79 results about "Vein thrombosis" patented technology

The invention discloses a venous thrombosis risk assessment method based on a large language model, and relates to the technical field of medical artificial intelligence, and the method comprises the steps: collecting thoracic surgery diagnosis and treatment data of a patient, carrying out the space-time alignment, generating a standard diagnosis and treatment data flow, and carrying out the homomorphic encryption of the standard diagnosis and treatment data flow, and forming an encrypted patient data package; inputting the encrypted patient data packet into a multi-task large language model, performing feature extraction and semantic coding by a feature coding layer, performing time sequence modeling and risk probability calculation by a risk quantification layer, and outputting a venous thromboembolism risk level of a patient; and performing feature decoupling and potential space mapping on the encrypted patient data packet to obtain thrombus semantic potential features. Through the multi-task large language model, the dual machine learning algorithm and the homomorphic encryption, the accuracy of venous thrombosis risk early warning is improved, and the safety of the risk assessment process is enhanced.

The invention discloses a deep venous thrombosis early warning method and system based on multi-modal physiological signals, and relates to the technical field of health monitoring. The method is used for realizing thrombus early recognition and graded early warning. The method comprises the following steps: synchronously acquiring physiological signals of lower limbs on two sides through a multi-modal sensing device, performing motion artifact elimination and signal quality screening, and generating preprocessed time sequence data; performing dynamic time warping and feature extraction on the time series data, calculating a bilateral symmetry index and an instantaneous and accumulated time-varying difference degree, and fusing the bilateral symmetry index and the instantaneous and accumulated time-varying difference degree with absolute physiological parameters to form a comprehensive risk assessment vector; establishing a dynamic baseline based on the historical risk vector, calculating a current deviation index, and recognizing an abnormal state in combination with a double-side cooperation mode; and according to the deviation index and the duration, in combination with the abnormality type and the severity, generating a graded early warning signal containing a risk grade and a disposal suggestion through multi-stage judgment, thereby realizing early warning and risk management of thrombus.

The invention discloses a deep vein thrombosis risk early warning health information system based on dynamic negative pressure monitoring and AI, and relates to the technical field of intelligent medical health information. Comprising a dynamic negative pressure sensor module, a multi-modal data acquisition module, a waveform primitive analysis module, a hierarchical attention fusion module, a risk assessment classifier module and an early warning output module. The dynamic negative pressure sensor module is used for continuously collecting dynamic negative pressure signals of the lower limbs of the user. According to the dynamic negative pressure monitoring and AI deep vein thrombosis risk early warning health information system, the problem of multi-source heterogeneous physiological data fusion is solved; an original dynamic negative pressure signal is converted into a symbolized primitive sequence with clear physiological significance, so that the data quality is fundamentally improved; according to the method, adaptive fusion of multi-modal data and accurate focusing of key time slices are realized, the specificity and robustness of a risk assessment model are improved, and a false alarm phenomenon caused by physiological activity interference is reduced.

The invention relates to the technical field of intelligent diagnosis and treatment, and discloses an intelligent diagnosis and treatment system for dynamic risk early warning and intervention of orthopedic patients, and the system comprises a dynamic monitoring end, an intelligent grading end, a precise intervention end, a voice alarm module and a doctor's advice cooperation module. A multi-source sensor is used for continuously collecting vital signs of a patient and local microcirculation and behavior data of an affected limb in real time, and dynamic fusion analysis is carried out based on an orthopedic specialized risk model, so that early abnormal changes of deep venous thrombosis, stress injury and falling risks can be recognized in real time; the method overcomes the hysteresis quality of traditional manual intermittent evaluation and static scale, ensures the accuracy and timeliness of early warning of severe risks, and reduces clinical risks caused by untimely intervention.

Processing generated sensor data of a mobile deep vein thrombosis (DVT) device may include identifying use of the mobile DVT device corresponding to a user. Sensor data associated with the user's identified use of the mobile DVT device may be generated. At least some of the generated sensor data may comprise use data associated with a duration of use of the mobile DVT device by the user. A protocol associated with use of the mobile DVT device may be processed. The generated use data and the protocol associated with use of the mobile DVT device may be correlated. Based on correlating the generated use data and the protocol, an alert associated with the generated use data and the protocol may be generated.

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The invention relates to the technical field of medical health monitoring, and discloses a foldable leg circumference measurement system and method for deep venous thrombosis monitoring, and the system comprises a foldable measurement main body, a bony marker positioning assembly, a sensing measurement assembly, a control module and a communication module; the measuring main body realizes radian adjustment and storage through a damping hinge and an elastic buckle, and the positioning assembly is attached to the patella through an arc-shaped clamping groove and is matched with a high-precision calibration ruler to complete standard site positioning; the sensing assembly collects perimeter and tension data, the control module carries out calibration through a weighted average algorithm, compares an uninjured side reference value and judges whether the data exceed the limit or not, early warning is triggered if the data exceed the limit continuously for three times, and the data are synchronized to a medical care terminal and a patient terminal. The method comprises the steps of site calibration, tension calibration, data processing and early warning archiving. The problems that a traditional measuring tool is low in precision and lags in early warning are solved, multi-scene standardized monitoring is achieved, and support is provided for early warning of thrombus.

The utility model discloses a kind of rehabilitation nursing beds, it is related to rehabilitation medical equipment technical field, including bedstead, the continuous disc motor is installed in the side end of bedstead.The utility model is provided with bedstead, support sliding slot, side position support frame, bottom screw rod motor, upper screw shaft motor, driving frame, far infrared heat therapy lamp, control screen, air pump, A road massage air bag and B road massage air bag, by bottom screw rod motor driving side position support frame moves to the position that far infrared heat therapy lamp needs to irradiate in support sliding slot, and by control screen controls the work of upper screw shaft motor to adjust the working height of driving frame, then A road massage air bag and B road massage air bag can be driven by two air pumps respectively to simulate muscle contraction to user by periodic inflation and deflation, promote lower limb blood circulation, cooperate far infrared heat therapy lamp can be carried out heat therapy, effectively prevent deep vein thrombosis suitable for long-term bedridden patient or postoperative rehabilitation training, the effect of multifunctional integration of lifting device use is improved.

The invention discloses an intermittent inflating and pressurizing device for preventing deep venous thrombosis, which comprises an adapting ring, an adapting bracket is arranged at the top end of the adapting ring, the adapting bracket is composed of a plurality of groups of bracket rods, connecting rods are arranged among the bracket rods, a supporting base plate is arranged on one side of the adapting bracket, and a plurality of connecting rods are arranged on the other side of the adapting bracket. A plurality of air bags are arranged on one side of the supporting gasket, the outer side of the adaptive support is sleeved with a flexible pad, the interior of each air bag is divided into a plurality of areas of different sizes, a controller is arranged on the other side of each flexible pad, and an air pump is arranged on one side of each controller; the adaptive ring adopts a combined innovative design of a semicircular supporting ring and a rotatable supporting sheet, the airbag system adopts a composite design of multi-region independent division and honeycomb-shaped soft plastic grids, and a plurality of independent regions divided according to a preset proportion inside are connected with an air pump through independent pipelines, so that differential pressure output of different regions can be realized; and the requirement of precise pressurization treatment is met.

This invention provides a lateral decubitus lower limb embedded positioning device, including a grooved support frame and an air supply tube. The grooved support frame includes a top support plate, a first support side plate, and a second support side plate. The first and second support side plates are connected to the two opposite long sides of the top support plate. The surface of the grooved support frame is covered with memory foam, and the surface of the memory foam is covered with a leather sleeve. The air supply tube is tightly wrapped with the memory foam and the leather sleeve at the corner connection between the inner surface of the top support plate and the first or second support side plate. The wall of the air supply tube has multiple air supply holes, one end of which is a closed end, and the other end is an open end used as an air inlet. The leather sleeve has multiple ventilation holes opposite to the air supply tube. This device can greatly shorten the lateral decubitus positioning time, put the patient in a comfortable and correct surgical position, effectively improve the success rate of surgery, reduce the occurrence of complications, and effectively warm the patient's lower limbs, reducing intraoperative hypothermia and the incidence of deep vein thrombosis.

1. Name of the product in this design: Anti-deep vein thrombosis pump. 2. Purpose of this design: for inflation. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

This invention discloses a non-invasive real-time monitoring and intervention system for preventing and treating lower extremity deep vein thrombosis (DVT). It is characterized by comprising an impedance monitoring module, a microcurrent stimulation module, and a data analysis and display module. The impedance monitoring module is connected to the data analysis and display module and includes an impedance measurement circuit and a ring-shaped flexible electrode patch. The ring-shaped flexible electrode patch employs a ring-shaped multi-electrode array composed of multiple sets of electrodes, with current injected into the distal electrodes and voltage difference detected at the proximal electrodes. The impedance monitoring module measures changes in lower extremity impedance through the ring-shaped multi-electrode array. The microcurrent stimulation module is connected to the data analysis and display module and uses a constant current source output. The data analysis and display module includes a main controller and a display. The main controller combines a machine learning model to predict DVT risk, achieving closed-loop control. This invention exhibits good stability, achieving non-invasive, real-time, continuous monitoring and active intervention, overcoming the shortcomings of existing monitoring and prevention technologies.

The application provides a use of a combination of metoclopramide and latanoprost for preparing an anticoagulant drug, and belongs to the technical field of biological medicines. It is accidentally found that the anticoagulant effect of patients with deep vein thrombosis combined with high intraocular pressure is improved after long-term continuous oral administration of metoclopramide. Thanks to this beneficial discovery, the application realizes good anticoagulant effect by applying the latanoprost liniment in a topical manner on the basis of oral administration of metoclopramide. The application is convenient to administer, has definite and sustained curative effect, and is safe and reliable. The application expands the optional range of anticoagulant drugs, and realizes better curative effect at the same time, and has outstanding technical advantages and wide popularization prospect.

The utility model discloses a leg circumference measuring device for a patient with venous thrombosis between lower limb vein muscles, which comprises a reference sheet with an inward concave structure attached to patella; the fixing band is arranged on the outer edge of the reference sheet and extends in the radial direction of the reference sheet; the hook-and-loop fastener is arranged on the outer side surface of the reference sheet and is bonded with the fixing band after the fixing band encircles the knee bend by a circle; the number of the scaleplates is two, and the two scaleplates are arranged on the upper side and the lower side of the reference sheet respectively and are symmetrical about the fixing band. The number of the measuring scale assemblies is two, and the measuring scale assemblies are arranged at the positions 10 cm and 15 cm away from the two rulers respectively. By means of the scheme, when the leg circumference of a patient is measured, operation can be simplified, and the accuracy of measured values can be effectively guaranteed.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

This invention belongs to the fields of biomedicine and molecular biology, focusing on the application of NAT10 and related biomolecules in the diagnosis and treatment of deep vein thrombosis (DVT). Specifically, this invention has found that NAT10 is a key initiator of endothelial cell ferroptosis, and its expression is significantly increased in DVT. The results indicate that inhibiting NAT10 reduces ac4C levels in DVT, thereby alleviating endothelial ferroptosis. However, decreased NAT10 expression leads to reduced HMOX1 stability and decreased Fe... 2+ The release and inhibition of lipid peroxidation make targeting the NAT10 / HMOX1 axis a potential treatment for DVT, and therefore this invention has good potential practical application value.

RNA interference (RNAi) agents for inhibiting the expression of Factor XI (FXI) are provided, as are pharmaceutical compositions comprising one or more FXI RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the FXI RNAi agent(s) to liver cells in vivo provides for inhibition of FXI gene expression and can provide for treatment of myocardial infarction, atrial fibrillation (AFib), deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, retinal artery occlusion, mesenteric ischemia, renal vein thrombosis, cerebral venous sinus thrombosis, venous thromboembolism due to deep vein thrombosis, and peripheral artery disease, as well as diseases and disorders associated with angioedema, thrombosis, and / or coagulation.

The utility model relates to the technical field of medical instruments, in particular to a sole sponge sleeve with an acupoint stimulation function. Comprising a massage plate, an air bag sleeve, an upper protection layer and a lower protection layer, the outer edge of the lower protection layer is provided with a son hook-and-loop fastener and an elastic band, and the end, away from the lower protection layer, of the elastic band is provided with a mother hook-and-loop fastener. The integrated sole sleeve is used for preventing deep vein thrombosis, the massage plate with the acupuncture point stimulation function is arranged, meanwhile, the wearing performance can be freely adjusted through the elastic band, the son hook-and-loop fastener and the mother hook-and-loop fastener, after wearing, when air waves are inflated and deflated, the massage plate can achieve acupuncture point stimulation, and the integrated sole sleeve is convenient to wear and high in practicability. And the functions of deep vein thrombosis prevention and acupoint stimulation massage are combined.

The invention discloses a surgical patient intelligent gradient pressure treatment system for preventing deep venous thrombosis, which relates to the technical field of pressure control and comprises a data acquisition and processing module, an intelligent gradient pressure regulation and control module and a real-time early warning module, pressure sensing points arranged on the air cushion are used for collecting pressure data in real time, a pressure data matrix is constructed after purification and restoration, a gradient pressure interval is set in combination with a clinical guide, an intelligent regulation and control strategy is generated, and dynamic adjustment of the pressure of the air cushion is achieved. The system has a real-time early warning function, can trigger an alarm when the pressure is abnormal, cooperates with the regulation and control module to carry out adaptive adjustment, effectively improves the prevention effect of deep venous thrombosis, and has a good clinical application value.

1. Name of the product in this design: Arteriovenous Pulse Pneumatic Compression Therapy Device. 2. Purpose of this design: It belongs to medical devices and is used for the prevention and treatment of deep vein thrombosis, varicose veins, etc. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention provides a liquid path assembly and an injection device, a double-flow-direction liquid path unit comprises a first fluid channel and a second fluid channel, a channel inner cavity of the first fluid channel is used for limiting fluid to flow only in a first flow direction, and a channel inner cavity of the second fluid channel is used for limiting fluid to flow only in a second flow direction. The direction of the first flow direction is different from the direction of the second flow direction, the single-flow-direction liquid path unit comprises a one-way fluid channel, a channel inner cavity of the one-way fluid channel is used for limiting fluid to flow only in the third flow direction, and the direction of the third flow direction is the same as the direction of the first flow direction or the direction of the second flow direction. According to the liquid path assembly and the injection device, the liquid path assembly is designed in a targeted mode, so that the injection device can have the functions of synchronous injection and suction, synchronous conveying of multiple substances and the like, the pressure in a blood vessel cavity is reduced, the flow of closed substances along with blood in the injection process is limited, and deep vein thrombosis or ectopic embolism is prevented.

The utility model discloses an auxiliary device for preventing lower limb deep vein thrombosis. The auxiliary device for preventing the lower limb deep venous thrombosis comprises two foot supporting plates used for supporting feet, a rotating shaft used for supporting the foot supporting plates to rotate, a driving mechanism used for providing power to drive the rotating shaft to rotate, a clutch mechanism used for disconnecting or connecting the driving mechanism and the rotating shaft, and a mounting base used for mounting the rotating shaft. The rotating shaft is rotatably arranged on the mounting seat, the two foot supporting plates are mounted on the rotating shaft, the driving mechanism is provided with an output shaft, and the clutch mechanism comprises a connecting sleeve used for connecting the output shaft and the rotating shaft and a shifting rod used for driving the connecting sleeve to move so that the output shaft and the rotating shaft can be disconnected or connected. The connecting sleeve is arranged on the output shaft or the rotating shaft in a sliding mode, and the connecting sleeve and the rotating shaft or the output shaft rotate synchronously. The auxiliary device for preventing the deep venous thrombosis of the lower limbs can assist a critical patient to do ankle pump movement and can also be matched with the patient to do ankle pump movement autonomously.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

Providing quinazolindione compounds and their uses. [Solution] Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The invention discloses a method for detecting deep venous thrombosis of a patient with traumatic craniocerebral injury, and relates to the technical field of deep venous thrombosis detection. The method comprises the following steps: acquiring deep vein images and physiological parameters, performing noise reduction, normalization and abnormal value elimination, extracting vein structures and suspected thrombus features, marking gray scale and morphological anomaly regions, and forming a feature vector library; analyzing a physiological parameter time sequence trend, dividing high, medium and low risks, and associating image analysis; weighting and fusing the image and the physiological parameters, judging a thrombus area and marking the type, the position and the size; the thrombus change is manually rechecked and dynamically monitored, and clinical intervention is associated to form a closed loop; and generating and filing an encrypted report, and synchronizing the encrypted report to an electronic medical record system. The thrombus detection comprehensiveness and accuracy are improved through multi-data fusion, dynamic monitoring and risk pre-judgment are achieved, the system adapts to clinical scenes, efficient support is provided for thrombus management of traumatic craniocerebral injury patients, and intervention opportunities and schemes are optimized.

The invention relates to a patient terminal, a medical care terminal and a lower limb deep vein thrombosis monitoring system, the patient terminal is in data connection with the medical care terminal, establishes data interaction with at least one monitoring device, and is used for obtaining scale data and / or physiological data related to prevention of lower limb deep vein thrombosis of a target patient; wherein the patient terminal is configured to obtain the core body temperature of a target patient and at least one lower limb far-end skin temperature by using monitoring equipment, and determine a temperature difference value based on the core body temperature and the at least one lower limb far-end skin temperature; determining the change rate of the temperature difference value related to time as the temperature difference fluctuation rate; when the temperature difference fluctuation ratio exceeds a temperature difference fluctuation ratio range preset by the medical care terminal, the patient terminal sends an emergency tag indicating an emergency situation and current scale data of a corresponding patient to the medical care terminal; and the medical care terminal analyzes the current scale data of the corresponding patient in an emergency mode and emergently determines whether an early warning signal needs to be sent to the patient terminal or not.

The invention relates to the technical field of intelligent wearing health monitoring, in particular to an intelligent sock and a deep vein thrombosis early warning method. The intelligent sock comprises a sock body, an air pump and a control device, an air bag is arranged on the inner side of the sock body, and a pressure sensor is arranged on the inner side of the air bag; a temperature sensor and a blood flow velocity sensor are arranged on the inner side of the sock body; the air pump, the pressure sensor, the temperature sensor and the blood flow velocity sensor are all electrically connected with the control device; the control device is used for calculating a deep venous thrombosis risk index according to the pressure, monitored by the pressure sensor, applied to the body surface of the user by the air bag, the skin temperature monitored by the temperature sensor and the venous blood flow speed monitored by the blood flow speed sensor, and sending out an early warning signal when the deep venous thrombosis risk index is larger than a preset early warning threshold value. The problem that a traditional stretch sock can only provide static pressure support and lacks monitoring capacity is solved, and quantitative evaluation and dynamic analysis of the DVT risk are achieved.

The utility model relates to medical instrument technical field, especially a kind of wearable prevention lower limb venous thrombosis formation fixer, including mounting plate, the mounting plate is provided with two, the inside surface lower part of two the mounting plate is fixedly installed with bearing and is inserted, two the bearing inside are fixedly installed with movable rod, the outside surface of two The movable rod is fixedly connected with anti-drop block, the upper part between two The mounting plate is fixedly connected with leg fixing assembly, two The movable rod between is fixedly connected with foot fixing assembly.The utility model relates to a kind of wearable prevention lower limb venous thrombosis formation fixer, by setting leg fixing assembly and foot fixing assembly, leg and foot can be stably fixed, maintain normal physiological posture, promote blood circulation, effectively prevent thrombosis, breathable sponge inner layer close to skin, soft and comfortable, can avoid skin allergy and discomfort, aluminium alloy middle layer provides solid support, ensure that leg posture is correct.

The application relates to a polypeptide functionalized gold nanocluster targeting neutrophils, a preparation method thereof and application thereof in preparation of an anti-thrombus drug, and belongs to the field of biomedical nanomaterials. The nanocluster is formed by Au-S coordination self-assembly of a thiol-containing targeting polypeptide and gold atoms. The polypeptide can specifically recognize neutrophil elastase (NE), realizes targeting of activated neutrophils and inhibits enzyme activity of the neutrophils. The nanocluster inhibits formation of neutrophil extracellular traps (NETs) induced by phorbol ester (PMA) or activated platelets, and shows reduction of histone citrullination (CitH3) level, extracellular DNA release and active oxygen (ROS) generation. In-vivo experiments show that the gold nanocluster is enriched at a thrombus site, and significantly reduces thrombus load in a deep vein thrombosis model and an FeCl3-induced arterial thrombosis model. The application plays an anti-thrombus role by inhibiting NETs.