18 results about "Vein thrombosis" patented technology

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The utility model discloses a kind of rehabilitation nursing beds, it is related to rehabilitation medical equipment technical field, including bedstead, the continuous disc motor is installed in the side end of bedstead.The utility model is provided with bedstead, support sliding slot, side position support frame, bottom screw rod motor, upper screw shaft motor, driving frame, far infrared heat therapy lamp, control screen, air pump, A road massage air bag and B road massage air bag, by bottom screw rod motor driving side position support frame moves to the position that far infrared heat therapy lamp needs to irradiate in support sliding slot, and by control screen controls the work of upper screw shaft motor to adjust the working height of driving frame, then A road massage air bag and B road massage air bag can be driven by two air pumps respectively to simulate muscle contraction to user by periodic inflation and deflation, promote lower limb blood circulation, cooperate far infrared heat therapy lamp can be carried out heat therapy, effectively prevent deep vein thrombosis suitable for long-term bedridden patient or postoperative rehabilitation training, the effect of multifunctional integration of lifting device use is improved.

This invention provides a lateral decubitus lower limb embedded positioning device, including a grooved support frame and an air supply tube. The grooved support frame includes a top support plate, a first support side plate, and a second support side plate. The first and second support side plates are connected to the two opposite long sides of the top support plate. The surface of the grooved support frame is covered with memory foam, and the surface of the memory foam is covered with a leather sleeve. The air supply tube is tightly wrapped with the memory foam and the leather sleeve at the corner connection between the inner surface of the top support plate and the first or second support side plate. The wall of the air supply tube has multiple air supply holes, one end of which is a closed end, and the other end is an open end used as an air inlet. The leather sleeve has multiple ventilation holes opposite to the air supply tube. This device can greatly shorten the lateral decubitus positioning time, put the patient in a comfortable and correct surgical position, effectively improve the success rate of surgery, reduce the occurrence of complications, and effectively warm the patient's lower limbs, reducing intraoperative hypothermia and the incidence of deep vein thrombosis.

1. Name of the product in this design: Anti-deep vein thrombosis pump. 2. Purpose of this design: for inflation. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

This invention discloses a non-invasive real-time monitoring and intervention system for preventing and treating lower extremity deep vein thrombosis (DVT). It is characterized by comprising an impedance monitoring module, a microcurrent stimulation module, and a data analysis and display module. The impedance monitoring module is connected to the data analysis and display module and includes an impedance measurement circuit and a ring-shaped flexible electrode patch. The ring-shaped flexible electrode patch employs a ring-shaped multi-electrode array composed of multiple sets of electrodes, with current injected into the distal electrodes and voltage difference detected at the proximal electrodes. The impedance monitoring module measures changes in lower extremity impedance through the ring-shaped multi-electrode array. The microcurrent stimulation module is connected to the data analysis and display module and uses a constant current source output. The data analysis and display module includes a main controller and a display. The main controller combines a machine learning model to predict DVT risk, achieving closed-loop control. This invention exhibits good stability, achieving non-invasive, real-time, continuous monitoring and active intervention, overcoming the shortcomings of existing monitoring and prevention technologies.

The application provides a use of a combination of metoclopramide and latanoprost for preparing an anticoagulant drug, and belongs to the technical field of biological medicines. It is accidentally found that the anticoagulant effect of patients with deep vein thrombosis combined with high intraocular pressure is improved after long-term continuous oral administration of metoclopramide. Thanks to this beneficial discovery, the application realizes good anticoagulant effect by applying the latanoprost liniment in a topical manner on the basis of oral administration of metoclopramide. The application is convenient to administer, has definite and sustained curative effect, and is safe and reliable. The application expands the optional range of anticoagulant drugs, and realizes better curative effect at the same time, and has outstanding technical advantages and wide popularization prospect.

This invention belongs to the fields of biomedicine and molecular biology, focusing on the application of NAT10 and related biomolecules in the diagnosis and treatment of deep vein thrombosis (DVT). Specifically, this invention has found that NAT10 is a key initiator of endothelial cell ferroptosis, and its expression is significantly increased in DVT. The results indicate that inhibiting NAT10 reduces ac4C levels in DVT, thereby alleviating endothelial ferroptosis. However, decreased NAT10 expression leads to reduced HMOX1 stability and decreased Fe... 2+ The release and inhibition of lipid peroxidation make targeting the NAT10 / HMOX1 axis a potential treatment for DVT, and therefore this invention has good potential practical application value.

RNA interference (RNAi) agents for inhibiting the expression of Factor XI (FXI) are provided, as are pharmaceutical compositions comprising one or more FXI RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the FXI RNAi agent(s) to liver cells in vivo provides for inhibition of FXI gene expression and can provide for treatment of myocardial infarction, atrial fibrillation (AFib), deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, retinal artery occlusion, mesenteric ischemia, renal vein thrombosis, cerebral venous sinus thrombosis, venous thromboembolism due to deep vein thrombosis, and peripheral artery disease, as well as diseases and disorders associated with angioedema, thrombosis, and / or coagulation.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

Providing quinazolindione compounds and their uses. [Solution] Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The utility model relates to medical instrument technical field, especially a kind of wearable prevention lower limb venous thrombosis formation fixer, including mounting plate, the mounting plate is provided with two, the inside surface lower part of two the mounting plate is fixedly installed with bearing and is inserted, two the bearing inside are fixedly installed with movable rod, the outside surface of two The movable rod is fixedly connected with anti-drop block, the upper part between two The mounting plate is fixedly connected with leg fixing assembly, two The movable rod between is fixedly connected with foot fixing assembly.The utility model relates to a kind of wearable prevention lower limb venous thrombosis formation fixer, by setting leg fixing assembly and foot fixing assembly, leg and foot can be stably fixed, maintain normal physiological posture, promote blood circulation, effectively prevent thrombosis, breathable sponge inner layer close to skin, soft and comfortable, can avoid skin allergy and discomfort, aluminium alloy middle layer provides solid support, ensure that leg posture is correct.

RNA interference (RNAi) agents for inhibiting the expression of Factor XI (FXI) are provided, as are pharmaceutical compositions comprising one or more FXI RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the FXI RNAi agent(s) to liver cells in vivo provides for inhibition of FXI gene expression and can provide for treatment of myocardial infarction, atrial fibrillation (AFib), deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, retinal artery occlusion, mesenteric ischemia, renal vein thrombosis, cerebral venous sinus thrombosis, venous thromboembolism due to deep vein thrombosis, and peripheral artery disease, as well as diseases and disorders associated with angioedema, thrombosis, and / or coagulation.

This utility model relates to a tool for measuring leg circumference, belonging to the field of medical auxiliary device technology. It includes a flexible measuring tape, and further includes a primary positioning ruler and a secondary positioning ruler that are slidably connected. The bottom of the secondary positioning ruler has a fixed piece and a movable piece slidably connected thereto. A flexible measuring tape is located on one side of the primary positioning ruler, and one end of the flexible tape is slidably connected to the primary positioning ruler. The secondary positioning ruler has an I-shaped structure, and a vertical through-type groove that cooperates with the secondary positioning ruler is opened at the center of the primary positioning ruler. The tool for measuring leg circumference provided by this utility model, through the cooperation of the primary positioning ruler, secondary positioning ruler, fixed piece, movable piece, and flexible measuring tape, can quickly and accurately locate the position 15cm above and 10cm below the midpoint of the patella for leg circumference measurement, comprehensively improving the convenience of leg circumference measurement when monitoring the treatment effect of lower extremity deep vein thrombosis.

This invention relates to the field of multi-source medical data processing, and more particularly to a data processing method for risk stratification of deep vein thrombosis in sepsis patients. First, based on the acquired raw patient data, a standardized time-series data table is obtained, thus yielding the baseline risk. Based on the standardized time-series data table, the reliability of standardized medical indicators is obtained, thus yielding a fusion value. Then, based on the fusion value and the standardized time-series data table, the inflammation-coagulation coupling index, the blood flow stasis driving intensity index, and the organ imbalance index are calculated respectively, and combined with the baseline risk to obtain the instantaneous risk potential. Based on the inflammation-coagulation coupling index, a gating factor is obtained, and combined with the instantaneous risk potential and the blood flow stasis driving intensity index, a risk state value is obtained, which is then converted into a risk probability to obtain the judgment result. This solves the problems of traditional static models failing to reflect the dynamic changes in risk with the condition, being sensitive to short-term fluctuations, and lacking continuity and stability in risk evolution.

The utility model relates to the technical field of medical auxiliary instruments, and discloses an ankle pump movement counter which comprises an angle adjusting assembly, a connecting base, a connecting block and a fixing block, the connecting base, the connecting block and the fixing block are of an integrated structure on the angle adjusting assembly, connecting rods are fixedly installed at the two ends, away from the center line, of the fixing block, and inserting sleeves are installed on the connecting rods in an inserted mode. The end, away from the connecting rod, of the inserting sleeve is fixedly provided with a connecting sleeve, and the end, away from the connecting rod, of the connecting sleeve is rotationally provided with an ankle connecting assembly. According to the ankle pump movement counter, the rotating rod drives the limiting rod to be clamped into the clamping groove of the bottom plate, the limiting effect can be achieved, multi-angle adjustment can be achieved, the movement amplitude can be dynamically adjusted according to the rehabilitation stage of a patient, excessive stretching is avoided, the universality of the whole counter during use is improved, and the ankle pump movement counter can be conveniently used and popularized; meanwhile, deep vein thrombosis can be prevented through ankle pump movement of dorsal stretching, dorsal flexion and ankle turning, the practicability is improved, and application and popularization can be facilitated.

1. The name of the design product: intermittent pneumatic compression system. 2. The use of the design product: the product belongs to medical devices, which helps to prevent deep vein thrombosis in patients at risk through sequential pressure on the lower limbs. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: front view. 5. The design claimed contains color.

The application discloses a kind of methods for constructing deep vein thrombosis mouse model by regulating Pyk2 gene expression.The method comprises the following steps: constructing knockdown or overexpression vector for Pyk2 gene; by tail vein injection, the vector is introduced into mouse in vivo, the in vivo transient regulation of Pyk2 gene is realized; the inferior vena stenosis method is used to induce deep vein thrombosis; the thrombus macroscopic morphology, wet weight, length and histopathology are detected.The application overcomes the limitation of existing gene knockout model, such as congenital, irreversible and systemic deletion, realizes the targeted, temporary and bidirectional flexible regulation of Pyk2 gene in vascular tissue, and the model has high stability and good repeatability.The model can simulate the pathological state under the same expression level of Pyk2, and is suitable for the screening, evaluation and deep vein thrombosis pathogenesis research of antithrombotic drugs.

This application relates to the technical field of medical devices, and in particular to a multimodal collaborative lower limb ankle pump motion assistive device, which includes a main controller, a foot drive module composed of bilinear push rods and universal ball joints, a calf gradient pressurization module with a multi-chamber airbag, and a carbon fiber support structure. This application achieves precise timing coordination of mechanical drive and pneumatic pressurization through the main controller. During plantar flexion, sequential pressurization is applied to the calf muscle group from distal to proximal, and pressure is simultaneously released during dorsiflexion, thus highly simulating the physiological muscle pump effect. The device supports multiple movement modes such as dorsiflexion, plantar flexion, and compound circumduction, and integrates pressure, angle, and hemodynamic monitoring units to achieve closed-loop feedback control and risk warning. This application can significantly improve the efficiency of lower limb venous blood return, effectively prevent deep vein thrombosis, reduce the workload of medical staff, and is suitable for various scenarios such as ICU critical care, postoperative rehabilitation, and long-distance travel.