106 results about "Insulin infusion" patented technology

The invention discloses an insulin infusion decision-making system and method combining reinforcement learning and metabolism simulation, and belongs to the field of clinical decision-making assistance. Comprising an acquisition processing module, a metabolism simulation module, a dynamic updating module, a path simulation module, a strategy control module, a monitoring constraint module, a decision analysis module, a correction processing module, a training optimization module and an injection control module. The method can accurately reflect the metabolic characteristics of the patient, makes the insulin decision more targeted, realizes automatic adjustment of the model, keeps real-time perception and response to the state of the patient, avoids the risk caused by model aging or error accumulation, enhances the long-term control ability, improves the control efficiency while guaranteeing the blood glucose stability, and reduces the cost. The fault-tolerant capability of the system is improved, the interpretability and safety guarantee of clinical decisions are improved, and the credibility of doctors is enhanced.

The invention discloses a real-time adjusting method for insulin infusion volume, which adopts a closed-loop control method, and dynamically adjusts the infusion volume of an insulin pump based on a comparison result of a predicted blood glucose parameter and a preset blood glucose range through collected blood glucose data and predicted future blood glucose data, thereby realizing more accurate blood glucose control. The invention further discloses a closed-loop infusion system designed based on the real-time adjustment method. The closed-loop infusion system comprises a controller, a blood glucose detection system, an insulin pump and a continuous glucose monitoring system. Compared with open-loop control, the closed-loop control can monitor the blood glucose level of the patient in real time and automatically adjust the insulin infusion amount according to real-time data, and the high-automation system can more accurately maintain the blood glucose within the target range and reduce blood glucose fluctuation. Moreover, the closed-loop control system reduces the requirements of patients or medical staff for manually calculating and adjusting the insulin dosage, so that personal errors are reduced, automatic adjustment can better adapt to individual differences and dynamic changes of the patients, the burden of the patients on blood glucose monitoring and insulin dosage adjustment is reduced, and the safety and effectiveness of treatment are improved.

The invention provides an intelligent insulin closed-loop infusion system for type 1 diabetes mellitus, and relates to the technical field of diabetes mellitus treatment equipment. The system comprises a blood glucose monitoring module, a control module, an insulin infusion module, a user interaction module, a wireless communication module and a power module, and closed-loop precise infusion of insulin is achieved through cooperation of the multiple modules. Wherein a closed-loop algorithm based on a dynamic basic rate formula is arranged in the control module, and the insulin infusion amount can be dynamically adjusted in combination with an LSTM blood glucose prediction model and a metabolic parameter least square method updating unit; the insulin infusion module adopts a micro peristaltic pump controlled by PWM (Pulse Width Modulation) and a current monitoring type blockage detection unit, so that the infusion precision and safety are guaranteed. According to the system, the blood glucose standard reaching time proportion can be increased to 78%, the hypoglycemia occurrence frequency is reduced to 0.8 times per week, the system is remarkably superior to a traditional insulin pump and a simple closed-loop system, meanwhile, the system has the advantages of being long in sensor service life and low in power consumption, and the treatment convenience and safety of type 1 diabetes patients are improved.

The invention discloses an insulin infusion control method and system for an insulin pump, and relates to the technical field of insulin infusion control, and the system comprises a dynamic monitoring module, a data analysis module, an evaluation adjustment module and an execution feedback module which operate in sequence; wherein the dynamic monitoring module is used for regularly detecting a blood glucose value once within a set time interval M, and acquiring the meal ordering amount and meal ordering time of a corresponding patient from a meal ordering system in real time under the condition that the patient uses the meal ordering system in a hospital; according to the technical key points, the insulin infusion rate can be more accurately adjusted by dynamically monitoring the blood glucose value and the ordering condition of a patient and combining data analysis so as to adapt to different requirements of the patient before and after a meal; the insulin infusion rate is adjusted in real time according to the ordering condition under the condition that the patient freely orders the food in the hospital, so that the flexibility and comfort of the patient in dining are improved, and the living quality and satisfaction of the patient are improved.

The invention belongs to the field of medical instruments, and provides an insulin infusion device for endocrinology department, comprising a positioning assembly, the positioning assembly comprises a positioning ring, two sides of the positioning ring are respectively provided with a first side connecting block and a second side connecting block, one side of the first side connecting block far away from the positioning ring is provided with a first binding belt, and the other side of the first side connecting block far away from the positioning ring is provided with a second binding belt; a second binding belt is arranged on the side, away from the positioning ring, of the second side edge connecting block. The length of the binding belt can be flexibly adjusted according to the body shape of a user, so that the binding belt is more convenient to adjust, the injector does not need to be held by hand and a piston of the injector does not need to be pushed in the injection process, meanwhile, the fixing ring ensures that a needle stably pierces, use is more convenient, and one person can complete use.

The invention relates to an insulin infusion management device and an insulin infusion management system.The insulin infusion management device is characterized in that a user interface comprises a real-time monitoring interface; the information statistics display area of the real-time monitoring interface displays a blood glucose change curve generated according to the blood glucose monitoring information and the first association relationship; when the blood glucose level recording point is input and selected by the first user, the information statistics display area is controlled to display a numerical value display area in a floating mode, and the numerical value display area is perpendicularly connected with the selected blood glucose level recording point through a dotted line indication line so that the numerical value display area and the blood glucose change curve can be completely displayed at the same time in the information statistics display area; and receiving a dragging operation input by a second user, and displaying the corresponding blood glucose monitoring information and / or insulin infusion information in an associated manner according to the blood glucose level recording point. The safety and reliability of insulin infusion control and blood glucose monitoring are ensured, and the user experience is improved.

Provided is a personalized artificial intelligence-based insulin dose determination system includes an interface layer capable of communicating with the insulin pump and the continuous blood glucose system, and signal-processing information from the insulin pump and the continuous blood glucose system, a control layer receiving the signal-processed information from the interface layer and generating output information associated with an insulin infusion amount, an outer safety layer determining whether or not the output information generated from the control layer satisfies a preset threshold condition, and delivering the output information to the interface layer when the output information satisfies the preset threshold condition, and a personalized safety layer receiving prescription information including Total Daily Dose of Insulin (TDD) information of the user from the outside to determine a personalized safety control variable, and transmitting the determined control variable as an input variable of the control layer.

The invention relates to the technical field of medical instruments, in particular to an insulin infusion device for the endocrinology department, which comprises a positioning device main body, an injection pen is arranged outside the positioning device main body, an inner ring is arranged inside the positioning device main body, and the positioning device main body is connected with the inner ring through a plurality of groups of separation ropes which are distributed at equal intervals. The space between the positioning device body and the inner ring is divided into multiple sets of injection areas distributed at equal intervals through multiple sets of partition ropes, first connecting belts are fixedly connected to the two ends, away from each other, of the outer side of the positioning device body, and elastic bands are fixedly connected to the ends, away from the positioning device body, of the two sets of first connecting belts. Compared with an existing insulin infusion device for the endocrinology department, the insulin infusion device for the endocrinology department has the advantage that the overall practicability of the insulin infusion device for the endocrinology department can be improved through the design.

A method of administering insulin to a patient to achieve and maintain euglycemia is disclosed. The method includes administering insulin to the patient at a drip rate that is based on a current blood glucose level of the patient and a weight of the patient. Insulin is administered during an initial phase, a transition phase (during which blood glucose level decreases slower than during the initial phase), and a maintenance phase. During the maintenance phase, the method includes adjusting the drip rate periodically based on a current drip rate and a percentage change in blood glucose level during a period of time. In addition, the maintenance phase considers a lookback period in which the drip rate is adjusted based on trends during the lookback period.

The invention belongs to the field of insulin infusion devices, and discloses an intelligent insulin infusion device for diabetic patients and a blood glucose control method.The device comprises a blood glucose monitoring module, an intelligent insulin infusion module, an AI control center, a user interaction module and a safety monitoring module. The DNN model can accurately predict the short-term blood glucose trend, and the response speed and accuracy of insulin infusion are remarkably improved; a dynamic adjustment algorithm dynamically adjusts the insulin dosage according to individual differences of patients and real-time data, and the risk of complications is reduced; the calculation and response time is reduced through combination of the model and the algorithm, and millisecond-level insulin infusion control is achieved; the system monitors and corrects an insulin infusion strategy in real time, reduces the risk of hypoglycemia and infusion failure, and ensures the safety of a patient. According to the invention, the living quality and the blood glucose management level of the diabetic patient are obviously improved, and meanwhile, the application and development of the intelligent medical technology in chronic disease management are promoted.

Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and / or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

The invention discloses an insulin infusion device for a diabetic patient and a control method, and relates to the technical field of medical instruments, a pump body in the device comprises a liquid medicine channel and a two-section type propelling mechanism connected with the liquid medicine channel in a sealed mode, and the two-section type propelling mechanism comprises a first-stage propelling mechanism, a second-stage propelling mechanism and a third-stage propelling mechanism which are sequentially and coaxially arranged in a nested mode, the driving rod, the first propelling lead screw and the second propelling lead screw are arranged on the base and are in threaded connection with one another, and the rotating motion of the driving rod is converted into axial motion of the first propelling lead screw and the second propelling lead screw; the stage switching detection assembly is used for detecting the displacement state of the first propelling screw rod and outputting a stage switching signal; the locking mechanism responds to a signal, and the driving rod and the first propelling lead screw are connected in a locking mode to enable the driving rod and the first propelling lead screw to rotate jointly. In the first stage, the efficiency requirement of large-dose infusion is met; in the second stage, precise propelling is achieved through the small screw pitch, and the precision requirement of small-dose infusion is met.

This invention discloses a novel centralized remote insulin infusion management method and system, relating to the field of diabetes telemedicine technology. The invention employs a dual-platform architecture separating monitoring and intervention, with the cloud server and dedicated monitoring station as independent cloud subsystems. A persistent WebSocket connection is established between the cloud and the execution terminal to complete identity verification and communication key negotiation. Remote commands are sequentially checked for legality and concurrent conflicts, and command issuance is controlled by a distributed concurrent lock at specified time intervals to prevent deadlock. After completing local security verification, the execution terminal forwards the command to the insulin pump, synchronizing the execution status to the cloud and management terminal in real time, achieving closed-loop control throughout the entire process. This invention significantly improves the real-time performance and security of remote insulin infusion, overcoming the shortcomings of traditional SMS remote control solutions, such as cumbersome processes, unreliable communication, and inability to adapt to centralized management.

The application discloses a closed-loop artificial pancreas insulin infusion control system, which comprises a detection module, a program module and an infusion module.The detection module is used for continuously detecting a current blood glucose value G.The program module is connected with the detection module, and a mixed artificial pancreas algorithm is preset in the program module, which is used for calculating an insulin infusion amount required by a user.The mixed artificial pancreas algorithm comprises a cPID algorithm and / or a cMPC algorithm.The input of the cPID algorithm is an intermediate value of the MPC algorithm, and the input of the cMPC algorithm is an output value of the PID algorithm.The infusion module is connected with the program module, and the program module sends the insulin infusion amount to the infusion module, and the infusion module infuses insulin according to the insulin infusion amount.Through deep combination of the PID algorithm and the MPC algorithm, the advantages of the PID algorithm and the MPC algorithm are fully utilized, the infusion result is more accurate and reliable, and the precise control of the closed-loop artificial pancreas insulin infusion system is realized.

Techniques disclosed herein related to controlling insulin delivery. In some embodiments, the techniques may involve delivering insulin via an insulin infusion device according to a closed-loop mode of delivery. The techniques may further involve determining, at a first time point, insulin delivery is to be switched from the closed-loop mode of delivery to a second mode of delivery. The techniques may further involve switching operation of the insulin infusion device to the second mode of delivery such that insulin is delivered via the insulin infusion device according to the second mode of delivery.

A method for controlling glucose in a flexibly configured dual-hormone artificial pancreas, which manages optional meal and / or exercise notifications using coordinated control actions, comprising the steps of: measuring a plasma glucose signal; calculating the increase (y) of the plasma glucose measurement; defining a model for the increase in plasma glucose; defining carbohydrate intake depending on the carbohydrate content estimated by the patient; and calculating the expected postprandial increase (y) of plasma glucose depending on the administered insulin bolus. * (s) step of defining the increase in corrected plasma glucose TIFF2026529166000143.tif69, corrected insulin infusion volume TIFF2026529166000144.tif59, and adjusted carbohydrate intake Steps to define TIFF2026529166000145.tif69; control action μ r and antagonistic control action μ cr The steps include defining a virtual control action μ(s) divided into and and a nominal value prefilter F r A method comprising the step of calculating a control action using a two-degree-of-freedom (2-DOF) feedback controller having (s).

The application discloses an insulin infusion decision system and method combining reinforcement learning and metabolic simulation, belongs to the field of clinical decision assistance, and comprises a collection and processing module, a metabolic simulation module, a dynamic updating module, a path simulation module, a strategy control module, a monitoring constraint module, a decision analysis module, a correction processing module, a training optimization module and an injection control module. The application can accurately reflect the metabolic characteristics of patients, make insulin decisions more targeted, realize automatic adjustment of the model, keep real-time perception and response to the state of the patient, avoid risks caused by model aging or error accumulation, enhance long-term control capability, improve control efficiency while ensuring blood glucose stability, improve system fault tolerance, improve the explainability and safety of clinical decisions, and enhance the trust of doctors.

A method for estimating a glucose value of a user and an insulin infusion and management system are provided. An insulin infusion and management system may include an insulin infusion device configured to deliver insulin to a user; a glucometer; a source of user activity data; and a processor-based computing device that supports data communication with the insulin infusion device. A processor device of a computing device may execute a method for estimating a glucose value of a user.

Techniques related to temporary setpoint values are disclosed. The techniques may involve causing operation of a fluid delivery device in a closed-loop mode for automatically delivering fluid based on a difference between a first setpoint value and an analyte concentration value during operation of the fluid delivery device in the closed-loop mode. Additionally, the techniques may involve obtaining a second setpoint value. The second setpoint value may be a temporary setpoint value to be used for a period of time to regulate fluid delivery, and the second setpoint value may be greater than the first setpoint value. The techniques may further involve causing operation of the fluid delivery device for automatically reducing fluid delivery for the period of time based on the second setpoint value.

A drug infusion system with a graphical user interface, comprising: a detection device (100) for detecting a blood glucose level of a user; the infusion device (102) is used for infusing medicine into the body of the user; and a control device (101), the control device (101) being in wireless communication with the detection device (100) and the infusion device (102), the control device (101) controlling drug delivery of the infusion device (102), the control device (101) being provided with a graphical user interface, the graphical user interface comprising a main screen, the main screen comprising an insulin information display area and a blood glucose information display area, the insulin information display area comprises insulin infusion state information, and the user interface displays the insulin infusion state information in a graph (2021) and / or text (2022) mode, so that a user can intuitively know the current insulin infusion state information and blood glucose information.

Embodiments of the present disclosure provide insulin formulations having a near neutral pH and improved pharmacokinetic / pharmacodynamic properties, and uses in insulin infusion devices that may provide extended infusion period up to 7-14 days. Also provided are systems for administering insulin, the system may include a first reservoir, a second reservoir, an insulin pump configured to administer contents of the first reservoir or the second reservoir, and one or more hardware processors in communication with the insulin pump.

The application discloses a personalized closed-loop artificial pancreas system, which comprises a detection module (100) for continuously detecting blood glucose values of a patient, an infusion module (102) for infusing insulin into the patient, and a program module (101) for controlling the detection module (100) and the infusion module (102). The program module (101) generates insulin infusion instructions according to the blood glucose values detected by the detection module (100) and controls the infusion module (102) to perform infusion. The program module (101) comprises a user interface. In response to an input of the patient, the program module (101) executes a corresponding meal mode function. The meal mode comprises a high-carbohydrate mode and a normal-carbohydrate meal mode. According to the input of the patient, the program module (101) executes the function of the high-carbohydrate mode or the normal-carbohydrate mode, so as to be applicable to people with different carbohydrate consumption habits, improve the adaptability of the closed-loop artificial pancreas to different people, and enable people with different carbohydrate consumption habits to maintain a satisfactory blood glucose control effect.

A personalized closed-loop infusion system and method. Relevant information of patients is uploaded to a cloud server (104), and is grouped on the basis of identifiable features of the patients; the relevant information of different patients, such as blood glucose data records and insulin infusion data records, is compared in a same group; and when the relevant information of the patients is the same or similar, insulin algorithm parameters of patients with well-controlled blood glucose can be used for modifying an insulin algorithm of patients with poorly-controlled blood glucose, and a closed-loop artificial pancreas system can quickly obtain personalized insulin algorithms suitable for the patients without the need of long-period learning of physiological characteristics and lifestyle habits of the patients, thereby benefiting diabetes treatment of the patients.

This application relates to a mobile control device, a device control method, and a computer program product. The mobile control device includes a first graphical element in its graphical user interface for receiving user-inputted high-dose infusion parameters. A first infusion limit in the memory limits the total sum of first high-dose infusion parameters input by the user within a preset time period, and a second infusion limit limits the total sum of second high-dose infusion parameters input by the user within a single day. A processor executes an early warning program: based on different comparison results between the total sum of first high-dose infusion parameters and the first infusion limit, and combined with different comparison results between the total sum of second high-dose infusion parameters and the second infusion limit, the processor controls the second graphical element to display different levels of infusion warnings. This improves the standardization and safety of insulin infusion when the user controls the insulin infusion device.

The invention relates to an equipment control method, insulin infusion equipment, a program product and a closed-loop infusion system, the equipment is applied to the insulin infusion equipment, the insulin infusion equipment comprises a touch screen, at least one memory and at least one processor, the touch screen is used for receiving user input, the memory stores executable instructions, and the processor is used for processing the executable instructions. When the processor executes the executable instructions, the processor is used for realizing the following method: monitoring whether a blood glucose influence event occurs during the operation period of the closed-loop operation mode; the blood glucose influence event comprises an event that the blood glucose level of the user is out of the target blood glucose range of the control parameter due to equipment operation and / or user activity; triggering a safety protection program under the condition that the occurrence of the blood glucose influence event is determined; and carrying out safety management on the closed-loop operation mode of the insulin infusion equipment through a safety protection program.

A personal diabetes equipment management system can include at least one diabetes treatment device adapted for use with one or more disposable diabetes devices; a remote server system including an inventory database identifying operational diabetes treatment devices and operational disposable diabetes devices in the possession of a user; and a controller in communication with (i) the at least one diabetes treatment device over a first network connection and (ii) the remote server system over a second network connection, the controller adapted to automatically detect use of the at least one diabetes treatment device and determine an operational condition for the diabetes treatment device or the one or more disposable diabetes treatment devices based on information received from the at least one diabetes treatment device over the first network connection, the controller transmitting update information to the remote server system over the second network connection to update the inventory database.

To provide a closed-loop blood glucose control system and method.SOLUTION: A control device (30) for determining a recommendation value of a control parameter of an insulin infusion device (20).SELECTED DRAWING: Figure 1

The invention relates to the technical field of medical health management, and particularly discloses a patient multi-parameter coupled venous insulin intelligent control method and a patient multi-parameter coupled venous insulin intelligent control system. The method realizes accurate regulation and control of the intravenous insulin infusion rate and ensures that the blood glucose level of a patient is maintained in a safe target interval, and specifically comprises the following steps: evaluating in-vivo energy conversion efficiency and night body sugar regulation efficiency, constructing a comprehensive feature vector by using the parameters, and inputting the comprehensive feature vector into a pre-trained random forest model; the blood glucose fluctuation range of a patient in the current and future preset time periods is predicted in combination with a blood glucose kinetic model, and an optimal insulin infusion rate adjustment strategy is calculated through an optimization algorithm based on a prediction result and a set target blood glucose interval, so that the insulin infusion rate is dynamically adjusted, and it is ensured that the blood glucose level is stably maintained in the target interval.

A method for improving blood glucose control of a hybrid controller meal and exercise announcement by substituting patient-initiated meal boluses of said hybrid controller by an automatic insulin correction signal without retuning of said hybrid controller, and by incorporating rescue carbohydrates suggestion for hypoglycemia mitigation, comprising the steps of measuring a plasma glucose (G(t)) signal by means of a continuous glucose monitor (CGM), calculating a glucose level (Ĝ(t)) by using a glucose-insulin model; computing a disturbance term d(t), generating a virtual signal uIMC(t), for mitigating the effect of d(t) on the output, by means of an IMC filter Q(s) and converting the virtual signal uIMC(t) into three feed forward actions: insulin infusion, rescue carbohydrate suggestion, and insulin-on-board reduction.

This invention discloses a closed-loop infusion system and method based on food image recognition. An imaging module acquires food images, and a food image recognition model analyzes these images to obtain food data. An insulin algorithm determines the patient's postprandial insulin infusion volume based on the food data and simulates the patient's postprandial blood glucose. While the artificial pancreas infuses insulin, real-time blood glucose data is monitored. The real-time blood glucose data is compared with the simulated blood glucose data, and the comparison results are used to correct the parameters of the insulin algorithm, making it more suitable for patients. This improves the accuracy and adaptability of the insulin algorithm and benefits the treatment of diabetes.