692 results about "Drug release" patented technology

The invention discloses an ultralow-viscosity water-in-oil vaccine adjuvant and a preparation method thereof, and the ultralow-viscosity water-in-oil vaccine adjuvant comprises the following components in percentage by weight: 73%-75% of oil for injection, 20%-23% of a compound emulsifier, 2%-7% of a stabilizer, 0.5%-1.5% of a chiral immunomodulator and 1%-2% of a temperature-responsive material, the preparation method comprises the following steps: heating oil for injection as an oil phase; adding the compound emulsifier, the stabilizer, the chiral immunomodulator and the temperature response type material into the oil phase, stirring until the materials are completely dissolved to form a uniform oil phase mixture, slowly adding the water phase into the oil phase mixture, performing high-speed shearing to form primary emulsion, homogenizing the primary emulsion, and performing freeze drying to obtain the chiral immunomodulator. And carrying out emulsion refining by adopting a micro-fluidic technology to obtain the ultralow-viscosity water-in-oil type vaccine adjuvant. The ultra-low viscosity and injection comfort are achieved, precise immunization is achieved for different pathogens, multiple immune pathways are activated at the same time, a wide and lasting protection effect is generated by training an immune mechanism, and the ultra-low viscosity and injection comfort have the intelligent drug release characteristic, excellent stability and broad-spectrum applicability.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention discloses a hydrogel dressing for treating atopic dermatitis and a preparation method and application thereof, and belongs to the technical field of skin medical materials. The dressing is prepared by taking a glycerol / water / ethanol ternary mixed solvent as a dissolving system, dissolving polyvinyl alcohol, tannic acid and aluminum trichloride to construct a polymer skeleton matrix, and then adding traditional Chinese medicine active ingredients. The preparation does not need complex temperature control curing, the ternary solvent can realize uniform dissolution and stable dispersion of the active ingredients, the effective ingredients are prevented from being damaged by high temperature, the encapsulation efficiency of the traditional Chinese medicine extract is more than 90%, and the medicine can be slowly released for 72 hours. The dressing has a multi-target anti-inflammatory effect, can reduce the level of TNF-alpha at a skin lesion and promote proliferation of keratinocytes, is excellent in tensile and torsional stability, and can be attached to the skin for a long time in a dynamic environment. The preparation method is simple in process, controllable in raw material cost, high in production efficiency, suitable for large-scale production, good in dressing biocompatibility, high in safety, suitable for treatment of atopic dermatitis of different severity degrees and large in clinical transformation potential.

The utility model discloses an electrode assembly. The electrode assembly comprises: an electrode wire, wherein the electrode wire comprises a guide wire and a stimulation end; the stimulation end is at least partially implanted into a target area, the stimulation end is provided with a plurality of stimulation contacts, and the stimulation contacts are electrically connected with the guide wire; the adjacent stimulation contacts are insulated and separated through an isolation structure, and the stimulation end is provided with at least one drug release channel; the medicine supply assembly comprises a medicine storage cavity and at least one medicine conveying channel, the medicine conveying channel is arranged in the electrode wire, one end of the medicine conveying channel is communicated with the medicine storage cavity, the medicine conveying channel is provided with at least one outer conveying channel, and the outer conveying channel is connected with the medicine release channel. According to the utility model, electric signal stimulation and drug release can be realized synchronously.

The invention discloses a design method and application of a tyrosinase (TYR) responsive drug for targeted therapy of melanoma, and belongs to the technical field of biological medicines. Based on the biological mechanism that TYR catalyzes tyrosine oxidation, a self-degradation connecting arm drug release strategy is combined, a similar 3-hydroxybenzyl alcohol structure is introduced to simulate a tyrosine substrate, specific recognition and activation of TYR on the drugs are achieved, and the problems that traditional chemotherapeutic drugs are poor in targeting property and serious in adverse reaction are hopefully solved.

The invention discloses a long-acting pellet suitable for gastric absorption and a preparation method of the long-acting pellet. The long-acting pellet is prepared from the following components in parts by mass: 0.01-1 part of a medicine, 1-2.5 parts of a filler, 0.2-0.7 part of a modified pore-foaming agent mixture, 1-2.5 parts of an improved adhesive mixture and 0.1-0.7 part of an improved sonokinetic response agent. Wherein the modified pore-foaming agent mixture is prepared from a modified pore-foaming agent and glycosylated saponin, the modified pore-foaming agent is prepared by mixing a pore-foaming agent and seleno-amino acid according to a mass ratio of 4: 1, the improved adhesive is mixed with the adhesive through BHP-SH, and ionic crosslinking is performed by using CaCl2 to form a covalent ion dual network, so that the stomach adhesiveness is enhanced; the sonokinetic response agent is improved by the coated poria cocos extract, and the long-acting pellet is prepared by adopting a wet granulation method or a fluidized bed method, has the characteristics of slow release, long acting, targeted stomach absorption and responsive drug release, and is suitable for treating stomach diseases such as gastritis.

The present invention provides a solid dispersion of compound 1 or a pharmaceutical salt thereof, comprising the compound 1 or the pharmaceutical salt thereof as an active ingredient and a carrier material, wherein the carrier material is selected from one, two, or more of polyvinylpyrrolidone (PVP), copovidone, polyvinylpyrrolidone-vinyl acetate copolymer, hydroxypropyl methylcellulose acetate succinate, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, hydroxypropyl methylcellulose, polyethylene glycol, and ethyl cellulose, enabling the drug to have good stability, dissolution, and therapeutic effects. The formulation of the present invention provides rapid drug release and can reduce the oral burden of large-dose tablets on menopausal patients, thereby improving treatment compliance and treatment efficiency.

The invention belongs to the technical field of tumor treatment, and particularly relates to a metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle and a preparation method and application thereof.The mesoporous organic silicon nanoparticle (MON) is prepared through a micelle / precursor co-template assembly method, then amination modification, carboxylation modification and drug co-loading are further conducted on the mesoporous organic silicon nanoparticle (MON), and the metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle is obtained. The DQMCTH nano-particles are prepared through the steps that DQMCTH nano-particles are taken as a raw material, a copper salt solution and a tannic acid (TA) solution are added and mixed, then a coordination complexation reaction is conducted, hyaluronic acid (HA) is added for modification, and the DQMCTH nano-particles obtained through the method are in a sphere-like shape, regular in shape, uniform in distribution and free of obvious dendritic branches and central radial pore channels. The polypeptide is effectively protected by MPN and is subjected to HA targeted modification; more importantly, the DQMCTH nanoparticles prepared by the method disclosed by the invention show pH / GSH / HAase triple sensitive drug release, and cell and animal experiment results show that the DQMCTH nanoparticles prepared by the method disclosed by the invention have relatively high anti-tumor activity on a drug-resistant breast cancer model.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The application provides a bupropion hydrochloride sustained-release tablet and a preparation method, and belongs to the technical field of pharmacy. The pharmaceutical composition contains 150 parts of bupropion hydrochloride, 122.5-157.5 parts of glycerin monostearate, 17.5-22.5 parts of triethyl citrate, 68-104 parts of microcrystalline cellulose and 2-6 parts of magnesium stearate, wherein the bupropion hydrochloride raw material and the glycerin monostearate and the triethyl citrate are prepared into a solid dispersion through a hot melt extrusion process. The application provides a bupropion hydrochloride sustained-release tablet which is stable in drug release, slow in growth of related substances, does not need to be coated and can be taken and eaten, and a preparation method.

The application discloses a phenylboronic acid-based zwitterionic surfactant and a preparation method and application thereof, wherein the phenylboronic acid group of the phenylboronic acid-based zwitterionic surfactant includes two isomers, i.e. m BDC n AB or p BDC n AB, and alkyl chain lengths are C 10 alkyl, C 12 alkyl and C 14 alkyl, and a total of six surfactants are abbreviated as BDC n AB. BDC n AB is mixed with dodecyl-dimethyl-1,2-dihydroxypropyl ammonium chloride to prepare a mixed micelle, and an asymmetric spacer group with a dynamic covalent bond combined by a borate ester bond is generated in situ under mild conditions of normal temperature and neutral pH, thereby obtaining a pH-responsive dimer surfactant, and the dimer surfactant has a pH response interval consistent with a drug release condition for treating cancer in a human body, and can be used for preparing a drug-loaded micelle for treating cancer in the human body.

The present invention discloses a drug release capsule comprising a housing, a first chamber located within the housing, a second chamber, a drug storage chamber provided within the first chamber, and piping connecting the drug storage chamber to an outlet on the housing. The piping has a control unit, which closes the drug release passage under the influence of the air pressure in the second chamber, and opens the drug release passage when the air pressure in the second chamber decreases and / or when the air pressure in the drug storage chamber increases. This facilitates the control of drug release from the drug release capsule.

The utility model belongs to the technical field of plant disease and insect pest control, and discloses a plant disease and insect pest fixed-point control device which comprises a first half ring and a second half ring, driving plates are fixed to the bottom faces of the first half ring and the second half ring correspondingly, and pesticide containers with the upper ends open are installed on the bottom faces of the multiple driving plates correspondingly; a plurality of drug release holes are formed in the side walls of the drug containers, a connecting rod is fixed to the side wall, close to the second semi-ring, of the first semi-ring, a connecting groove matched with the connecting rod is formed in the side wall, close to the first semi-ring, of the second semi-ring, and a limiting assembly used for limiting the connecting rod is arranged on the second semi-ring. The effect of improving the structural strength of the prevention and treatment device is achieved.

The invention provides a meat preservation method with self-assembled nanoparticles cooperating with a three-layer controlled release film. The method comprises the following steps: S1, selecting fresh meat, removing impurities, cleaning, detecting the muscle fiber density and the total number of initial bacterial colonies, classifying the meat into I / II / III classes according to the standard, and pre-cooling and discharging acid for 18-24 hours under the conditions that the temperature is 0-2 DEG C, the air speed is 0.3-0.5 m / s and the humidity is 85-90%; s2.2, graded loading of dormant-state self-assembled nanoparticles at the temperature of 2-4 DEG C, I-type dip coating, II-type ultrasonic-assisted dip coating, III-type high-pressure atomization spraying and air drying in a blast environment after loading; s3, filling three layers of controlled release films, vacuumizing to-0.095 to-0.09 MPa, keeping for 20 seconds, filling customized controlled atmosphere according to grades, and then performing heat sealing; and S4.0, refrigerating at 0-4 DEG C. By constructing a synergistic mechanism that the self-assembled nano-particle adsorption layer recognizes a decay signal in a close range and the three layers of controlled release films release drugs in a linkage mode and strengthen barrier, the limitation that traditional preservation is passively inhibited and active ingredients are lost quickly is broken through, and the technical problems that bacteriostasis is not lasting, the water-retaining property is poor and sensory quality is prone to deterioration are fundamentally solved; and the fresh-keeping efficiency and the meat quality are both improved.

The invention discloses bacteriostatic gel for gynecology and a preparation method thereof, and relates to the technical field of bacteriostatic gel. The antibacterial gel is prepared from a gel matrix, a plant extracting solution, antibacterial peptide, a humectant, astaxanthin microcapsules and a specific buffer solution. The buffer solution contains sodium citrate, hyaluronic acid and citric acid, and intelligent regulation and control of the drug release behavior of the astaxanthin microcapsule are realized by utilizing the synergistic effect of a hyaluronic acid and citric acid buffer system and preferably adopting hyaluronic acid compounded or modified with different molecular weights. The gel can maintain stable drug release in a normal vagina and pathological fluctuation pH environment, and trigger accelerated release in a high active oxygen inflammation environment, so that the problems that the release behavior is greatly influenced by environmental fluctuation and cannot adapt to different disease stages in the prior art are effectively solved, accurate and personalized drug delivery is realized, and the drug delivery efficiency is improved. The antibacterial agent has the advantages of good antibacterial effect and high environmental adaptability.

The scheme provides a kind of engineered exosome double drug delivery system loaded with ergosterol and its preparation method and application, belongs to the field of nanomaterials and nanobiomedicine, based on the innovative ROS-responsive nanomaterial CHPG design, load the active ingredient ergosterol to play the role of treatment and repair, which realizes the blood-brain barrier penetration and precise drug release in lesion area through targeted functional modification;It is wrapped in the nasal mucosa-derived stem cell exosome to form a drug delivery system Exo@Erg-CHPG-M, which combines the natural biological characteristics of exosome and the precise targeting advantage of nanomicelle, significantly improves the drug delivery efficiency, in vitro and animal model verification show that, the system can improve the neurological impairment and brain tissue injury after ischemic stroke by synergistically regulating inflammation and neural repair pathways, the scheme provides a new technical scheme for the precise treatment of central nervous system diseases such as cerebral stroke.

The invention relates to the technical field of pharmaceutical preparations and biological materials, and discloses a pH-responsive hippophae rhamnoides pectin-based intelligent sustained-release microsphere and a preparation method thereof, the pH-responsive hippophae rhamnoides pectin-based intelligent sustained-release microsphere comprises a wall material and a core material; the wall material is composed of a gel network formed by cross-linking carboxymethylated sea buckthorn pectin through multivalent metal ions; the core material comprises a therapeutic active substance and photothermal conversion nanoparticles, and the photothermal conversion nanoparticles are dispersed in the gel network. According to the pH-responsive hippophae rhamnoides pectin-based intelligent sustained-release microsphere and the preparation method thereof, by virtue of good biocompatibility, biodegradability and inherent biological activity of natural hippophae rhamnoides pectin, the cross-linking ability and pH sensitivity of the hippophae rhamnoides pectin are further optimized after carboxymethylation modification, and the pH-responsive hippophae rhamnoides pectin-based intelligent sustained-release microsphere is matched with polydopamine nanoparticles with excellent drug loading performance and photothermal conversion characteristic; a dual intelligent sustained-release system with pH response and photo-thermal response is constructed, and the problems that a traditional drug carrier is poor in biocompatibility, drug release lacks targeting and controllability and the like are effectively solved.

The invention discloses a modified glutinous rice flour auxiliary material for controllable release medicine tablets and a preparation process of the modified glutinous rice flour auxiliary material, and relates to the technical field of biological medicines.The multifunctional auxiliary material with a specific microstructure and corrosion dynamic characteristics is obtained by taking glutinous rice flour with the amylopectin content larger than or equal to 80% as a raw material and conducting a three-stage process of pretreatment, directional modification and aftertreatment; the tablet has the functions of filling, bonding, disintegrating or skeleton controlled release, and can accurately regulate and control the drug release according to the dosage form demand. The invention aims to solve the problems that the traditional auxiliary material has a single function and is difficult to adapt to the release requirements of multiple types of drugs, realizes the multifunctional integration of the natural auxiliary material and the controllability of the release behavior, and remarkably improves the suitability of the preparation and the process stability.

The invention relates to a riociguat prodrug as shown in a formula X or pharmaceutically acceptable salt thereof, a preparation method, an intermediate and a pharmaceutical composition thereof. The prodrug takes amino of riociguat as a modification site and is connected through an ester carrier, drug release is triggered by utilizing lung amidase, and lung targeted delivery is realized by adjusting a lipid-water partition coefficient. Pharmacokinetic studies show that the prodrug can significantly improve the drug concentration and total exposure of the lung, reduce the blood concentration of the whole body, and show excellent lung targeting characteristics. The invention also provides a pharmaceutical composition (preferably an inhalation preparation) containing the prodrug, and an application of the prodrug in preparation of drugs for preventing, treating, treating or relieving pulmonary arterial hypertension of patients. .

This application belongs to the field of medical devices and relates to an intraoral drug delivery device. The drug delivery device includes a substrate that can be disposed on a tooth crown. The substrate has a drug storage unit. When the substrate is disposed on the tooth crown, the drug storage unit can release drug outwards. Alternatively, the drug delivery device includes an adhesive layer that can adhere to the tooth crown, the adhesive layer containing a drug mixture. By disposing the substrate on the tooth crown and having the drug storage unit disposed therein, the drug can be released, providing therapeutic or nursing effects to the tooth crown, oral cavity, or body.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

This invention discloses a composite nanodelivery system encapsulated in a fusion membrane, its preparation method, and its applications. The nanodelivery system comprises a Ti3C2 / TiO2 / CuInS2 composite material, oxaliplatin loaded thereon, and a fusion membrane encapsulating the outer layer; the fusion membrane is formed by the fusion of Fusobacterium nucleatum extravesicles and M1 macrophage membranes. This invention also discloses a method for preparing the nanodelivery system, including the steps of preparing the Ti3C2 / TiO2 / CuInS2 composite material, preparing the fusion membrane, loading oxaliplatin, and encapsulating it in the fusion membrane. The nanodelivery system prepared by this invention exhibits pH-responsive drug release characteristics, generating H2S in the tumor microenvironment and H2 under light irradiation, while also possessing photocatalytic activity. This invention combines chemotherapy, photoelectrocatalytic therapy, and the regulation of multiple active substances, and can be used to prepare drugs for treating malignant tumors of the digestive system.

The invention discloses a double-response controlled-release hydrogel for promoting wound healing of astaxanthin and an amino small molecule drug as well as a preparation method and application of the hydrogel, and belongs to the field of biomedical materials. The material is composed of a drug-loaded nano-micelle and a self-healing hydrogel network. Hydrophilic modification of astaxanthin and dynamic coupling of the astaxanthin and an amino small molecule drug are achieved through an astaxanthin-polyethylene glycol-benzaldehyde intermediate, and the drug-loaded nano-micelle has the pH response drug release capacity; the hydrogel network is formed by crosslinking phenylboronic acid modified carboxymethyl chitosan and dopamine through dynamic phenylboronic acid ester bonds, and has ROS responsiveness and self-healing characteristics; the multifunctional intelligent wound dressing can intelligently respond to high ROS and acidic pH microenvironment of chronic wounds, controllably release astaxanthin and amino-containing small molecule drugs, synergistically remove ROS, improve cell oxidative stress, inhibit inflammation, promote blood vessel and tissue regeneration and accelerate chronic wound healing, is excellent in self-healing performance and biocompatibility, and is an ideal multifunctional intelligent wound dressing.

The present application provides a drug-loaded microsphere for loading polypeptide drugs, the polypeptide drug delivery drug-loaded microsphere is W1 / O / W2 structure, which is composed of polypeptide drug active substance and hydrophilic gel as the inner water phase (W1), organic solvent of water-insoluble polymer as the oil phase (O), and solution containing emulsifier as the outer water phase (W2). The sustained-release microsphere of the present application introduces hydrophilic temperature-sensitive gel and water-insoluble polymer to co-load drugs, increases the hydrophilicity of the carrier, and reduces the solubility of polypeptide drugs by preparing metal ion-polypeptide drug active substance insoluble complex, thereby controlling the drug release behavior. Compared with the conventional microsphere, the sustained-release microsphere of the present application has the advantages of reducing drug burst release, shortening the drug release platform period, making the overall drug release behavior of the drug tend to zero-order release, releasing more stably, and improving the compliance of the microsphere preparation.

The application belongs to the technical field of medical biomaterials, and particularly relates to an interpenetrating network polymer based on phosphorylcholine polymer and a preparation method and application thereof. The application provides a sequential interpenetrating network method, which comprises the following steps: preparing a monomer infiltration solution containing phosphorylcholine monomer, polyethylene glycol methacrylate, dimethylaminoethyl methacrylate, butyl methacrylate, hydroxyethyl methacrylate, ethylene glycol methacrylate, a crosslinking agent and an initiator; dipping a high-molecular polymer matrix into the monomer infiltration solution, and performing ultrasonic oscillation treatment to promote the infiltration of monomers into the interior of the matrix; and performing a polymerization reaction to obtain a final product after washing; the material prepared by the application has excellent thermal stability, excellent swelling performance, intelligent pH response drug release capacity and biocompatibility, and is suitable for the fields of biological medicine and cosmetics.

The invention discloses a drug-coated prostate balloon dilatation catheter control system, relates to the technical field of medical instruments, and aims to solve the technical problems of uncontrollable drug release, extensive dilatation process and lack of quantitative evaluation in existing drug balloon therapy. The system integrates a high-precision pressure sensing module, a micro piezoelectric pump control module, a man-machine interaction module and a data processing module. The system carries out real-time closed-loop control on the internal pressure of the balloon through a self-adaptive PID algorithm, and precise execution of a preset pressure curve is achieved. The innovation of the method lies in that a drug release quantitative estimation model based on pressure-time integration (AUC) is created for the first time, the model can calculate and display the estimated drug release amount in the treatment process in real time, and physical operation parameters are directly associated with biological effects; the device has the effects of realizing accurate and constant control of the dilatation pressure and improving the operation safety.

The utility model relates to the technical field of medical supplies, in particular to degradable medicine-carrying hemostatic cotton with a double-layer structure, which comprises an internal hemostatic layer and an external functional layer wrapping the hemostatic layer, and the hemostatic layer and the functional layer are respectively formed by freeze-drying same polymer solutions with relatively high mass concentration and relatively low mass concentration. The functional layer is loaded with drugs, the porosity of the hemostatic layer is 60%-80%, and the porosity of the functional layer is 80%-90%. The high-concentration and low-porosity inner hemostatic layer provides mechanical compression force to play a role in rapid hemostasis in the initial stage, the low-concentration and high-porosity outer functional layer can be rapidly degraded, both compression strength and degradation speed are considered and balanced, meanwhile, the outer functional layer is used for loading drugs, and the outer functional layer has the characteristics of high porosity and rapid degradation, so that the effect of rapid hemostasis in the initial stage is achieved. The effect of rapidly releasing the medicine is achieved, it can be ensured that the medicine can be rapidly released to the bleeding part, and wound healing is promoted.

The utility model discloses a kind of human middle hole acupoint patches with double-sided medicine component structure, belong to acupoint patch field, including substrate, the downside of the substrate is provided with medicine release layer, the downside of the medicine release layer is provided with medicine sheet, the upper end of the substrate is provided with first base layer, the upside of the first base layer is glued with covering layer, the upside of the first base layer is provided with first incense piece, the downside of the covering layer is provided with second incense piece;By setting medicine sheet, first incense piece and second incense piece on the upper and lower sides of substrate respectively, so that acupoint patch can be in the meantime in human middle hole, through first incense piece and second incense piece reasonable use the special position of human middle hole, better through human respiration, more fully utilize the comprehensive treatment effect of medicine, aromatic medicine and aromatic essential oil to human body.

The invention relates to an ROS-responsive macrophage-chondrocyte dual-targeting nano-micelle and a preparation method and application thereof, HA capable of targeting and highly expressing CD44 cells is taken as a carrier skeleton, chemical coupling with TK and CUR is carried out in sequence, self-assembly is carried out through intermolecular force to form a stable nano-micelle, and drugs JPH203 and KGN are entrapped at the same time, so that efficient loading and targeting delivery are realized. The HA can be specifically combined with RAW264.7 macrophages and articular cartilage cells for highly expressing a CD44 receptor in an inflammatory state, and is actively delivered in a targeting manner. The ROS response characteristic of TK is utilized, oxidative fracture is carried out in an OA high ROS microenvironment, and micelles are triggered to disintegrate and release drugs accurately. The released JPH203 can inhibit an inflammatory mTOR pathway and effectively resist inflammation, and KGN is beneficial to promoting cartilage cell proliferation and effectively collecting and promoting differentiation of mesenchymal stem cells into cartilage cells, so that in-situ cartilage regeneration is realized, and a more efficient solution with low side effects is provided for osteoarthritis treatment.

The application relates to the field of medical devices, and particularly discloses a drug releasing capsule device based on an external rotating magnetic field, which comprises a capsule shell, a medicine liquid is stored in the capsule shell, a drug releasing hole is arranged in the lateral wall of the capsule shell, and a spiral strip is arranged on the outer lateral wall of the capsule shell; a medicine pushing rod is slidably arranged in the capsule shell, a stop block is fixedly connected to the medicine pushing rod, the stop block slides along the inner lateral wall of the capsule shell and is used for shielding or opening the drug releasing hole; a first magnet is rotatably arranged in the capsule shell and is driven to rotate by the external rotating magnetic field; a cylindrical cam is coaxially fixed to the first magnet and is used for converting the rotating torque of the first magnet into an axial pushing force to push the medicine pushing rod; a spring is arranged in the capsule shell and is used for applying an elastic force opposite to the axial pushing force to the medicine pushing rod; and a second magnet is fixedly arranged in the capsule shell and is used for keeping the capsule shell fixed under the action of an external static magnetic field. The application adopts a non-contact magnetic driving mode and can realize fixed-point drug releasing and multiple quantitative drug releasing.