88 results about "Frontal lobe" patented technology

The invention concerns a prosthesis wherein the contact surfaces of the femoral part (i), the insert (3) and the knee joint are defined by the combination of two curves, a spiral-type curve in the saggital plane following an undulating curve (sinusoidal) in the frontal plane. The latter comprises two concave lateral parts and a central dome-shaped convex part, the three parts being connected without any angulation, protuberance, or flat parts or bends and providing continuous medio-lateral contact on the three zones, from complete extension to complete bending, and a concave-convex nesting in the central zone.

Stuttering-treatment techniques using neural stimulation and / or drug delivery. One or more electrodes and / or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient's vocal folds, can be used for generating a signal responsive to activity of the patient's speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.

A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°-180°-90°) for whole body MR Spectroscopy. Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. A combination of different MRI transmit / receive rf coils is used. The cross peak intensities excited by the proposed 2D sequence are asymmetric with respect to the diagonal peaks. Localized COSY spectra of cerebral frontal and occipital gray / white matter regions in fifteen healthy controls are presented.

Stuttering-treatment techniques using neural stimulation and / or drug delivery. One or more electrodes and / or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient's vocal folds, can be used for generating a signal responsive to activity of the patient's speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.

The present invention relates to compositions and methods for the detecting, preventing, treating, and empirically investigating seizures and seizure related disorders (e.g., West syndrome, TSC, childhood absence epilepsy, benign focal epilepsies of childhood, juvenile myoclonic epilepsy (JME), temperol lobe epilepsy, frontal lobe epilepsy, Lennox-Gastaut syndrome, occipital lobe epilepsy). In particular, the present invention provides compositions and methods for detecting, treating, preventing and empirical investigating seizures and seizure related disorders through inhibition of mTOR function. In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents (e.g., rapamycin) in the detecting, preventing, treating, and empirical investigating of seizures and seizure related disorders.

The present invention provides systems, apparatus and methods for treating nerve disorders in the brain. An electrode is introduced into a patient's sinus cavity and an electrical impulse is applied to the electrode to modulate one or more target nerves in the brain to treat the disorder. In preferred embodiments, the electrode is positioned within a sinus cavity adjacent to or near the frontal cortex of the brain and the electrical signal is sufficient to modulate, stimulate and / or inhibit nerves within the frontal cortex. The electrode may be movable between a collapsed or compact configuration for introduction into the sinus cavity and an expanded configuration for contacting tissue within the sinus cavity to deliver the electrical impulse through the tissue to the target nerves in the brain.

A system and methods of computer-aided diagnosis for ophthalmology are described that includes acquiring OCT data, determining an RPE fit from the OCT data, and displaying en face images based on the RPE fit.

Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to and / or during sleep to enhance sleep, which may be particularly beneficial to treat insomnia.

The present invention relates to use of small RNA molecule, is especially use of miRNA-34a, and belongs to the field of biomedicine material technology. By means of Northern process and other process, miRNA-34a is determined to be the age related expression, and by means of the contrast to the prefrontal lobe cortical tissue miRNA' s of rats in different age sections, it is found that the expression of miRNA-34a in the pallium of rhesus and the prefrontal lobe cortex of rat exhibits age dependent change. The present invention establishes a rat neuron AD cell model for the research of possible action mechanism of miRNA-34a. By means of further transfecting miRNA-34a precursor, miRNA-34a antisense RNA and other contrasts, it is found that miRNA-34a possesses neuron apoptosis effect of antagonizing A-beta induction.

An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.

A method and apparatus are disclosed that automatically interject brain activations into video imaging activities or other activities of daily living. During a video game, for example, an interrupt causes a pause in the game and a commencement of an activity involving but not limited to bilateral portions of the body, the peripheral vision of the game-player, and a visual pursuit-type and saccadic-type action on the video screen. Alternatively, the brain activation can be merged into the content of the video game so as to be generally indistinguishable to the user. Automatic feedback from the system encourages more frequent brain activations when performance is determined to be diminished and less frequent brain activations when performance is determined to be enhanced. The combination of events in the activity is believed to engage the frontal lobes of the brain as well as other brain structures and stimulate brain health.

A method for determining an individual's intensity of focused attention, comprising the steps of: obtaining a representative frontal lobe brainwave signal from at least one first sensor in an electrically connective relation to the individual's frontal lobe; obtaining a representative reference signal from at least one second sensor in an electrically connective relation to a more electrically-neutral location; subtracting the representative reference signal from the representative frontal lobe brainwave signal to produce a difference frontal lobe brainwave signal, and processing the difference frontal lobe brainwave signal to produce an Attention Indicator signal indicative of the individual's intensity of focused attention, where the Attention Indicator signal is inversely proportional to any mathematical transformation of an amplitude measure of the difference frontal lobe brainwave signal; inputting the Attention Indicator signal to a device; and, repeating these steps, as desired. The mathematical transformation can relate to amplitude, power or any linear, logarithmic or exponential transformation thereof.

The described embodiments relate generally to methods, systems and devices for sleep stage determination using frontal electrodes. Certain embodiments relate to a system for sleep stage determination comprising a sensing unit and a processing unit. The sensing unit is positioned over a forehead area of a patient and has first, second and third electrodes for positioning at locations on or adjacent the forehead area for detecting electrical potentials of a human head. The processing unit is coupled to the sensing unit for receiving biological signals corresponding to the detected electrical potentials and processing the biological signals to determine a sleep stage of the patient. The processing of the biological signals is based on a plurality of rules.

The invention provides methods and compositions for augmenting bioenergetic metabolism in the frontal brain involving administration of a cytidine-containing or uridine-containing compound to a human.

A sexual device to be worn externally by a woman, man, or transgender person, that will allow said wearer to artificially inseminate a sexual partner by use of pseudo natural means. That is, a harness device constructed material so that the frontal lobe of the device is a dildo with cylindrical tubing constructed to run horizontally through the center, with a predetermined length of tubing remaining outside the distal end of dildo; the distal end of tubing is attached to a syringe that is attached to the side of the harness so that the wearer can manipulate the amount of semen fluid that flows through the syringe. The device provides a method for pseudo genital-to-genital sexual contact between two partners to artificially inseminate in a way other than the use of the “syringe through the vaginal canal” method, or any other methods that are currently used for artificial insemination.

The invention provides an implantable intracranial device for the site-specific delivery of a pharmaceutically active agent to a human or animal for treating a mental or neurological disorder, such as Alzheimer's disease, schizophrenia or other psychoses. The biodegradable device includes a pharmaceutically active agent for treating the disorder, polymeric nano-lipoparticles into or onto which the pharmaceutically active agent is embedded; and a polymeric matrix or scaffold incorporating the nano-lipoparticles. The nano-lipoparticles can be in the form of nano-liposhells or nano-lipobubbles. The nano-liposhells or nano-lipobubbles can include an essential fatty acid or can be conjugated to a peptide ligand which targets the device to a specific cell into which the therapeutic agent can be delivered. The device can be implanted in the sub-arachnoid space in the region of the frontal lobe of the brain.

The invention discloses an emotion regulation ability survey method based on frontal lobe EEG lateralization and ERP. Resting state EEG signals and task state EEG signals are acquired; filtering and down-sampling preprocessing is performed on the acquired resting state EEG signals and the task state EEG signals; power spectrum feature extraction is performed; event related potential extraction isperformed; the lateralization coefficient B and the P300 difference coefficient E are calculated; if B>0 and E>0, the emotion regulation ability is great; if B>0 or E>0, the emotion regulation abilityis common; and if B<0 and E<0, the emotion regulation ability is poor. The diagnostic error caused by subjectivity can be avoided, the objective and reliable result based on the electroencephalogramcan be provided, and a set of perfect neural survey method can be obtained through further research so that the emotion regulation ability survey accuracy can be enhanced and the considerable social benefit and economic benefit can be acquired.

Methods, systems and devices for reducing anxiety, including increasing relaxation and / or calm. In some variations these methods may include reducing anxiety, increase relaxation and / or calm by non-invasive temperature regulation of the frontal cortex prior to and / or during sleep. The subject may have an anxiety disorder, or may not have a diagnosed anxiety disorder.

The present invention relates to an automatic cardiopulmonary resuscitation (CPR) device which, even in the middle of performing cardiopulmonary resuscitation, can measure an electrocardiogram and oxygen saturation, can measure an electroencephalogram so as to detect in real time a brain activity indicative of the degree of blood circulation in the brain, has a defibrillation function, can use a brain activity index as a CPR signal indicating the degree of cardiopulmonary resuscitation, and can remotely monitor biometric signals at a pre-hospital stage. The present invention provides a cardiopulmonary resuscitation device comprising: an electroencephalogram detection unit for detecting an electroencephalogram signal from the frontal lobe; and a calculation processing unit for detecting a brain activity index, which is used as a CPR signal indicating the degree of cardiopulmonary resuscitation, from the electroencephalogram signal received from the electroencephalogram detection unit, wherein the calculation processing unit derives, as the brain activity index, one or more of the burst suppression ratio (BSR), the beta ratio, and the SynchFastSlow (relative synchrony of fast and slow wave, SFS). The calculation processing unit eliminates noise from the electroencephalogram signal received from the electroencephalogram detection unit, and derives the beta ratio from the electroencephalogram signal, from which noise has been eliminated, using the following formula: Beta Ratio = log[spectral power (30-47 Hz) / spectral power (11-20 Hz)] (where, spectral power (30-47 Hz) denotes the spectral power in the 30-47 Hz band of the electroencephalogram, and spectral power (11-20 Hz) denotes the spectral power in the 11-20 Hz band of the electroencephalogram).

A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.

A method of commanding and controlling a mobile apparatus (wheelchair) based on the assimilation of visual parameter and brain activity data includes validating a desired position of gaze (the iris) in the environment using the physiological brain characteristics of the potentials mentioned in P300 and SSVEP. These supply a control unit and are used to assess the user's state of mental fatigue using an algorithm based on the theory of evidence. A unit detecting the user's emotional state is also implemented using the alpha and beta waves from the parietal, central and frontal region of the cerebral cortex and the user's heart rhythm. The assimilation between these two units makes it possible to define a mode of operation in real time: manual, semi-autonomous or autonomous, which corresponds to the user's emotional or fatigue states as well as the characterization of the environment (safe path, detection of obstacles, locked situation).

Provided is a health diagnosis apparatus and method in which brain waves are sequentially measured from the frontal lobe of a human body that is to be diagnosed when the eyes are in an eyes-open and eyes-closed state, the measured brain waves are fast Fourier transformed to then be accumulated, and then the health conditions of the respective portions of the human body can be determined according to the patterns with respective frequencies. The health condition diagnosis method includes measuring brain waves; performing a fast-Fourier-transform on the measured brain waves; classifying the frequency-based brain wave data into opened and closed eye state brain waves to thus accumulate the classified result; finding a specific frequency and a pattern thereof which repeats from the accumulated brain wave data; correspondingly connecting the frequency and the respective portions of the human body based on the specific frequency pattern; and determining the health condition of the human body. The frequency-based health condition determination is based on clinic test results.

This invention is a validation process for ipsative assessments. Respondents are connected to an Electroencephalograph (EEG) and some or all of the ipsative assessment questions are asked again while connected to the EEG. The EEG measuring frontal lobe responses in terms of gamma waves is compared with the assessment questions. Positive responses provide one frontal lobe response in terms of gamma waves, negative or false answers provide a different gamma response and neutral questions provide a neutral gamma response. Reading the responses then tells whether the respondent initially responded with integrity, if so the assessment is validated.

A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.