66 results about "Nervous tissue" patented technology

According to the displacement modulation and optical assistance-based SERF atom magnetometer magnetic imaging method, an SERF atom magnetometer integrated with a magnetic flux guider is used as a magnetic sensor, and low-frequency magnetic field modulation is introduced to the magnetic sensor by controlling a to-be-tested sample to perform periodic infinitesimal displacement in the sensitive direction of the magnetic sensor; the modulation signal is demodulated by combining a phase-locked amplification technology, and a magnetic response signal subjected to phase-locked demodulation at each spatial position is extracted; constructing a magnetic response matrix through two-dimensional track scanning of micron-order step pitch; an image acquisition module and a reflection optical assembly are introduced for spatial registration so as to monitor the relative position in real time, and the visibility and controllability of the magnetic imaging process are guaranteed; the point-by-point detection of fT-level weak magnetic signals can be realized on the premise that an array structure is not needed; the low-frequency noise interference can be effectively inhibited, the stability and definition of direct-current and low-frequency magnetic field imaging are improved, and the method is suitable for high-resolution space imaging application of weak magnetic sources such as magnetic domain structures, nervous tissue slices and ancient rock samples.

The invention relates to the field of neuroscience experiments, and discloses a method for accurately adjusting the precision of targeted light and calibrating neuron sampling images, which comprises the following steps of: 1, acquiring image data containing neuron activity information; step 2, preprocessing the image data to remove artifact noise; step 3, modeling the deformation of the nervous tissue based on the image data; step 4, regulating and controlling optical system parameters for targeted light stimulation according to a deformation modeling result; and 5, closed-loop updating is performed on the modeling result and the regulation and control parameters based on feedback image data, the image data in the step 1 comprises a calcium imaging image and a targeted light feedback image which are synchronously acquired, the calcium imaging image is used for reflecting neuron activity, and the targeted light feedback image is used for calibrating a light spot position. By adopting an accurate calcium imaging technology and a targeted light feedback image synchronous acquisition scheme, real-time synchronization of neuron activity and light spot position is realized.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

The present disclosure provides a method of producing a non-human mammalian animal model comprising human neural tissue, the method comprising introducing a first human neural organoid into a central nervous system location of a newborn non-human mammal; and allowing the newborn non-human mammal to mature to produce the non-human mammalian animal model comprising human neural tissue. The present disclosure provides a method of modeling a neuropsychiatric disorder. The present disclosure also provides a method of determining the effectiveness of a candidate agent on a neuropsychiatric disorder. The present disclosure provides a method for altering the behavior of a mammal. Also provided are non-human mammalian animal models comprising human neural tissue.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to a three-dimensional electric signal acquisition and stimulation neural electrode device, which comprises a tissue culture component, a plane patch type electrode assembly, an invasive electrode assembly and an artificial intelligence (AI) control system, and is characterized in that the tissue culture component is used for culturing nervous tissues or organoids and supporting electrodes to measure and stimulate electric signals; the plane patch type electrode assembly carries out local field potential collection and surface electrical stimulation, and the intrusive electrode assembly is inserted into nervous tissue or an organ-like body to carry out collection and stimulation of deep three-dimensional action electric signals. And the artificial intelligence (AI) control system is used for receiving pose information of the plane patch type electrode assembly and the intrusive type electrode assembly and the collected electric signals in real time, analyzing and judging the pose information and the collected electric signals, and then feeding back and regulating the position postures of the plane patch type electrode assembly and the intrusive type electrode assembly. The device provided by the invention realizes long-term comprehensive acquisition and recording of tissue electric signals in a three-dimensional space through the composite neural electrode device and artificial intelligence feedback control of the poses of the electrodes.

The present invention relates to a system and method for selectively and reversibly modulating targeted nervous or non-nervous tissue of a nervous system for the treatment of pain. Electrical stimulation is delivered to the treatment site which selectively and reversibly modulates the targeted nervous or non-nervous tissue of the nervous structure, inhibiting pain while preserving other motor and motor functions and proprioception.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to methods and compositions for preventing or treating a neuropathology in a subject associated with or induced or caused by a P. gingivalis infection, preventing the deposition of or reducing the level of P. gingivalis gingipain in neuronal tissue, delaying the onset of a P. gingivalis-induced or associated neuropathology, for preventing or slowing the rate of abnormal protein deposition in the neuronal tissue, and / or reducing neuroinflammation, the methods comprising administering an RNA polynucleotide encoding a protein comprising or consisting of: - one or more amino acid sequences of an active site of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto; and / or - the amino acid sequence of one or more adhesin binding motifs (ABMs) of an adhesin domain of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto, wherein the polynucleotide is capable of being translated in a mammalian cell.

The invention relates to the technical field of traditional Chinese medicines, relates to new application of a traditional Chinese medicine composition, and in particular relates to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating migraine. The traditional Chinese medicine composition is prepared from cassia twig, white peony root, honey-fried licorice root, ginger, jujube, ginseng, Chinese angelica, salted morinda officinalis and dwarf lilyturf tuber. The traditional Chinese medicine composition provided by the invention can obviously reduce serum NO and trigeminal nervous tissue SP content of migraine rats, increase trigeminal nervous tissue DA content, obviously improve head and face pain threshold and brain tissue DA content of the migraine rats and reduce brain tissue PGE2 content, and has a good treatment effect on migraine.

Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and / or a renal branch artery proximate a renal parenchyma.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention provides a force feedback instruction output method in neurosurgical operation simulation, which comprises the following steps: S1, initializing force feedback equipment, creating a high-frequency service circulation thread and respectively configuring independent control channels of left and right hand surgical instruments; s2, collecting encoder data, joint angles and surgical instrument tail end pose information of the force feedback equipment in real time; s3, analyzing the data flow of the encoder data, and extracting a clamping angle state signal of the surgical instrument, a suction force state signal of an aspirator and an instrument replacement control signal; s4, dynamically calculating an interaction force between the nervous tissue and the surgical instrument based on the biomechanical model, and generating a six-degree-of-freedom force feedback instruction; s5, sending the feedback instruction to force feedback equipment, and updating the state of the instrument model in the three-dimensional operation scene; and S6, monitoring the running state of the force feedback equipment, and closing feedback output and releasing resources when the force feedback equipment is abnormal or the operation is terminated. The tactile feedback core pain point in neurosurgery simulation is solved.

A method of activating a piezoelectric neuroconduit guide scaffold including a plurality of aligned piezoelectric polymer nanofibers, the method including mechanically stimulating the piezoelectric neuroconduit guide scaffold with hydro-acoustic waves or shockwaves to remotely activate a piezoelectric effect of the nanofibrous scaffolds that induces a mechano-electrical stimulus on neural cells cultured on the scaffold, wherein the mechano-electrical stimulus promotes nerve fiber outgrowth from the neuronal cells. Some aspects relate to seeding individual components of neural tissues on the piezoelectric neuroconduit guide scaffold, wherein the hydro-acoustic stimulation induces neural tissue formation. In other aspects, the piezoelectric neuroconduit guide scaffold is implanted in a damaged neural tissue, wherein stimulating the piezoelectric neuroconduit guide scaffold by the application of shockwaves promotes nerve fiber outgrowth that bridges a nerve gap to induce nerve regeneration or reinnervation of the damaged neural tissue.

The present invention relates to the field of neuroscience, and proposes a method and system for realizing the cause identification of ischemic stroke based on neuroimaging, wherein the method comprises: obtaining a patient's brain nerve image, including CT and MRI scan images, diagnosing and analyzing the stroke patient, extracting the vascular load value by identifying the vascular tissue and the high-density sign of the cerebral artery in the CT scan image, identifying the thrombus pore through the MRI scan image, extracting the thrombus morphological characteristics, calculating the thrombus shape coefficient, combining the vascular load value and the thrombus shape coefficient, determining the abnormal area in the brain nerve image, identifying the ischemic area, and detecting the damaged nerve tissue, and finally, using the cause identification network to classify the lesions of the damaged nerve tissue, correlating the cause of stroke with the clinical index, and generating a cause report. The present invention can improve the accuracy of the cause identification of ischemic stroke.

Device for the preventive blocking of neurotropic viruses in the peripheral nervous system, comprising a biochemical injection system for the localized release of a neurospecific binding molecule, a detection unit for the identification of viral particles in neuromuscular tissue, and a receptor bait structure for binding viral glycoproteins with affinity for neuronal receptors, characterized in that the device prevents retrograde axonal viral transmission without permanently impairing the conductivity of the nerve tissue.

The application belongs to the technical field of medical imaging, and particularly discloses a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. A plurality of tomographic images of a to-be-measured part are collected by an ultrasonic tomography system; a YOLO target detection network is used to locate a nerve tissue of each tomographic image; then a U-Net segmentation network is used for pixel-level segmentation to obtain a pixel-level probability map of the nerve tissue; an uncertainty of a pixel in the pixel-level probability map is modeled by using a membership modeling mechanism to adaptively weight a membership degree of the nerve tissue, so that an accurate segmentation result is obtained; the accurate segmentation result is taken as an observation of Kalman filtering, prediction and updating are performed based on the Kalman filtering, and an optimal state estimation of the nerve tissue is obtained; and a three-dimensional model of the peripheral nerve tissue is reconstructed by using the optimal state estimation of each tomographic image. The application can significantly improve the segmentation accuracy and structural integrity of the nerve tissue.

The invention belongs to the technical field of medical imaging, and particularly relates to a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. Acquiring a plurality of frames of tomographic images of the to-be-detected part through an ultrasonic tomography system; using a YOLO target detection network to position the nervous tissue of each frame of cross-sectional image; performing pixel-level segmentation by adopting a U-Net segmentation network to obtain a pixel-level probability graph of the nervous tissue; modeling the uncertainty of pixels in the pixel-level probability graph by adopting a membership modeling mechanism so as to perform adaptive weighting on the membership degree of the nervous tissue to obtain an accurate segmentation result; taking the accurate segmentation result as the observed quantity of Kalman filtering, and performing prediction and updating based on Kalman filtering to obtain the optimal state estimation of the nervous tissue; and reconstructing the optimal state estimation of each frame of cross-sectional image to obtain a three-dimensional model of the peripheral nervous tissue. According to the method, the segmentation precision and the structural integrity of the nervous tissue can be remarkably improved.

The disclosure relates, in some aspects, to modified adeno-associated virus (AAV) capsid proteins and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding modified AAV9 capsid proteins. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue or peripheral nervous tissue of a subject.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

The invention provides a disposable capillary dilation end-to-end anastomat. The disposable capillary dilation end-to-end anastomat comprises a limiting sliding rod; the two sliding seats are arranged along the limiting sliding rod in a sliding manner; the two sets of grabbing and expanding assemblies are symmetrically arranged on the sliding seat, each set of grabbing and expanding assembly comprises a connecting rod A and a connecting rod B which are arranged in the sliding seat in a penetrating mode, the same end of the connecting rod A and the same end of the connecting rod B are provided with a grabbing and expanding end A and a grabbing and expanding end B respectively, and the connecting rod A and the connecting rod B are perpendicular to the length direction of the limiting sliding rod; the driving assembly is used for driving the connecting rod A and the connecting rod B to move so that the grabbing expansion end A and the grabbing expansion end B can get close to or get away from each other. The problem that in the microvessel and nervous tissue anastomosis process, the continuous actions of capturing, aligning, expanding, approaching and rotation preventing of the stump are difficult is effectively solved, the blood vessel stump is more stable and more convenient to capture, the stump is more uniform in stress, the blood vessel stump is expanded to be in a horn shape, the suturing efficiency is effectively improved, the suturing difficulty is reduced, and the suturing time is shortened.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The present invention relates to the field of medical tissue wrappers for internal anatomy and uses and methods of using the medical tissue wrappers to treat nerve injury. In particular, the present invention relates to a medical tissue wrap for nervous tissue to support repair of peripheral nerve injury by promoting secure application of the medical tissue wrap. Thus, a medical tissue wrap (10) for a mammalian internal anatomy is proposed wherein the medical tissue wrap (10) is formed by a curled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thus defines a longitudinal through-hole (16) for receiving a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced from the circumferential inner end portion (20) by a discontinuous pitch in the circumferential direction. According to other aspects, a medical tissue wrap includes structural outer surface modifications at opposite longitudinal end portions of a wall thereof.

Methods and systems for analyzing and selecting therapy configurations for use in stimulating nervous tissue. A probabilistic shell related to the likelihood that electrical stimulation emanating to a given volume of nervous tissue will cause a therapeutic outcome is incorporated in a system for analyzing anatomical and other data, including lead location relative to the neuroanatomy. Metrics for analyzing therapy configurations may then be calculated and the process of identifying therapy configurations that may be beneficial may be enhanced.

The invention provides a Janus membrane with tissue adhesiveness, a preparation method of the Janus membrane and application of the Janus membrane to neural restoration. The Janus membrane with the tissue adhesiveness comprises an electrospun fiber layer and an oriented hydrogel fiber layer with the tissue adhesiveness. The electrospun fiber layer is used as a non-viscous isolation layer, has good mechanical properties and air permeability, and can effectively avoid adhesion and compression of surrounding tissues; the oriented hydrogel fiber layer has unique tissue adhesiveness and an oriented structure, the tissue adhesiveness characteristic of the oriented hydrogel fiber layer can ensure that the oriented hydrogel fiber layer is tightly attached to nervous tissues, and the oriented structure can guide directional regeneration of nerves, so that the nerve regeneration efficiency is remarkably improved, directional adhesion and migration of cells can be induced, axons are promoted to extend in a specific direction, and the nerve regeneration effect is improved. Therefore, the formation of neuroma is effectively prevented. The Janus membrane and a nerve broken end are bonded without tension and curled to form an exclusive catheter which is adaptive to various nerve diameters and complex branch structures.

The invention relates to the technical field of artificial intelligence, in particular to a biological robot based on a deep learning model, the robot comprises a biological tissue carrier, the carrier is composed of living cells, muscular tissues or nervous tissues; the multi-mode sensor array is used for collecting the pH value, the temperature and the mechanical pressure in the environment in real time; the embedded deep learning processor adopts a low-power-consumption neuromorphic chip; the bionic driving device is used for converting the electric signal sent by the processor into mechanical motion; by integrating innovative technologies such as vascularization 3D biological printing, dynamic micro-fluidic culture, GAN optimization interface and transfer learning adaptation, the performance and manufacturing efficiency of the biological robot are remarkably improved, the long-term survival rate of biological tissues can be improved through the graded vascular network design, the differentiation efficiency of functional tissues is improved through a dynamic micro-fluidic system, and the biological robot is suitable for being used in a large scale. The fractal interface optimized by the GAN reduces the contact impedance and improves the transmission efficiency of biological-electronic signals.