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6 results about "Thrombosis prevention" patented technology
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Thrombosis prevention or thromboprophylaxis is medical treatment to prevent the development of thrombosis (blood clots inside blood vessels) in those considered at risk for developing thrombosis. Some people are at a higher risk for the formation of blood clots than others. Prevention measures or interventions are usually begun after surgery as people are at higher risk due to immobility. There are medication-based interventions and non-medication-based interventions. The risk of developing blood clots can be modified by life style modifications, the discontinuation of oral contraceptives, and weight loss. In those at high risk both interventions are often used. The treatments to prevent the formation of blood clots is balanced against the risk of bleeding.
Thrombolytic agents for intravascular clots
Provided is a thrombolytic agent for ‘intravascular thrombus’, and more particularly, to a thrombolytic agent having a thrombo-recognition domain and a thrombolytic domain. It also relates to a polypeptide for thrombolysis of an intravascular thrombus, a gene for that polypeptide, and a pharmaceutical composition containing the same. The polypeptide that recognizes ‘intravascular thrombus’ and dissolves thrombus of the present invention is characterized in that it consists of a thrombolytic domain comprising the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain comprising the amino acid sequence set forth in SEQ ID NO: 3 or SEQ ID NO: 4. According to the present invention, the polypeptide for dissolving thrombus by recognizing ‘intravascular thrombus’ dissolves thrombus in the blood of a mammal without serious bleeding side effects has a preventive and therapeutic effect on thrombosis, thus preventing thrombosis and related diseases.
Owner:JINIS
A post-knee surgery distal deep vein thrombosis prediction system
The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.
Owner:LUOYANG MENGJIN DISTRICT TRADITIONAL CHINESE MEDICINE HOSPITAL
Wearable prophylactic lower extremity deep vein thrombosis holder
The utility model relates to medical instrument technical field, especially a kind of wearable prevention lower limb venous thrombosis formation fixer, including mounting plate, the mounting plate is provided with two, the inside surface lower part of two the mounting plate is fixedly installed with bearing and is inserted, two the bearing inside are fixedly installed with movable rod, the outside surface of two The movable rod is fixedly connected with anti-drop block, the upper part between two The mounting plate is fixedly connected with leg fixing assembly, two The movable rod between is fixedly connected with foot fixing assembly.The utility model relates to a kind of wearable prevention lower limb venous thrombosis formation fixer, by setting leg fixing assembly and foot fixing assembly, leg and foot can be stably fixed, maintain normal physiological posture, promote blood circulation, effectively prevent thrombosis, breathable sponge inner layer close to skin, soft and comfortable, can avoid skin allergy and discomfort, aluminium alloy middle layer provides solid support, ensure that leg posture is correct.
Owner:SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL
Thrombosis risk prediction method and system based on coupling of drinking water and exercise data
This invention belongs to the field of thrombosis risk prediction technology, and relates to a method and system for thrombosis risk prediction based on the coupling of drinking water and exercise data. This invention integrates wearable devices and intelligent sensing devices to collect real-time temporal data of the user's lower limb movement and water intake, and combines this with individual physiological parameters to construct a personalized physiological dynamic model. This personalized physiological dynamic model dynamically simulates continuous changes in blood viscosity, lower limb blood flow velocity, and blood retention, generating a risk prediction trajectory for future time periods. When the risk exceeds a threshold, multiple intervention strategy packages are tested in a virtual environment to evaluate their impact on physiological state, and a preferred intervention strategy package that balances risk elimination effectiveness and execution cost index is selected based on a multi-objective optimization algorithm. Finally, personalized risk control guidance information containing the preferred intervention strategy is output, effectively improving the timeliness and personalization of thrombosis prevention.
Owner:WUXI NO 9 PEOPLES HOSPITAL
Non-thrombogenic devices for treating edema
The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and / or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.
Owner:WHITE SWELL MEDICAL LTD
A thrombosis prevention exercise device
The utility model relates to medical instrument technical field discloses a kind of thrombus prevention exercise devices, including bottom plate, the front and rear sides of bottom plate are respectively fixedly connected with support rod one, the inside of two support rod one is respectively slidably connected with slide bar, the inside of two slide bars is respectively threadedly connected with nut one, the inside of left side of two slide bars is respectively rotatably connected with shaft, the similar side of two shafts is respectively fixedly connected with support rod two, the similar side of two support rod two is fixedly connected with two slide rails, the inside of two slide rails is respectively slidably connected with multiple sliding blocks, the right side of multiple sliding blocks is all fixedly connected with connecting pad. In the utility model, the problem of unstable fixation of the thrombus prevention exercise device during use is effectively addressed. The fixation stability of the thrombus prevention exercise device during use is improved, providing a more reliable and safe user experience.
Owner:PEKING UNIV INT HOSPITAL