1702 results about "Drug release" patented technology

The invention relates to the technical field of atomizers, and particularly discloses a medical atomizer self-adaptive control method and system based on real-time expiration amount feedback, the system comprises a control module, an atomization execution module and a respiration characteristic analysis module, and the control module is in communication connection with the atomization execution module and the respiration characteristic analysis module; the respiration characteristic analysis module is used for acquiring a dynamic respiration characteristic data set of a user in real time and sending the dynamic respiration characteristic data set of the user to the control module; and the control module is used for acquiring a respiration evaluation index according to the user dynamic respiration characteristic data set, acquiring atomization control information of operation of an atomizer in real time, and acquiring a user respiration-atomization matching degree according to the respiration evaluation index and the atomization control information. Atomization parameters are deeply matched with the breathing state and the individual characteristics of a patient, the medicine deposition efficiency and the treatment accuracy are improved, and in the aspect of data monitoring and application, the atomization execution module monitors medicine release data in stages.

The invention relates to the technical field of biological medicine, and discloses a pharmaceutical composition of paclitaxel dimer prodrug nanoparticles and a traditional Chinese medicine compound and application of the pharmaceutical composition, and the pharmaceutical composition is composed of Qiyuansanlong prescription freeze-dried powder and paclitaxel dimer prodrug nanoparticles; wherein the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) or GSH (glutathione) response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs), and the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) and GSH response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs). According to the pharmaceutical composition disclosed by the invention, a traditional Chinese and western medicine synergistic treatment system is innovatively constructed, and the advantage of multi-dimensional synergistic interaction is shown. Firstly, an NQO1 / GSH double-response type intelligent release system is adopted, and a biomarker highly expressed by tumor tissue can be specifically responded to realize precise drug release, so that the PTX concentration in tumors is improved compared with that of a traditional dosage form, and meanwhile, the drug circulation time is prolonged. Secondly, the active ingredients in the Qiyuansanlong prescription freeze-dried powder can significantly down-regulate the PD-L1 expression level, synergistically enhance CD4 + T and CD8 + T cell infiltration, and form chemical-immune dual killing effects.

The invention provides an injectable short-fiber-based hydrogel tissue repair material with an electric response characteristic as well as a preparation method and application thereof, and the injectable short-fiber-based hydrogel tissue repair material with the electric response characteristic is prepared by taking a natural polymer material loaded with bioactive factors as a core layer material and a biodegradable material as a shell layer material through a coaxial electrostatic spinning technology. The method comprises the following steps: preparing short fibers with a core-shell structure, uniformly mixing the short fibers with a hydrogel matrix, injecting and filling a tissue defect part, and carrying out ultraviolet curing to form the tissue repair material. The injectable short-fiber-based hydrogel tissue repair material with the electrical response characteristic provided by the invention has piezoelectric characteristic and injectable characteristic, can generate electrical response through mechanical stimulation so as to promote cell proliferation and tissue repair, and also has controllable drug release capacity and good mechanical adaptability; the method is suitable for application scenes of complex tissue damage repair such as diabetes infected wound repair, articular cartilage repair, oral barrier membrane repair, abdominal wall defect repair and the like.

Systems and methods for applying therapeutic ultrasound to the brain to compensate for attenuation and dephasing of ultrasound by each individual's head. The compensation is based on relative ultrasound through-transmit measurements, which are performed using a set of ultrasonic emitters over one side of the head and a set of receivers on the other side. The measurements are performed with the head absent and present. Based on the difference between these measurements, the set of ultrasound waves is adjusted to compensate for attenuations and dephasing caused by the ultrasound wave passing into the head through the scalp and skull. The adjusted set of ultrasound waves provides intended, deterministic ultrasound intensity at the target location. The deterministic delivery enables safe and effective ultrasonic neuromodulation, local drug release from nanoparticle carriers, and microbubble-based disruption of blood-brain barrier for the delivery of drugs, genes, and stem cells across the blood-brain barrier.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention relates to the field of biomedical materials, in particular to composite hydrogel as well as a preparation method and application thereof. The composite hydrogel prepared by the invention realizes step-by-step release and time sequence regulation of a polypeptide drug through the combined action of Gel-PBA and GelMA: the anti-inflammatory peptide (Ac2-26) is quickly released under the conditions of high ROS and low pH, so that inflammation and pyroptosis are reduced; osteogenic peptide (OGP) is continuously and slowly released, and osteogenic differentiation is promoted. The step-by-step release mechanism of the anti-inflammatory peptide and the osteogenic peptide can realize accurate drug release, and is helpful for synergistically regulating inflammation and promoting bone regeneration. The composite hydrogel is used as a biological medicine material, can realize timely anti-inflammatory effect and long-term osteogenesis in a complex pathological environment such as diabetic periodontitis, and has a good application prospect.

Various embodiments disclosed relate to polymer-encapsulated drug particles and a drug-releasing coating including the same, as well as drug-coated balloon catheters for treating, preventing, or reducing the recurrence of strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes the polymer-encapsulated drug particles; or a drug-releasing coating including the polymer-encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses a self-power-generation stomach residence electronic capsule and application thereof, and belongs to the technical field of medical capsules, the self-power-generation stomach residence electronic capsule structurally comprises a capsule shell, and a self-power-generation stomach residence unit, a drug release unit and a circuit system which are arranged in the capsule shell; the self-generating stomach residence unit structure comprises an anode, a plurality of elastic support arms, a cathode and a fastener, and the fastener fixes the plurality of elastic support arms between the anode and the cathode; the anode and the cathode are subjected to primary battery reaction in a gastric juice environment to generate power; the drug release unit is detachably connected with the self-generating gastric residence unit, the drug release unit comprises a drug cabin and a propelling module, the propelling module comprises an electrolyte, an isolating membrane and a propellant, the isolating membrane plays a role in isolating the electrolyte and the propellant and can be dissolved by the electrolyte under the condition that voltage is applied, and the drug cabin is connected with the drug cabin. After the electrolyte is in contact with the propellant, pushing force is generated to release the medicine in the medicine cabin.

The invention relates to the technical field of medicines, in particular to a sustained-release coating as well as a preparation method and application thereof. The coating adopts a three-layer gradient structure design and comprises an inner layer coating, a middle layer coating and an outer layer coating, and the layers are compounded and matched through ethyl cellulose and hydroxypropyl methylcellulose with different molecular weights and are combined with talcum powder filling amount with gradient decreasing and a triethyl citrate plasticizer, so that accurate regulation and control of drug release are realized. Through hierarchical swelling-diffusion dynamic balance, burst release is inhibited, the inner layer has high talcum powder content to resist initial swelling stress, the outer layer has low filling amount to maintain hydrophobic continuity, interface defects are reduced in combination with high-temperature curing, and the release stability and long-term storage performance of drugs such as dihydroergoline mesylate are remarkably improved; the problems of sudden release, damp-heat sensitivity, impurity generation and the like of a traditional single-layer coating are solved.

An emulsion comprises a first discontinuous phase comprising first droplets, a second discontinuous phase comprising second droplets, and a continuous aqueous phase. The first droplets include at least one first surfactant and at least one first fluorocarbon, and have a first diameter of more than 100 nm. The second droplets include at least one surfactant, at least one drug, and at least one solvent, and have a second diameter of no more than 100 nm.

The invention relates to a structural design, synthesis and application of a biomass carbon dot modified poly L-cysteine-S-S-carboxylic acid amphiphilic polypeptide. The invention provides a structural design, synthesis and application of poly (L-cysteine-S-S-carboxylic acid) amphiphilic polypeptide (P-L-cys) modified by biomass carbon dots (CDs). Comprising synthesis of P-L-cys which contains hydrophobic groups, provides hydrophilic and functionalized carboxyl and provides reduction response by disulfide bonds, synthesis of CDs and CDs modified P-L-cys (CDs (at) P-L-cys), and the macroscopic performance change of the polypeptide is explored from regulation factors of a polypeptide secondary structure and a self-assembly nanostructure assembly mechanism. The P-L-cys and the CDs (at) P-L-cys prepared by the invention have functionalization, fluorescence imaging and dual-response drug release and have particle sizes suitable for drug delivery and enrichment, and the CDs also provide a photo-thermal and photodynamic synergistic treatment effect and have good application prospects in the fields of drug delivery, cancer resistance and the like.

The invention relates to the field of biological medicine, in particular to IMSFs hydrogel, a ferroptosis induction system, a preparation method and application. The IMSFs hydrogel comprises a hydrogel body, and ferroferric oxide nanoparticles and sorafenib are loaded in the hydrogel body in a wrapping manner. The IMSFs hydrogel can be used as an injectable cascade ferroptosis anti-cancer drug. The preparation method of the IMSFs hydrogel comprises the following steps: firstly, preparing a silk fibroin-hyaluronic acid hydrogel body: dissolving silk hydrogel and hyaluronic acid in a lithium bromide solution; bDDE is added into the dissolved solution, and incubation is carried out; then dialyzing and washing with deionized water to obtain a silk fibroin-hyaluronic acid hydrogel body; and then loading the sorafenib nanoparticles and the ferroferric oxide nanoparticles into the silk fibroin-hyaluronic acid hydrogel body. The IMSFs hydrogel disclosed by the invention integrates magnetic thermal response and drug controlled release, and can be injected to a tumor site, so that the treatment effect on TNBC is remarkably improved.

The invention provides an inhalable tanshinone IIA lipid nanocrystal as well as a preparation method and application thereof, and the inhalable tanshinone IIA lipid nanocrystal is mainly formed by entrapping tanshinone IIA by using dipalmitoyl phosphatidylcholine DPPC and dipalmitoyl phosphatidyl ethanolamine DPPE as mixed phospholipids in the presence of a stabilizer. Compared with the prior art, the inhalable tanshinone IIA lipid nanocrystal disclosed by the invention has the advantages that by improving the physicochemical property and drug release behavior of TA, the lung retention volume of TA after aerosol inhalation is obviously increased, the retention time of TA in the lung is prolonged, and the risk of toxic and side effects caused by whole-body escape of drugs is reduced; the treatment effect on idiopathic pulmonary fibrosis is improved, and the compliance of a patient is improved.

The invention discloses a drug eluting stent, which comprises a stent main body and a plurality of thorn-shaped components, the stent main body has a radially compressible contraction state and a radially self-expanding expansion state to support blood vessels, and the plurality of thorn-shaped components are arranged on the outer surface of the stent main body and coated with a drug coating for inhibiting vascular restenosis. The spine-shaped components are arranged on the stent body and are configured to protrude towards the outer side of the stent body from the outer surface of the stent body to penetrate into calcified lesions on the inner wall of a blood vessel when the stent body is switched from the contraction state to the expansion state, each spine-shaped component is provided with a part capable of generating elastic deformation, and the spine-shaped components are configured to be capable of generating deformation in a self-adaptive mode according to the thickness of the contacted calcified lesions. Therefore, the medicine can be uniformly distributed in a target lesion area, and the utilization rate of the medicine and the treatment effect are remarkably improved.

The invention discloses an intelligent atomization control method and system for respiratory tract treatment and a storage medium, and relates to the technical field of atomization control. During operation of the system, a multi-mode patient respiratory behavior monitoring module is used for capturing real-time respiratory frequency, depth, rhythm, cough characteristics and atomization efficacy based on a non-contact sonic sensor and lung sound analysis; the method comprises the following steps: monitoring environment humidity, temperature and aerosol diffusion rate in real time, analyzing the influence of the environment humidity, temperature and aerosol diffusion rate on drug mist particle size and sedimentation behavior, controlling atomization particle size through a variable-frequency ultrasonic exciter, calculating to obtain an intelligent atomization curative effect adaptation index AEAI, dynamically adjusting particle size distribution according to the real-time inhalation demand of a patient and environment parameters, and combining with respiration monitoring data to obtain the intelligent atomization curative effect adaptation index AEAI. According to the method, the medicine mist release opportunity is adjusted in real time, threshold value comparison is carried out by monitoring respiratory resistance changes and real-time feedback of lung sound characteristic improvement degree, a medicine release strategy is obtained, and remote doctor viewing and parameter adjusting functions are provided.

The invention discloses a preparation method of a conductive thermal response drug release suture line, the obtained suture line has an inner conductive sensing functional coating and an outer thermal response drug-loading temperature-sensitive hydrogel functional coating, the inner coating has conductivity, heating property and wound sensing function, and the outer coating has thermal response drug-loading temperature-sensitive hydrogel functional coating. The outer coating has the functions of adhesion, drug carrying and thermal response drug release, the suture line is simple in process and convenient to operate, drug release can be regulated and controlled according to conductive thermal response, and the requirements of postoperative wound monitoring and on-demand treatment can be met.

The invention belongs to the field of biological functional materials, and discloses rare earth up-conversion nanoparticles as well as a preparation method and application thereof. The rare earth up-conversion nanoparticles comprise an inner core and a shell layer, and the shell layer is formed by growing on the surface of the inner core through a one-pot method; the inner core is formed by taking beta-NaYF4 as a matrix and doping 0.4%-0.6% of Tm and 25% of Yb with rare earth nanoparticles; the chemical composition of the shell layer is NaYF4; the particle size of the core-shell double-layer structure of the rare earth up-conversion nanoparticle is 246.7 + / -43.2 nm; the polymer HPMCP is used for wrapping up-conversion nanoparticles and a prodrug for drug delivery and enteric release; 800nm up-conversion light generated by irradiation of low-power 980nm laser is used for nano material tracking, and ultraviolet up-conversion luminescence is generated under irradiation of high-power 980nm near-infrared laser to decompose prodrugs for drug release.

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention discloses a self-crosslinking hydrogel with a tertiary amine group and preparation and application thereof, and belongs to the field of biomedical polymer materials, the self-crosslinking hydrogel comprises aminophenylboronic acid modified oxidized glucan, tertiary amine compound modified oxidized glucan and a solvent medium; the preparation method comprises the following steps: dissolving amino phenylboronic acid modified oxidized dextran and tertiary amine compound modified oxidized dextran in a solvent medium, mixing, standing for a certain time, and carrying out self-crosslinking to obtain the self-crosslinking hydrogel with tertiary amine groups. A cross-linking point (phenylboronic acid) of the gel network is a response unit of glucose. In addition, the hydrogel can effectively avoid uncontrollable drug release caused by non-responsive factors, and the response release efficiency of the drug is improved; by loading the hypoglycemic drug insulin to be applied to the treatment research process of diabetes, the occurrence of hypoglycemia can be avoided, and meanwhile, the possibility is provided for realizing intelligent controlled release of insulin through blood glucose response.

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention relates to the technical field of biomedical materials, and discloses a thrombectomy stent support material and a preparation process thereof, the thrombectomy stent support material comprises the following components by mass: 60-70% of a polysebacic diglyceride prepolymer; 25-35% of a dynamic covalent bond cross-linking agent; 5%-10% of carboxylated nano-diamond; 3 to 5 percent of temperature-sensitive and photo-thermal dual-response microspheres; the dynamic covalent bond cross-linking agent is composed of 4-formyl phenylboronic acid and hexamethylenediamine according to a molar ratio of 1: (1-3); the microsphere is prepared from poly (N-isopropylacrylamide), a gold nanorod and a recombinant tissue type plasminogen activating agent, and by combining a low-temperature 3D printing technology, the material can form a complex bionic structure, the mechanical strength is dynamically adjusted along with the physiological environment after implantation, and the material is safely degraded after functions are completed. The material is suitable for the scenes of cardiovascular and cerebrovascular stents, bone repair instruments and the like, has treatment accuracy, manufacturing suitability and clinical safety, and solves the problems of non-degradability, sudden drug release, mechanical mismatch and the like of traditional implants.

The embodiment of the invention provides breast cancer targeting nanoparticles as well as a preparation method and application thereof. According to the embodiment of the invention, the breast cancer targeting nanoparticles are synthesized by preparing the pH sensitive polymer, carrying out co-coupling modification on the pH response polymer and the folic acid albumin nano-carrier and utilizing a controlled desolvation method; the breast cancer targeting nanoparticle is combined with a nano preparation passive targeting strategy, a tumor microenvironment stimulation response strategy and a folic acid active targeting strategy, the effects of an EPR effect, PEG shedding, charge overturning, folic acid ligand-receptor combination and the like are utilized, precise targeting and specific response of tumors are achieved, and targeted accumulation of drugs in a tumor microenvironment is comprehensively improved. Therefore, the breast cancer targeting nanoparticles prepared by the embodiment have the advantages of high targeting property, drug controlled release, improvement of solubility and absorptivity of indissolvable drugs and the like, so that the curative effect of the drugs can be enhanced, the toxic and side effects can be reduced, and the breast cancer targeting nanoparticles have wide application prospects in the field of anti-tumor treatment.

The invention discloses a preparation method and application of a double-layer sound transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing, and belongs to the technical field of gel dressings. The preparation method comprises the following steps: taking vinyl silicone oil and silicon dioxide as raw materials, preparing upper-layer silica gel by adopting a double-component uniform mixing method, and then laminating the upper-layer silica gel and lower-layer berberine-loaded gelatin microsphere hydrogel by adopting a self-laminating method, thereby obtaining the double-layer sound-transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing. By means of the broad-spectrum antibacterial function of berberine, the efficient drug loading function and slow drug release function of gelatin microspheres, the sound transmission and swelling functions of lower hydrogel and the supporting function of upper hydrogel, ultrasonic inspection is conducted through a dressing covering layer, an ultrasonic scanning supporting plane is provided, ultrasonic waves penetrate through the dressing, good imaging is formed, and the application prospect is wide. And antibacterial and repairing effects on local wounds are realized at the same time.

The invention discloses a dual-mode response type postoperative infection early-warning intelligent dressing and a preparation method thereof, which are urgent for a novel postoperative dressing with precise infection monitoring, intelligent drug release, excellent material performance, reliable intelligent remote management and low-cost mass production potential. The invention aims at solving the problems of the existing dressing in all directions through an innovative technical scheme. According to the dual-mode response type postoperative infection early-warning intelligent dressing and the preparation method thereof, infection signals are accurately captured, intervention is performed in advance, through cooperative monitoring of the pH sensor (the detection error is + / -0.1) and the temperature sensor (the precision is + / -0.1 DEG C), compared with a traditional single-mode dressing, infection symptoms (for example, the pH is larger than 7.5, and the temperature is larger than 37.5 DEG C) are found 12-48 hours earlier, the infection early-warning accuracy rate is increased to 95% or above, and the application range is wide. The self-calibration technology has the advantages that background interference of double emission silicon points (427nm / 500nm fluorescence peaks) is eliminated through the fluorescence intensity ratio, errors of single-wavelength detection are avoided, and the method is suitable for a complex wound environment.

The invention provides bioactive conductive hydrogel as well as preparation and application thereof. The hydrogel comprises a dynamic non-covalent cross-linked network which is composed of natural macromolecules and at least comprises a reversible and environment-responsive cross-linking mode; the responsive conductive component is connected with the dynamic non-covalent cross-linked network through a covalent bond or a coordinate bond, the electrical property of the responsive conductive component changes along with the change of the wound surface microenvironment, and electrical signal feedback of the wound surface state is provided through the change of the electrical property; and the active substance is connected to the dynamic non-covalent cross-linked network through a responsive chemical bond, and the responsive chemical bond is broken under specific conditions of a wound surface microenvironment to release the active substance. Compared with the prior art, the integrated design of active oxygen monitoring and drug release is realized for the first time, the wound healing time (about 30-40%) can be remarkably shortened, the complication risk is reduced, and an innovative solution is provided for wound management in an intelligent medical mode.

The invention relates to the field of nano drug delivery systems, in particular to composite hydrogel targeting macrophage mitochondria as well as a preparation method and application of the composite hydrogel. The ROS response type liposome composite injectable hydrogel targeting the macrophage mitochondria is prepared by compounding the cationic liposome and the hydrogel, can be used as a nano drug delivery system suitable for oral local drug delivery, has good biocompatibility, and can target the mitochondria. The composite hydrogel is easy to prepare, easy to administrate and high in viscosity, has the characteristics of continuous drug release mode, minimum dosage frequency, low drug toxicity and the like, and is beneficial to being widely applied to treatment of periodontitis related diseases.

The invention relates to a Cu2-xSe-Pt nano material, a microneedle patch, a preparation method and application. The Cu < 2-x > Se (at) Pt nano material is composed of a Cu < 2-x > Se nanosphere and platinum modified on the surface of the Cu < 2-x > Se nanosphere in situ. The invention provides a preparation method of a Cu2-xSe-Pt nano-material, which comprises the following steps: adding PSS, SeO2 and AA into water, heating and stirring, adding copper salt and AA, reacting, and adding water and a hexachloroplatinic acid solution to obtain the Cu2-xSe-Pt nano-material. The invention provides an application of a Cu < 2-x > Se (at) Pt nano material. The invention also provides a microneedle patch as well as a preparation method and application thereof. The invention provides a novel material for resisting multi-drug-resistant bacteria, which solves the problems that the existing single antibacterial strategy is limited and the expected curative effect cannot be achieved, also solves the problem of cytotoxicity of the existing nano enzyme, realizes deep drug delivery, ensures efficient local drug release and avoids systemic toxicity.