1359 results about "Drug release" patented technology

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention discloses a zinc polyphenol complex suppository as well as a preparation method and application thereof. The preparation process mainly comprises two steps as follows: a, preparation of EGCG-Zn metal polyphenol complex nanoparticles; and b, preparing the nano complex suppository. The method is simple in process, green, environment-friendly and suitable for large-scale preparation. The prepared EGCG-Zn nanoparticles are uniform in particle size and good in stability, and have good antioxidant, anti-inflammatory and tissue repair activity based on a complex network structure formed by self-assembly of EGCG and zinc ions. The nano-particles are firstly treated by adopting a drug pretreatment carrier and then loaded in a suppository matrix to construct a rectal administration type nano-suppository, so that targeted and continuous local drug effect release can be realized. In intervention of radioactive intestinal injury, the suppository not only can relieve oxidative stress and inflammatory response, but also can promote regeneration and repair of intestinal mucosa, and has good treatment potential and clinical application prospect.

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a preparation method and application of a double-layer sound transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing, and belongs to the technical field of gel dressings. The preparation method comprises the following steps: taking vinyl silicone oil and silicon dioxide as raw materials, preparing upper-layer silica gel by adopting a double-component uniform mixing method, and then laminating the upper-layer silica gel and lower-layer berberine-loaded gelatin microsphere hydrogel by adopting a self-laminating method, thereby obtaining the double-layer sound-transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing. By means of the broad-spectrum antibacterial function of berberine, the efficient drug loading function and slow drug release function of gelatin microspheres, the sound transmission and swelling functions of lower hydrogel and the supporting function of upper hydrogel, ultrasonic inspection is conducted through a dressing covering layer, an ultrasonic scanning supporting plane is provided, ultrasonic waves penetrate through the dressing, good imaging is formed, and the application prospect is wide. And antibacterial and repairing effects on local wounds are realized at the same time.

The invention discloses a dual-mode response type postoperative infection early-warning intelligent dressing and a preparation method thereof, which are urgent for a novel postoperative dressing with precise infection monitoring, intelligent drug release, excellent material performance, reliable intelligent remote management and low-cost mass production potential. The invention aims at solving the problems of the existing dressing in all directions through an innovative technical scheme. According to the dual-mode response type postoperative infection early-warning intelligent dressing and the preparation method thereof, infection signals are accurately captured, intervention is performed in advance, through cooperative monitoring of the pH sensor (the detection error is + / -0.1) and the temperature sensor (the precision is + / -0.1 DEG C), compared with a traditional single-mode dressing, infection symptoms (for example, the pH is larger than 7.5, and the temperature is larger than 37.5 DEG C) are found 12-48 hours earlier, the infection early-warning accuracy rate is increased to 95% or above, and the application range is wide. The self-calibration technology has the advantages that background interference of double emission silicon points (427nm / 500nm fluorescence peaks) is eliminated through the fluorescence intensity ratio, errors of single-wavelength detection are avoided, and the method is suitable for a complex wound environment.

The invention provides bioactive conductive hydrogel as well as preparation and application thereof. The hydrogel comprises a dynamic non-covalent cross-linked network which is composed of natural macromolecules and at least comprises a reversible and environment-responsive cross-linking mode; the responsive conductive component is connected with the dynamic non-covalent cross-linked network through a covalent bond or a coordinate bond, the electrical property of the responsive conductive component changes along with the change of the wound surface microenvironment, and electrical signal feedback of the wound surface state is provided through the change of the electrical property; and the active substance is connected to the dynamic non-covalent cross-linked network through a responsive chemical bond, and the responsive chemical bond is broken under specific conditions of a wound surface microenvironment to release the active substance. Compared with the prior art, the integrated design of active oxygen monitoring and drug release is realized for the first time, the wound healing time (about 30-40%) can be remarkably shortened, the complication risk is reduced, and an innovative solution is provided for wound management in an intelligent medical mode.

The invention relates to a Cu2-xSe-Pt nano material, a microneedle patch, a preparation method and application. The Cu < 2-x > Se (at) Pt nano material is composed of a Cu < 2-x > Se nanosphere and platinum modified on the surface of the Cu < 2-x > Se nanosphere in situ. The invention provides a preparation method of a Cu2-xSe-Pt nano-material, which comprises the following steps: adding PSS, SeO2 and AA into water, heating and stirring, adding copper salt and AA, reacting, and adding water and a hexachloroplatinic acid solution to obtain the Cu2-xSe-Pt nano-material. The invention provides an application of a Cu < 2-x > Se (at) Pt nano material. The invention also provides a microneedle patch as well as a preparation method and application thereof. The invention provides a novel material for resisting multi-drug-resistant bacteria, which solves the problems that the existing single antibacterial strategy is limited and the expected curative effect cannot be achieved, also solves the problem of cytotoxicity of the existing nano enzyme, realizes deep drug delivery, ensures efficient local drug release and avoids systemic toxicity.

The invention discloses a non-invasive intestinal flora fixed-point sampling and drug release device, and belongs to the technical field of micro-ecological diagnosis and treatment. The device comprises a shell, an internal storage bin, a medicine loading cavity and a channel switching mechanism. The shell adopts a capsule-shaped design, and an enteric coating is arranged on the surface of the shell, so that the function is started after the shell reaches a specified position of an intestinal tract. Through the internal ingenious mechanism linkage design, the device can firstly complete non-invasive fixed-point sampling of intestinal contents, and after the sampling action is completed, a drug release mechanism is automatically triggered, so that accurate drug delivery of the same part is realized. Cooperative operation of sampling and drug release in time sequence and space is achieved, and the problems of pain, disjunction of the diagnosis and treatment process, poor drug targeting and the like caused by traditional invasive operation are effectively solved. The device is flexible in structural design, has the advantages of being noninvasive, efficient, accurate in time sequence control and the like, and is suitable for integrated application of diagnosis and treatment of various digestive tract diseases such as inflammatory bowel disease management, micro-ecological regulation and the like.

The invention belongs to the technical field of drug delivery systems, and discloses a two-dimensional vermiculite-based drug delivery system and a preparation method and application thereof. The preparation method comprises the following steps: carrying out ion exchange on expanded vermiculite, NaCl and LiCl, stripping by using a mechanical stripping sheet, centrifuging to obtain a two-dimensional vermiculite nanosheet dispersion liquid, dispersing a drug in the two-dimensional vermiculite nanosheet dispersion liquid, and forming a film to obtain the two-dimensional vermiculite-based drug delivery unit. The drug is synergistically loaded between layers and on the surface of the vermiculite; rich hydroxyl groups and interlayer cations on the end surface of the vermiculite interact with the drug, so that the drug release time is relatively long; the vermiculite-based drug delivery system can realize gradient order release of drugs according to a sequence from the surface to the interlayer through pH response of an affected part. Meanwhile, the vermiculite-based drug delivery system provides an antibacterial effect through enzyme-like catalytic activity, and avoids the problems of abuse of antibiotics and drug resistance.

The invention provides conductive dual-network hydrogel carrying MOF (Metal Organic Framework) as well as a preparation method and application of the conductive dual-network hydrogel, and belongs to the technical field of hydrogel preparation. The preparation method comprises the following steps: preparing a hydrogel substrate from a neutral polymer monomer, a polyelectrolyte monomer, an MOF material and a conductive material, putting the hydrogel substrate into a growth solution of the MOF material and a mixed solution of an anti-inflammatory drug, and promoting uniform generation of an MOF nanosheet film on the surface of the hydrogel substrate and carrying of the drug under high-temperature and high-pressure conditions. And thus, the conductive dual-network hydrogel carrying the MOF is prepared. The double-network hydrogel prepared in the invention has excellent mechanical properties, conductivity and antibacterial properties, and can realize controllable and accurate drug release.

The invention discloses a drug targeted delivery device and method, and belongs to the technical field of intelligent medical treatment. The device comprises the following modules: an intelligent targeted recognition module for accurately recognizing a gastric cancer specific molecular marker and improving the selectivity and specificity of targeted recognition in combination with a dynamic surface modification strategy; the microenvironment real-time monitoring module is used for monitoring key physiological parameters of the gastric cancer microenvironment in real time; the intelligent path planning module is used for dynamically calculating and optimizing a drug delivery path and realizing accurate drug positioning; the personalized drug administration regulation and control module is used for accurately predicting the drug dosage demand of an individual and dynamically and finely adjusting the drug administration amount in real time; the drug resistance risk management module is used for early warning a drug resistance risk in advance and automatically generating a personalized alternative drug administration strategy through multi-dimensional drug resistance analysis and real-time early warning; and the intelligent drug release module adopts a temperature-sensitive / pH-sensitive polymer shell layer and a nano valve to control drug release, so that precise gradient release of drug concentration is realized.

The invention discloses an anti-tumor drug delivery system based on click chemistry and a hollow covalent organic framework material as well as a preparation method and application of the anti-tumor drug delivery system, and belongs to the technical field of novel biomedical materials. The anti-tumor drug delivery system based on the click chemistry and the hollow covalent organic framework material comprises a bowl-shaped hollow covalent organic framework material carrier, and a click chemistry prodrug 1 and a click chemistry prodrug 2 which are loaded in the bowl-shaped hollow covalent organic framework material carrier, the click chemistry prodrug 1 is a compound containing an aldehyde group, and the click chemistry prodrug 2 is a compound containing an amino group. By combining the high-specificity reaction of click chemistry with the excellent drug loading performance of HCOF, accurate drug release can be realized in a tumor-specific microenvironment, the toxicity of normal cells can be remarkably reduced, the treatment effect is improved, and a wide clinical application prospect is shown.

The invention belongs to the technical field of biomedical materials, and relates to a composite dressing with sequential response and functional synergy as well as preparation and application thereof, the composite dressing is of a double-layer composite structure, and comprises a PVA-GOx-MnO2 hydrogel layer and a temperature-sensitive micro-nanofiber membrane layer; the PVA-GOx-MnO2 hydrogel precursor solution is prepared by adding glucose oxidase and MnO2 nano particles into a polyvinyl alcohol solution under the condition of ice bath, and the PVA-GOx-MnO2 hydrogel precursor solution is prepared by adding glucose oxidase and MnO2 nano particles into the polyvinyl alcohol solution; the preparation method comprises the following steps: placing the temperature-sensitive micro-nano fiber membrane on a PVA-GOx-MnO2 hydrogel precursor solution or immersing the temperature-sensitive micro-nano fiber membrane in the PVA-GOx-MnO2 hydrogel precursor solution, carrying out crosslinking treatment, and demolding to obtain the composite dressing. The application is as follows: the material is used as a diabetic chronic wound repair material. The problems that an existing diabetes wound dressing is weak in microenvironment regulation and control capacity and the drug release time is not matched are solved; the preparation method is simple; the healing efficiency and the treatment safety of diabetic wounds are remarkably improved during application.

The embodiment of the invention provides a melanoma postoperative wound intelligent dressing, and belongs to the technical field of intelligent medical treatment. The intelligent dressing for the wound after the melanoma operation comprises a multiple monitoring module, an intelligent processing module and an on-demand drug delivery module which are arranged on a dressing base body, the multiple monitoring module is used for acquiring biological signals of a wound surface microenvironment in real time; and the intelligent processing unit analyzes the biological signal to generate a wound state judgment result, and controls the on-demand drug delivery module to trigger electrical stimulation or thermal stimulation based on the wound state judgment result so as to realize on-demand drug release. According to the scheme, the deep learning intelligent early warning model fusing the generative adversarial network and the Transform structure is constructed, high-precision analysis and dynamic risk judgment of melanoma postoperative wound multi-dimensional time sequence data are achieved, and the accuracy and stability of wound state recognition are effectively improved.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention relates to the technical field of biology, in particular to silymarin inclusion compound lipidosome and a preparation method and application thereof. The silymarin inclusion compound liposome is prepared from the following components in parts by weight: 10 to 48 parts of silymarin, 10 to 53 parts of phospholipid, 5 to 10 parts of Arabic gum and 25 to 70 parts of cyclodextrin. According to the invention, cyclodextrin and phospholipid are combined to form a double-drug-loading structure; on the basis, Arabic gum is used as a film-forming agent to form a protective film on the surface of the liposome, so that the stability of the system is further improved; the silymarin inclusion compound is encapsulated in a water phase in the liposome, and meanwhile, part of free silymarin is encapsulated in a lipid bilayer. According to the structure, the solubility and the encapsulation efficiency of the silymarin are remarkably improved, the liposome stability is enhanced, the drug release is effectively controlled, and the silymarin inclusion compound lipid is simple in preparation process and suitable for industrial production.

The invention provides preparation of ROS responsive lipidosome and application of the ROS responsive lipidosome in anti-pancreatic cancer drugs, and belongs to the technical field of ROS responsive lipidosome preparation. The liposome can synergistically deliver formononetin and salvianolic acid B, overcomes the defects of formononetin and salvianolic acid B in the aspects of solubility, stability and bioavailability, and improves the curative effect of formononetin and salvianolic acid B in pancreatic cancer treatment. The ROS-responsive formononetin liposome and the salvianolic acid B liposome are wrapped by the cell-derived nano-vesicles through co-extrusion with the nano-vesicles on the outer layer, so that the ROS-responsive liposome is prepared. The liposome can be used for preparing anti-pancreatic cancer drugs, realizes targeted treatment of pancreatic cancer, inhibition of pancreatic cancer cell proliferation, promotion of pancreatic cancer cell apoptosis and improvement of pancreatic cancer tumor microenvironment energy metabolism disorder, and has the advantages of high biological safety, controllable drug release and the like.

The invention discloses an ultralow-viscosity water-in-oil vaccine adjuvant and a preparation method thereof, and the ultralow-viscosity water-in-oil vaccine adjuvant comprises the following components in percentage by weight: 73%-75% of oil for injection, 20%-23% of a compound emulsifier, 2%-7% of a stabilizer, 0.5%-1.5% of a chiral immunomodulator and 1%-2% of a temperature-responsive material, the preparation method comprises the following steps: heating oil for injection as an oil phase; adding the compound emulsifier, the stabilizer, the chiral immunomodulator and the temperature response type material into the oil phase, stirring until the materials are completely dissolved to form a uniform oil phase mixture, slowly adding the water phase into the oil phase mixture, performing high-speed shearing to form primary emulsion, homogenizing the primary emulsion, and performing freeze drying to obtain the chiral immunomodulator. And carrying out emulsion refining by adopting a micro-fluidic technology to obtain the ultralow-viscosity water-in-oil type vaccine adjuvant. The ultra-low viscosity and injection comfort are achieved, precise immunization is achieved for different pathogens, multiple immune pathways are activated at the same time, a wide and lasting protection effect is generated by training an immune mechanism, and the ultra-low viscosity and injection comfort have the intelligent drug release characteristic, excellent stability and broad-spectrum applicability.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

The invention relates to a preparation method and application of dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody, and belongs to the technical field of tumors. According to the invention, the dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody is prepared, and the hydrogel is constructed on the basis of dynamic crosslinking of phenylboronic acid modified hyaluronic acid (HA-PBA) and tannic acid (TA) through a borate bond, and has excellent tissue adhesion and programmed drug release characteristics.

The present invention discloses a light-responsive Pickering emulsion that is synergistically stabilized by a spiropyran ionic liquid and UiO-66-NH2. The Pickering emulsion comprises an oil-water phase, and its stabilizer is a spiropyran ionic liquid and a metal-organic framework material UiO-66-NH2. The stable Pickering emulsion can undergo demulsification under additional visible light irradiation. When further irradiated with ultraviolet light, the system can be re-emulsified to form a stable Pickering emulsion. The Pickering emulsion provided by the present invention can be used for the Click reaction of hydrophilic azide compounds and terminal alkynyl compounds. Through reversible visible light and ultraviolet light regulation, the catalyst and spiropyran ionic liquid can be recycled, and the Pickering emulsion has application value in the fields of controlled drug release and sustainable catalysis.

The invention discloses a balloon catheter pressure applying device for thrombus treatment and vascular embolism, and relates to the technical field of medical instruments, the balloon catheter pressure applying device comprises a first catheter, the first catheter is sleeved with a second catheter, the front end of the second catheter is fixedly connected with a memory metal net bag, the second catheter is sleeved with a third catheter, and the third catheter is fixedly connected with a memory metal net bag. A fourth catheter is fixedly connected to the outer side of the third catheter, a rear balloon is fixedly connected to the outer side of the front end of the air delivery pipe, an exhaust head is fixedly connected to the front end of the first catheter, a front balloon is fixedly connected to the outer side of the exhaust head, and a thrombus removing assembly used for assisting in removing thrombus is arranged on the outer side of the front end of the first catheter. According to the thrombus treatment vascular embolism balloon catheter, the thrombus dissolving medicine in the medicine storage balloon membrane is squeezed out through the pressure applying device, the thrombus dissolving medicine can penetrate through the memory metal net bag to move to the embolism position, thrombus is dissolved, and the thrombus can be better removed through cooperation with the thrombus removing assembly.

The invention discloses a magnetic control soft robot with electrical stimulation and drug release functions, and relates to the technical field of medical instruments. In the magnetic control soft robot provided by the invention, the magnetic layer is used for driving the body to move and position in the gastrointestinal tract under the driving of an external magnetic field; the electric control layer is used for supplying power and is responsible for controlling the opportunity and parameters of electric stimulation and controlling a drug release instruction; after a microneedle of the conductive hydrogel microneedle layer penetrates into tissue, nerve endings or muscle cells can be stimulated by applying a weak electric signal so as to regulate gastrointestinal motility, relieve pain and the like, a drug can be loaded in the microneedle, and when the electric signal is applied, the drug can be loaded in the microneedle by means of electromigration, electroosmosis and the like. Triggering the drug to be controllably released into the target tissue as required; the adhesive layer is used for temporarily anchoring the robot at a specific working position of the gastrointestinal tract; according to the magnetic control soft robot and the preparation method thereof, the comprehensive requirements of gastrointestinal tract disease treatment can be met.

The invention relates to the technical field of biological medicine nano-drug delivery, in particular to a nano-drug delivery system based on a metal polyphenol network, and solves the problems that an existing MPN nano-drug delivery system is low in drug loading capacity, obvious in burst release, poor in stability, single in response and lack of targeting capacity. The system comprises a nanoparticle core formed by self-assembly of metal ions and polyphenol compounds, the surface of the nanoparticle core is coated with a biocompatible polymer shell, a hydrophobic drug is loaded inside the nanoparticle core, the particle size of the nanoparticle core is 50-300 nanometers, the nanoparticle core has pH responsiveness and a dynamic reversible coordination structure, and an organic solvent is not needed in the preparation process. The drug loading efficiency is remarkably improved, burst release is inhibited, the in-vivo stability is enhanced, tumor microenvironment responsive drug release is achieved, the circulation time is prolonged through the polymer shell, tumor accumulation is improved, and a safe and controllable delivery platform is provided for precise and efficient treatment.

The invention relates to the technical field of dental intelligent adjuvant therapy, and discloses an adjuvant therapy system and method for difficult-to-inverse suppurative periapical periodontitis, and the system comprises a multi-modal image fusion module which fuses CT / OCT images to generate a three-dimensional diagram, segments an infected region through a lightweight CNN, and outputs a probability diagram; the reinforcement learning debridement navigation module is used for optimizing the dentin injury risk by combining a biological membrane thickness dynamic planning path on the basis of a DDPG algorithm; the intelligent medicine control module is used for positioning a catheter according to an infection map, triggering medicine release by a pH / enzyme sensor and adjusting delivery pressure by PID; the biosensor monitoring module is used for detecting inflammatory factors, predicting the recurrence risk through LSTM, and triggering image rescanning and path updating when a threshold value is exceeded. Through multi-modal image fusion, reinforcement learning dynamic debridement navigation, microenvironment response type drug control and time sequence prediction closed-loop feedback, accurate elimination and relapse active inhibition of periapical periodontitis focuses are realized.

The invention provides a nano-drug delivery system for treating fatty liver based on liposome, exosome and metal organic framework synergistic targeting and a preparation method of the nano-drug delivery system, and relates to the technical field of novel nano-material preparation, the nano-drug delivery system comprises liposome, mesenchymal stem cell exosome and metal organic framework nanoparticles; the liposome is used as a carrier and entraps the metal organic framework nano-particles, the mesenchymal stem cell exosome and the miR-204-3p which have a slow release characteristic. By integrating the advantages of the liposome, the exosome and the metal organic framework, the synergistic treatment of the MASLD is realized. According to the system, lipidosome is adopted as an intelligent carrier, MOF nanoparticles and mesenchymal stem cell exosomes with slow release characteristics are entrapped, and therapeutic miR-204-3p is loaded at the same time. The MOF material has functions of drug controlled release and active oxygen removal, and synergistically exerts anti-oxidation, anti-inflammatory and anti-fibrosis effects with the exosome and miRNA. The system has a pH response characteristic, and can intelligently release drugs in an acidic microenvironment of an MASLD focus to realize targeted treatment of the liver.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.