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180 results about "Stimulus response" patented technology

Access Control System using Stimulus Evoked Cognitive Response

The ACSSECR invention is a biometric access control system and methodology that measures cognitive, psychophysiological responses to stimuli to confirm the identity of an individual. As an alternative to “Logging in” with a user ID and password, this cognitive biometric authentication system is used for “Cogging in” to a system with user ID and user-selected “Cogkey”. ACSSECR is designed for strict access control scenarios where significant authentication confidence is required to gain access to controlled information, facilities, systems, vehicles, or devices. The system takes advantage of a behavioral and physiological characteristic of humans that is an unconscious response to a stimulus. The Event Related Potential (ERP) response (specifically the P3 ERP) involuntarily occurs when an individual perceives and reacts to an unexpected, task-relevant event. The task is for the user to recognize their Cogkey which is presented infrequently amidst more frequent non-target stimuli. There is no requirement for extensive enrollment by users, only the recognition of their Cogkey. The basic system does not store biometric data for comparison, but rather measures the user's Cogkey recognition responses in comparison to non-Cogkey stimulus responses. An individual can have multiple personas with different Cog keys.
Owner:PERINI II REMO PETER

Double-shell medicine sustained and controlled releasing carrier material and preparation method and application thereof

The invention relates to carrier materials of medicament sustained controlled release, a process for preparing the carrier materials and usage, in particular relating to carrier materials of double shell medicament sustained controlled release of a hollow silicon dioxde micro-balloon coated by pluralities layers f polyelectrolyte membranes, and the making method and usage of the carrier materials of double shell medicament sustained controlled release. The materials are prepared by the hollow silicon dioxde micro-balloon and the compatible polyelectrolyte. An inner shell of the carrier material of double shell medicament sustained controlled release is the hollow silicon dioxde micro-balloon, and an outer shell is composed of polarities layers of the polyelectrolyte membranes. A cavity of the hollow silicon dioxde micro-balloon can be a container for carrying medicament, and the polarities layers of the polyelectrolyte membranes of the outer shell can control the release rate of medicament molecules under different external environments. The carrier materials of double shell medicament sustained controlled release of the invention have high medicament-carrying capacity, and have certain targeting function, and environmental stimulus response of the medicament is release-controllable.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI

Nano particle-polymer injectable composite hydrogel double drug loading system and preparation method thereof

The invention belongs to the field of synthesis of drug carrier base materials and provides a nano particle-polymer injectable composite hydrogel double drug loading system and a preparation method thereof. The double drug loading system is loaded with not only an anti-cancer drug I of which polymer nano particles are synthesized through a disulfide bond cross-linking agent by taking acrylic acidand 4-vinylphenylboric acid as monomers, but also an anti-cancer drug II of which injectable hydrogel is synthesized through Michael addition reaction between a macromolecular cross-linking agent witha sulfhydryl functional group and a polymer containing a catechol functional group aiming at the drug loading capacity, the action time, the treatment effect and other demands. The bi-stimulus response is pH stimulus response and reducing stimulus response of glutathione to the disulfide bond cross-linking agent in a tumor cell environment respectively, the interaction between the nano particlesand the drug I as well as the degradation process of the nano particle can be affected, and the long-term delivery of the drug I is realized. The nano particle-polymer injectable composite hydrogel double drug loading system provided by the invention realizes the effects of local long-time administration, step-by-step osmotic treatment and combined treatment of a variety of drugs.
Owner:NANJING UNIV OF POSTS & TELECOMM

Sol system used for preparing pH-sensitive double-network hydrogel, hydrogel and application

The invention belongs to the field of environmental-stimulus-response-type medicines, and particularly relates to a sol system used for preparing pH-sensitive double-network hydrogel, the hydrogel andapplication. The sol system is prepared from gelatin methacryloyl, oxidized alginate, a photoinitiator, gentamicin and mesoporous silica nano particles loaded with phenamil medicinal molecules, the sol system is transformed from sol to gel fast under ultraviolet irradiation, thus the pH-sensitive double-network hydrogel can be obtained, and the hydrogel is excellent in physical and chemical property and good in biocompatibility, can effectively control release of an antibacterial medicine GS and an osteogenic differentiation promoting medicine phenamil, prevent early infection of a graft, induce C2C12 cell osteogenic differentiation, and promote endogenous bone generation. Based on the character that the sol system is transformed from the sol to the gel fast under ultraviolet irradiation,in practical application, in-situ gelation can be conducted by means of minimally-invasive injection, and the requirements of complex orbital bone defect repair can be met, so that the sol system used for preparing the pH-sensitive double-network hydrogel has important values in orbit repair and reconstruction.
Owner:WENZHOU MEDICAL UNIV

Gel-in-oil-in-water emulsion as well as preparation method and application thereof

The invention provides gel-in-oil-in-water emulsion as well as a preparation method and an application thereof. The gel-in-oil-in-water emulsion comprises an internal gel phase, an oil phase and an external water phase, wherein the internal gel phase is coated with the oil phase which is coated with the external water phase. The gel-in-oil-in-water emulsion can be used as a delivery carrier for human or animals, the internal gel phase has good biocompatibility, can be prepared under mild conditions and has environmental stimulus response, a multiple emulsion structure is prepared under mild conditions, and poor stability of multiple emulsion is improved greatly; efficient loading and activity retention of hydrophilic and hydrophobic substances especially bioactive substances can be realized, the condition that in-situ gel can only realize local drug delivery is improved, and the gel-in-oil-in-water emulsion can realize targeted delivery and intelligent controllable release on human andanimals and has extensive application prospects in the fields of vaccine adjuvant preparation, sustained and controlled drug release, targeted drug delivery, disease diagnosis and daily chemical products.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Preparation method for POSS/PDMAEMA organic/inorganic hybrid material according to thiol-ene click chemistry method

InactiveCN104558321AImprove performanceSmall sizeDimethylphenylphosphineDual response
The invention relates to a preparation method for a POSS/PDMAEMA organic/inorganic hybrid material according to a thiol-ene click chemistry method. The preparation method comprises the following steps: obtaining PDMAEMA through synthesis according to an RAFT polymerization method; taking dimethyl phenylphosphine as a catalyst, taking n-hexylamine as a reducer, and conducting a reduction reaction on a dithioester group at the tail end of PDMAEMA to generate sulfydryl; conducting thiol-Michael addition reactions on the double bonds of PDMAEMA containing sulfydryl and POSS containing ethenyl according to the thiol-ene click chemistry method to generate a POSS/PDMAEMA organic/inorganic hybrid material with a temperature/pH dual response. The preparation method has the advantages that the prepared POSS/PDMAEMA organic/inorganic hybrid material is small in size, stable in chemical bond, and uniform in particle diameter; due to a click reaction to PDMAEMA, the hydrophilic performance of POSS is effectively improved; in a water solution, the POSS/PDMAEMA organic/inorganic hybrid material is excellent in temperature sensibility and pH sensibility; due to a special structure and the stimulus response performance, the POSS/PDMAEMA organic/inorganic hybrid material is a new-generation environment-friendly new material product, and can be applied to drug carrying, targeted release, metal ion recovery, environmental pollutant adsorption and other fields.
Owner:TONGJI UNIV

High-stability strong physical unclonable function circuit and design method therefor

The invention is suitable for the fields of information security and integrated circuits, and provides a high-stability strong physical unclonable function circuit and a design method therefor. The physical unclonable function circuit comprises a time delay generation module, a time delay comparison module, a response calculation module and a stability judgment module, wherein the time delay generation module is used for transmitting the same jump through a plurality of time delay paths according to an input stimulus of the strong physical unclonable function circuit and generating a plurality of time delay values; the time delay comparison module is used for selecting out multiple pairs of time delay values from the time delay values, performing time delay difference comparison and dividing the time delay differences of the pairs of time delay values into a plurality of grades according to difference values; the response calculation unit is used for calculating an output response of the strong physical unclonable function circuit according to the time delay difference grade of each pair of time delay values; and the stability judgment module is used for judging whether a stimulus response pair is stable or not according to the time delay difference grade of each pair of time delay values. According to the circuit and the method, while the attack resistance of the strong physical unclonable function circuit is ensured, the time delay difference can be measured online in real time, so that the stability is greatly improved.
Owner:INST OF COMPUTING TECH CHINESE ACAD OF SCI

Polyurethane associative thickener with double stimulus response and preparation method thereof

The invention discloses a polyurethane associative thickener with double stimulus response and a preparation method thereof. The preparation method is characterized in that under the nitrogen gas protection, 4-hydroxyazobenzene methanol and halogenated alkyl ferrocene are dissolved; an acid binding agent is added; after the complete reaction, filtering is performed when the materials are hot; filtering liquid is collected; when the filtering liquid is cooled to room temperature, the filtering liquid is poured into saturated salt solution to obtain yellow precipitates; filtering is performed; the precipitates are washed; recrystallization is performed to obtain an end capping agent; under the nitrogen gas protection, a polyethylene glycol and methylbenzene mixture is subjected to temperature rise and water removal; after the solution is cooled, a catalyst and diisocyanate are added; temperature rise reaction is performed to obtain a methylbenzene solution of polyurethane prepolymers; the end capping agent is added; the temperature is raised to 70 to 100 DEG C for continuous reaction and end capping. The polyurethane associative thickener can effectively improve the viscosity of thewater solution in lower consumption; after ultraviolet light irradiation, the solution viscosity can be greatly reduced; after the oxidation, the solution viscosity can be greatly reduced; meanwhile,after the illumination and oxidation, the solution viscosity is greatly reduced.
Owner:SOUTH CHINA UNIV OF TECH
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