90 results about "Insulin infusion" patented technology

The invention discloses an insulin infusion decision-making system and method combining reinforcement learning and metabolism simulation, and belongs to the field of clinical decision-making assistance. Comprising an acquisition processing module, a metabolism simulation module, a dynamic updating module, a path simulation module, a strategy control module, a monitoring constraint module, a decision analysis module, a correction processing module, a training optimization module and an injection control module. The method can accurately reflect the metabolic characteristics of the patient, makes the insulin decision more targeted, realizes automatic adjustment of the model, keeps real-time perception and response to the state of the patient, avoids the risk caused by model aging or error accumulation, enhances the long-term control ability, improves the control efficiency while guaranteeing the blood glucose stability, and reduces the cost. The fault-tolerant capability of the system is improved, the interpretability and safety guarantee of clinical decisions are improved, and the credibility of doctors is enhanced.

The invention discloses a real-time adjusting method for insulin infusion volume, which adopts a closed-loop control method, and dynamically adjusts the infusion volume of an insulin pump based on a comparison result of a predicted blood glucose parameter and a preset blood glucose range through collected blood glucose data and predicted future blood glucose data, thereby realizing more accurate blood glucose control. The invention further discloses a closed-loop infusion system designed based on the real-time adjustment method. The closed-loop infusion system comprises a controller, a blood glucose detection system, an insulin pump and a continuous glucose monitoring system. Compared with open-loop control, the closed-loop control can monitor the blood glucose level of the patient in real time and automatically adjust the insulin infusion amount according to real-time data, and the high-automation system can more accurately maintain the blood glucose within the target range and reduce blood glucose fluctuation. Moreover, the closed-loop control system reduces the requirements of patients or medical staff for manually calculating and adjusting the insulin dosage, so that personal errors are reduced, automatic adjustment can better adapt to individual differences and dynamic changes of the patients, the burden of the patients on blood glucose monitoring and insulin dosage adjustment is reduced, and the safety and effectiveness of treatment are improved.

The invention provides an intelligent insulin closed-loop infusion system for type 1 diabetes mellitus, and relates to the technical field of diabetes mellitus treatment equipment. The system comprises a blood glucose monitoring module, a control module, an insulin infusion module, a user interaction module, a wireless communication module and a power module, and closed-loop precise infusion of insulin is achieved through cooperation of the multiple modules. Wherein a closed-loop algorithm based on a dynamic basic rate formula is arranged in the control module, and the insulin infusion amount can be dynamically adjusted in combination with an LSTM blood glucose prediction model and a metabolic parameter least square method updating unit; the insulin infusion module adopts a micro peristaltic pump controlled by PWM (Pulse Width Modulation) and a current monitoring type blockage detection unit, so that the infusion precision and safety are guaranteed. According to the system, the blood glucose standard reaching time proportion can be increased to 78%, the hypoglycemia occurrence frequency is reduced to 0.8 times per week, the system is remarkably superior to a traditional insulin pump and a simple closed-loop system, meanwhile, the system has the advantages of being long in sensor service life and low in power consumption, and the treatment convenience and safety of type 1 diabetes patients are improved.

The invention discloses an insulin infusion control method and system for an insulin pump, and relates to the technical field of insulin infusion control, and the system comprises a dynamic monitoring module, a data analysis module, an evaluation adjustment module and an execution feedback module which operate in sequence; wherein the dynamic monitoring module is used for regularly detecting a blood glucose value once within a set time interval M, and acquiring the meal ordering amount and meal ordering time of a corresponding patient from a meal ordering system in real time under the condition that the patient uses the meal ordering system in a hospital; according to the technical key points, the insulin infusion rate can be more accurately adjusted by dynamically monitoring the blood glucose value and the ordering condition of a patient and combining data analysis so as to adapt to different requirements of the patient before and after a meal; the insulin infusion rate is adjusted in real time according to the ordering condition under the condition that the patient freely orders the food in the hospital, so that the flexibility and comfort of the patient in dining are improved, and the living quality and satisfaction of the patient are improved.

The invention belongs to the field of medical instruments, and provides an insulin infusion device for endocrinology department, comprising a positioning assembly, the positioning assembly comprises a positioning ring, two sides of the positioning ring are respectively provided with a first side connecting block and a second side connecting block, one side of the first side connecting block far away from the positioning ring is provided with a first binding belt, and the other side of the first side connecting block far away from the positioning ring is provided with a second binding belt; a second binding belt is arranged on the side, away from the positioning ring, of the second side edge connecting block. The length of the binding belt can be flexibly adjusted according to the body shape of a user, so that the binding belt is more convenient to adjust, the injector does not need to be held by hand and a piston of the injector does not need to be pushed in the injection process, meanwhile, the fixing ring ensures that a needle stably pierces, use is more convenient, and one person can complete use.

Provided is a personalized artificial intelligence-based insulin dose determination system includes an interface layer capable of communicating with the insulin pump and the continuous blood glucose system, and signal-processing information from the insulin pump and the continuous blood glucose system, a control layer receiving the signal-processed information from the interface layer and generating output information associated with an insulin infusion amount, an outer safety layer determining whether or not the output information generated from the control layer satisfies a preset threshold condition, and delivering the output information to the interface layer when the output information satisfies the preset threshold condition, and a personalized safety layer receiving prescription information including Total Daily Dose of Insulin (TDD) information of the user from the outside to determine a personalized safety control variable, and transmitting the determined control variable as an input variable of the control layer.

A method of administering insulin to a patient to achieve and maintain euglycemia is disclosed. The method includes administering insulin to the patient at a drip rate that is based on a current blood glucose level of the patient and a weight of the patient. Insulin is administered during an initial phase, a transition phase (during which blood glucose level decreases slower than during the initial phase), and a maintenance phase. During the maintenance phase, the method includes adjusting the drip rate periodically based on a current drip rate and a percentage change in blood glucose level during a period of time. In addition, the maintenance phase considers a lookback period in which the drip rate is adjusted based on trends during the lookback period.

Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and / or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

The invention discloses an insulin infusion device for a diabetic patient and a control method, and relates to the technical field of medical instruments, a pump body in the device comprises a liquid medicine channel and a two-section type propelling mechanism connected with the liquid medicine channel in a sealed mode, and the two-section type propelling mechanism comprises a first-stage propelling mechanism, a second-stage propelling mechanism and a third-stage propelling mechanism which are sequentially and coaxially arranged in a nested mode, the driving rod, the first propelling lead screw and the second propelling lead screw are arranged on the base and are in threaded connection with one another, and the rotating motion of the driving rod is converted into axial motion of the first propelling lead screw and the second propelling lead screw; the stage switching detection assembly is used for detecting the displacement state of the first propelling screw rod and outputting a stage switching signal; the locking mechanism responds to a signal, and the driving rod and the first propelling lead screw are connected in a locking mode to enable the driving rod and the first propelling lead screw to rotate jointly. In the first stage, the efficiency requirement of large-dose infusion is met; in the second stage, precise propelling is achieved through the small screw pitch, and the precision requirement of small-dose infusion is met.

This invention discloses a novel centralized remote insulin infusion management method and system, relating to the field of diabetes telemedicine technology. The invention employs a dual-platform architecture separating monitoring and intervention, with the cloud server and dedicated monitoring station as independent cloud subsystems. A persistent WebSocket connection is established between the cloud and the execution terminal to complete identity verification and communication key negotiation. Remote commands are sequentially checked for legality and concurrent conflicts, and command issuance is controlled by a distributed concurrent lock at specified time intervals to prevent deadlock. After completing local security verification, the execution terminal forwards the command to the insulin pump, synchronizing the execution status to the cloud and management terminal in real time, achieving closed-loop control throughout the entire process. This invention significantly improves the real-time performance and security of remote insulin infusion, overcoming the shortcomings of traditional SMS remote control solutions, such as cumbersome processes, unreliable communication, and inability to adapt to centralized management.

The application discloses a closed-loop artificial pancreas insulin infusion control system, which comprises a detection module, a program module and an infusion module.The detection module is used for continuously detecting a current blood glucose value G.The program module is connected with the detection module, and a mixed artificial pancreas algorithm is preset in the program module, which is used for calculating an insulin infusion amount required by a user.The mixed artificial pancreas algorithm comprises a cPID algorithm and / or a cMPC algorithm.The input of the cPID algorithm is an intermediate value of the MPC algorithm, and the input of the cMPC algorithm is an output value of the PID algorithm.The infusion module is connected with the program module, and the program module sends the insulin infusion amount to the infusion module, and the infusion module infuses insulin according to the insulin infusion amount.Through deep combination of the PID algorithm and the MPC algorithm, the advantages of the PID algorithm and the MPC algorithm are fully utilized, the infusion result is more accurate and reliable, and the precise control of the closed-loop artificial pancreas insulin infusion system is realized.

Techniques disclosed herein related to controlling insulin delivery. In some embodiments, the techniques may involve delivering insulin via an insulin infusion device according to a closed-loop mode of delivery. The techniques may further involve determining, at a first time point, insulin delivery is to be switched from the closed-loop mode of delivery to a second mode of delivery. The techniques may further involve switching operation of the insulin infusion device to the second mode of delivery such that insulin is delivered via the insulin infusion device according to the second mode of delivery.

A method for controlling glucose in a flexibly configured dual-hormone artificial pancreas, which manages optional meal and / or exercise notifications using coordinated control actions, comprising the steps of: measuring a plasma glucose signal; calculating the increase (y) of the plasma glucose measurement; defining a model for the increase in plasma glucose; defining carbohydrate intake depending on the carbohydrate content estimated by the patient; and calculating the expected postprandial increase (y) of plasma glucose depending on the administered insulin bolus. * (s) step of defining the increase in corrected plasma glucose TIFF2026529166000143.tif69, corrected insulin infusion volume TIFF2026529166000144.tif59, and adjusted carbohydrate intake Steps to define TIFF2026529166000145.tif69; control action μ r and antagonistic control action μ cr The steps include defining a virtual control action μ(s) divided into and and a nominal value prefilter F r A method comprising the step of calculating a control action using a two-degree-of-freedom (2-DOF) feedback controller having (s).

The application discloses an insulin infusion decision system and method combining reinforcement learning and metabolic simulation, belongs to the field of clinical decision assistance, and comprises a collection and processing module, a metabolic simulation module, a dynamic updating module, a path simulation module, a strategy control module, a monitoring constraint module, a decision analysis module, a correction processing module, a training optimization module and an injection control module. The application can accurately reflect the metabolic characteristics of patients, make insulin decisions more targeted, realize automatic adjustment of the model, keep real-time perception and response to the state of the patient, avoid risks caused by model aging or error accumulation, enhance long-term control capability, improve control efficiency while ensuring blood glucose stability, improve system fault tolerance, improve the explainability and safety of clinical decisions, and enhance the trust of doctors.

Techniques related to temporary setpoint values are disclosed. The techniques may involve causing operation of a fluid delivery device in a closed-loop mode for automatically delivering fluid based on a difference between a first setpoint value and an analyte concentration value during operation of the fluid delivery device in the closed-loop mode. Additionally, the techniques may involve obtaining a second setpoint value. The second setpoint value may be a temporary setpoint value to be used for a period of time to regulate fluid delivery, and the second setpoint value may be greater than the first setpoint value. The techniques may further involve causing operation of the fluid delivery device for automatically reducing fluid delivery for the period of time based on the second setpoint value.

The application discloses a personalized closed-loop artificial pancreas system, which comprises a detection module (100) for continuously detecting blood glucose values of a patient, an infusion module (102) for infusing insulin into the patient, and a program module (101) for controlling the detection module (100) and the infusion module (102). The program module (101) generates insulin infusion instructions according to the blood glucose values detected by the detection module (100) and controls the infusion module (102) to perform infusion. The program module (101) comprises a user interface. In response to an input of the patient, the program module (101) executes a corresponding meal mode function. The meal mode comprises a high-carbohydrate mode and a normal-carbohydrate meal mode. According to the input of the patient, the program module (101) executes the function of the high-carbohydrate mode or the normal-carbohydrate mode, so as to be applicable to people with different carbohydrate consumption habits, improve the adaptability of the closed-loop artificial pancreas to different people, and enable people with different carbohydrate consumption habits to maintain a satisfactory blood glucose control effect.

A personalized closed-loop infusion system and method. Relevant information of patients is uploaded to a cloud server (104), and is grouped on the basis of identifiable features of the patients; the relevant information of different patients, such as blood glucose data records and insulin infusion data records, is compared in a same group; and when the relevant information of the patients is the same or similar, insulin algorithm parameters of patients with well-controlled blood glucose can be used for modifying an insulin algorithm of patients with poorly-controlled blood glucose, and a closed-loop artificial pancreas system can quickly obtain personalized insulin algorithms suitable for the patients without the need of long-period learning of physiological characteristics and lifestyle habits of the patients, thereby benefiting diabetes treatment of the patients.

This application relates to a mobile control device, a device control method, and a computer program product. The mobile control device includes a first graphical element in its graphical user interface for receiving user-inputted high-dose infusion parameters. A first infusion limit in the memory limits the total sum of first high-dose infusion parameters input by the user within a preset time period, and a second infusion limit limits the total sum of second high-dose infusion parameters input by the user within a single day. A processor executes an early warning program: based on different comparison results between the total sum of first high-dose infusion parameters and the first infusion limit, and combined with different comparison results between the total sum of second high-dose infusion parameters and the second infusion limit, the processor controls the second graphical element to display different levels of infusion warnings. This improves the standardization and safety of insulin infusion when the user controls the insulin infusion device.

The invention relates to an equipment control method, insulin infusion equipment, a program product and a closed-loop infusion system, the equipment is applied to the insulin infusion equipment, the insulin infusion equipment comprises a touch screen, at least one memory and at least one processor, the touch screen is used for receiving user input, the memory stores executable instructions, and the processor is used for processing the executable instructions. When the processor executes the executable instructions, the processor is used for realizing the following method: monitoring whether a blood glucose influence event occurs during the operation period of the closed-loop operation mode; the blood glucose influence event comprises an event that the blood glucose level of the user is out of the target blood glucose range of the control parameter due to equipment operation and / or user activity; triggering a safety protection program under the condition that the occurrence of the blood glucose influence event is determined; and carrying out safety management on the closed-loop operation mode of the insulin infusion equipment through a safety protection program.

To provide a closed-loop blood glucose control system and method.SOLUTION: A control device (30) for determining a recommendation value of a control parameter of an insulin infusion device (20).SELECTED DRAWING: Figure 1

The invention relates to the technical field of medical health management, and particularly discloses a patient multi-parameter coupled venous insulin intelligent control method and a patient multi-parameter coupled venous insulin intelligent control system. The method realizes accurate regulation and control of the intravenous insulin infusion rate and ensures that the blood glucose level of a patient is maintained in a safe target interval, and specifically comprises the following steps: evaluating in-vivo energy conversion efficiency and night body sugar regulation efficiency, constructing a comprehensive feature vector by using the parameters, and inputting the comprehensive feature vector into a pre-trained random forest model; the blood glucose fluctuation range of a patient in the current and future preset time periods is predicted in combination with a blood glucose kinetic model, and an optimal insulin infusion rate adjustment strategy is calculated through an optimization algorithm based on a prediction result and a set target blood glucose interval, so that the insulin infusion rate is dynamically adjusted, and it is ensured that the blood glucose level is stably maintained in the target interval.

This invention discloses a closed-loop infusion system and method based on food image recognition. An imaging module acquires food images, and a food image recognition model analyzes these images to obtain food data. An insulin algorithm determines the patient's postprandial insulin infusion volume based on the food data and simulates the patient's postprandial blood glucose. While the artificial pancreas infuses insulin, real-time blood glucose data is monitored. The real-time blood glucose data is compared with the simulated blood glucose data, and the comparison results are used to correct the parameters of the insulin algorithm, making it more suitable for patients. This improves the accuracy and adaptability of the insulin algorithm and benefits the treatment of diabetes.

A method, system, and computer readable medium for a dual mode closed loop control (CLC) system is provided that integrates each of (i) an adaptive, individualized model predictive control (MPC) control law that adjusts the control strength of insulin infusion as a function of recent past control actions, glucose measurements, and derivatives thereof, (ii) an automatic bolus priming system (BPS) that commands an extra insulin injection upon detection of a viable metabolic condition (e.g., an unannounced meal), and (iii) a hyperglycemia mitigation system (HMS) to avoid pervasive hyperglycemia.

The invention discloses a pen type insulin syringe with digital display and data transmission functions. The pen type insulin syringe comprises a shell assembly, a refill sleeve, a shell lock, a dose adjusting knob, a hollow penetrating contact type rotary encoder, an injection driving mechanism, a dose memory display module, an injection dose indication window and an NFC data transmission system. When the device works, the dose adjusting knob is pulled out in the axial direction of the shell assembly, locking of the clamping structure on the dose adjusting knob is relieved, the dose adjusting knob is made to rotate freely, then the hollow penetrating contact type rotary encoder is driven by the dose adjusting knob to conduct dose adjustment, and after dose parameter setting is completed, the injection button is pressed in the axial direction, so that the dose parameter setting is completed. The injection driving mechanism is triggered to move along a preset track so as to push the medicament to complete the injection process. High-precision digital control and intelligent data management in the insulin infusion process are achieved, the accuracy of dose adjustment and injection is remarkably improved, and the convenience of user operation experience and medication compliance management is also optimized.

The invention relates to the technical field of medical equipment, and discloses a diabetic insulin infusion device which comprises a mounting shell, a medicine storage shell is fixedly mounted in the middle of the top end of the mounting shell, a containing cavity used for containing insulin is formed in the medicine storage shell, and a protective shell is detachably connected to one side of the top of the mounting shell; a driving motor is fixedly mounted on the inner side of the protective shell, a fixed seat is fixedly connected to the inner bottom wall of the capacity cavity, a movable rod is slidably connected to an inner through hole of the fixed seat, a rotating shaft is movably connected to the interior of the capacity cavity through a bearing, and a driving part is fixedly connected to the middle side of the exterior of the rotating shaft; and the inner side of the driving piece is rotationally connected with a hinge rod. Through the targeted anti-blocking design, the continuity and smoothness of insulin delivery in the infusion tube can be continuously guaranteed, abnormal blood glucose fluctuation caused by infusion interruption and the risk of hypoglycemia caused by blind supplementary infusion after blockage is removed are avoided, and the stability and accuracy of insulin infusion are remarkably improved.

An insulin infusion system is provided with a manual insertion device having a dual retraction spring (230) configuration for automatic introducer needle (222) retraction. A button (200) of the insertion device is used to insert the introducer needle (222) and catheter (202), and once the introducer needle (222) and catheter (202) have been fully inserted, a rotating engagement releases the dual retraction springs (230) such that the introducer needle (222) automatically retracts, leaving the catheter (202) in the body of the user. An end of the introducer needle (222) remains in the inserted catheter (202) and / or in the septum (206) of the inserted catheter (202) to provide an uninterrupted fluid path.

The fluid conveying equipment comprises a medicine storage device, a rotating sleeve, a ratchet wheel, a ratchet wheel transmission part and a power assembly, and a piston rod of the medicine storage device is sleeved with the rotating sleeve in a threaded connection mode; the ratchet wheel is mounted on the rotating sleeve in a circumferential limiting manner; the ratchet wheel transmission part is elastically clamped on the tooth surface of the ratchet wheel; the power assembly is in transmission connection with the ratchet wheel transmission part and used for driving the ratchet wheel transmission part to do reciprocating rectilinear motion so as to drive the ratchet wheel to rotate in the single circumferential direction. According to the fluid conveying equipment, transmission of infusion control over liquid medicine in the medicine storage device can be achieved through one ratchet wheel, so that the structure of the fluid conveying equipment can be simplified, the size is reduced, and the control precision and reliability of the fluid conveying equipment in the working process are improved.

A method, system, and computer-readable medium are provided for a dual mode closed loop control (CLC) system that integrates each of (i) an adaptive, personalized model predictive control (MPC) control law that adjusts the control intensity of insulin infusion according to recent past control actions, glucose measurements, and derivatives thereof, and (ii) an adaptive, personalized model predictive control (MPC) control law that adjusts the control intensity of insulin infusion according to the recent past control actions, glucose measurements, and derivatives thereof. In one embodiment, the system includes (i) an insulin injection system (e.g., an automated meal dose initiation system (BPS) that commands additional insulin injection upon detection of viable metabolic conditions (e.g., unnotified feeding), and (iii) a hyperglycemia relief system (HMS) to avoid prevalent hyperglycemia.

This application relates to an interface display method, system, central station, readable storage medium, and program product, applied to a blood glucose monitoring system. The method includes: responding to a user-inputted multi-bed observation mode command, controlling the display interface of the blood glucose monitoring system to display multiple display segments; after each display segment completes device binding operations with a blood glucose monitoring device and an insulin infusion device, controlling the information display area in the display segment to display blood glucose measurement values ​​collected during the operation of the blood glucose monitoring device and insulin infusion information implemented during the operation of the insulin infusion device; in the event that at least one abnormal event is detected during the operation of the blood glucose monitoring device and / or insulin infusion device, obtaining alarm reminder information to be displayed according to abnormal event alarm rules; and controlling the alarm display area in the display segment to display the alarm reminder information. This method reduces the maintenance workload caused by the dispersion of devices and data by integrating the management of different devices.

The application discloses a closed-loop artificial pancreas insulin infusion control system, which comprises a detection module, an infusion module, a program module and an electronic module.The detection module is used for continuously detecting the current blood glucose value in a user's body; the infusion module comprises an infusion processor, a second processor and a program module; the infusion processor is used for calculating a first insulin infusion amount I1 according to the current blood glucose value by a first algorithm; the second processor is used for calculating a second insulin infusion amount I2 according to the current blood glucose value by a second algorithm; the program module is connected with the detection module and used for controlling the detection module and the infusion module; and the electronic module is used for optimizing and calculating the first insulin infusion amount I1 and the second insulin infusion amount I2 by a third algorithm to obtain a final insulin infusion amount I3, and sending the final insulin infusion amount I3 to the infusion module, so that the infusion module performs insulin infusion according to the final infusion amount I3.Through further processing of the result, the infusion result is more accurate and reliable, and the precise control of the closed-loop artificial pancreas insulin infusion system is realized.