63 results about "Thrombosis prevention" patented technology

Provided are an siRNA which inhibits plasma coagulation factor XI gene expression, a pharmaceutical composition containing the siRNA, a conjugate, a reagent kit, and a use of the siRNA, the pharmaceutical composition thereof and the conjugate in preparing a drug used for treating and / or preventing thrombotic diseases and ischemic strokes.

The utility model discloses a special thrombus-preventing massager for PICC (peripherally inserted central catheter) puncture, which comprises a mounting block, a binding piece is arranged on one side of the mounting block, a groove is formed in one side of the mounting block, a plurality of slots penetrating through the mounting block are formed in the groove, a rotating column is mounted in the slots in a penetrating manner, and the rotating column penetrates through the mounting block. Rolling massage pieces are arranged at the lower ends of the rotating columns, inclined limiting grooves are formed in the inner sides of the inserting grooves, the inclined limiting grooves are spiral along the inner walls of the inserting grooves, limiting rods are fixedly installed on the outer sides of the rotating columns, the number of the limiting rods is the same as that of the inclined limiting grooves in one inserting groove, and the limiting rods penetrate through the inclined limiting grooves; and a lifting plate is mounted on the top surfaces of the plurality of rotating columns. The lifting plate and the rotating column are controlled to reciprocate, and when the rotating column reciprocates, the limiting rod is limited by the inclined limiting groove and can drive the rotating column to rotate, so that the rolling friction piece has the massage effect of pressing and rolling.

The embodiment of the invention provides a pulse control system and device of a ventricular catheter pump, and relates to the technical field of artificial hearts. When controlling the ventricular catheter pump, the pulse control equipment executes the following pulse control method: applying a pulse control signal to a driving assembly of the ventricular catheter pump, wherein the pulse control signal is a periodic pulse signal containing a pulse rotating speed; and according to the pulse control signal, the driving assembly is controlled to alternately operate according to a set operation rotating speed and a pulse rotating speed, so that the ventricular catheter pump generates periodic pulse jitter. By applying the scheme provided by the embodiment, thrombosis is effectively prevented, and the operation safety of the ventricular catheter pump is improved.

The present invention discloses an auxiliary support device for patients with lower limb thrombosis, which relates to the technical field of medical rehabilitation equipment, including lower limb sleeves and foot sleeves, wherein two lower limb sleeves and two foot sleeves are provided, and a sanitary isolation replacement component for keeping the auxiliary lower limb clean is installed on the lower limb sleeve, and a blowing activity auxiliary component for heat dissipation and auxiliary joint movement is installed on the outer surface of the lower limb sleeve. The auxiliary support device for patients with lower limb thrombosis replaces the isolation cotton roll under the action of the rotation and reeling of the reeling shaft, thereby ensuring that the patient's lower limb sleeve remains in a better clean state when the patient uses it next time, avoiding bacterial infection after the patient wears the unsanitary lower limb sleeve, and exercising the patient's foot joints by reminding the patient's feet to perform an upward lifting action. Lifting the feet upward can exercise the calf muscles, including the gastrocnemius muscle and the tibialis anterior muscle, and can also help promote blood circulation in the lower limbs, which helps to reduce lower limb edema and prevent the risk of thrombosis.

A DVT prevention and / or mitigation device includes a wearable band having an inflatable bladder with an inflatable portion. When the wearable band is disposed about a user's leg, a majority of the inflatable portion of the inflatable bladder is positionable between the user's knee and a midpoint of the user's gastrocnemius muscle. The inflatable bladder is also inflatable to apply pressure to a portion of the user's gastrocnemius muscle, and a source of compressed air is coupled to the wearable band to deliver continuous compression cycles to the inflatable bladder at a frequency of at least 3 cycles per minute, each compression cycle having a compression period and a peak inflation pressure to induce cyclic flow in the user's venous valve sinuses from each successive inflation.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from aspirin, atorvastatin, valsartan, hydrochlorothiazide, folic acid substances and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has the advantages that the pharmaceutical composition provided by the invention has a multi-target synergistic prevention effect on vascular diseases, especially cerebral embolism, that is, the composition not only can reduce blood pressure, blood fat and blood homocysteine level, but also has an effect of preventing thrombosis, and reduces the risk of cerebral apoplexy. In addition, the form of the pharmaceutical composition is beneficial to improving the medication compliance of patients.

Disclosed relates to novel Pyrimidine annulated derivatives of Formula (I) and the preparation methods of these compounds, and to their use as P2Y12 receptor antagonists in the treatment and / or prevention of thrombosis or related disorders.

The invention relates to the technical field of thrombus resistance instruments, in particular to an electric adjustable ultrasonic developing thrombus resistance instrument. In order to solve the problems that venous thromboembolism occurs frequently after a surgical operation, existing prevention means have defects, and the clinical requirements for reducing the occurrence rate and the death rate are difficult to meet, the following technical scheme is provided that the venous thromboembolism prevention device comprises a bearing table, the bearing table comprises a head plate, and a fixing plate is hinged to one side of the head plate; a sliding plate is arranged below the fixed plate in a sliding mode, and a foot plate is hinged to the side, away from the fixed plate, of the sliding plate; the fixed frame is arranged below the bearing table and is used for supporting; and the adjusting mechanism is mounted on the fixed frame and is used for adjusting the distance between the head plate and the foot plate. The device can effectively adapt to different patients and flexibly adjust the body position, and thrombus prevention and monitoring are integrated, so that the occurrence rate and death rate of venous thrombus are reduced, and the pain and risk of the patients are reduced.

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more compounds of Formula I compounds, and methods for using the compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Methods of inhibiting platelet activation and aggregation using peptide vaccines having binding specificity for the α subunit of the (Na++K+)-ATPase are provided, along with methods for inhibiting or preventing or treating thrombosis without causing bleeding.

The invention provides a radial artery compressor for critical patients in the department of cardiology, and belongs to the technical field of medical instruments. Comprising a fixing plate, and a bandage is arranged on the outer side of the fixing plate; the device further comprises a pressing assembly, the pressing assembly is used for conducting pressing hemostasis on a hemostasis point at the radial artery of the patient, and the pressing assembly is connected with the fixing plate. The pressing assembly comprises a rotary knob rotationally connected into the fixing plate, a rotary rod is in threaded connection with the interior of the rotary knob, a connecting plate is fixedly connected to the bottom end of the rotary rod, sliding rods are symmetrically and slidably connected into the two ends of the connecting plate, and the two ends of the sliding rods penetrate through the connecting plate and are fixedly connected with pressing heads. The massaging assembly is additionally arranged on the pressing assembly, so that the hemostasis point can be intermittently pressed and loosened, the position of the massaging assembly does not need to be adjusted, massaging can be directly carried out after loosening, the operation process is simplified, secondary wearing is avoided, it can be ensured that the hemostasis point is continuously pressed without a window period, and meanwhile risks such as thrombosis or vascular occlusion are prevented.

The invention discloses a natural functional component for preventing and improving cardiovascular diseases of pets. The natural functional component comprises an earthworm protein extract and a leech extract, the earthworm protein extract accounts for 20wt%-40wt% of the natural functional components; the ratio of the leech extract in the natural functional components is 10wt%-30wt%; the invention also comprises a feed containing the natural functional components for preventing and improving cardiovascular diseases of pets. The traditional Chinese medicine composition has the effects of resisting blood coagulation, thrombus, inflammation and oxidative stress, can prevent thrombosis, relieve inflammatory response, reduce free radical damage and protect the health of heart and cerebral vessels, and plays a role in preventing and improving cardiovascular diseases of pets; the pet feed additive can be added into feed to protect pet health.

The application provides a radial artery compressor for critical patients in a cardiology department, and belongs to the technical field of medical devices. The radial artery compressor comprises a fixing plate, a bandage is arranged on the outer side of the fixing plate, a pressing assembly is further arranged, the pressing assembly is used for pressing and stopping bleeding at a hemostatic point of a radial artery of a patient, and the pressing assembly is connected with the fixing plate. The pressing assembly comprises a knob rotatably connected in the fixing plate, a rotating rod is threadedly connected in the knob, a connecting plate is fixedly connected to the bottom end of the rotating rod, slide rods are symmetrically and slidably connected in the connecting plate, and the two ends of the slide rods penetrate through the connecting plate and are fixedly connected with compression heads. The application adds a pressing and rubbing assembly to the pressing assembly, intermittent compression and release of the hemostatic point can be realized, the position of the pressing and rubbing assembly does not need to be adjusted, the pressing and rubbing can be directly performed after release, the operation process is simplified, secondary wearing is avoided, the continuous pressing of the hemostatic point without an empty window period can be ensured, and risks such as thrombosis and vascular occlusion can be prevented.

The present disclosure relates to novel pyrimidine cyclized derivatives of formula (I) and methods for preparing these compounds, as well as the use of P2Y 12 and their use as receptor antagonists. [Case 1] TIFF2024545365000028.tif48170

A method for administering a dosage of Apixaban to a patient for the treatment or prevention of thrombosis, the method comprising: administering a dosage of Apixaban to the patient, wherein the dosage of apixaban is determined by: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric of the patient; and processing, using one or more processors, the patient data with a dosage calculator to determine the dosage of Apixaban for the patient, wherein the dosage calculator is derived from a plasma level prediction model that predicts Apixaban drug plasma levels, and the dosage calculator determines the dosage for the patient based in part on the kidney function metric of the patient.

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

The application specifically discloses a kind of nanovaccine for thrombosis prevention and its preparation method and application, it is related to thrombotic disease, especially related to the nanovaccine for treating thrombotic disease.The nanovaccine provided by the application has good immunogenicity without macromolecular heterologous protein carrier such as KLH;The process simplicity and repeatability are improved by reducing complex chemical coupling and purification steps;The dependence on traditional high-stimulating immune adjuvant is reduced, and the biological safety is improved;The stability of antigen in gastrointestinal environment is significantly improved;Active targeting delivery of M cells and dendritic cells is realized;Dendritic cell maturation and antigen presentation are promoted, and mucosal immunity and systemic immunity level are improved;The advantages such as effectively inhibiting thrombosis are realized, and a new type of oral antithrombotic vaccine system with high compliance suitable for long-term thrombosis prevention is constructed.

Provided are an siRNA which inhibits plasma coagulation factor XI gene expression, a pharmaceutical composition containing the siRNA, a conjugate, a reagent kit, and a use of the siRNA, the pharmaceutical composition thereof and the conjugate in preparing a drug used for treating and / or preventing thrombotic diseases and ischemic strokes.

The factor Xia inhibitor milvexian has therapeutic properties useful in the treatment and / or prevention of thrombotic and thromboembolic disorders.

The utility model discloses an adjustable thrombus prevention pressure belt structure which comprises a pressure elastic belt, and a matrix type constraint adjusting assembly is arranged on one side of the pressure elastic belt. The matrix type binding adjusting assembly comprises a plurality of mounting grooves formed in the pressure elastic belt, the mounting grooves penetrate through the whole pressure elastic belt, adjusting binding belts are arranged in the mounting grooves, and one ends of the adjusting binding belts extend into the mounting grooves to be fixedly connected with the ends, away from the mounting grooves, in the pressure elastic belt. A worker can pull the operation block step by step from bottom to top to drive the adjusting belt arranged in the elastic belt body to conduct contraction constraint, accurate pressure control can be achieved through contraction constraint, finally, bonding and fixing are conducted through the third hook face of the hook-and-loop fastener, overall preliminary fixing is conducted through the first hook face of the hook-and-loop fastener and the mounting groove in the whole process, and the fixing effect is good. Then the adjusting binding belt is used for targeted fixation attached to the skin of the patient, and finally the operation block and the adjusting belt are used for precise pressure output.

The application provides a jugular vein thrombus prevention device, which comprises a shell, mounting plates are arranged at both ends of the shell, the shell and the mounting plates are connected through a driving assembly to drive the mounting plates to reciprocate in a ring direction. One end of each of the two groups of mounting plates is provided with a mounting shell, a plurality of first massage columns are arranged on the mounting shell; a flexible belt is arranged on the mounting shell in a hinged manner, a plurality of second massage columns are arranged on one side of the flexible belt, a control plate is further arranged in the mounting shell and is slidably arranged along an axis of the mounting shell, one end of the control plate is provided with a flexible plate, and one end of the flexible plate is connected with the flexible belt. An adjusting mechanism connected with the control plate is further arranged in the mounting shell, and the control plate is driven to slide along the axis of the mounting shell through the adjusting mechanism. The device can be fixed on the neck of a patient, the two groups of mounting shells and the flexible belt are driven to reciprocate through the driving assembly, and the first massage columns and the second massage columns massage the jugular vein of the patient, so that the thrombus of the neck is effectively prevented.

The invention discloses an application of radix pseudostellariae cyclic peptide B in antithrombotic drugs, and the radix pseudostellariae cyclic peptide B directly acts on vascular endothelial cells, promotes release of antithrombotic molecules such as nitric oxide and the like, and enhances vasodilatation and antithrombotic ability; the radix pseudostellariae cyclic peptide B can down-regulate expression of thrombus-related genes and reduce generation of thrombus-promoting factors such as inflammatory molecules, and the effects of the radix pseudostellariae cyclic peptide B in the aspects of improving heart functions, promoting angiogenesis and the like indicate that the radix pseudostellariae cyclic peptide B possibly has antithrombotic potential and shows positive effects in improving and preventing thrombus formation and the development process of thrombus. The possibility that the compound is used as a potential antithrombotic drug is strongly indicated, and a new research direction and hope are brought to the field of antithrombotic treatment.

The invention belongs to the technical field of massage equipment, particularly relates to a lower limb venous thrombosis prevention massager and a use method thereof, and provides the following scheme aiming at the problems that an existing traditional lower limb venous thrombosis prevention method is not convenient to operate, and part of existing massage equipment is single in function, not good enough in use flexibility and the like. The massage device comprises two massage device bodies, each massage device body is composed of a massage device shell and two cambered surface connecting parts, the two cambered surface connecting parts are fixedly installed at the two ends of the massage device shell respectively, and massage grooves are formed in the tops of the massage device bodies. According to the lower limb venous thrombosis prevention massager, rolling, pressing, beating and other massage modes are integrated, leg blood circulation is promoted in an all-around mode, thrombosis is effectively prevented, the flexible adjusting mechanism adapts to different body types, the optimized massage assembly design is combined with good heat dissipation and covering functions, the massage effect is guaranteed, and meanwhile the massage effect is improved. And the use safety and comfort of the user are ensured.

Provided is a thrombolytic agent for ‘intravascular thrombus’, and more particularly, to a thrombolytic agent having a thrombo-recognition domain and a thrombolytic domain. It also relates to a polypeptide for thrombolysis of an intravascular thrombus, a gene for that polypeptide, and a pharmaceutical composition containing the same. The polypeptide that recognizes ‘intravascular thrombus’ and dissolves thrombus of the present invention is characterized in that it consists of a thrombolytic domain comprising the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain comprising the amino acid sequence set forth in SEQ ID NO: 3 or SEQ ID NO: 4. According to the present invention, the polypeptide for dissolving thrombus by recognizing ‘intravascular thrombus’ dissolves thrombus in the blood of a mammal without serious bleeding side effects has a preventive and therapeutic effect on thrombosis, thus preventing thrombosis and related diseases.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

The invention relates to the technical field of thrombus prevention, and discloses an ankle exercise device for thrombus prevention, comprising a base; a hinged shaft is fixedly arranged on the base in the width direction of the base, a driving plate is fixedly arranged at the bottom of the pedal mechanism, and the upper end of the driving plate is rotationally installed on the hinged shaft; the adjusting mechanism comprises a plate body, a first push plate and a second push plate, the plate body is slidably installed on the base in the length direction of the base, the first push plate is located at the end away from the first fixing belt, and the driving plate is located between the first push plate and the second push plate; the driving mechanism is fixedly installed on the base, the driving mechanism is in transmission connection with the second push plate, and the driving mechanism is used for driving the adjusting mechanism to move; and the damping mechanism is arranged between the driving plate and the second push plate. The device is used for solving the problems that in the prior art, the resistance is inconvenient to adjust, and in the initial rehabilitation stage, a patient often gives up exercise due to pain or weakness, and the exercise effect is poor.

The invention provides a thrombus prevention method and system based on digital clinical precise execution, and relates to the technical field of digital medical treatment, and the method comprises the steps: obtaining clinical data of a patient, and determining a thromboembolism risk level, a bleeding risk level and a mechanical prevention taboo state of the patient based on a preset rule; based on the combined state of the three evaluation results, generating a thrombus prevention measure scheme for the patient through a preset prevention strategy decision rule; monitoring clinical data changes in the hospitalization process of the patient in real time, when it is detected that the risk level or the taboo state is changed, comparing the consistency of a current execution scheme with a scheme regenerated based on the changed state, and if the current execution scheme is not consistent with the scheme regenerated based on the changed state, generating preventive measure adjustment reminding information; and pushing the scheme or the adjustment prompt to a clinical medical care terminal. According to the invention, intelligent decision and dynamic adjustment of thrombus prevention can be realized, the accuracy and timeliness of prevention measures are improved, and medical risks are reduced.

The present invention provides a fusion protein comprising: a tissue plasminogen activator or a variant thereof; a disintegrant or a variant thereof; and a connector; a linker connects a tissue plasminogen activator or a variant thereof and a disintegrant protein or a variant thereof, and includes an amino acid sequence represented by any one of SEQ ID NOs: 1 to 7. The invention also provides a method for treating or preventing diseases related to thrombosis by using the fusion protein.

The utility model relates to medical instrument technical field, especially a kind of wearable prevention lower limb venous thrombosis formation fixer, including mounting plate, the mounting plate is provided with two, the inside surface lower part of two the mounting plate is fixedly installed with bearing and is inserted, two the bearing inside are fixedly installed with movable rod, the outside surface of two The movable rod is fixedly connected with anti-drop block, the upper part between two The mounting plate is fixedly connected with leg fixing assembly, two The movable rod between is fixedly connected with foot fixing assembly.The utility model relates to a kind of wearable prevention lower limb venous thrombosis formation fixer, by setting leg fixing assembly and foot fixing assembly, leg and foot can be stably fixed, maintain normal physiological posture, promote blood circulation, effectively prevent thrombosis, breathable sponge inner layer close to skin, soft and comfortable, can avoid skin allergy and discomfort, aluminium alloy middle layer provides solid support, ensure that leg posture is correct.

The utility model discloses a visual thrombus prevention warning clock, which belongs to the technical field of medical instruments and comprises a shell, a magnetic plate is fixed on one side of the shell through a screw, a clock face is arranged on the shell opposite to the magnetic plate side, and the clock face is sequentially green, yellow, red and dark red along the clockwise direction. Pointers rotatably connected to the interior of the shell are arranged in the middle of the clock face, a warning area starting on the shell is arranged on one side of the clock face and comprises a content display groove and a color display groove above the content display groove, and a content replacement assembly corresponding to the content display groove is arranged in the shell. A color display assembly is arranged in the shell corresponding to the color display groove, and a control knob which rotates in the shell is arranged between the warning area and the clock face; the warning clock can enable a patient to visually know the thrombus condition, plays a role in warning the patient, can be directly pasted on the bed head, and is convenient to use.