13results about How to "Prevent restenosis" patented technology

The invention relates to the technical field of medical instruments, and discloses a carotid artery micro-net woven stent. The stent comprises a stent main body divided into a stent middle part and a stent end part, the stent main body comprises a first stent, a second stent and a plurality of connecting structures, and the first stent and the second stent are both in a hollow pipe shape and are connected with each other through the connecting structures; the first support and the second support are connected at multiple positions through a plurality of connecting structures, so that movement of the first support and the second support can be limited, and the connecting structures comprise the first connecting structure and the second connecting structure. The two different connecting structures are arranged on the stent body, so that the requirement for different slippage degrees of the ends and the middle is met, layers of the intravascular stent are attached during use, the structural integrity of the stent is kept, the stent is tightly attached to a blood vessel, and good supporting and effective covering are achieved.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent. According to the specific technical scheme, the intravascular stent comprises a stent skeleton, after the stent skeleton is subjected to surface treatment, at least one layer of film covering section is arranged outside the stent skeleton, and medicine release sections are arranged at the two ends of the stent skeleton. The problems that in the drug release process of an existing stent, the drug release rate is uneven, biocompatibility is poor, and thrombus and restenosis are caused by a metal stent are solved.

The invention discloses a covered stent, which relates to the technical field of interventional medical instruments and comprises a covered stent section and bare stent sections connected to two axial ends of the covered stent section. The covered stent section comprises a stent main body in a pipe network shape and a tubular covering film covering the surface of the stent main body; the bare stent section comprises a bare stent connected to the axial end part of the covered stent section; the bare stent is formed by weaving a first metal wire in a spiral spring shape, and the stent main body is formed by weaving a second metal wire in a spiral spring shape; and the bare stent is loaded with an anti-hyperplasia drug. The bare stents are arranged at the two ends of the covered stent section, the anti-hyperplasia medicine is loaded on the bare stents, the bare stents are formed by weaving the first metal wires in the spiral spring shape, the bare stents can better conform to the inner cavity of a blood vessel, stimulation to the blood vessel is reduced, and therefore hyperplasia of smooth muscle cells of the blood vessel is reduced; the anti-hyperplasia drug can inhibit hyperplasia of vascular smooth muscle cells, and finally the situation that the two ends of the covered stent are narrow is prevented or reduced.

The invention discloses a preparation method and application of gel bio-ink for 3D printing of a small-diameter artificial blood vessel. The preparation method comprises the following steps: providing methylacryloylated recombinant collagen; providing methacrylated hyaluronic acid; the gel bio-ink for preparing the 3D printing small-diameter artificial blood vessel is obtained by taking methylacryloylated recombinant collagen and methylacryloylated hyaluronic acid as raw materials. The gel bio-ink has a strong photocuring characteristic and has a shear thinning characteristic required by bio-printing, an artificial blood vessel stent with the diameter of 6 mm and the height of 1 cm can be successfully prepared through a photocuring 3D printing technology, and the artificial blood vessel stent meets the size requirement of small-diameter blood vessels. An intravascular stent printed by using the gel bio-ink has the advantages of good blood compatibility, effective promotion of rapid endothelialization of the stent, prevention of vascular restenosis and the like, is a potential candidate of a small-caliber blood vessel substitute in the future, and has a wide application prospect in the artificial blood vessel market.

The utility model belongs to the technical field of medical instruments, and discloses a ureteral stent. The ureteral stent comprises a metal framework, the metal framework is of a spiral spring structure, an elastic thin film is partially or completely attached to the inner side and / or the outer side of the metal framework, the thin film is formed by covering a film when the spiral spring structure is pulled open to generate a gap, and when the spiral spring structure is released and restored to a natural state, the elastic thin film is attached to the metal framework. The thin film is extruded by the rebounded spiral spring structure, and the thin film and the metal framework are encircled to form an impermeable tube cavity. Due to the fact that the elastic thin film is attached to the inner side and / or the outer side of the metal framework, when the metal framework is stretched or compressed, complete impermeability can be kept, no gap is generated at the bending gap of the ureteral stent, ureteral wall tissue proliferative ingrowth is avoided, restenosis of the ureter is effectively avoided, and the ureteral stent has the advantages of being simple in structure and convenient to use. The clinical experience of the patient is greatly improved, and the pain is relieved.

The utility model discloses a medicine support which comprises a support body, the support body comprises a plurality of supporting frames, and every two adjacent supporting frames are connected with each other. A first open groove and a plurality of second open grooves are formed in the outer wall of the supporting frame, the supporting frame is divided into a plurality of independent areas by the first open groove and the second open grooves, and a plurality of micropores are formed in each area; the first open groove and the second open groove are filled with anti-inflammatory drugs; the micropores are filled with an anti-atherosclerosis medicine; an anti-proliferation drug is sprayed on the outer wall of the stent body, and the anti-proliferation drug covers the anti-atherosclerosis drug and the anti-inflammatory drug. Therefore, the pathological process can be accurately matched, different drugs are made to act on different time periods after the PCI operation respectively, different effects are achieved according to the pathological characteristics of the different time periods, short-term stent restenosis is prevented, and long-term stent restenosis can be effectively prevented.

The invention discloses a thoracic vertebra vertebral plate reconstruction system and an application method thereof.The thoracic vertebra vertebral plate reconstruction system comprises an arch bridge type artificial vertebral plate and fixing screws, the arch bridge type artificial vertebral plate comprises an arc-shaped body, two fixing plates and anti-skid teeth, and the two fixing plates are arranged at the two ends of the arc-shaped body respectively; the anti-skid teeth are arranged at the joint of the fixed plate and the arc-shaped main body, and are arranged on one side far away from the arc shape; a mounting hole is formed in the middle of the fixing plate, and the fixing screw is matched with the fixing plate. According to the thoracic vertebra vertebral plate reconstruction system and the application method thereof, the artificial vertebral plate reconstruction system is simple in structure, convenient to install and beneficial to thoracic vertebra bone tissue growth.

The invention discloses a covered stent, and relates to the technical field of interventional medical instruments, the covered stent is in a hollow tube shape, the covered stent comprises a covered stent section, the covered stent section comprises a stent, an outer covering film covering the outer surface of the stent, and an inner covering film covering the inner surface of the stent; an anti-hyperplasia drug is arranged on the stent, the outer covering film comprises one or more layers of porous films, the inner covering film comprises one or more layers of porous films, and the outer covering film and the inner covering film are suitable for delaying the release speed of the anti-hyperplasia drug on the stent. The anti-hyperplasia medicine is arranged on the stent body of the covered stent and in the area between the inner covering film and the outer covering film, and the inner covering film and the outer covering film have a certain blocking effect on medicine diffusion, so that the anti-hyperplasia medicine can be slowly released, and restenosis of blood vessels at the covered stent can be prevented.

The invention discloses a rolling scoring balloon, which relates to the technical field of medical devices, and includes a catheter and a balloon connected to the distal end of the catheter; the balloon is suitable for contraction and expansion, a guide rail is arranged on the outer wall of the balloon, a drug loading groove suitable for placing drugs is arranged in the guide rail, a scoring piece connected to the guide rail in a rolling manner is arranged on the guide rail, and a groove is arranged on the scoring piece. In this arrangement, drugs are placed in the guide rail, and delivered to the location of the diseased tissue in the state of balloon contraction, and the balloon is expanded after reaching the location of the diseased tissue, so that the scoring piece contacts the location of the diseased tissue, and the scoring piece is close to the location of the diseased tissue for rolling cutting, when the scoring piece rolls to make the groove located in the guide rail, the groove can be filled with drugs, the scoring piece continues to roll, the groove filled with drugs rotates and brings the drugs to the location of the diseased tissue, and extends into the cutting position to reach the middle membrane, so that the drugs of the existing scoring balloons are delivered to the diseased tissue deeper, and the treatment effect is better.

The invention relates to the technical field of medical apparatus and instruments, and provides a film-covered drug-loaded stent and a preparation method of the film-covered drug-loaded stent. The inner membrane is strip-shaped, and the outer side of the inner membrane is spirally attached to the inner wall of the stent body; the medicine carrying film is in a strip shape, is arranged on the outer side of the stent body corresponding to the inner film, and is attached to the outer side of the stent body and the inner film; the outer membrane is arranged on the outermost side of the stent, covers the stent body and the medicine carrying membrane and is attached to the part, not attached to the medicine carrying membrane, of the inner membrane, the outer membrane comprises a first area and a second area, the first area comprises the part corresponding to the inner membrane, and the second area comprises the part corresponding to the spiral gap of the inner membrane; the total endothelialization cycle of the second area, the stent body part corresponding to the second area and the inner side of the inner membrane is smaller than the degradation cycle of the first area and smaller than the degradation cycle of the inner membrane. The drug-loaded membrane is wrapped in the inner membrane and the outer membrane, and the outer membrane is divided into different areas, so that rapid endothelialization of the stent is realized, and excessive cell proliferation is avoided.

A balloon catheter system includes a catheter, a buffer tube, and a balloon assembly with enhanced cutting effect, wherein the balloon assembly includes a balloon and a metal mesh wrapped around the outside of the balloon, wherein the metal mesh includes a connecting proximal end, a connecting distal end, and an action segment connected therebetween, wherein the connecting distal end is connected to the distal end of the balloon, wherein a plurality of auxiliary cutting elements are dispersedly arranged on the action segment, wherein the catheter passes through the buffer tube and is connected to the proximal end of the balloon, wherein the proximal end of the buffer tube is connected to the outside of the catheter, and the distal end of the buffer tube is connected to the connecting proximal end. The present invention can accurately locate in a blood vessel, can provide an expansion force far greater than that of a traditional structure, can effectively expand even a highly calcified lesion, improves drug utilization, reduces vascular damage, and reduces restenosis rate, and is worthy of promotion and use in this field.

The invention discloses a polyester / silk composite vascular stent coating with a bionic interface and a preparation method thereof, comprising the following steps: (1) spinning silk nanofibers on the surface of a core rod by electrospinning technology, and then quickly dipping them in a modified silk fibroin mixed solution mixed with a flexible cross-linking agent, and then rotating and drying and repeating this step several times to form an inner layer of the vascular stent coating; (2) weaving a polyester tubular fabric on the basis of the inner layer of the stent coating by weaving technology to form a core layer of the vascular stent coating; (3) dipping the core layer of the stent coating in a modified silk fibroin mixed solution mixed with a flexible cross-linking agent, rotating and drying and repeating this step several times to form a vascular stent coating with layers of tight connection, and finally immersing the nanofibers in deionized water to dissolve the nanofibers to form a coating inner surface with a tightly connected flat island-shaped microscopic morphology, thereby obtaining a polyester / silk composite vascular stent coating with a bionic vascular endothelial interface that can quickly induce endothelialization.

This invention relates to the field of medical device manufacturing technology, and in particular to a method for preparing a composite material stent and the stent made therefrom. The method includes the following steps: Step S1, preparation of magnesium alloy tubing and initial processing of the skeleton; Step S2, surface pretreatment of the skeleton; Step S3, construction of an intermediate bonding layer; Step S4, coating with a PLLA outer layer; Step S5, molding and post-processing; Step S6, final inspection and sterilization. This invention achieves synergistically enhanced mechanical properties. The magnesium alloy core provides strong initial support, while the PLLA outer layer provides supplementary support. It also exhibits controllable degradation performance; the PLLA outer layer effectively delays the corrosion of the magnesium alloy by chloride ions and other substances in body fluids, extending the support time. The PLLA outer layer isolates the magnesium alloy from direct contact with blood, further reducing the risk of thrombosis. The specially designed intermediate bonding layer structure ensures the structural integrity of the stent during its service life.