7443results about "Medical simulation" patented technology

A federated distributed computational system enables secure biological data analysis and genomic medicine with enhanced oncological therapy capabilities. The system implements patient-specific tumor-on-a-chip analysis through microfluidic control systems and cellular heterogeneity preservation, while integrating fluorescence-enhanced diagnostics using CRISPR-LNP targeting and robotic surgical navigation. The architecture coordinates spatiotemporal analysis of gene therapy delivery through molecular imaging and immune response tracking, and implements bridge RNA integration with multi-target synchronization. Treatment selection is optimized through multi-criteria scoring and patient-specific simulation modeling. Each federated node contains a local processing unit for biological data analysis, privacy preservation protocols, and a hierarchical knowledge graph structure. The system implements cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration, enabling research institutions to collaborate on complex, large-scale biological analyses while maintaining strict data privacy controls.

A federated distributed computational system enables secure oncological therapy optimization through robotic integration. The system establishes a distributed graph architecture with secure communication channels connecting computational nodes, implementing encryption protocols for cross-institutional data exchange. Each node contains processing capabilities for fluorescence-guided imaging, uncertainty quantification, and expert knowledge integration while maintaining hierarchical knowledge graphs of oncological biomarkers, interventions, and outcomes. The system coordinates domain-specific knowledge through token-space communication and implements an advanced robotic integration system for surgical interventions using spatiotemporal tumor mapping, multi-modal fluorescence imaging, surgical robot coordination, and space-time stabilized mesh management. Key capabilities include wavelength-specific multi-modal fluorescence detection, combined epistemic and aleatoric uncertainty estimation, tensor-based data integration with adaptive dimensionality control, and light cone search for adaptive treatment optimization—all while maintaining strict privacy controls.

The invention relates to the technical field of medical image diagnosis, and discloses a medical image automatic diagnosis method and system based on deep learning. According to the method, multi-modal medical image data of a target object is acquired and standardized, a two-channel convolutional neural network is utilized to extract features, the features are processed through cross-modal feature fusion, adaptive attention weight distribution and other technologies, a cascaded two-way long-short-term memory network is adopted for modeling, abnormity is detected based on a probabilistic graph model, and the target object is identified. And the nidus is segmented by a multi-scale context information enhancement module, and finally a diagnosis suggestion is generated by a diagnosis inference engine driven by a knowledge graph. The system comprises a multi-modal image acquisition interface module, a distributed feature calculation cluster, a visual interaction terminal and a security audit module. According to the method, the accuracy and efficiency of medical image diagnosis can be improved, comprehensive diagnosis reference is provided for doctors, and meanwhile data safety and privacy are guaranteed.

A federated distributed computational system enables secure oncological therapy optimization through multi-expert integration and advanced uncertainty quantification. The system implements a multi-expert integration framework that coordinates domain-specific knowledge through token-space communication for precision oncological treatment, while maintaining secure cross-institutional data exchange. The architecture coordinates multi-scale spatiotemporal synchronization across computational nodes, with each node containing local processing capabilities for fluorescence-guided imaging, uncertainty quantification, and expert knowledge integration. Through a distributed graph architecture, the system enables advanced fluorescence imaging with wavelength-specific targeting, multi-level uncertainty estimation combining epistemic and aleatoric approaches, and multi-scale tensor-based integration with adaptive dimensionality control. The system implements light cone search and planning for adaptive treatment strategy optimization, enabling medical institutions and research organizations to collaborate on complex oncological therapy projects while maintaining strict data privacy controls.

The invention provides an artificial intelligence-based ultrasonic image data classification method and system, and the method comprises the steps: firstly obtaining a real-time ultrasonic scanning signal sequence containing the time sequence change characteristics of a tissue elastic parameter and a hemodynamic parameter, carrying out the noise suppression and motion artifact compensation processing, generating a standardized ultrasonic image sequence, and marking the coordinates of an anatomical boundary; then performing multi-scale anatomical structure decomposition on the ultrasonic image to obtain a local feature map set of different organization levels, inputting the local feature map set into a cascade deep classification network, and realizing cross-frame feature fusion and dynamic weight adjustment through spatial-temporal feature alignment and a multi-granularity attention distribution module to obtain a spatial-temporal feature fusion model; and the abnormal region classification probability distribution and the spatial topological relation graph are output, finally, a multi-modal diagnosis report is generated according to the abnormal region classification probability distribution and the spatial topological relation graph, an interactive three-dimensional visual interface containing risk level labels and treatment suggestions is generated after the multi-modal diagnosis report is compared with historical cases, and ultrasonic image classification accuracy and diagnosis efficiency are improved.

A federated distributed computational system enables secure biological data analysis and genomic medicine through hybrid simulation capabilities. The system implements a hybrid simulation orchestrator that coordinates classical numerical simulations with machine learning models for biological system analysis, while maintaining secure cross-institutional data exchange. The architecture coordinates multi-scale spatiotemporal synchronization across computational nodes, with each node containing local processing capabilities for biological data analysis and privacy preservation protocols. The system implements cellular machinery assembly analysis, real-time patient data integration, and multi-modal image integration with spatiotemporal health data annotation. Through a distributed graph architecture, the system enables cross-species genetic analysis, environmental response modeling, and multi-scale tensor-based data integration with adaptive dimensionality control. The system implements real-time therapeutic response prediction through multi-modal data analysis, enabling research institutions to collaborate on complex biological analyses while maintaining strict data privacy controls.

The invention relates to the technical field of medical intelligent scheduling, in particular to a patient flow data visualization adjusting system and method, and the system comprises a global dynamic sensing unit, a medical intelligent evolution center, a space-time mirror image twinning module, a multi-dimensional decision optimization matrix, and a risk closed-loop management and control unit. The global dynamic sensing unit gathers data to construct a diagnosis and treatment panorama; the medical intelligent evolution center is used for building a medical process evolution system to form a three-dimensional cognitive architecture; the space-time mirror image twinning module is used for constructing physical virtual space mapping, and forming a diagnosis and treatment resource space-time distribution path based on Internet of Things position data and a digital twinning technology; the multi-dimensional decision optimization matrix extracts patient flow data according to the space-time simulation path and a multi-target model, and generates a resource scheduling scheme; and the risk closed-loop management and control unit is used for evaluating the risk, marking congestion early warning and dynamically optimizing a regulation and control strategy and a threshold value. Therefore, the problems of data isolation, poor resource configuration efficiency, insufficient real-time performance and the like in the prior art are solved.

A spatiotemporal modeling system for Personal Health Database (PHDB) platforms integrates diverse health data types into a comprehensive 4D model of an individual's health status. By combining genomic, imaging, clinical, and real-time health data, the system creates a dynamic, time-based representation of the user's anatomy and physiology. This model enables real-time analysis, pattern recognition, and predictive forecasting of health outcomes. The system preprocesses and aligns data from various sources, constructs a detailed spatial framework, and continuously updates the model with new inputs. Through interactive visualizations, it provides users and healthcare providers with intuitive, personalized insights for improved health management and decision-making.

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and / or track coronary artery disease.

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and / or track coronary artery disease.

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and / or track coronary artery disease.

The invention relates to the technical field of medical rehabilitation, and discloses a lower limb weight-bearing gait rehabilitation training system which comprises a data acquisition module, a data processing and analysis module, a patient individualized modeling module, an intelligent decision and control module, a rehabilitation execution module and a man-machine interaction and medical information interface module which are in communication connection through a network. The data acquisition module is used for acquiring multi-modal data of a patient in real time, and the multi-modal data comprises static sign data, dynamic physiological parameters, kinematics and dynamics parameters and non-motion physiological and psychological state data; and the data processing and analysis module is used for carrying out preprocessing, feature extraction and deep analysis on the original data, and outputting a structured patient individualized feature vector and an evaluation result. According to the invention, a patient three-dimensional skeletal muscle digital twinborn model is constructed through the patient individualized modeling module, and in combination with a continuous learning intelligent model library, body sign differences of different patients can be accurately adapted.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

The invention discloses an acute and critical disease nursing training system and method based on vr, and relates to the technical field of medical systems. A learning mode and an assessment mode are selected through a handle trigger; in the learning mode, the nursing operation process is dynamically displayed through vr glasses and a scene generation engine, and the scene generation engine constructs a disease evolution path based on a knowledge graph and associates user historical data to match personalized teaching cases; receiving a selection instruction of a user for an assessment item in the assessment mode, receiving an operation instruction of the user at the same time, recording time sequence data of an operation path and selecting a behavior logic chain; generating a score according to a dynamic scoring algorithm including an operation track accuracy parameter and a decision timeliness parameter; the user is personally on the scene to carry out nursing training and examination on acute and critical diseases, and trial and error in a highly-simulated critical scene are carried out; a targeted training scene is intelligently pushed according to the specialty and ability of the user; and the speed and quality of acute and critical disease nursing are balanced through multi-dimensional scoring.

Systems and methods are disclosed for determining blood flow characteristics of a patient. One method includes: receiving, in an electronic storage medium, patient-specific image data of at least a portion of vasculature of the patient having geometric features at one or more points; generating a patient-specific reduced order model from the received image data, the patient-specific reduced order model comprising estimates of impedance values and a simplification of the geometric features at the one or more points of the vasculature of the patient; creating a feature vector comprising the estimates of impedance values and geometric features for each of the one or more points of the patient-specific reduced order model; and determining blood flow characteristics at the one or more points of the patient-specific reduced order model using a machine learning algorithm trained to predict blood flow characteristics based on the created feature vectors at the one or more points.

The invention relates to the technical field of ophthalmology medical diagnosis, and discloses a three-dimensional reconstruction-based fundus focus intelligent labeling method and diagnosis system. The method comprises the following steps: receiving multi-modal image data streams such as fundus color photos, OCT images and FFA images of an ophthalmological patient; performing spatial registration and feature fusion by using a pre-trained lesion feature fusion model to generate a three-dimensional lesion probability distribution diagram and a lesion category confidence matrix; constructing an adaptive annotation threshold model to generate a multi-modal annotation instruction set; based on the focus development chain model, focus development is simulated, and instruction set parameters are optimized and labeled; and iteratively optimizing through a distributed reinforcement learning framework, and outputting the focus labeling action sequence to an ophthalmology diagnosis platform. According to the method, multi-modal image information can be integrated, the diagnosis accuracy and efficiency are improved, personalized diagnosis is realized, resources are reasonably utilized, and powerful support is provided for ophthalmic disease diagnosis.

A computer-implemented method for processing medical images may comprise: receiving image data for a patient; based on the received image data, determining: a patient-specific epicardial adipose tissue (EAT) metric or a patient-specific pericoronary adipose tissue (PCAT) metric, and at least one other patient-specific metric, and using the EAT metric or the PCAT metric, and the at least one other patient-specific metric, to determine a risk score for the patient or to classify a disease state of the patient.

A computer-implemented method for processing medical images may comprise: receiving image data for a patient; based on the received image data, determining: a patient-specific epicardial adipose tissue (EAT) metric or a patient-specific pericoronary adipose tissue (PCAT) metric, and at least one other patient-specific metric, and using the EAT metric or the PCAT metric, and the at least one other patient-specific metric, to determine a risk score for the patient or to classify a disease state of the patient.

An apparatus for performing a vascular assessment is disclosed. The apparatus creates a three-dimensional model that is representative of a coronary vessel tree of a patient based on at least two angiographic images. The apparatus estimates first blood flow resistance values for points along at least some vascular segments of the coronary vessel tree using vascular geometrical dimensions of the three-dimensional model. The apparatus also estimates second blood flow resistance values for the points along the at least some vascular segments of the coronary vessel tree using a volume of a crown of the vascular segment downstream from the respective point. The apparatus determines fractional flow reserve (“FFR”) by calculating a ratio of the first blood flow resistance values and the second blood flow resistance values at each of the points along the at least some vascular segments of the coronary vessel tree.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

The invention discloses an infection risk dynamic assessment method based on deep learning, and relates to the technical field of intelligent monitoring. Multi-source heterogeneous data are integrated by calling a pre-trained deep learning model, a basic regeneration number (R0) value set is calculated based on an SEIR infection model, the basic regeneration number (R0) value set serves as a node initial feature of a space-time diagram network, and a double-layer dynamic network is constructed to generate a regional vulnerability scoring matrix. And calculating a global infection risk index through the linear combination vulnerability score and the R0 numerical set, and generating a prediction infection density matrix and a hierarchical prevention and control strategy when the index exceeds a preset threshold. And further comparing a prediction result with actually measured infection data, dynamically adjusting a symptom keyword weight and a medical resource dependency parameter, and triggering online incremental learning of the model to optimize evaluation precision. Dynamic adaptation of multi-source data fusion modeling and prevention and control strategies is achieved, and the timeliness of infection risk assessment and the scientificity of prevention and control decisions are remarkably improved.

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

The embodiment of the invention relates to a processing method and device of an Alzheimer disease risk prediction model. The method comprises the steps that DT I-ALPS feature information of dementia crowds and healthy crowds of a specified age group is obtained in a big data collection and volunteer recruitment mode, and a corresponding model data set is constructed and recorded as a first data set; constructing a three-classification prediction model for predicting the risk of the Alzheimer's disease as an Alzheimer's disease risk prediction model corresponding to a specified age group; training an Alzheimer disease risk prediction model based on the first data set; after model training is finished, DT I-ALPS feature information, input by the user, of any tested person of the specified age group is input into the Alzheimer disease risk prediction model for prediction, and a corresponding classification probability vector is obtained and fed back to the current user. According to the invention, prediction accuracy and prediction stability can be improved.

Systems and methods are disclosed for diagnosis, risk assessment, and / or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel or generating a risk score for risk of disease for the patient's bowel, based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel.

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user; calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics; receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and / or sensor data of the user's physiological characteristics; and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.

Systems and methods are disclosed for diagnosis, risk assessment, and / or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel.

The invention discloses a plastic effect simulation display method and system based on a 3D simulation technology, and relates to the technical field of medical information, and the method comprises the steps: collecting the facial data of a patient, and constructing a multi-level facial structure initial model; constructing a hybrid deformation model; individual characteristic parameters of a patient are extracted, and an individual biomechanical parameter set is generated through the biomechanical parameter prediction network; applying the personalized biomechanical parameter set to the mixed deformation model; operation input parameters of plastic surgery are received, and the deformation result of each layer of structure is calculated and displayed in real time based on a GPU parallel computing framework; constructing a tissue healing and recovery kinetic model, and generating appearance prediction data at different postoperative time points in combination with the deformation result; and performing three-dimensional visualization processing on the appearance prediction data. According to the method, CT / MRI, 3D structured light scanning and expression dynamic video sequences are creatively integrated, the limitation of traditional single-mode data modeling is broken through, and the soft tissue boundary recognition precision is remarkably improved.