild conditions and has environmental stimulus response, a multiple emulsion structure is prepared under mild conditions, and poor stability of multiple emulsion is improved greatly; efficient loading and activity retention of hydrophilic and hydrophobic substances especially bioactive substances can be realized, the condition that in-situ gel can only realize local drug delivery is improved, and the gel-in-oil-in-water emulsion can realize targeted delivery and intelligent controllable release on human andanimals and has extensive application prospects in the fields of vaccine adjuvant preparation, sustained and controlled drug release, targeted drug delivery, disease diagnosis and daily chemical products.

The invention discloses an oil-based drilling cutting treatment method. The oil-based drilling cutting treatment method comprises oil-based drilling cutting extraction, separation of an extract liquor, recycling of a switchable solvent, repeated separation and extraction, oil-based drilling cutting component analysis and the like. The method can be performed under a mild condition without high temperature, high pressure and other additional conditions, and changes of hydrophilic performance of the solvent can be intelligently controlled under the stimulus-response of CO2; the viscosity reduction effect on oil-based drilling cuttings is good, the separation capacity for mineral oil in the oil-based drilling cuttings is good, the recovery rate of oil can be up to 95% or higher, the ignition point of the switchable solvent CyNMe2 is high, the method does not have a biological accumulation effect, the recovery rate of the solvent can be up to 85% or higher, and the recovery efficiency can be further improved with methods such as infrared heating, addition of chemical agents and the like.

This method of determining an intracochlea tissue impedance comprises using at least two stimulating electrodes to apply an electrical stimulus to intracochlea tissue. A voltage caused by the stimulus is measured between two measuring electrodes distinct from the stimulating electrodes. From the voltage a stimulus-response characteristic of tissue between the two measuring electrodes is determined. This allows the tissue / electrode interface impedance and potential and the tissue impedance and potential to be uniquely determined. In turn, modiolus currents can be estimated in monopolar stimulation mode. Also provided is automated initiation of re-mapping of the device when tissue characteristics change.

The invention relates to the technical field of software drivers, in particular to a carbon nanocomposite fiber based multi-stimulus response driver of a core-shell structure. Organic fibers with highstrength are adopted, the organic fibers are twisted and prepared into a yarn with a certain twist, the organic yarn is used as a core, a carbon nano film with a certain twist angle is wound througha concentric shaft coating device, and silicone rubber is infiltrated at the film to serve as an outer shell. The carbon nanocomposite fiber of the core-shell structure is twisted to form the yarn ofa spiral structure, the carbon nanotube composite yarn of the spiral structure is used as an electrically conductive fiber material, mechanical vibration output with high deformation and high frequency can be continuously generated after a certain amount of current passes through the fiber material, and the mechanical vibration output can be used as an efficient driver. In addition, being capableof responding quickly and efficiently to external electrothermal stimuli, the multi-stimulus response driver provided by the invention can also be used for driving by solvents and thermal stimuli, canbe used in different occasions according to needs, and has broad application prospects.

A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli. The response curves show how the phenotype of one or more cells changes in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype or signature for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The signatures are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. To facilitate the comparison of stimuli, distances between points on the response curves are calculated. First, the response curves may be aligned on a coordinate representing a separate distance, r, from a common point of negative control (e.g., the point where no stimulus is applied). Integration on r may be used to compute the distance between two response curves. The distance between response curves is used to classify stimuli.

The invention relates to a preparation method for a POSS / PDMAEMA organic / inorganic hybrid material according to a thiol-ene click chemistry method. The preparation method comprises the following steps: obtaining PDMAEMA through synthesis according to an RAFT polymerization method; taking dimethyl phenylphosphine as a catalyst, taking n-hexylamine as a reducer, and conducting a reduction reaction on a dithioester group at the tail end of PDMAEMA to generate sulfydryl; conducting thiol-Michael addition reactions on the double bonds of PDMAEMA containing sulfydryl and POSS containing ethenyl according to the thiol-ene click chemistry method to generate a POSS / PDMAEMA organic / inorganic hybrid material with a temperature / pH dual response. The preparation method has the advantages that the prepared POSS / PDMAEMA organic / inorganic hybrid material is small in size, stable in chemical bond, and uniform in particle diameter; due to a click reaction to PDMAEMA, the hydrophilic performance of POSS is effectively improved; in a water solution, the POSS / PDMAEMA organic / inorganic hybrid material is excellent in temperature sensibility and pH sensibility; due to a special structure and the stimulus response performance, the POSS / PDMAEMA organic / inorganic hybrid material is a new-generation environment-friendly new material product, and can be applied to drug carrying, targeted release, metal ion recovery, environmental pollutant adsorption and other fields.

The invention is suitable for the fields of information security and integrated circuits, and provides a high-stability strong physical unclonable function circuit and a design method therefor. The physical unclonable function circuit comprises a time delay generation module, a time delay comparison module, a response calculation module and a stability judgment module, wherein the time delay generation module is used for transmitting the same jump through a plurality of time delay paths according to an input stimulus of the strong physical unclonable function circuit and generating a plurality of time delay values; the time delay comparison module is used for selecting out multiple pairs of time delay values from the time delay values, performing time delay difference comparison and dividing the time delay differences of the pairs of time delay values into a plurality of grades according to difference values; the response calculation unit is used for calculating an output response of the strong physical unclonable function circuit according to the time delay difference grade of each pair of time delay values; and the stability judgment module is used for judging whether a stimulus response pair is stable or not according to the time delay difference grade of each pair of time delay values. According to the circuit and the method, while the attack resistance of the strong physical unclonable function circuit is ensured, the time delay difference can be measured online in real time, so that the stability is greatly improved.

An operating system configured to support cognitive capable environments is described. The system comprises a memory structure and an I / O process configured to update inputs and outputs. The operating system further includes a process to determine changes to symbols within the symbol space due to the stimulus and create STM images of the inputs. Additional processes are configured to pass stimulations between connecting symbols, measure temporal and spatial properties of images, filter the STM images based upon the properties, and propagate stimuli through hereditary structures. Further processes analyze propagated symbol groups of STM images for novel distinctions, create new symbols, connect novel stimuli together for symbol groupings, update existing symbols to include connections to the new symbols, and assign weights to the connections. Additional processes form stimulus-response pairs from received images, provide time-based erosion of connection weights of symbols and adapt learned responses to long term memories.

The invention discloses a double-stimulus response hydrogel with cyclodextrin and a preparation method thereof. A gel macromolecular chain is provided with a cyclodextrin group, a temperature sensitive unit and a pH value sensitive unit, wherein the weight percentage of the cyclodextrin group contained in a gel macromolecule is 14%-57%; the temperature sensitive unit is isopropyl acrylamide, and the weight percentage of the temperature sensitive unit in the gel macromolecule is 20%-50%; the pH value sensitive unit is acrylic acid, and the weight percentage of the pH value sensitive unit in the gel macromolecule is 14%-57%. According to the invention, the prepared carrier hydrogel can be used for loading of a large quantity of drug molecules by introducing cyclodextrin and the temperature and pH value response structure units; when outside temperature and a pH value are changed, the responsive change of regulating the release speed of drugs can be generated. The preparation process of the provided double-stimulus response carrier hydrogel with the cyclodextrin group is simple and convenient and easy to realize.

The invention discloses a polyurethane associative thickener with double stimulus response and a preparation method thereof. The preparation method is characterized in that under the nitrogen gas protection, 4-hydroxyazobenzene methanol and halogenated alkyl ferrocene are dissolved; an acid binding agent is added; after the complete reaction, filtering is performed when the materials are hot; filtering liquid is collected; when the filtering liquid is cooled to room temperature, the filtering liquid is poured into saturated salt solution to obtain yellow precipitates; filtering is performed; the precipitates are washed; recrystallization is performed to obtain an end capping agent; under the nitrogen gas protection, a polyethylene glycol and methylbenzene mixture is subjected to temperature rise and water removal; after the solution is cooled, a catalyst and diisocyanate are added; temperature rise reaction is performed to obtain a methylbenzene solution of polyurethane prepolymers; the end capping agent is added; the temperature is raised to 70 to 100 DEG C for continuous reaction and end capping. The polyurethane associative thickener can effectively improve the viscosity of thewater solution in lower consumption; after ultraviolet light irradiation, the solution viscosity can be greatly reduced; after the oxidation, the solution viscosity can be greatly reduced; meanwhile,after the illumination and oxidation, the solution viscosity is greatly reduced.

The present invention relates to a method for calibrating a receiver device or a stimulus-response system comprising a receiver device. The method comprises the steps ofgenerating at least one tone with a repeatable and known phase value, said at least one tone being stepped in frequency to cover a given set of calibration tones, and applying the at least one tone to the receiver device or to the stimulus-response system,generating a reference signal, which is phase-coherent with the at least one tone, to measure in a phase-coherent way with the receiver device or with the stimulus-response system the at least one tone,measuring at least the phase of the at least one tone using the receiver device or the stimulus-response system,determining at least phase-related information for calibration coefficients at the given set of calibration tones by calculating a phase deviation of the measured phase from the known phase value of the at least one tone.