39 results about "Thrombosis prevention" patented technology

Provided are an siRNA which inhibits plasma coagulation factor XI gene expression, a pharmaceutical composition containing the siRNA, a conjugate, a reagent kit, and a use of the siRNA, the pharmaceutical composition thereof and the conjugate in preparing a drug used for treating and / or preventing thrombotic diseases and ischemic strokes.

The present invention discloses an auxiliary support device for patients with lower limb thrombosis, which relates to the technical field of medical rehabilitation equipment, including lower limb sleeves and foot sleeves, wherein two lower limb sleeves and two foot sleeves are provided, and a sanitary isolation replacement component for keeping the auxiliary lower limb clean is installed on the lower limb sleeve, and a blowing activity auxiliary component for heat dissipation and auxiliary joint movement is installed on the outer surface of the lower limb sleeve. The auxiliary support device for patients with lower limb thrombosis replaces the isolation cotton roll under the action of the rotation and reeling of the reeling shaft, thereby ensuring that the patient's lower limb sleeve remains in a better clean state when the patient uses it next time, avoiding bacterial infection after the patient wears the unsanitary lower limb sleeve, and exercising the patient's foot joints by reminding the patient's feet to perform an upward lifting action. Lifting the feet upward can exercise the calf muscles, including the gastrocnemius muscle and the tibialis anterior muscle, and can also help promote blood circulation in the lower limbs, which helps to reduce lower limb edema and prevent the risk of thrombosis.

A DVT prevention and / or mitigation device includes a wearable band having an inflatable bladder with an inflatable portion. When the wearable band is disposed about a user's leg, a majority of the inflatable portion of the inflatable bladder is positionable between the user's knee and a midpoint of the user's gastrocnemius muscle. The inflatable bladder is also inflatable to apply pressure to a portion of the user's gastrocnemius muscle, and a source of compressed air is coupled to the wearable band to deliver continuous compression cycles to the inflatable bladder at a frequency of at least 3 cycles per minute, each compression cycle having a compression period and a peak inflation pressure to induce cyclic flow in the user's venous valve sinuses from each successive inflation.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from aspirin, atorvastatin, valsartan, hydrochlorothiazide, folic acid substances and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has the advantages that the pharmaceutical composition provided by the invention has a multi-target synergistic prevention effect on vascular diseases, especially cerebral embolism, that is, the composition not only can reduce blood pressure, blood fat and blood homocysteine level, but also has an effect of preventing thrombosis, and reduces the risk of cerebral apoplexy. In addition, the form of the pharmaceutical composition is beneficial to improving the medication compliance of patients.

The invention relates to the technical field of thrombus resistance instruments, in particular to an electric adjustable ultrasonic developing thrombus resistance instrument. In order to solve the problems that venous thromboembolism occurs frequently after a surgical operation, existing prevention means have defects, and the clinical requirements for reducing the occurrence rate and the death rate are difficult to meet, the following technical scheme is provided that the venous thromboembolism prevention device comprises a bearing table, the bearing table comprises a head plate, and a fixing plate is hinged to one side of the head plate; a sliding plate is arranged below the fixed plate in a sliding mode, and a foot plate is hinged to the side, away from the fixed plate, of the sliding plate; the fixed frame is arranged below the bearing table and is used for supporting; and the adjusting mechanism is mounted on the fixed frame and is used for adjusting the distance between the head plate and the foot plate. The device can effectively adapt to different patients and flexibly adjust the body position, and thrombus prevention and monitoring are integrated, so that the occurrence rate and death rate of venous thrombus are reduced, and the pain and risk of the patients are reduced.

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more compounds of Formula I compounds, and methods for using the compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Methods of inhibiting platelet activation and aggregation using peptide vaccines having binding specificity for the α subunit of the (Na++K+)-ATPase are provided, along with methods for inhibiting or preventing or treating thrombosis without causing bleeding.

The invention provides a radial artery compressor for critical patients in the department of cardiology, and belongs to the technical field of medical instruments. Comprising a fixing plate, and a bandage is arranged on the outer side of the fixing plate; the device further comprises a pressing assembly, the pressing assembly is used for conducting pressing hemostasis on a hemostasis point at the radial artery of the patient, and the pressing assembly is connected with the fixing plate. The pressing assembly comprises a rotary knob rotationally connected into the fixing plate, a rotary rod is in threaded connection with the interior of the rotary knob, a connecting plate is fixedly connected to the bottom end of the rotary rod, sliding rods are symmetrically and slidably connected into the two ends of the connecting plate, and the two ends of the sliding rods penetrate through the connecting plate and are fixedly connected with pressing heads. The massaging assembly is additionally arranged on the pressing assembly, so that the hemostasis point can be intermittently pressed and loosened, the position of the massaging assembly does not need to be adjusted, massaging can be directly carried out after loosening, the operation process is simplified, secondary wearing is avoided, it can be ensured that the hemostasis point is continuously pressed without a window period, and meanwhile risks such as thrombosis or vascular occlusion are prevented.

The invention discloses a natural functional component for preventing and improving cardiovascular diseases of pets. The natural functional component comprises an earthworm protein extract and a leech extract, the earthworm protein extract accounts for 20wt%-40wt% of the natural functional components; the ratio of the leech extract in the natural functional components is 10wt%-30wt%; the invention also comprises a feed containing the natural functional components for preventing and improving cardiovascular diseases of pets. The traditional Chinese medicine composition has the effects of resisting blood coagulation, thrombus, inflammation and oxidative stress, can prevent thrombosis, relieve inflammatory response, reduce free radical damage and protect the health of heart and cerebral vessels, and plays a role in preventing and improving cardiovascular diseases of pets; the pet feed additive can be added into feed to protect pet health.

The application provides a radial artery compressor for critical patients in a cardiology department, and belongs to the technical field of medical devices. The radial artery compressor comprises a fixing plate, a bandage is arranged on the outer side of the fixing plate, a pressing assembly is further arranged, the pressing assembly is used for pressing and stopping bleeding at a hemostatic point of a radial artery of a patient, and the pressing assembly is connected with the fixing plate. The pressing assembly comprises a knob rotatably connected in the fixing plate, a rotating rod is threadedly connected in the knob, a connecting plate is fixedly connected to the bottom end of the rotating rod, slide rods are symmetrically and slidably connected in the connecting plate, and the two ends of the slide rods penetrate through the connecting plate and are fixedly connected with compression heads. The application adds a pressing and rubbing assembly to the pressing assembly, intermittent compression and release of the hemostatic point can be realized, the position of the pressing and rubbing assembly does not need to be adjusted, the pressing and rubbing can be directly performed after release, the operation process is simplified, secondary wearing is avoided, the continuous pressing of the hemostatic point without an empty window period can be ensured, and risks such as thrombosis and vascular occlusion can be prevented.

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

The application specifically discloses a kind of nanovaccine for thrombosis prevention and its preparation method and application, it is related to thrombotic disease, especially related to the nanovaccine for treating thrombotic disease.The nanovaccine provided by the application has good immunogenicity without macromolecular heterologous protein carrier such as KLH;The process simplicity and repeatability are improved by reducing complex chemical coupling and purification steps;The dependence on traditional high-stimulating immune adjuvant is reduced, and the biological safety is improved;The stability of antigen in gastrointestinal environment is significantly improved;Active targeting delivery of M cells and dendritic cells is realized;Dendritic cell maturation and antigen presentation are promoted, and mucosal immunity and systemic immunity level are improved;The advantages such as effectively inhibiting thrombosis are realized, and a new type of oral antithrombotic vaccine system with high compliance suitable for long-term thrombosis prevention is constructed.

The utility model discloses an adjustable thrombus prevention pressure belt structure which comprises a pressure elastic belt, and a matrix type constraint adjusting assembly is arranged on one side of the pressure elastic belt. The matrix type binding adjusting assembly comprises a plurality of mounting grooves formed in the pressure elastic belt, the mounting grooves penetrate through the whole pressure elastic belt, adjusting binding belts are arranged in the mounting grooves, and one ends of the adjusting binding belts extend into the mounting grooves to be fixedly connected with the ends, away from the mounting grooves, in the pressure elastic belt. A worker can pull the operation block step by step from bottom to top to drive the adjusting belt arranged in the elastic belt body to conduct contraction constraint, accurate pressure control can be achieved through contraction constraint, finally, bonding and fixing are conducted through the third hook face of the hook-and-loop fastener, overall preliminary fixing is conducted through the first hook face of the hook-and-loop fastener and the mounting groove in the whole process, and the fixing effect is good. Then the adjusting binding belt is used for targeted fixation attached to the skin of the patient, and finally the operation block and the adjusting belt are used for precise pressure output.

The application provides a jugular vein thrombus prevention device, which comprises a shell, mounting plates are arranged at both ends of the shell, the shell and the mounting plates are connected through a driving assembly to drive the mounting plates to reciprocate in a ring direction. One end of each of the two groups of mounting plates is provided with a mounting shell, a plurality of first massage columns are arranged on the mounting shell; a flexible belt is arranged on the mounting shell in a hinged manner, a plurality of second massage columns are arranged on one side of the flexible belt, a control plate is further arranged in the mounting shell and is slidably arranged along an axis of the mounting shell, one end of the control plate is provided with a flexible plate, and one end of the flexible plate is connected with the flexible belt. An adjusting mechanism connected with the control plate is further arranged in the mounting shell, and the control plate is driven to slide along the axis of the mounting shell through the adjusting mechanism. The device can be fixed on the neck of a patient, the two groups of mounting shells and the flexible belt are driven to reciprocate through the driving assembly, and the first massage columns and the second massage columns massage the jugular vein of the patient, so that the thrombus of the neck is effectively prevented.

Provided is a thrombolytic agent for ‘intravascular thrombus’, and more particularly, to a thrombolytic agent having a thrombo-recognition domain and a thrombolytic domain. It also relates to a polypeptide for thrombolysis of an intravascular thrombus, a gene for that polypeptide, and a pharmaceutical composition containing the same. The polypeptide that recognizes ‘intravascular thrombus’ and dissolves thrombus of the present invention is characterized in that it consists of a thrombolytic domain comprising the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain comprising the amino acid sequence set forth in SEQ ID NO: 3 or SEQ ID NO: 4. According to the present invention, the polypeptide for dissolving thrombus by recognizing ‘intravascular thrombus’ dissolves thrombus in the blood of a mammal without serious bleeding side effects has a preventive and therapeutic effect on thrombosis, thus preventing thrombosis and related diseases.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

The invention relates to the technical field of thrombus prevention, and discloses an ankle exercise device for thrombus prevention, comprising a base; a hinged shaft is fixedly arranged on the base in the width direction of the base, a driving plate is fixedly arranged at the bottom of the pedal mechanism, and the upper end of the driving plate is rotationally installed on the hinged shaft; the adjusting mechanism comprises a plate body, a first push plate and a second push plate, the plate body is slidably installed on the base in the length direction of the base, the first push plate is located at the end away from the first fixing belt, and the driving plate is located between the first push plate and the second push plate; the driving mechanism is fixedly installed on the base, the driving mechanism is in transmission connection with the second push plate, and the driving mechanism is used for driving the adjusting mechanism to move; and the damping mechanism is arranged between the driving plate and the second push plate. The device is used for solving the problems that in the prior art, the resistance is inconvenient to adjust, and in the initial rehabilitation stage, a patient often gives up exercise due to pain or weakness, and the exercise effect is poor.

The invention provides a thrombus prevention method and system based on digital clinical precise execution, and relates to the technical field of digital medical treatment, and the method comprises the steps: obtaining clinical data of a patient, and determining a thromboembolism risk level, a bleeding risk level and a mechanical prevention taboo state of the patient based on a preset rule; based on the combined state of the three evaluation results, generating a thrombus prevention measure scheme for the patient through a preset prevention strategy decision rule; monitoring clinical data changes in the hospitalization process of the patient in real time, when it is detected that the risk level or the taboo state is changed, comparing the consistency of a current execution scheme with a scheme regenerated based on the changed state, and if the current execution scheme is not consistent with the scheme regenerated based on the changed state, generating preventive measure adjustment reminding information; and pushing the scheme or the adjustment prompt to a clinical medical care terminal. According to the invention, intelligent decision and dynamic adjustment of thrombus prevention can be realized, the accuracy and timeliness of prevention measures are improved, and medical risks are reduced.

The utility model relates to medical instrument technical field, especially a kind of wearable prevention lower limb venous thrombosis formation fixer, including mounting plate, the mounting plate is provided with two, the inside surface lower part of two the mounting plate is fixedly installed with bearing and is inserted, two the bearing inside are fixedly installed with movable rod, the outside surface of two The movable rod is fixedly connected with anti-drop block, the upper part between two The mounting plate is fixedly connected with leg fixing assembly, two The movable rod between is fixedly connected with foot fixing assembly.The utility model relates to a kind of wearable prevention lower limb venous thrombosis formation fixer, by setting leg fixing assembly and foot fixing assembly, leg and foot can be stably fixed, maintain normal physiological posture, promote blood circulation, effectively prevent thrombosis, breathable sponge inner layer close to skin, soft and comfortable, can avoid skin allergy and discomfort, aluminium alloy middle layer provides solid support, ensure that leg posture is correct.

The invention discloses a lophatherum gracile extract in preparation of a medicine for treating and preventing thrombosis and application of the lophatherum gracile extract in preparation of the medicine for treating and preventing thrombosis, and the medicine comprises the lophatherum gracile extract. The common lophatherum herb extract can inhibit platelet agonist-induced platelet blood clot formation so as to prevent and treat thrombosis, and can inhibit a platelet agonist-induced platelet aggregation function so as to prevent and treat thrombosis. A platelet activation function induced by a platelet agonist can be inhibited so as to prevent and treat thrombosis, and platelet microtubule morphological change induced by the platelet agonist can be inhibited so as to prevent and treat thrombosis; the invention proves that the lophatherum gracile extract has the effects of inhibiting platelet aggregation, activation, particle release and microtubule morphological change for the first time, has small toxic and side effects, provides a new research and development direction for clinical treatment of thrombotic diseases, and shows that the lophatherum gracile extract can be used as a new type of health care product medicine for preventing thrombotic diseases.

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

The invention relates to the technical field of pressed candies, and discloses a black fungus pressed polysaccharide tablet candy and a processing method thereof. Comprising the following raw materials: 10%-16% of auricularia auricula polysaccharide powder, 5%-11% of a lycium ruthenicum extract, 5%-11% of a Chinese wolfberry extract, 8%-14% of red date powder, 3%-9% of a ganoderma lucidum extract, 30% of maltose, 15% of xylitol, 3%-6% of vegetable gum, 2% of citric acid and 2% of natural perfume. The black fungus polysaccharide, the lycium ruthenicum, the lycium barbarum, the red dates and other natural components have various biological activities, and can help to regulate blood sugar, reduce blood fat and improve blood circulation. Researches show that polysaccharide components in black fungus have good anti-oxidation and anti-inflammatory effects, and are beneficial to enhancing vascular elasticity and preventing thrombosis, so that the risk of cardiovascular and cerebrovascular diseases is effectively reduced, and especially for cerebral apoplexy patients, the recurrence probability of the cerebral apoplexy patients can be reduced.

The invention provides a traditional Chinese medicine composition for treating thyroid postoperative parathyroid hypofunction (hereinafter referred to as subthyroid hyperthyroidism). Specifically, the invention develops a traditional Chinese medicine composition for treating thyroid postoperation combined parathyroid hypofunction for the first time, and the traditional Chinese medicine composition is prepared from the following raw material medicines: 240g of raw astragalus membranaceus, 12g of angelica sinensis, 9g of radix paeoniae rubra, 6g of ligusticum wallichii, 6g of lumbricus, 6g of fried peach kernel, 6g of safflower and 12g of kudzu vine root. The traditional Chinese medicine composition can improve the PTH recovery rate, shorten the PTH recovery time, reduce the total calcium supplement amount, relieve low-calcium clinical symptoms caused by thyroid subtraction after the thyroid surgery to a certain extent, promote qi and blood circulation of the whole body after the surgery, prevent thrombosis, promote wound healing and shorten the hospitalization time at the same time, meets the clinical requirements, and is worthy of popularization and application. The current situation that traditional Chinese medicine prescriptions combined with parathyroid hypofunction after thyroid surgery are insufficient is made up.

This invention belongs to the field of thrombosis risk prediction technology, and relates to a method and system for thrombosis risk prediction based on the coupling of drinking water and exercise data. This invention integrates wearable devices and intelligent sensing devices to collect real-time temporal data of the user's lower limb movement and water intake, and combines this with individual physiological parameters to construct a personalized physiological dynamic model. This personalized physiological dynamic model dynamically simulates continuous changes in blood viscosity, lower limb blood flow velocity, and blood retention, generating a risk prediction trajectory for future time periods. When the risk exceeds a threshold, multiple intervention strategy packages are tested in a virtual environment to evaluate their impact on physiological state, and a preferred intervention strategy package that balances risk elimination effectiveness and execution cost index is selected based on a multi-objective optimization algorithm. Finally, personalized risk control guidance information containing the preferred intervention strategy is output, effectively improving the timeliness and personalization of thrombosis prevention.

The application provides a Pediococcus pentosaceus strain NCU16V with thrombus prevention and cerebral ischemic injury prevention, a microbial inoculum containing the same and application, and relates to the technical field of microorganisms.The preservation number of the Pediococcus pentosaceus strain NCU16V is CGMCC No.35427.The Pediococcus pentosaceus strain NCU16V has good gastrointestinal digestion tolerance, and has a high survival rate after being digested in simulated artificial gastric juice and intestinal juice for 3 hours, as verified by the research of the application.Meanwhile, it is verified that the Pediococcus pentosaceus strain NCU16V and the microbial inoculum containing the same can be widely applied in drugs for preventing thrombosis, drugs for relieving brain tissue injury after cerebral ischemia and preparation of ginkgo fermented products with thrombosis prevention.

The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and / or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.

A medical device may include a medical device body and / or a coating on the medical device body. The medical device body and / or the coating may be formed from a polyurethane-based resin, which may be a reaction product of ingredients including: a diisocyanate; a chain extender; a polyglycol; and a biomimetic functional modifier. The ingredients of the reaction product may further include an additional ionically-charged modifier and / or a low-surface energy modifier. The biomimetic functional modifier may aid in prevention of thrombus formation, resistance to biofilm colonization, and inhibition of adverse tissue inflammatory response to medical implants. In addition, an ionic active agent may be ionically bound to the biomimetic functional modifier and the additional ionically-charged modifier for active and controlled release. The biomimetic functional modifier may include a phosphorylcholine functional group. The biomimetic functional modifier may be glycerophosphorylcholine. The medical device body may include a catheter tube body.

Provided are an siRNA which inhibits plasma coagulation factor XI gene expression, a pharmaceutical composition containing the siRNA, a conjugate, a reagent kit, and a use of the siRNA, the pharmaceutical composition thereof and the conjugate in preparing a drug used for treating and / or preventing thrombotic diseases and ischemic strokes.

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

The invention belongs to the technical field of preparation of fermented biogen, and particularly relates to lactobacillus rhamnosus fermented biogen, a preparation method of the lactobacillus rhamnosus fermented biogen and application of the lactobacillus rhamnosus fermented biogen to improvement of atherosclerosis, reduction of thrombosis risk and regulation of ceramide metabolism. In the preparation process of the lactobacillus fermented biogen, yeast protein releases polypeptide with vasodilation and inflammation inhibition functions, and after the polypeptide is matched with anthocyanin and araboxylan oligosaccharide which have the functions of regulating ceramide metabolism and protecting the cardiovascular system, the activity of the polypeptide is improved; under the fermentation action of the lactobacillus rhamnosus NKU ML1-2, lactobacillus fermentation postbiotics with the function of protecting heart and cerebral vessels are formed, and the lactobacillus fermentation postbiotics as a dietary nutrition intervention means can directly act on vascular cells through multiple ways to promote the function repair of endothelial cells; apoptosis and oxidative damage of endothelial cells are inhibited, generation of ceramide substances is regulated, and an innovative nutrition intervention strategy is provided for prevention and treatment of atherosclerosis related diseases and prevention of thrombosis.