51 results about "Nervous tissue" patented technology

According to the displacement modulation and optical assistance-based SERF atom magnetometer magnetic imaging method, an SERF atom magnetometer integrated with a magnetic flux guider is used as a magnetic sensor, and low-frequency magnetic field modulation is introduced to the magnetic sensor by controlling a to-be-tested sample to perform periodic infinitesimal displacement in the sensitive direction of the magnetic sensor; the modulation signal is demodulated by combining a phase-locked amplification technology, and a magnetic response signal subjected to phase-locked demodulation at each spatial position is extracted; constructing a magnetic response matrix through two-dimensional track scanning of micron-order step pitch; an image acquisition module and a reflection optical assembly are introduced for spatial registration so as to monitor the relative position in real time, and the visibility and controllability of the magnetic imaging process are guaranteed; the point-by-point detection of fT-level weak magnetic signals can be realized on the premise that an array structure is not needed; the low-frequency noise interference can be effectively inhibited, the stability and definition of direct-current and low-frequency magnetic field imaging are improved, and the method is suitable for high-resolution space imaging application of weak magnetic sources such as magnetic domain structures, nervous tissue slices and ancient rock samples.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The invention relates to the technical field of intraoperative intelligent monitoring, and particularly discloses a spinal canal debonding method and system for real-time state evaluation, and the method comprises the steps: collecting neural structure microcirculation blood flow data in real time through integrating a micro-sensing unit at a working end part of a surgical instrument, and extracting blood flow oscillation frequency and capillary hematocrit parameters; performing multi-scale signal decomposition on the blood flow oscillation frequency to obtain an energy distribution parameter, and performing dynamic mode recognition on the hematocrit data to obtain a main variation characteristic value; fusing the two characteristic parameters to generate a nervous tissue vitality index; inputting the index into a pre-trained neural network for time sequence feature analysis, and outputting a graded ischemia risk early warning signal; the operation rhythm is automatically adjusted through a decision tree control mechanism based on the early warning signal, and self-adaptive regulation and control according to the state of the nervous tissue are achieved; the technical problem that the risk of neural ischemia cannot be monitored in real time in a traditional spinal canal release operation is solved, and occult nerve injury caused by asymptomatic neural ischemia can be prevented.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

The present disclosure provides a method of producing a non-human mammalian animal model comprising human neural tissue, the method comprising introducing a first human neural organoid into a central nervous system location of a newborn non-human mammal; and allowing the newborn non-human mammal to mature to produce the non-human mammalian animal model comprising human neural tissue. The present disclosure provides a method of modeling a neuropsychiatric disorder. The present disclosure also provides a method of determining the effectiveness of a candidate agent on a neuropsychiatric disorder. The present disclosure provides a method for altering the behavior of a mammal. Also provided are non-human mammalian animal models comprising human neural tissue.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention relates to methods and compositions for preventing or treating a neuropathology in a subject associated with or induced or caused by a P. gingivalis infection, preventing the deposition of or reducing the level of P. gingivalis gingipain in neuronal tissue, delaying the onset of a P. gingivalis-induced or associated neuropathology, for preventing or slowing the rate of abnormal protein deposition in the neuronal tissue, and / or reducing neuroinflammation, the methods comprising administering an RNA polynucleotide encoding a protein comprising or consisting of: - one or more amino acid sequences of an active site of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto; and / or - the amino acid sequence of one or more adhesin binding motifs (ABMs) of an adhesin domain of an Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto, wherein the polynucleotide is capable of being translated in a mammalian cell.

The invention relates to the technical field of traditional Chinese medicines, relates to new application of a traditional Chinese medicine composition, and in particular relates to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating migraine. The traditional Chinese medicine composition is prepared from cassia twig, white peony root, honey-fried licorice root, ginger, jujube, ginseng, Chinese angelica, salted morinda officinalis and dwarf lilyturf tuber. The traditional Chinese medicine composition provided by the invention can obviously reduce serum NO and trigeminal nervous tissue SP content of migraine rats, increase trigeminal nervous tissue DA content, obviously improve head and face pain threshold and brain tissue DA content of the migraine rats and reduce brain tissue PGE2 content, and has a good treatment effect on migraine.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention provides a force feedback instruction output method in neurosurgical operation simulation, which comprises the following steps: S1, initializing force feedback equipment, creating a high-frequency service circulation thread and respectively configuring independent control channels of left and right hand surgical instruments; s2, collecting encoder data, joint angles and surgical instrument tail end pose information of the force feedback equipment in real time; s3, analyzing the data flow of the encoder data, and extracting a clamping angle state signal of the surgical instrument, a suction force state signal of an aspirator and an instrument replacement control signal; s4, dynamically calculating an interaction force between the nervous tissue and the surgical instrument based on the biomechanical model, and generating a six-degree-of-freedom force feedback instruction; s5, sending the feedback instruction to force feedback equipment, and updating the state of the instrument model in the three-dimensional operation scene; and S6, monitoring the running state of the force feedback equipment, and closing feedback output and releasing resources when the force feedback equipment is abnormal or the operation is terminated. The tactile feedback core pain point in neurosurgery simulation is solved.

A method of activating a piezoelectric neuroconduit guide scaffold including a plurality of aligned piezoelectric polymer nanofibers, the method including mechanically stimulating the piezoelectric neuroconduit guide scaffold with hydro-acoustic waves or shockwaves to remotely activate a piezoelectric effect of the nanofibrous scaffolds that induces a mechano-electrical stimulus on neural cells cultured on the scaffold, wherein the mechano-electrical stimulus promotes nerve fiber outgrowth from the neuronal cells. Some aspects relate to seeding individual components of neural tissues on the piezoelectric neuroconduit guide scaffold, wherein the hydro-acoustic stimulation induces neural tissue formation. In other aspects, the piezoelectric neuroconduit guide scaffold is implanted in a damaged neural tissue, wherein stimulating the piezoelectric neuroconduit guide scaffold by the application of shockwaves promotes nerve fiber outgrowth that bridges a nerve gap to induce nerve regeneration or reinnervation of the damaged neural tissue.

Device for the preventive blocking of neurotropic viruses in the peripheral nervous system, comprising a biochemical injection system for the localized release of a neurospecific binding molecule, a detection unit for the identification of viral particles in neuromuscular tissue, and a receptor bait structure for binding viral glycoproteins with affinity for neuronal receptors, characterized in that the device prevents retrograde axonal viral transmission without permanently impairing the conductivity of the nerve tissue.

The application belongs to the technical field of medical imaging, and particularly discloses a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. A plurality of tomographic images of a to-be-measured part are collected by an ultrasonic tomography system; a YOLO target detection network is used to locate a nerve tissue of each tomographic image; then a U-Net segmentation network is used for pixel-level segmentation to obtain a pixel-level probability map of the nerve tissue; an uncertainty of a pixel in the pixel-level probability map is modeled by using a membership modeling mechanism to adaptively weight a membership degree of the nerve tissue, so that an accurate segmentation result is obtained; the accurate segmentation result is taken as an observation of Kalman filtering, prediction and updating are performed based on the Kalman filtering, and an optimal state estimation of the nerve tissue is obtained; and a three-dimensional model of the peripheral nerve tissue is reconstructed by using the optimal state estimation of each tomographic image. The application can significantly improve the segmentation accuracy and structural integrity of the nerve tissue.

The invention belongs to the technical field of medical imaging, and particularly relates to a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. Acquiring a plurality of frames of tomographic images of the to-be-detected part through an ultrasonic tomography system; using a YOLO target detection network to position the nervous tissue of each frame of cross-sectional image; performing pixel-level segmentation by adopting a U-Net segmentation network to obtain a pixel-level probability graph of the nervous tissue; modeling the uncertainty of pixels in the pixel-level probability graph by adopting a membership modeling mechanism so as to perform adaptive weighting on the membership degree of the nervous tissue to obtain an accurate segmentation result; taking the accurate segmentation result as the observed quantity of Kalman filtering, and performing prediction and updating based on Kalman filtering to obtain the optimal state estimation of the nervous tissue; and reconstructing the optimal state estimation of each frame of cross-sectional image to obtain a three-dimensional model of the peripheral nervous tissue. According to the method, the segmentation precision and the structural integrity of the nervous tissue can be remarkably improved.

The disclosure relates, in some aspects, to modified adeno-associated virus (AAV) capsid proteins and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding modified AAV9 capsid proteins. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue or peripheral nervous tissue of a subject.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

The invention provides a disposable capillary dilation end-to-end anastomat. The disposable capillary dilation end-to-end anastomat comprises a limiting sliding rod; the two sliding seats are arranged along the limiting sliding rod in a sliding manner; the two sets of grabbing and expanding assemblies are symmetrically arranged on the sliding seat, each set of grabbing and expanding assembly comprises a connecting rod A and a connecting rod B which are arranged in the sliding seat in a penetrating mode, the same end of the connecting rod A and the same end of the connecting rod B are provided with a grabbing and expanding end A and a grabbing and expanding end B respectively, and the connecting rod A and the connecting rod B are perpendicular to the length direction of the limiting sliding rod; the driving assembly is used for driving the connecting rod A and the connecting rod B to move so that the grabbing expansion end A and the grabbing expansion end B can get close to or get away from each other. The problem that in the microvessel and nervous tissue anastomosis process, the continuous actions of capturing, aligning, expanding, approaching and rotation preventing of the stump are difficult is effectively solved, the blood vessel stump is more stable and more convenient to capture, the stump is more uniform in stress, the blood vessel stump is expanded to be in a horn shape, the suturing efficiency is effectively improved, the suturing difficulty is reduced, and the suturing time is shortened.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The present invention relates to the field of medical tissue wrappers for internal anatomy and uses and methods of using the medical tissue wrappers to treat nerve injury. In particular, the present invention relates to a medical tissue wrap for nervous tissue to support repair of peripheral nerve injury by promoting secure application of the medical tissue wrap. Thus, a medical tissue wrap (10) for a mammalian internal anatomy is proposed wherein the medical tissue wrap (10) is formed by a curled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thus defines a longitudinal through-hole (16) for receiving a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced from the circumferential inner end portion (20) by a discontinuous pitch in the circumferential direction. According to other aspects, a medical tissue wrap includes structural outer surface modifications at opposite longitudinal end portions of a wall thereof.

Methods and systems for analyzing and selecting therapy configurations for use in stimulating nervous tissue. A probabilistic shell related to the likelihood that electrical stimulation emanating to a given volume of nervous tissue will cause a therapeutic outcome is incorporated in a system for analyzing anatomical and other data, including lead location relative to the neuroanatomy. Metrics for analyzing therapy configurations may then be calculated and the process of identifying therapy configurations that may be beneficial may be enhanced.

The invention provides a Janus membrane with tissue adhesiveness, a preparation method of the Janus membrane and application of the Janus membrane to neural restoration. The Janus membrane with the tissue adhesiveness comprises an electrospun fiber layer and an oriented hydrogel fiber layer with the tissue adhesiveness. The electrospun fiber layer is used as a non-viscous isolation layer, has good mechanical properties and air permeability, and can effectively avoid adhesion and compression of surrounding tissues; the oriented hydrogel fiber layer has unique tissue adhesiveness and an oriented structure, the tissue adhesiveness characteristic of the oriented hydrogel fiber layer can ensure that the oriented hydrogel fiber layer is tightly attached to nervous tissues, and the oriented structure can guide directional regeneration of nerves, so that the nerve regeneration efficiency is remarkably improved, directional adhesion and migration of cells can be induced, axons are promoted to extend in a specific direction, and the nerve regeneration effect is improved. Therefore, the formation of neuroma is effectively prevented. The Janus membrane and a nerve broken end are bonded without tension and curled to form an exclusive catheter which is adaptive to various nerve diameters and complex branch structures.

The utility model discloses a plasma surgical electrode for treating rhinitis, which comprises an outer tube, a handle arranged at the rear end of the outer tube 1, a cable connector arranged on the handle, an inner tube with a cavity structure inside and connected in the outer tube in a matched manner, an electrode tip arranged at the front end of the inner tube, and a wire connected between the electrode tip and the cable connector, the cable joint is connected with the host, the electrode tip comprises an upper insulating head and a lower insulating head which are assembled into an integrated structure, a positive working electrode and a negative working electrode which are arranged on the upper insulating head and are connected with a lead, and a thermocouple for monitoring temperature, and the positive working electrode and the negative working electrode are respectively positioned on two sides of the upper insulating head. The structure is simple and reasonable, stable and reliable, assembly and disassembly are convenient, and the ablation treatment effect on the posterior lower nasal nervous tissue is effectively improved.

The present invention relates to the field of information delivery and relates to spatial information compression and delivery. The present invention provides a device for delivering event information to a nervous system after spatial compression and a method for fine regulation and control of large-scale neurons. The device comprises an imaging system for respectively coding event information into a plurality of patterns, a plurality of optic nervous systems for using a minimum information unit coded in the patterns to regulate and control the activity of single neurons in a nervous system, and a pattern projection system for respectively projecting the plurality of patterns coded by the imaging system to the optic nerve systems. The device and method solve the problems of low information transmission efficiency of existing neural electrodes, and foreign body response between the neural electrodes and a nervous system which causes mechanical damage to nervous tissues, achieve fine regulation and control of neurons in a large-scale neuron cluster, and achieve high-bandwidth input of multi-dimensional event information to a whole brain region of the nervous system.

A nervous tissue imaging system includes a pair of matched filters, including an excitation light filter that only passes excitation light in a first wavelength range from 365 nm to 400 nm, and a received light detection filter that only passes received light in a second wavelength range from 433 nm to 450 nm. An endoscope is connected with a first source optical train for guiding excitation light through the first source optical train and the excitation light filter to uniformly illuminate the excitation light on a patient's tissue region of interest inside an enclosed cavity of the patient's body. The endoscope is connected to a camera device and a receiving optical train and the received light detection filter for receiving and passing into the camera device light signals including autofluorescence light in the second wavelength range from healthy nervous tissue in the patient's tissue region of interest.

Described herein are robotically coordinated systems and methods for safe and efficient spinal decompression and bone milling. In various embodiments, a robotic spinal surgery system is provided with at least three robotic arms co-located on a single mobile base wherein the movement of the robotic arms is coordinated by a central control unit on the base. The system further comprises tools for spinal decompression, elements for protection of nervous tissue and navigation cameras. The nerve protection elements are placed between bony anatomy structures and nervous structures to prevent contact of the spinal decompression tools with the nervous structures. The nerve protection elements further include safety components that can optionally close electrical circuits with the decompression tools and sense or stimulate the nervous structures. Methods of deploying the inventive system in surgery are also provided.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

The invention discloses a medicine for treating postherpetic neuralgia and a preparation method thereof, and belongs to the technical field of medicines for herpes zoster. Aiming at postherpetic neuralgia, the traditional Chinese medicine composition treats both symptoms and root causes through the synergistic effect of all the components, gypsum is used, and rhizoma coptidis, radix scutellariae, cortex phellodendri and fructus gardeniae are combined, so that the traditional Chinese medicine composition has the effects of strongly clearing heat, purging fire, detoxifying, removing residual damp-heat toxin and relieving causalgia; salvia miltiorrhiza, radix paeoniae rubra, moutan bark and motherwort synergistically promote blood circulation, remove blood stasis, cool blood and improve microcirculation so as to relieve stabbing pain. Scorpio, centipede, lumbricus and other insect drugs go deep into meridians and collaterals to dispel wind and dredge collaterals and strongly relieve Mangnolia officinalis and trifoliate orange have the effects of promoting qi circulation, reducing phlegm and smoothing qi to promote drug efficacy; radix astragali, glossy privet fruit and sliced cornu cervi tonify qi, nourish yin, warm, dredge and repair, and strengthen healthy qi to promote regeneration of nervous tissues; herba schizonepetae and mint dispel wind and permeate superficies, and guide the medicine to directly reach According to the formula, the neuralgia with various properties can be quickly relieved, inflammation can be radically eliminated, circulation can be improved, and nerves can be repaired.

To provide an internal or external pulse generation and / or stimulation engine system for facilitating interruption, modification, and / or attenuation of a biological signal through a nervous tissue including processing of a biological tissue, a cardiac tissue, or the other potential sensitive tissue within a nervous system tissue.SOLUTION: This specification discloses a system that may include a neuromodulation device configured to operate in a plurality of electrical modulation modes by using a single architecture, and discloses a method.SELECTED DRAWING: Figure 1