2410 results about "Drug release" patented technology

Provided in the present invention is a new cationic lipid containing two tertiary amine groups. The structure is as shown in general formula (1), wherein the definition of each symbol in the formula is consistent with that described herein. The cationic lipid containing two tertiary amine groups is a pharmaceutically acceptable, biodegradable or highly biocompatible cationic lipid, and has the advantages of low toxicity, low immunogenicity and high biocompatibility. In the present invention, one or more biodegradable groups are contained between the hydrophilic head and the lipophilic tail chain of the cationic lipid containing two tertiary amine groups, thus preventing the endosome storage of an LNP prepared therefrom, increasing the endosome escape efficiency of the LNP in cells, and promoting the release of drugs into cytoplasm to serve the function thereof.

The invention belongs to the technical field of medical materials, and relates to a titanium-based implant surface dual drug release system and a preparation method and application thereof. Comprising a titanium-based implant and a hydrogel layer attached to the surface of the titanium-based implant, the surface of the titanium-based implant is of a nanotube array structure, zinc oxide nanoparticles and up-conversion luminescent material particles are arranged between the titanium-based implant and the hydrogel layer, and MgO2 nanoparticles are loaded in the hydrogel layer; wherein the material of the up-conversion luminescent material particles is NaYF4: Yb < 3 + >, Er < 3 + >, and the hydrogel layer is composed of gelatin-sodium alginate hydrogel. The titanium-based implant surface dual-drug release system provided by the invention can realize loading of different drugs, can be used for treating various diseases, has a better time sequence control effect, is long in action time and low in cost, and has a wide application prospect.

The invention relates to the technical field of pharmaceutical chemicals, and discloses sequential drug release liposome hydrogel and a preparation method and application thereof, and the preparation method of the liposome hydrogel comprises the following steps: step 1, preparation of drug-loaded positive charge liposome; step 2, preparing phenylboronic acid modified polysaccharide; and step 3, carrying out vortex mixing on the drug-loaded positive charge liposome solution, the phenylboronic acid modified polysaccharide hydrogel precursor powder and the spermidine solution to obtain the liposome hydrogel. According to the sequential drug release liposome hydrogel as well as the preparation method and the application thereof, the liposome hydrogel is prepared by taking high-molecular hyaluronic acid and phenylboronic acid as main raw materials, and the liposome hydrogel has microenvironment responsiveness and time-space characteristics of drug release, and can be used for treating osteoarthritis in an environment with active oxygen increase, so that the drug release effect is good, and the drug release effect is good. The functions of early-stage anti-inflammation and continuous cartilage regeneration are achieved by sequentially releasing double drugs, synovitis can be effectively relieved, cartilage regeneration can be promoted, and the compound can be used for preparing drugs for treating osteoarthritis.

The invention discloses a drug electric controlled release hydrogel patch for wound healing, and belongs to the technical field of biomedical materials, the hydrogel patch comprises sheet electrodes, conductive hydrogel, a liquid storage tank and a flexible circuit, the two sheet electrodes are respectively attached to two side surfaces of the conductive hydrogel to form a sandwich structure, and a hole is formed in the middle of one sheet electrode; the two sheet electrodes are connected to the flexible circuit through wires, and the flexible circuit controls the two sheet electrodes to generate voltage difference. The liquid storage tank is used for storing a medicine solution and comprises a liquid storage tank cavity and a liquid storage tank hole, the conductive hydrogel and the liquid storage tank cavity form a closed space through the liquid storage tank hole, one part of the conductive hydrogel is exposed outside, and the other part of the conductive hydrogel is in the liquid storage tank cavity; the conductive hydrogel is exposed outside, and the surface, attached with the sheet-shaped electrode with a hole in the middle, of the conductive hydrogel is a treatment surface facing a wound surface. The hydrogel patch can realize long-term continuous supplement of drugs in hydrogel and program-controlled drug release, and wound healing is promoted through cooperation of electrical stimulation and drug release.

The invention relates to the technical field of atomizers, and particularly discloses a medical atomizer self-adaptive control method and system based on real-time expiration amount feedback, the system comprises a control module, an atomization execution module and a respiration characteristic analysis module, and the control module is in communication connection with the atomization execution module and the respiration characteristic analysis module; the respiration characteristic analysis module is used for acquiring a dynamic respiration characteristic data set of a user in real time and sending the dynamic respiration characteristic data set of the user to the control module; and the control module is used for acquiring a respiration evaluation index according to the user dynamic respiration characteristic data set, acquiring atomization control information of operation of an atomizer in real time, and acquiring a user respiration-atomization matching degree according to the respiration evaluation index and the atomization control information. Atomization parameters are deeply matched with the breathing state and the individual characteristics of a patient, the medicine deposition efficiency and the treatment accuracy are improved, and in the aspect of data monitoring and application, the atomization execution module monitors medicine release data in stages.

The invention relates to the technical field of biological medicine, and discloses a pharmaceutical composition of paclitaxel dimer prodrug nanoparticles and a traditional Chinese medicine compound and application of the pharmaceutical composition, and the pharmaceutical composition is composed of Qiyuansanlong prescription freeze-dried powder and paclitaxel dimer prodrug nanoparticles; wherein the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) or GSH (glutathione) response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs), and the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) and GSH response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs). According to the pharmaceutical composition disclosed by the invention, a traditional Chinese and western medicine synergistic treatment system is innovatively constructed, and the advantage of multi-dimensional synergistic interaction is shown. Firstly, an NQO1 / GSH double-response type intelligent release system is adopted, and a biomarker highly expressed by tumor tissue can be specifically responded to realize precise drug release, so that the PTX concentration in tumors is improved compared with that of a traditional dosage form, and meanwhile, the drug circulation time is prolonged. Secondly, the active ingredients in the Qiyuansanlong prescription freeze-dried powder can significantly down-regulate the PD-L1 expression level, synergistically enhance CD4 + T and CD8 + T cell infiltration, and form chemical-immune dual killing effects.

The invention provides a preparation method and application of a high-efficiency encapsulated pH-responsive drug-loaded liposome. According to the method, two-phase fluid of a medicine aqueous solution and a lipid component organic solution in a micro-channel is accurately controlled, and the efficiently encapsulated liposome is prepared from bottom to top by utilizing a micro-mixing technology. Compared with a conventional passive drug loading method which is relatively low in encapsulation efficiency in preparation of hydrophilic drug nano-liposomes, the method provided by the invention can improve the encapsulation efficiency to be close to 95% under optimized prescription and process conditions. According to the invention, by adjusting the proportion of each component in the prescription and the preparation process, the release behavior of liposome drugs such as adriamycin and the like can be adjusted, and the drug release shows pH responsiveness. Through efficient encapsulation of adriamycin and the like and pH-responsive release of the liposome dosage form, the effects of efficacy enhancement and toxicity reduction are achieved in the anti-tumor treatment aspect.

The invention discloses a hospital automatic drug delivery system with controllable drug concentration, comprising: a drug delivery device for delivering drugs into the body of a patient; the concentration sensor is used for monitoring the concentration index of the medicine in the body of the patient in real time; the control unit is used for receiving the signal from the drug release calculation module and controlling the conveying rate of the drug delivery device according to a set drug concentration range; the medicine release calculation module is used for calculating the release amount and the delivery rate of the medicine according to the preset value and the medicine concentration obtained by the feedback module, and generating a control instruction; and the feedback module is used for calculating the drug concentration according to the measurement result of the concentration sensor. By controlling the concentration of the drug in the target area in the drug delivery process, it is guaranteed that the drug can be stably released and delivered to the target area under the preset concentration.

The invention provides an injectable short-fiber-based hydrogel tissue repair material with an electric response characteristic as well as a preparation method and application thereof, and the injectable short-fiber-based hydrogel tissue repair material with the electric response characteristic is prepared by taking a natural polymer material loaded with bioactive factors as a core layer material and a biodegradable material as a shell layer material through a coaxial electrostatic spinning technology. The method comprises the following steps: preparing short fibers with a core-shell structure, uniformly mixing the short fibers with a hydrogel matrix, injecting and filling a tissue defect part, and carrying out ultraviolet curing to form the tissue repair material. The injectable short-fiber-based hydrogel tissue repair material with the electrical response characteristic provided by the invention has piezoelectric characteristic and injectable characteristic, can generate electrical response through mechanical stimulation so as to promote cell proliferation and tissue repair, and also has controllable drug release capacity and good mechanical adaptability; the method is suitable for application scenes of complex tissue damage repair such as diabetes infected wound repair, articular cartilage repair, oral barrier membrane repair, abdominal wall defect repair and the like.

The invention provides gastric residence systems with specifically tailored architectures and methods for making such systems. The components of the gastric residence systems can be manufactured by three-dimensional printing or by co-extrusion. The ability to construct precise architectures for the systems provides excellent control over drug release, in vivo stability, and residence time of the systems.

The invention discloses a drug-loaded rod core, a raw material composition thereof, an implant, preparation and application. The raw material composition of the drug-loaded rod core comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; 0.45 to 20 parts of hydrogen-containing silicone oil; the content of a catalyst is greater than or equal to 0.000002 part, preferably 0.000002-1 part; wherein the average particle size of the active pharmaceutical ingredients is 1-1000 nm. According to the invention, the drug active ingredients with the average particle size of 1-1000nm are adopted, so that the solubility of the drug can be obviously improved; the compatibility with silicon rubber is better, the release speed of the obtained skeleton type implant and storage type implant is obviously improved, and the drug release behavior is stable; meanwhile, the application range is wide, the preparation method is suitable for various drugs, and large-dose stable release is achieved.

Various embodiments disclosed relate to polymer encapsulated drug particles and drug release coatings comprising the polymer encapsulated drug particles, as well as drug coated balloon catheters for treating, preventing, or reducing recurrence of body lumen stenosis and methods of use thereof. A drug coated balloon catheter for delivering a therapeutic agent to a body lumen stenosis target site includes an elongated balloon. The balloon catheter includes a coating layer covering the outer surface of the balloon. The coating layer comprises: polymer encapsulated drug particles; or a drug release coating comprising polymer encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

Systems and methods for applying therapeutic ultrasound to the brain to compensate for attenuation and dephasing of ultrasound by each individual's head. The compensation is based on relative ultrasound through-transmit measurements, which are performed using a set of ultrasonic emitters over one side of the head and a set of receivers on the other side. The measurements are performed with the head absent and present. Based on the difference between these measurements, the set of ultrasound waves is adjusted to compensate for attenuations and dephasing caused by the ultrasound wave passing into the head through the scalp and skull. The adjusted set of ultrasound waves provides intended, deterministic ultrasound intensity at the target location. The deterministic delivery enables safe and effective ultrasonic neuromodulation, local drug release from nanoparticle carriers, and microbubble-based disruption of blood-brain barrier for the delivery of drugs, genes, and stem cells across the blood-brain barrier.

The present invention relates to a natural light crosslinked hydrogel comprising MXene and a method for preparing same. The present invention provides a natural polymeric hydrogel formed through natural light crosslinking in a non-harmful visible light spectrum. As the hydrogel comprises a drug and MXene, the hydrogel exhibits excellent biocompatibility with no cytotoxicity. It has been confirmed that the hydrogel can maximize a wound healing effect by modulating photothermal reactions and controlling drug release. Accordingly, the hydrogel may be effectively used for wound treatment as a pharmaceutical composition, a quasi-drug composition, and a cosmetic composition.

The invention discloses functional injection type bionic hydrogel for promoting bone healing and a preparation method thereof, and relates to the technical field of medical instruments. The hydrogel has good functional characteristics, is a biomimetic material prepared on the basis of methacrylated gelatin, and aims to regulate and control the degradation rate, the drug release mechanism and diversified synergistic treatment and promote bone repair and regeneration; according to the hydrogel, matching of the degradation rate and the bone regeneration rate is achieved through reasonable matching, stem cell osteogenic differentiation and angiogenesis are promoted, ultrasonic controlled-release drug release and synergistic controlled-release of active factors are achieved, inflammation is reduced, and the bone repair process is promoted; the calcium phosphate bone cement provides biocompatibility and bone conductivity, and the nano clay releases active ions to improve the microenvironment and promote bone repair; in addition, the magnetic nanoparticles and a static magnetic field have synergistic interaction, the bone healing process is further accelerated, and treatment effect monitoring is enhanced through magnetic resonance imaging.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention relates to the field of biomedical materials, in particular to composite hydrogel as well as a preparation method and application thereof. The composite hydrogel prepared by the invention realizes step-by-step release and time sequence regulation of a polypeptide drug through the combined action of Gel-PBA and GelMA: the anti-inflammatory peptide (Ac2-26) is quickly released under the conditions of high ROS and low pH, so that inflammation and pyroptosis are reduced; osteogenic peptide (OGP) is continuously and slowly released, and osteogenic differentiation is promoted. The step-by-step release mechanism of the anti-inflammatory peptide and the osteogenic peptide can realize accurate drug release, and is helpful for synergistically regulating inflammation and promoting bone regeneration. The composite hydrogel is used as a biological medicine material, can realize timely anti-inflammatory effect and long-term osteogenesis in a complex pathological environment such as diabetic periodontitis, and has a good application prospect.

The invention discloses a bone regeneration promoting drug-loaded skull implant with a bionic structure and a preparation method of the bone regeneration promoting drug-loaded skull implant, and belongs to the technical field of medical materials. The skull implant is prepared through a flat plate mold pressing technology and is of a bionic three-layer structure, the upper layer and the lower layer of the haft tube imitating structures and the middle layer of the bone trabecula imitating structure are prepared through the water-soluble core, a vascularization channel can be provided, and bone tissue climbing is promoted; a polydopamine-carboxymethyl chitosan coating is used for carrying out surface modification on a porous structure of the implant, hydroxyapatite in-situ forming and bone regeneration promoting medicine loading are achieved through an impregnation process, and the polydopamine coating can provide a hydration environment; hydroxyapatite in-situ forming increases biocompatibility on the premise of not influencing the mechanical properties of implants, in addition, hydroxyapatite degradation and drug release can jointly induce bone tissue regeneration, and skull repair is promoted.

According to the method, a one-pot copolymerization method is adopted, MBAA and borax serve as cross-linking agents, zwitterionic polyelectrolyte hydrogel containing SBMA, PVA, THMA and AMPS is prepared, and the zwitterionic polyelectrolyte hydrogel has excellent adhesion performance and biocompatibility and is suitable for the field of biological medicine. According to the method, the physical characteristics of the hydrogel are enhanced due to crosslinking sites and hydrogen bonds of polyvinyl alcohol. The cationic and anionic groups of SBMA improve the adhesion performance, and the reaction monomer THMA provides hydrogen-bond interaction to further promote adhesion, so that the prepared hydrogel adhesive shows excellent adhesion performance and biocompatibility, and is suitable for biological medicine application of wound dressing, drug release systems, tissue engineering and the like.

Various embodiments disclosed relate to polymer-encapsulated drug particles and a drug-releasing coating including the same, as well as drug-coated balloon catheters for treating, preventing, or reducing the recurrence of strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes the polymer-encapsulated drug particles; or a drug-releasing coating including the polymer-encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

The invention provides a decellularized amnion matrix hydrogel and a preparation method thereof. The preparation method comprises the following steps: amnion tissue pretreatment, cleaning, decellularization, grinding, freeze-drying, digestion and acid-base neutralization. According to the decellularized amnion matrix hydrogel, active cells are removed while collagen, fibronectin, glycoprotein and other components in an amnion cell matrix are reserved, and the immunogenicity of the decellularized amnion matrix hydrogel is reduced from the source. The decellularized amniotic membrane matrix hydrogel provided by the invention can simulate the microenvironment of in-vivo cells, provides support and signals required by cell adhesion and growth, can be used for constructing a tissue engineering scaffold, and provides support for directional growth and tissue regeneration of cells. Besides, the decellularized amniotic membrane matrix hydrogel can also be used as a drug carrier for in-vivo drug release and treatment, and has very high application potential in medical research and clinical application.

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses a self-power-generation stomach residence electronic capsule and application thereof, and belongs to the technical field of medical capsules, the self-power-generation stomach residence electronic capsule structurally comprises a capsule shell, and a self-power-generation stomach residence unit, a drug release unit and a circuit system which are arranged in the capsule shell; the self-generating stomach residence unit structure comprises an anode, a plurality of elastic support arms, a cathode and a fastener, and the fastener fixes the plurality of elastic support arms between the anode and the cathode; the anode and the cathode are subjected to primary battery reaction in a gastric juice environment to generate power; the drug release unit is detachably connected with the self-generating gastric residence unit, the drug release unit comprises a drug cabin and a propelling module, the propelling module comprises an electrolyte, an isolating membrane and a propellant, the isolating membrane plays a role in isolating the electrolyte and the propellant and can be dissolved by the electrolyte under the condition that voltage is applied, and the drug cabin is connected with the drug cabin. After the electrolyte is in contact with the propellant, pushing force is generated to release the medicine in the medicine cabin.

The invention belongs to the technical field of biomedical high-molecular polymer materials, and discloses a pH and temperature dual-response lignin-based amphiphilic polymer and micelle as well as a preparation method and an application of the pH and temperature dual-response lignin-based amphiphilic polymer and micelle. The preparation method of the polymer comprises the following steps: purifying the alkali lignin, preparing a macroinitiator AL-Br based on the alkali lignin, and then preparing the lignin-based amphiphilic polymer with double responses of pH and temperature. The polymerization process is controllable, and the usage amount of copper is lower than 500 ppm. The lignin polymer disclosed by the invention can be self-assembled into nano-scale micelles in a water medium, the structure is stable, and AgNPs and an entrapped hydrophobic anticancer drug CPT can be simultaneously prepared in situ. The obtained single nano-carrier system has good silver nanoparticle stabilizing capacity, in-vitro pH and temperature double-response drug release capacity and excellent cytotoxicity and antibacterial capacity, can achieve the anti-tumor and antibacterial purposes at the same time, and is well applied to preparation of drugs with anti-tumor and antibacterial effects at the same time.

The invention relates to the technical field of medicines, in particular to a sustained-release coating as well as a preparation method and application thereof. The coating adopts a three-layer gradient structure design and comprises an inner layer coating, a middle layer coating and an outer layer coating, and the layers are compounded and matched through ethyl cellulose and hydroxypropyl methylcellulose with different molecular weights and are combined with talcum powder filling amount with gradient decreasing and a triethyl citrate plasticizer, so that accurate regulation and control of drug release are realized. Through hierarchical swelling-diffusion dynamic balance, burst release is inhibited, the inner layer has high talcum powder content to resist initial swelling stress, the outer layer has low filling amount to maintain hydrophobic continuity, interface defects are reduced in combination with high-temperature curing, and the release stability and long-term storage performance of drugs such as dihydroergoline mesylate are remarkably improved; the problems of sudden release, damp-heat sensitivity, impurity generation and the like of a traditional single-layer coating are solved.

An emulsion comprises a first discontinuous phase comprising first droplets, a second discontinuous phase comprising second droplets, and a continuous aqueous phase. The first droplets include at least one first surfactant and at least one first fluorocarbon, and have a first diameter of more than 100 nm. The second droplets include at least one surfactant, at least one drug, and at least one solvent, and have a second diameter of no more than 100 nm.

The invention relates to a degradable surgical suture capable of self-constricting under the driving of near-infrared light and accelerating wound healing as well as a preparation method and application of the degradable surgical suture, and the degradable surgical suture capable of self-constricting under the driving of the near-infrared light is developed by virtue of a photo-thermal conversion effect of polydopamine on the basis of a thermal response characteristic of a shape memory material. And on the basis, a thermal control drug release system is endowed to the suture line to synergistically accelerate the wound healing process, and various suture problems confronted by the internal wound of the body are solved.

The invention relates to a structural design, synthesis and application of a biomass carbon dot modified poly L-cysteine-S-S-carboxylic acid amphiphilic polypeptide. The invention provides a structural design, synthesis and application of poly (L-cysteine-S-S-carboxylic acid) amphiphilic polypeptide (P-L-cys) modified by biomass carbon dots (CDs). Comprising synthesis of P-L-cys which contains hydrophobic groups, provides hydrophilic and functionalized carboxyl and provides reduction response by disulfide bonds, synthesis of CDs and CDs modified P-L-cys (CDs (at) P-L-cys), and the macroscopic performance change of the polypeptide is explored from regulation factors of a polypeptide secondary structure and a self-assembly nanostructure assembly mechanism. The P-L-cys and the CDs (at) P-L-cys prepared by the invention have functionalization, fluorescence imaging and dual-response drug release and have particle sizes suitable for drug delivery and enrichment, and the CDs also provide a photo-thermal and photodynamic synergistic treatment effect and have good application prospects in the fields of drug delivery, cancer resistance and the like.

The invention relates to the field of biological medicine, in particular to IMSFs hydrogel, a ferroptosis induction system, a preparation method and application. The IMSFs hydrogel comprises a hydrogel body, and ferroferric oxide nanoparticles and sorafenib are loaded in the hydrogel body in a wrapping manner. The IMSFs hydrogel can be used as an injectable cascade ferroptosis anti-cancer drug. The preparation method of the IMSFs hydrogel comprises the following steps: firstly, preparing a silk fibroin-hyaluronic acid hydrogel body: dissolving silk hydrogel and hyaluronic acid in a lithium bromide solution; bDDE is added into the dissolved solution, and incubation is carried out; then dialyzing and washing with deionized water to obtain a silk fibroin-hyaluronic acid hydrogel body; and then loading the sorafenib nanoparticles and the ferroferric oxide nanoparticles into the silk fibroin-hyaluronic acid hydrogel body. The IMSFs hydrogel disclosed by the invention integrates magnetic thermal response and drug controlled release, and can be injected to a tumor site, so that the treatment effect on TNBC is remarkably improved.