34 results about "Nervous tissue" patented technology

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to methods and compositions for preventing or treating a neuropathology in a subject associated with or induced or caused by a P. gingivalis infection, preventing the deposition of or reducing the level of P. gingivalis gingipain in neuronal tissue, delaying the onset of a P. gingivalis-induced or associated neuropathology, for preventing or slowing the rate of abnormal protein deposition in the neuronal tissue, and / or reducing neuroinflammation, the methods comprising administering an RNA polynucleotide encoding a protein comprising or consisting of: - one or more amino acid sequences of an active site of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto; and / or - the amino acid sequence of one or more adhesin binding motifs (ABMs) of an adhesin domain of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto, wherein the polynucleotide is capable of being translated in a mammalian cell.

The invention relates to the technical field of traditional Chinese medicines, relates to new application of a traditional Chinese medicine composition, and in particular relates to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating migraine. The traditional Chinese medicine composition is prepared from cassia twig, white peony root, honey-fried licorice root, ginger, jujube, ginseng, Chinese angelica, salted morinda officinalis and dwarf lilyturf tuber. The traditional Chinese medicine composition provided by the invention can obviously reduce serum NO and trigeminal nervous tissue SP content of migraine rats, increase trigeminal nervous tissue DA content, obviously improve head and face pain threshold and brain tissue DA content of the migraine rats and reduce brain tissue PGE2 content, and has a good treatment effect on migraine.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention provides a force feedback instruction output method in neurosurgical operation simulation, which comprises the following steps: S1, initializing force feedback equipment, creating a high-frequency service circulation thread and respectively configuring independent control channels of left and right hand surgical instruments; s2, collecting encoder data, joint angles and surgical instrument tail end pose information of the force feedback equipment in real time; s3, analyzing the data flow of the encoder data, and extracting a clamping angle state signal of the surgical instrument, a suction force state signal of an aspirator and an instrument replacement control signal; s4, dynamically calculating an interaction force between the nervous tissue and the surgical instrument based on the biomechanical model, and generating a six-degree-of-freedom force feedback instruction; s5, sending the feedback instruction to force feedback equipment, and updating the state of the instrument model in the three-dimensional operation scene; and S6, monitoring the running state of the force feedback equipment, and closing feedback output and releasing resources when the force feedback equipment is abnormal or the operation is terminated. The tactile feedback core pain point in neurosurgery simulation is solved.

A method of activating a piezoelectric neuroconduit guide scaffold including a plurality of aligned piezoelectric polymer nanofibers, the method including mechanically stimulating the piezoelectric neuroconduit guide scaffold with hydro-acoustic waves or shockwaves to remotely activate a piezoelectric effect of the nanofibrous scaffolds that induces a mechano-electrical stimulus on neural cells cultured on the scaffold, wherein the mechano-electrical stimulus promotes nerve fiber outgrowth from the neuronal cells. Some aspects relate to seeding individual components of neural tissues on the piezoelectric neuroconduit guide scaffold, wherein the hydro-acoustic stimulation induces neural tissue formation. In other aspects, the piezoelectric neuroconduit guide scaffold is implanted in a damaged neural tissue, wherein stimulating the piezoelectric neuroconduit guide scaffold by the application of shockwaves promotes nerve fiber outgrowth that bridges a nerve gap to induce nerve regeneration or reinnervation of the damaged neural tissue.

Device for the preventive blocking of neurotropic viruses in the peripheral nervous system, comprising a biochemical injection system for the localized release of a neurospecific binding molecule, a detection unit for the identification of viral particles in neuromuscular tissue, and a receptor bait structure for binding viral glycoproteins with affinity for neuronal receptors, characterized in that the device prevents retrograde axonal viral transmission without permanently impairing the conductivity of the nerve tissue.

The application belongs to the technical field of medical imaging, and particularly discloses a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. A plurality of tomographic images of a to-be-measured part are collected by an ultrasonic tomography system; a YOLO target detection network is used to locate a nerve tissue of each tomographic image; then a U-Net segmentation network is used for pixel-level segmentation to obtain a pixel-level probability map of the nerve tissue; an uncertainty of a pixel in the pixel-level probability map is modeled by using a membership modeling mechanism to adaptively weight a membership degree of the nerve tissue, so that an accurate segmentation result is obtained; the accurate segmentation result is taken as an observation of Kalman filtering, prediction and updating are performed based on the Kalman filtering, and an optimal state estimation of the nerve tissue is obtained; and a three-dimensional model of the peripheral nerve tissue is reconstructed by using the optimal state estimation of each tomographic image. The application can significantly improve the segmentation accuracy and structural integrity of the nerve tissue.

The invention belongs to the technical field of medical imaging, and particularly relates to a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. Acquiring a plurality of frames of tomographic images of the to-be-detected part through an ultrasonic tomography system; using a YOLO target detection network to position the nervous tissue of each frame of cross-sectional image; performing pixel-level segmentation by adopting a U-Net segmentation network to obtain a pixel-level probability graph of the nervous tissue; modeling the uncertainty of pixels in the pixel-level probability graph by adopting a membership modeling mechanism so as to perform adaptive weighting on the membership degree of the nervous tissue to obtain an accurate segmentation result; taking the accurate segmentation result as the observed quantity of Kalman filtering, and performing prediction and updating based on Kalman filtering to obtain the optimal state estimation of the nervous tissue; and reconstructing the optimal state estimation of each frame of cross-sectional image to obtain a three-dimensional model of the peripheral nervous tissue. According to the method, the segmentation precision and the structural integrity of the nervous tissue can be remarkably improved.

The disclosure relates, in some aspects, to modified adeno-associated virus (AAV) capsid proteins and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding modified AAV9 capsid proteins. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue or peripheral nervous tissue of a subject.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Methods and systems for analyzing and selecting therapy configurations for use in stimulating nervous tissue. A probabilistic shell related to the likelihood that electrical stimulation emanating to a given volume of nervous tissue will cause a therapeutic outcome is incorporated in a system for analyzing anatomical and other data, including lead location relative to the neuroanatomy. Metrics for analyzing therapy configurations may then be calculated and the process of identifying therapy configurations that may be beneficial may be enhanced.

The utility model discloses a plasma surgical electrode for treating rhinitis, which comprises an outer tube, a handle arranged at the rear end of the outer tube 1, a cable connector arranged on the handle, an inner tube with a cavity structure inside and connected in the outer tube in a matched manner, an electrode tip arranged at the front end of the inner tube, and a wire connected between the electrode tip and the cable connector, the cable joint is connected with the host, the electrode tip comprises an upper insulating head and a lower insulating head which are assembled into an integrated structure, a positive working electrode and a negative working electrode which are arranged on the upper insulating head and are connected with a lead, and a thermocouple for monitoring temperature, and the positive working electrode and the negative working electrode are respectively positioned on two sides of the upper insulating head. The structure is simple and reasonable, stable and reliable, assembly and disassembly are convenient, and the ablation treatment effect on the posterior lower nasal nervous tissue is effectively improved.

The present invention relates to the field of information delivery and relates to spatial information compression and delivery. The present invention provides a device for delivering event information to a nervous system after spatial compression and a method for fine regulation and control of large-scale neurons. The device comprises an imaging system for respectively coding event information into a plurality of patterns, a plurality of optic nervous systems for using a minimum information unit coded in the patterns to regulate and control the activity of single neurons in a nervous system, and a pattern projection system for respectively projecting the plurality of patterns coded by the imaging system to the optic nerve systems. The device and method solve the problems of low information transmission efficiency of existing neural electrodes, and foreign body response between the neural electrodes and a nervous system which causes mechanical damage to nervous tissues, achieve fine regulation and control of neurons in a large-scale neuron cluster, and achieve high-bandwidth input of multi-dimensional event information to a whole brain region of the nervous system.

A nervous tissue imaging system includes a pair of matched filters, including an excitation light filter that only passes excitation light in a first wavelength range from 365 nm to 400 nm, and a received light detection filter that only passes received light in a second wavelength range from 433 nm to 450 nm. An endoscope is connected with a first source optical train for guiding excitation light through the first source optical train and the excitation light filter to uniformly illuminate the excitation light on a patient's tissue region of interest inside an enclosed cavity of the patient's body. The endoscope is connected to a camera device and a receiving optical train and the received light detection filter for receiving and passing into the camera device light signals including autofluorescence light in the second wavelength range from healthy nervous tissue in the patient's tissue region of interest.

Described herein are robotically coordinated systems and methods for safe and efficient spinal decompression and bone milling. In various embodiments, a robotic spinal surgery system is provided with at least three robotic arms co-located on a single mobile base wherein the movement of the robotic arms is coordinated by a central control unit on the base. The system further comprises tools for spinal decompression, elements for protection of nervous tissue and navigation cameras. The nerve protection elements are placed between bony anatomy structures and nervous structures to prevent contact of the spinal decompression tools with the nervous structures. The nerve protection elements further include safety components that can optionally close electrical circuits with the decompression tools and sense or stimulate the nervous structures. Methods of deploying the inventive system in surgery are also provided.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The invention discloses a medicine for treating postherpetic neuralgia and a preparation method thereof, and belongs to the technical field of medicines for herpes zoster. Aiming at postherpetic neuralgia, the traditional Chinese medicine composition treats both symptoms and root causes through the synergistic effect of all the components, gypsum is used, and rhizoma coptidis, radix scutellariae, cortex phellodendri and fructus gardeniae are combined, so that the traditional Chinese medicine composition has the effects of strongly clearing heat, purging fire, detoxifying, removing residual damp-heat toxin and relieving causalgia; salvia miltiorrhiza, radix paeoniae rubra, moutan bark and motherwort synergistically promote blood circulation, remove blood stasis, cool blood and improve microcirculation so as to relieve stabbing pain. Scorpio, centipede, lumbricus and other insect drugs go deep into meridians and collaterals to dispel wind and dredge collaterals and strongly relieve Mangnolia officinalis and trifoliate orange have the effects of promoting qi circulation, reducing phlegm and smoothing qi to promote drug efficacy; radix astragali, glossy privet fruit and sliced cornu cervi tonify qi, nourish yin, warm, dredge and repair, and strengthen healthy qi to promote regeneration of nervous tissues; herba schizonepetae and mint dispel wind and permeate superficies, and guide the medicine to directly reach According to the formula, the neuralgia with various properties can be quickly relieved, inflammation can be radically eliminated, circulation can be improved, and nerves can be repaired.

The invention provides a flexible photoelectric dual-mode nerve probe and a preparation method thereof, the flexible photoelectric dual-mode nerve probe is a photoelectric integrated dual-mode probe obtained by combining polymer optical waveguide preparation and flexible nerve electrode preparation based on an MEMS (Micro Electro Mechanical System) process, and the flexible photoelectric dual-mode nerve probe comprises a flexible circuit, a flexible waveguide and the like. The flexible waveguide is utilized to introduce optical signals, specific types of neurons in an implantation area can be stimulated, then electrophysiological signals are detected through the flexible circuit, specific optical stimulation and electrophysiological recording with high time-space precision are achieved, and a novel nerve closed-loop regulation tool is provided and can be used for understanding and controlling a nervous system. The flexible photoelectric dual-mode nerve probe has the advantages of small size and high flexibility, and can be compatible with a nervous tissue system for a long time, so that long-term nerve closed-loop regulation is realized. Meanwhile, customization and batch production can be achieved, and the method has the advantages of being high in flexibility and low in cost.

The invention particularly discloses a preparation method and application of high-purity neural stem cells. The method comprises the following steps: firstly, acquiring haploid neural stem cells, injecting the haploid neural stem cells into blastocysts, and culturing to form chimera embryos; separating nervous tissues from the embryos and dissociating the nervous tissues into mixed cell populations; finally, the target cells are efficiently enriched through a magnetic separation technology by utilizing the functionalized magnetic nanoparticles with the surfaces modified with the neural stem cell specific antibodies. According to the method, the genetic homogeneity advantage of a haploid technology, the in-vivo bionic development environment of chimera embryos and the label-free and high-precision purification capacity of magnetic separation are creatively fused, and the key technical bottlenecks of low purity, high heterogeneity and complex genetic background in traditional neural stem cell preparation are solved. The invention also provides the high-purity neural stem cell population prepared by the method, the special functionalized magnetic nanoparticles and application of the functionalized magnetic nanoparticles. The obtained cell population is high in purity and stable in function, and has important application value in the fields of disease modeling, drug screening, cell therapy and the like.

Disclosed herein are systems and methods for nerve conduction block. The systems and methods can utilize at least one renewable electrode. The methods can include delivering a first direct current with a first polarity to an electrode proximate nervous tissue sufficient to block conduction in the nervous tissue. Delivering the first direct current can place the nervous tissue in a hypersuppressed state at least partially preventing conduction of the nervous tissue after cessation of delivering of the first direct current. The nervous tissue can be maintained in the hypersuppressed state for a desired period, such as at least about 1 minute.

A method for treatment of incontinence by targeted nerve stimulation where a signal generator is provided to generate a stimulation signal to modulate a patient's voiding disorder having the symptoms of abnormal urgency, incontinence or retention. A stimulator targets a portion of the patient's nervous tissue where the nervous tissue may be the patient's saphenous nerve, the patient's lateral plantar nerve or the patient's medial plantar nerve. The stimulation signal is applied to the patient's nervous tissue to activate the nervous tissue in order to modulate the voiding disorder.

The present invention relates to a neural tissue unit comprising dopaminergic neurons and neural progenitor cells, said unit being organized in three dimensions (3D) and having a largest dimension less than 600 µm. The invention also relates to its use as a drug, particularly in the prevention and / or treatment of neurodegenerative diseases by implanting said unit alone or encapsulated in a cellular microcompartment in the nervous system of a mammal, especially a human.

The invention discloses a polydopamine modified cerium oxide composite temperature-sensitive hydrogel as well as a preparation method and application thereof. The composite hydrogel is composed of a chitosan / sodium beta-glycerophosphate temperature-sensitive hydrogel matrix and polydopamine modified cerium oxide nanoparticles uniformly dispersed in the matrix. The preparation method of the composite hydrogel comprises the following steps: polymerizing on the surfaces of the cerium oxide nanoparticles under a weak alkaline condition to form a polydopamine coating layer; and then mixing with a chitosan solution and beta-sodium glycerophosphate at a low temperature. The material disclosed by the invention is in an injectable liquid state at low temperature, can be quickly converted into solid gel with relatively strong adhesion performance under body temperature and near-infrared light irradiation, and is firmly adhered to wet nervous tissues, so that suture-free fixation is realized, and the clinical operation difficulty can be remarkably simplified. The photothermal effect of polydopamine is utilized to promote the local metabolism and repair process, regeneration of peripheral nerves can be effectively promoted, formation of traumatic neuroma after amputation is remarkably inhibited, and the method has good application prospects in the field of nerve repair.

Described herein are robotically coordinated systems and methods for safe and efficient spinal decompression and bone milling. In various embodiments, a robotic spinal surgery system is provided with at least three robotic arms co-located on a single mobile base wherein the movement of the robotic arms is coordinated by a central control unit on the base. The system further comprises tools for spinal decompression, elements for protection of nervous tissue and navigation cameras. The nerve protection elements are placed between bony anatomy structures and nervous structures to prevent contact of the spinal decompression tools with the nervous structures. The nerve protection elements further include safety components that can optionally close electrical circuits with the decompression tools and sense or stimulate the nervous structures. Methods of deploying the inventive system in surgery are also provided.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.