310 results about "Stimulation Parameter" patented technology

The invention discloses a disturbance of consciousness stimulation regulation and control system and method fused with electroencephalogram connection recognition. The system comprises a simulated electroencephalogram signal data acquisition stage, a connection recognition analysis stage, a stimulation parameter optimization stage and an executable stimulation instruction conversion stage. The method has the following advantages and effects that a whole-electroencephalogram activity distribution diagram is generated by simulating an electroencephalogram signal data acquisition stage, a key connection area is identified, and a brain function connection map is generated by utilizing a function connection analysis network and a phase synchronization algorithm in a connection identification analysis stage; in the stimulation parameter optimization stage, space-time correlation between a whole electroencephalogram activity distribution map and a brain function connection map is established, a multi-objective optimization algorithm is adopted to generate an optimized stimulation parameter set through a fusion network, and finally, in the executable stimulation instruction conversion stage, the optimized stimulation parameter set is converted into an executable stimulation instruction based on a self-adaptive control model. Therefore, the accuracy and the self-adaptive capability of electroencephalogram signal stimulation regulation and control are remarkably improved.

The invention relates to the technical field of nervous system dysfunction, in particular to a nerve regulation and control system for degenerative disease treatment based on multi-modal physiological feedback, which comprises a central processing unit, an optical radiation applicator, a mechanical vibration applicator, an integrated biological signal sensing array and a man-machine interaction module, cooperative stimulation is applied by using a multispectral light source and a broadband vibrator, and multi-dimensional physiological signals such as heart rate variability, myoelectricity, galvanic skin and the like are monitored in real time through a sensor array. A multi-parameter adaptive control algorithm built in the central processing unit can dynamically and intelligently adjust stimulation parameters based on the feedback signals to form an accurate personalized treatment closed loop. Meanwhile, the safety monitoring module based on the biological thermal model ensures the safety boundary of the treatment process. According to the invention, intelligent, self-adaptive and non-invasive treatment of nerve dysfunction is realized.

The invention provides a transcranial magnetoacoustic stimulation closed-loop feedback method and system based on electroencephalogram guidance. The method comprises the steps that original electroencephalogram signals of a target brain area are collected and preprocessed; target brain region activity features are extracted based on the preprocessed electroencephalogram signals, and the neural activity state of the target brain region is judged according to the target brain region activity features; according to the state judgment result, initial stimulation parameters are generated and optimized in combination with a preset stimulation response model; the generated initial stimulation parameters are converted into actual stimulation signals, the transcranial magnetoacoustic stimulation device is controlled to execute ultrasonic and magnetic field stimulation on the target brain area, and closed-loop feedback is conducted according to the activity state of the target brain area. According to the method, the limitation of a traditional transcranial stimulation method in the aspects of real-time feedback, individualized adaptation, artifact interference and safety control is effectively solved, accurate, controllable and individualized intervention of the neural activity of the target brain region is achieved, and a repeatable, safe and efficient technical means is provided for nerve regulation and control research and clinical application.

A medical apparatus for a patient comprises an implantable system. The implantable system comprises a first implantable device comprising: at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; and an implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters. The apparatus is configured to randomly vary at least one of the one or more stimulation parameters. Methods of providing stimulation energy with randomly varying stimulation parameters are also provided.

The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.

The invention relates to the technical field of medical treatment, and provides a portable brain-limb cooperative tremor regulation and control method, which comprises the following steps: collecting motion data of a hand of a user; identifying individualized tremor frequency of the user in real time based on the motion data of the hand of the user; based on the identified individualized tremor frequency, band-pass filtering with the individualized tremor frequency as the center is carried out on the tremor signal after high-pass filtering, and the current tremor phase is detected; based on the individualized tremor frequency and the tremor phase, generating percutaneous introduction mode stimulation parameters and starting stimulation; generating transcranial time domain interference stimulation parameters and starting stimulation at a specific time point after the transcranial introduction mode stimulation is started; the transcranial time domain interference stimulation and the transcutaneous afferent mode stimulation are cooperatively controlled for intervention; the tremor intensity change is monitored in real time, stimulation parameters are dynamically adjusted, and closed-loop control is formed. According to the technical scheme, through the integrated design of real-time sensing, dual-mode cooperation and closed-loop regulation, tremor efficient suppression and portable treatment are achieved.

The invention relates to an in-vitro program controller and a control method thereof. The in-vitro program controller comprises a sensor and a processor, and the processor sets the working power of the implantable nerve stimulator, a temperature early warning value and a temperature upper limit value greater than the temperature early warning value according to the stimulation parameters; when the movement of the in-vitro program control instrument is determined at every reference time interval or according to the posture change detected by the sensor, a data reading instruction is sent to the implantable nerve stimulator so as to read the working power and temperature of the implantable nerve stimulator; increasing, decreasing or maintaining the transmitting power according to the comparison between the read working power and the set working power; according to the fact that the read temperature is larger than or equal to the set temperature early warning value and smaller than the set temperature upper limit value, the transmitting power is reduced; and sending a stimulation stop instruction when the read temperature is greater than or equal to a set temperature upper limit value. According to the invention, the working power, temperature and the like of the implantable nerve stimulator can be monitored and adjusted, so that safe treatment of a patient is ensured.

The invention discloses a wireless charging pelvic floor muscle rehabilitation treatment system, method and equipment and a medium, and relates to the technical field of rehabilitation physiotherapy. A pelvic floor host is arranged to collect a first electromyographic signal of pelvic floor muscles, a first body surface electrode host synchronously collects a second electromyographic signal of abdominal muscles, power frequency notch processing is carried out on the two signals to improve signal quality, and then an abdominal muscle participation degree coefficient is calculated based on the processed signals. The coefficient can accurately quantify the compensation degree of abdominal muscles in pelvic floor muscle training. And the main controller adjusts the electrical stimulation parameters of the pelvic floor host in real time according to the abdominal muscle participation degree coefficient, and when the abdominal muscle compensation is detected to be obvious, the target electrical stimulation parameters are adjusted to inhibit the excessive participation of the abdominal muscle, so that the pelvic floor muscle can obtain more accurate training stimulation. Meanwhile, the system is further provided with a wireless charging storage box, a convenient wireless charging function can be provided for the treatment probe, and the use convenience of the equipment is improved.

The invention relates to the technical field of medical instruments, in particular to a nerve stimulation method and device based on adaptive posture detection. The method comprises the following steps: in a posture calibration stage, acquiring data through an acceleration sensor, and carrying out smoothing processing by utilizing an optimized Kalman filtering algorithm; according to the calculated resultant acceleration standard deviation, distinguishing a dynamic posture from a static posture, correspondingly establishing a resultant acceleration standard deviation interval for the dynamic posture, and establishing an included angle interval between three axes and a horizontal plane for the static posture; in the posture detection stage, by calculating the resultant acceleration standard deviation of real-time data, the dynamic and static types are judged firstly, and then the resultant acceleration standard deviation is matched with the corresponding calibration interval to recognize the specific posture. And finally, dynamically adjusting nerve stimulation parameters according to the identified postures.

The invention provides an Alzheimer's disease intervention rehabilitation system based on photoacoustic magnetic vibration wave resonance, and relates to the technical field of medical health. The system comprises a data acquisition unit, a correction unit, a stimulation unit and an evaluation feedback unit. The data acquisition unit is used for acquiring multi-dimensional data such as electroencephalogram signals and pathology associated data of a user and extracting target neural oscillation features from the multi-dimensional data; a correction unit constructs a brain structure-pathology association model, and performs pathology association correction on the target neural oscillation features; and the stimulation unit generates co-stimulation containing at least two modes of light, sound, magnetism and vibration based on the corrected features, configures stimulation parameters according to a predetermined time domain or frequency domain relationship, and intervenes the coupling target. And the evaluation feedback unit evaluates the intervention effect by collecting the stimulated multi-dimensional data. According to the method, the multi-mode stimulation is bound with the pathological-neural oscillation coupling characteristics, so that accurate and collaborative intervention aiming at the pathophysiological mechanism of the Alzheimer's disease is realized.

A neuromodulation system disclosed herein improves urethral function, provides personalized stimulating parameters, and allows the patients to regain control of their bladders according to several implementations. A neuromodulation system disclosed herein provides bilateral stimulation and sensing, and personalized machine learning classifiers for adaptive stimulation. The system may include one or more electrode leads implanted in a first lateral side of the patient and one or more second electrode leads implanted in a second lateral side of the patient opposite the first lateral side. Mixed urinary incontinence and other conditions are treated using electrical stimulation, according to several implementations.

The invention discloses a stimulation system and method of a multi-site electrode patch for percutaneous spinal cord electrical stimulation, and belongs to the field of noninvasive electrical stimulation analgesia technologies and stimulation control systems thereof. The system comprises a multi-site electrode patch, a flexible substrate of which is provided with a plurality of electrode units in an integrated manner, and the electrode units are arranged along a preset direction; the patch is used for being attached to a corresponding spinal cord segment area on the body surface of a subject; the stimulator is electrically connected with the multi-site electrode patch and used for generating and outputting electrical stimulation signals to at least one pair of electrode units of the multi-site electrode patch; and the control module is connected with the stimulator and is used for receiving an instruction input by a user, configuring the activation state, the combination mode and the stimulation parameters of the electrode units and realizing selective or combined activation of the electrode units. According to the system, a plurality of electrode units are integrated on the same electrode patch, and unified management of a stimulator and a control module is combined, so that flexible configuration of activation states and combination modes of the electrode units is realized.

The invention relates to a non-invasive brain stimulation self-adaptive closed-loop regulation and control system. The system comprises a task interaction module which is configured to present a time sensing task to a target object and receive an interaction instruction of the target object; the non-invasive brain stimulation module is used for performing non-invasive brain stimulation; the sensing acquisition module is used for acquiring electroencephalogram data and behavioral data of a target object; the closed-loop regulation and control module comprises at least one block-level regulation and control primary unit, and each block-level regulation and control primary unit comprises a plurality of block-level regulation and control primary units; the trial secondary regulation and control primary unit is used for generating a first feature vector in real time on the basis of the currently collected electroencephalogram data and behavioral data so as to obtain a stimulation parameter of the next trial in the current block; the block-level regulation and control first-level unit is used for processing the currently collected electroencephalogram data and behavioral data to obtain a second feature vector, and based on the second feature vector, adaptive search is carried out under security constraints to obtain stimulation parameters of a next block. By adopting the method, the stability of the stimulation effect can be improved.

The invention discloses an intelligent feature cognition detection device for visual detection. The intelligent feature cognition detection device comprises a multi-modal sensing module, a dynamic stimulation generation unit, an intelligent feature analysis unit and a dynamic cognition evaluation unit, according to the method, eye movement, pupil and electroencephalogram three-mode data are integrated, the sampling rate and precision are better than those of the prior art, environment self-adaptive calibration is combined, data integrity is improved, and the nerve and behavior process of visual feature cognition can be comprehensively reflected. Based on a linkage mechanism of a cognitive state and stimulation parameters, four types of stimulants close to an actual detection scene are generated, real-time adjustment of complexity, duration and interval is supported, the method is adaptive to testees with different cognitive levels, and compared with a fixed stimulation scheme, the relevance between a detection result and actual post ability is improved.

The invention discloses an intelligent biological eardrum based on individualized 3D printing and a preparation method thereof, and belongs to the technical field of medical instruments, and the eardrum comprises an individualized eardrum substrate, a PEDOT: PSS flexible electrode array integrated on the inner surface of the substrate, a multi-frequency bioelectrical impedance detection module, a VCT module and a central processing unit. Through multi-frequency bioelectrical impedance detection and VCT imaging, an auricle conductivity distribution map can be reconstructed, a nerve active area can be accurately identified, and personalized transcutaneous nerve electrical stimulation parameters can be generated. The invention further provides a corresponding intelligent nerve regulation and control system, a preparation method and a parameter adjustment method based on physiological signal feedback, an integrated solution from individualized manufacturing, precise recognition to self-adaptive closed-loop regulation and control is achieved, and the intelligent nerve regulation and control system is particularly suitable for individualized nerve regulation and control treatment of irritable bowel syndrome and other diseases; the problems of low stimulation precision, lack of individuation, poor comfort, no closed-loop feedback and the like in the prior art are effectively solved.

The invention discloses a cerebral cortex stimulation central nervous regulation system and method based on a pulse magnetic coil, and the system comprises a pulse magnetic stimulation module, a neural signal collection module, a central control module and a man-machine interaction module, and is additionally provided with a three-dimensional positioning module and a multi-level safety monitoring module. The pulse magnetic stimulation module generates a focused pulse magnetic field, the neural signal acquisition module acquires multi-brain-region electric signals, and the central control module dynamically regulates stimulation parameters after analyzing the signals to form closed-loop regulation; the three-dimensional positioning module ensures accurate positioning of the coil, the safety monitoring module monitors parameters in real time and triggers emergency protection, and the man-machine interaction module realizes convenient operation and data management. According to the method, adjustment is completed through initialization, signal acquisition and analysis, precise stimulation, positioning adjustment and safety monitoring. The scheme is non-invasive, accurate, safe and suitable for nerve research and disease treatment, the regulation effect and use safety are improved, and development of the nerve regulation technology is promoted.

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

The invention provides an electrical stimulation and lower limb exoskeleton device fusion control method and system, and the method comprises the steps: driving an exoskeleton to move through bottom admittance control based on the actual human-computer interaction torque and expected torque of a knee joint and reference trajectory data of the knee joint in a gait cycle, and triggering ankle joint electrical stimulation through a fixed stimulation parameter group; after the gait cycle is finished, torque errors are calculated, and periodic iteration updating is conducted on the knee joint reference trajectory data through an iterative learning control algorithm till convergence is conducted to obtain target knee joint reference trajectory data; and then determining a target moment of a gait phase based on the target knee joint reference trajectory data, and obtaining a corresponding target stimulation parameter group from the set stimulation parameter time mapping library to replace the fixed stimulation parameter group for subsequent stimulation. According to the method, through single-cycle and cross-cycle trajectory iteration, the adaptation defect of a traditional fixed trajectory is avoided, the stimulation parameters are synchronously optimized, and the dorsiflexion assisting effect is indirectly improved.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

This invention discloses a multimodal acupoint targeted stimulation and feedback rehabilitation device. The device integrates focused ultrasound, transcutaneous electrical stimulation, and thermotherapy modules to form a composite stimulation unit. It monitors the physiological response of acupoints in real time using bioimpedance spectroscopy and PPG optical sensors, and calculates the "Deqi Index" (DI) based on a weighted fusion of normalized impedance decrease rate and blood flow increase rate. It combines RGB-D visual dynamic tracking of acupoint coordinates and provides location confirmation through a wearable force feedback device. The central control unit adaptively adjusts various stimulation parameters based on the DI value, forming a closed-loop control of perception-decision-execution. This invention solves the problems of existing devices having a single stimulation modality, lacking objective feedback, and inaccurate positioning, significantly improving the accuracy, effectiveness, and intelligence level of acupoint rehabilitation therapy.

The invention relates to a nerve stimulator, a control method of the nerve stimulator and a storage medium, and the nerve stimulator comprises a control unit which is used for controlling a signal generator; a signal generator for generating a stimulation signal, the energy of the stimulation signal satisfying an energy relationship, the energy relationship being accumulation of the charge with respect to time based on the waveform; and the output unit is used for outputting the stimulation signal. According to the application, the problem that the stimulation parameters of the stimulation equipment are easy to fail in adaptation is solved.

Systems and methods for adjusting neural therapy patterns of a neuromodulation system in response to each of patient events and passage of time. Initial stimulation parameters are set and used to start a stimulation period. As time passes or events occur, the neuromodulation system adjusts the stimulation parameters according to a preset temporal pattern. Further examples include handling of patient requests for therapy changes, and acute testing for complex stimulation patterns.

The invention discloses a table type midnight-noon ebb-flow neuromuscular electrical stimulation system and an electrical stimulation instrument, and relates to the technical field of neurological rehabilitation, the system comprises an acupuncture point precise positioning module, which integrates image acquisition and algorithm, and outputs acupuncture point three-dimensional coordinates; the qi and blood quantification module is used for calculating qi and blood indexes by using various sensors in combination with the midnight-noon ebb- The stimulation parameter mapping module generates personalized parameters according to the time and qi and blood data; the electrical stimulation execution module accurately applies thorns and dynamically adjusts the thorns; the curative effect closed-loop optimization module monitors feedback, iteratively optimizes parameters and generates a curative effect report; precise positioning and dynamic quantification of acupuncture points are realized by integrating image acquisition, algorithms and the like, and transformation of the midnight-noon ebb-flow therapy is promoted; a corresponding relation is established to generate a personalized stimulation scheme, a curative effect closed-loop optimization mechanism is constructed, the traditional limitation is broken, the individual physiological state is fit, the treatment effect is improved, an efficient scheme is provided for neuromuscular electrical stimulation, and fusion of the traditional Chinese medicine theory and the modern technology is promoted.

Implantable medical device for stimulating a heart includes a proximal electrode pole, and first and second distal electrode poles. During operation, the device performs: a) detecting an intrinsic atrial contraction of the heart; b) detecting an intrinsic ventricular contraction of the heart; c) determining a first intrinsic atrioventricular conduction time between i) the intrinsic atrial contraction or the stimulation of the atrium and ii) the intrinsic ventricular contraction detected with the first distal electrode pole; and determining a second intrinsic atrioventricular conduction time between i) the intrinsic atrial contraction or the stimulation of the atrium and iii) the intrinsic ventricular contraction detected with the second distal electrode pole; d) setting a stimulated atrioventricular conduction time for stimulating the ventricle of the heart with the first and / or second distal electrode poles, the stimulated atrioventricular conduction time being shorter than the shorter of the first and second intrinsic atrioventricular conduction times.

The present disclosure relates to a method for suggesting personalized and symptom-specific DBS stimulation parameters, comprising the steps of: creating a three-dimensional symptom network library comprising a data-driven three-dimensional model of symptom-specific nerve tracts in a stereotactic space established based on a detailed and comprehensive pathway profile; registering patient data with the three-dimensional symptom network library to analyze how an electrode of a single patient is mapped thereto; stimulation parameters are derived and suggested from baseline symptom severity characteristics for each patient. Another object of the invention relates to a system for predicting DBS parameters, the system comprising an interface for providing DBS parameters to an electrode and receiving signals from a patient, and a computer programmable unit comprising a data memory for storing a network library of three-dimensional symptoms, the three-dimensional symptom network library includes a stored data driven three-dimensional model of symptom-specific nerve tracts in a stereotactic space established based on detailed and comprehensive pathways for predicting DBS parameters.

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

The invention relates to the technical field of sleep quality monitoring, and provides a non-intrusive user sleep quality monitoring method and system.The comprehensive and intelligent sleep quality monitoring system is constructed by organically integrating a feature analysis module, a parameter optimization module, a phase synchronization module and a double-loop feedback module, all the modules cooperate with one another and share data, and therefore the sleep quality of a user can be effectively monitored. The sleep quality of a user is analyzed, monitored and intervened from multiple dimensions, the feature analysis module provides rich and accurate feature data for follow-up, the parameter optimization module determines stimulation parameters based on the feature data and physiological features of the user, and the phase synchronization module optimizes stimulation signals according to the stimulation parameters and brain phase differences. And the double-loop feedback module monitors the stimulation effect in real time and dynamically adjusts the stimulation effect, so that the system adaptively adjusts the intervention mode according to the real-time sleep state and individual difference of the user, and the accuracy and effectiveness of sleep quality monitoring and improvement are improved.