91 results about "Nervous tissue" patented technology

The invention provides a full hydrogel neural electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEAs layer, a PSFD hydrogel layer and an MHD layer. The invention further provides a preparation method and application of the full-hydrogel neural electrode. According to the invention, a PEDOT: PSS hydrogel conductive path with ultrahigh conductivity is provided, so that the recording capability of the PEDOT: PSS hydrogel conductive path is achieved compared with that of a metal electrode; according to the full-hydrogel neural electrode disclosed by the invention, due to tight interlayer combination, excellent interface compliance is ensured by introducing dopamine into each layer of the full-hydrogel neural electrode, so that the full-hydrogel neural electrode can be attached to a complex geometrical shape of a soft nervous tissue, and interface mismatching among a conductive layer, a packaging layer, a shielding layer and a tissue-electrode interface is avoided; the natural polymer packaging layer improves the compatibility, and the electromagnetic shielding layer is used for improving the signal-to-noise ratio. The full-hydrogel neural electrode can provide artificial electrical stimulation for the cerebral cortex of a rat during epileptic seizure, and the prepared full-hydrogel neural electrode has the potential to become a valuable tool for better understanding the development and functions of brain diseases and neurodegenerative diseases and treating the neurodegenerative diseases.

According to the displacement modulation and optical assistance-based SERF atom magnetometer magnetic imaging method, an SERF atom magnetometer integrated with a magnetic flux guider is used as a magnetic sensor, and low-frequency magnetic field modulation is introduced to the magnetic sensor by controlling a to-be-tested sample to perform periodic infinitesimal displacement in the sensitive direction of the magnetic sensor; the modulation signal is demodulated by combining a phase-locked amplification technology, and a magnetic response signal subjected to phase-locked demodulation at each spatial position is extracted; constructing a magnetic response matrix through two-dimensional track scanning of micron-order step pitch; an image acquisition module and a reflection optical assembly are introduced for spatial registration so as to monitor the relative position in real time, and the visibility and controllability of the magnetic imaging process are guaranteed; the point-by-point detection of fT-level weak magnetic signals can be realized on the premise that an array structure is not needed; the low-frequency noise interference can be effectively inhibited, the stability and definition of direct-current and low-frequency magnetic field imaging are improved, and the method is suitable for high-resolution space imaging application of weak magnetic sources such as magnetic domain structures, nervous tissue slices and ancient rock samples.

The invention relates to the field of neuroscience experiments, and discloses a method for accurately adjusting the precision of targeted light and calibrating neuron sampling images, which comprises the following steps of: 1, acquiring image data containing neuron activity information; step 2, preprocessing the image data to remove artifact noise; step 3, modeling the deformation of the nervous tissue based on the image data; step 4, regulating and controlling optical system parameters for targeted light stimulation according to a deformation modeling result; and 5, closed-loop updating is performed on the modeling result and the regulation and control parameters based on feedback image data, the image data in the step 1 comprises a calcium imaging image and a targeted light feedback image which are synchronously acquired, the calcium imaging image is used for reflecting neuron activity, and the targeted light feedback image is used for calibrating a light spot position. By adopting an accurate calcium imaging technology and a targeted light feedback image synchronous acquisition scheme, real-time synchronization of neuron activity and light spot position is realized.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

The invention discloses a neurosurgery clinical operation data analysis system and a neurosurgery clinical operation data analysis method, and belongs to the field of electronic digital data processing. According to the obtained operation recovery effect evaluation result, recovery abnormity early warning is carried out, the nervous tissue recovery effect in the hand postoperative recovery process is accurately analyzed through the nervous tissue recovery image, and meanwhile the operation position neural control recovery effect is comprehensively analyzed through the difference of limb training positions. And then the nerve tissue recovery effect and the nerve control recovery effect are synthesized to accurately evaluate the operation recovery effect, so that the evaluation efficiency and accuracy of the operation recovery effect are improved.

The invention relates to spatial information compression and delivery, and belongs to the field of information delivery. The invention provides a device for delivering event information to a nervous system after spatial compression and a method for fine regulation and control of large-scale neurons. The device comprises an imaging system for respectively coding event information into a plurality of patterns, and a plurality of optic nervous systems for regulating and controlling the activity of a single neuron in a nervous system by using a minimum information unit coded in the patterns, and the pattern projection system is used for respectively projecting the plurality of patterns coded by the imaging system to each optic nerve system. According to the device and the method, the problems that an existing neural electrode is low in information transmission efficiency, immunological rejection exists between the neural electrode and a nervous system, and nervous tissues are mechanically damaged are solved, fine regulation and control of all neurons in a large-scale neuron cluster are achieved, and high-bandwidth input of multi-dimensional event information to a whole brain area of the nervous system is achieved.

The invention relates to the technical field of surgical aspirators, and discloses a neurosurgical aspirator which comprises an aspiration body and further comprises a shell, the aspiration body is arranged in the shell, a positioning assembly is arranged between the aspiration body and the shell, a plurality of sliding grooves are formed in the shell in a penetrating mode, and the positioning assembly comprises a positioning ring, a locking ring, a connecting ring and a plurality of connecting rods. The connecting rods are arranged in the sliding grooves respectively, the locking ring is in threaded connection with the outer wall of the shell, the positioning ring is arranged at the ends, close to the locking ring, of the connecting rods, the connecting ring is arranged at the ends, away from the locking ring, of the connecting rods, and the attraction body is located in the connecting ring. By forming the sliding groove in the shell, the connecting rod is slidably installed in the sliding groove, the position of the connecting rod in the sliding groove is adjusted through the connecting ring, then the length of the positioning ring and the length of the suction body are controlled, a doctor can suck wounds with different depths conveniently, and meanwhile the positioning ring is matched to prevent the suction body from making direct contact with nervous tissue; and secondary injury in the operation process is prevented.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

Provided are a polylactic acid and a use of a copolymer thereof in the preparation of a drug for promoting nerve growth and repair. The molecular weight of the polylactic acid and the copolymer thereof is 400-300 k Da. The drug has the following effects: 1) promoting the growth of nerve cells and nervous tissue; 2) promoting repair of nerve cells and nervous tissue; and 3) treating or preventing a peripheral nerve injury, a spinal cord injury, peripheral neuropathy, and neuritis. The molecular weight is preferably 5000-100 k Da. It is found for the first time that the polylactic acid and the copolymer thereof have a protective effect on nerves, and can promote nerve growth and a nerve injury repair.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

The invention provides an application of polylactic acid and a copolymer thereof in preparation of a medicine for promoting nerve growth and repairing, the molecular weight of the polylactic acid and the copolymer thereof is 400-300k Da, and the medicine has the following effects: 1) promoting growth of nerve cells and nerve tissues; 2) promoting the repair of nerve cells and nerve tissues; 3) treating or preventing peripheral nerve injury, spinal cord injury, peripheral neuropathy and neuritis; preferably, the molecular weight is in the range of 5000 to 100 k Da. The invention discovers that polylactic acid and the copolymer thereof have a protection effect on nerves for the first time, and can promote growth of the nerves and repair of nerve injury.

The present disclosure provides a method of producing a non-human mammalian animal model comprising human neural tissue, the method comprising introducing a first human neural organoid into a central nervous system location of a newborn non-human mammal; and allowing the newborn non-human mammal to mature to produce the non-human mammalian animal model comprising human neural tissue. The present disclosure provides a method of modeling a neuropsychiatric disorder. The present disclosure also provides a method of determining the effectiveness of a candidate agent on a neuropsychiatric disorder. The present disclosure provides a method for altering the behavior of a mammal. Also provided are non-human mammalian animal models comprising human neural tissue.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The utility model belongs to the field of neurosurgery, and provides an air bag spreader for neurosurgery, which comprises a puncture mechanism and a spreading mechanism arranged on the puncture mechanism, the double-layer air bag is inflated to be completely expanded and unfolded, so that an operation channel with the diameter of 10 mm is formed for medical staff to conduct treatment or examination work, brain tissue is flexibly expanded through the double-layer air bag, damage is small, more nerve tissue is protected especially in some nerve nucleuses with many nucleuses or in the middle of white matter fibers, and the brain tissue is protected. And meanwhile, the double-layer air bag is transparent and visible and is provided with scales, so that the condition of deep tissues can be known, and convenience is brought to personnel to use.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to a three-dimensional electric signal acquisition and stimulation neural electrode device, which comprises a tissue culture component, a plane patch type electrode assembly, an invasive electrode assembly and an artificial intelligence (AI) control system, and is characterized in that the tissue culture component is used for culturing nervous tissues or organoids and supporting electrodes to measure and stimulate electric signals; the plane patch type electrode assembly carries out local field potential collection and surface electrical stimulation, and the intrusive electrode assembly is inserted into nervous tissue or an organ-like body to carry out collection and stimulation of deep three-dimensional action electric signals. And the artificial intelligence (AI) control system is used for receiving pose information of the plane patch type electrode assembly and the intrusive type electrode assembly and the collected electric signals in real time, analyzing and judging the pose information and the collected electric signals, and then feeding back and regulating the position postures of the plane patch type electrode assembly and the intrusive type electrode assembly. The device provided by the invention realizes long-term comprehensive acquisition and recording of tissue electric signals in a three-dimensional space through the composite neural electrode device and artificial intelligence feedback control of the poses of the electrodes.

The present invention relates to a system and method for selectively and reversibly modulating targeted nervous or non-nervous tissue of a nervous system for the treatment of pain. Electrical stimulation is delivered to the treatment site which selectively and reversibly modulates the targeted nervous or non-nervous tissue of the nervous structure, inhibiting pain while preserving other motor and motor functions and proprioception.

An artificial neural network based platform uses a validated multilayer convolutional network for neurological analysis configured for segmenting data sets of neurological scans of a specific given patient. The validated multilayer convolutional network of the platform includes classification of neurological tissue within classification voxels of at least one patient data set by the validated multilayer convolutional network for neurological analysis with each classification voxel of the at least one patient data set assigned a label, wherein the implementing the validated multilayer convolutional network includes at least one of i) mapping neurologic tissue or ii) mapping of a neurological tumor of a patient.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to methods and compositions for preventing or treating a neuropathology in a subject associated with or induced or caused by a P. gingivalis infection, preventing the deposition of or reducing the level of P. gingivalis gingipain in neuronal tissue, delaying the onset of a P. gingivalis-induced or associated neuropathology, for preventing or slowing the rate of abnormal protein deposition in the neuronal tissue, and / or reducing neuroinflammation, the methods comprising administering an RNA polynucleotide encoding a protein comprising or consisting of: - one or more amino acid sequences of an active site of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto; and / or - the amino acid sequence of one or more adhesin binding motifs (ABMs) of an adhesin domain of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto, wherein the polynucleotide is capable of being translated in a mammalian cell.

The invention relates to the technical field of traditional Chinese medicines, relates to new application of a traditional Chinese medicine composition, and in particular relates to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating migraine. The traditional Chinese medicine composition is prepared from cassia twig, white peony root, honey-fried licorice root, ginger, jujube, ginseng, Chinese angelica, salted morinda officinalis and dwarf lilyturf tuber. The traditional Chinese medicine composition provided by the invention can obviously reduce serum NO and trigeminal nervous tissue SP content of migraine rats, increase trigeminal nervous tissue DA content, obviously improve head and face pain threshold and brain tissue DA content of the migraine rats and reduce brain tissue PGE2 content, and has a good treatment effect on migraine.

Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and / or a renal branch artery proximate a renal parenchyma.

A radiosurgical method for treating cardiorenal disease of a patient, the method including directing radiosurgery radiation from outside the patient towards one or more target treatment regions encompassing sympathetic ganglia of the patient so as to inhibit the cardiorenal disease. In an exemplary embodiment, the method further includes acquiring three dimensional planning image data encompassing the first and second renal arteries, planning an ionizing radiation treatment of first and second target regions using the three dimensional planning image data so as to mitigate the hypertension, the first and second target regions encompassing neural tissue of or proximate to the first and second renal arteries, respectively, and remodeling the target regions by directing the planned radiation from outside the body toward the target regions.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention provides a force feedback instruction output method in neurosurgical operation simulation, which comprises the following steps: S1, initializing force feedback equipment, creating a high-frequency service circulation thread and respectively configuring independent control channels of left and right hand surgical instruments; s2, collecting encoder data, joint angles and surgical instrument tail end pose information of the force feedback equipment in real time; s3, analyzing the data flow of the encoder data, and extracting a clamping angle state signal of the surgical instrument, a suction force state signal of an aspirator and an instrument replacement control signal; s4, dynamically calculating an interaction force between the nervous tissue and the surgical instrument based on the biomechanical model, and generating a six-degree-of-freedom force feedback instruction; s5, sending the feedback instruction to force feedback equipment, and updating the state of the instrument model in the three-dimensional operation scene; and S6, monitoring the running state of the force feedback equipment, and closing feedback output and releasing resources when the force feedback equipment is abnormal or the operation is terminated. The tactile feedback core pain point in neurosurgery simulation is solved.

A method of activating a piezoelectric neuroconduit guide scaffold including a plurality of aligned piezoelectric polymer nanofibers, the method including mechanically stimulating the piezoelectric neuroconduit guide scaffold with hydro-acoustic waves or shockwaves to remotely activate a piezoelectric effect of the nanofibrous scaffolds that induces a mechano-electrical stimulus on neural cells cultured on the scaffold, wherein the mechano-electrical stimulus promotes nerve fiber outgrowth from the neuronal cells. Some aspects relate to seeding individual components of neural tissues on the piezoelectric neuroconduit guide scaffold, wherein the hydro-acoustic stimulation induces neural tissue formation. In other aspects, the piezoelectric neuroconduit guide scaffold is implanted in a damaged neural tissue, wherein stimulating the piezoelectric neuroconduit guide scaffold by the application of shockwaves promotes nerve fiber outgrowth that bridges a nerve gap to induce nerve regeneration or reinnervation of the damaged neural tissue.

The present invention relates to the field of neuroscience, and proposes a method and system for realizing the cause identification of ischemic stroke based on neuroimaging, wherein the method comprises: obtaining a patient's brain nerve image, including CT and MRI scan images, diagnosing and analyzing the stroke patient, extracting the vascular load value by identifying the vascular tissue and the high-density sign of the cerebral artery in the CT scan image, identifying the thrombus pore through the MRI scan image, extracting the thrombus morphological characteristics, calculating the thrombus shape coefficient, combining the vascular load value and the thrombus shape coefficient, determining the abnormal area in the brain nerve image, identifying the ischemic area, and detecting the damaged nerve tissue, and finally, using the cause identification network to classify the lesions of the damaged nerve tissue, correlating the cause of stroke with the clinical index, and generating a cause report. The present invention can improve the accuracy of the cause identification of ischemic stroke.

The invention relates to the technical field of medical instruments, in particular to a hemiplegic upper limb multifunctional corrector which comprises a wrist component, an elbow component and a shoulder component. The wearable structure is adopted, the wrist, the elbow and the shoulder of a patient are covered at the same time, and integral fixing correction and targeted treatment can be conducted on the upper limb of the affected side at the same time. The treatment assembly is arranged and can massage and release muscles by integrating air pressure massage, thermal stimulation and electrical stimulation, so that the effect of relieving muscular tension is achieved. Wherein the electrical stimulation assembly can release medium-frequency electrical stimulation signals or low-frequency electrical stimulation signals, medium-frequency electrical stimulation has the effects of activating blood, relieving swelling and pain, and low-frequency electrical stimulation can promote recovery of nervous tissue functions at corresponding positions. Therefore, nerves and muscles of a patient are treated in all directions, muscular tension of the patient is reduced, and the problem of muscle tension of the patient is avoided.

Device for the preventive blocking of neurotropic viruses in the peripheral nervous system, comprising a biochemical injection system for the localized release of a neurospecific binding molecule, a detection unit for the identification of viral particles in neuromuscular tissue, and a receptor bait structure for binding viral glycoproteins with affinity for neuronal receptors, characterized in that the device prevents retrograde axonal viral transmission without permanently impairing the conductivity of the nerve tissue.