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2022 results about "Physiological function" patented technology

Spinal interbody fusion device and method

InactiveUS20050027359A1Resist translationalResist rotational movementInternal osteosythesisBone implantSpinal columnBending of plates
A disc replacement spinal interbody fusion device is provided having a central sleeve with oppositely left and right-hand threaded axial bores with different diameters. Circumferential threaded apertures are located on the sleeve and open into the sleeve bores. The device has two opposing plates which are oval-shaped and centrally, axially bored. Each plate has a perpendicular shaft with an axial bore which communicates with the shaft bore. The first shaft has external left-hand threads and the second shaft has external right-hand threads, each to mate with different bores of the sleeve. The outside diameter of the first shaft is smaller than the inside diameter of the second shaft, allowing the two shafts to axially engage. The spinal interbody fusion device operates like a turnbuckle, vertically expanding when the sleeve is rotated in one direction and retracting when the sleeve is rotated in the opposite direction. The assembled device defines an open channel axially. Once the fusion device is set at its proper height, set screws are threaded into circumferential apertures of the sleeve to compress against the shaft threads of each plate to maintain a fixed height. In situ, axial loading of the spinal column upon the fusion device creates a bending moment manifested by a flexing action of the plates to generate opposing axial directional forces which replicate the physiological function of shock absorption, load bearing and load transmission.
Owner:MASHBURN M LAINE

Contrast agent imaging with destruction pulses in diagnostic medical ultrasound

The invention is directed to improvements in diagnostic medical ultrasound contrast agent imaging. In a preferred embodiment, high pulse repetition frequency (HPRF) destruction pulses are fired at a rate higher than necessary for receiving returning echoes. Pulse parameters can also be changed between the plurality of contrast agent-destroying pulses. Other preferred embodiments of the invention are directed to simultaneous transmission of multiple beams of destruction pulses. Destruction frames that consist of a plurality of destruction pulses can be triggered and swept over the entire region of tissue being imaged and at a variety of focal depths from the transmitter. The destruction frames are fired at some time triggered from a timer or some fixed part of a physiological signal, such as an ECG signal. Other preferred embodiments of the invention are directed to continuous low power imaging pulses alternating with destruction pulses triggered at a fixed point of a physiological signal, and a comparison of the received signals from imaging pulses fired before and after the destruction pulses. Alternatively, destruction pulses are triggered at a fixed point on a physiological signal different from the fixed point of a physiological signal used to trigger imaging pulses. In another embodiment, triggered destruction frames are used to enable a comparison of imaging frames in order to determine physiological functions, such as perfusion of blood in cardiac tissue. Finally, in another embodiment, destruction pulses are combined with subharmonic imaging.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC

Fluid sampling, analysis and delivery system

The lack of safe, reliable, automated and clinically acceptable blood sampling has been the main problem precluding the development of real-time systems for blood analysis and subsequent closed-loop physiological function control. While the analysis of a static blood sample in laboratory conditions has been rapidly advancing in reliability and blood volume reduction, non-invasive real-time blood analysis performed in vivo (while the blood is circulating in the body) has been elusive and unreliable. In this study we propose an innovative idea for semi-invasive blood sampling and analysis, which resembles the operation of a mosquito. At a miniature scale the proposed system does penetrate the skin to extract a static blood sample for further analysis, but the extent of this penetration, and the fact that it can be made painless, is particularly attractive for such applications as automated glucose analysis for closed-loop control of insulin infusion (artificial pancreas), continuous drug monitoring, or even periodic DNA analysis for security and identification purposes. These design aspects are described, and a specific implementation, applying MEMS (Micro Electro Mechanical Systems) technology, is suggested. The proposed microsystem is a matrix of individually controllable e-Mosquito™ cells, packaged in a disposable patch and attached to the skin, could be an avenue for real-time semi-invasive blood analysis and diagnostics.
Owner:UNIV TECH INT

Chinese medicinal herb additive for egg chickens and application

The invention discloses a Chinese medicinal herb additive for egg chickens and application. The Chinese medicinal herb additive comprises membranous milkvetch root, eucommia bark, honeysuckle, jiuyue, Weeping Forsythiae Capsule, szechwon tangshen root, sanguisorba, hawthorn, Indian Buead, officinal magnolia bark, Chinese pulsatilla root, giant knotweed rhizome, ricepaperplant pith, largehead atractylodes rhizome, tangerine peel, malt, indigowoad root, swordlike atractylodes rhizome, indigowoad leaf, three immortals, liquorice, cyrtomium fortune, nutgrass galingale rhizome, chatoyancy, calamus and pinellia tuber, and mixture of the compositions is added with calcium bicarbonate, phytase, vitamin E and methionine. The Chinese medicinal herb additive effectively promotes absorption of nutrient, can prevent and control diseases, strengthen quality of eggshells, reduce the broken egg rate and soft-shell eggs, abnormal eggs and sand shell eggs, can effectively prevent bird flu, prevent and control diseases such as laxness, feather pecking, hair shedding, anus pecking, salpingitis, respiratory disease and the like, can achieve good effect with a dosage of about 4 percent, cannot damage physiological functions of the egg chickens, and can prolong egg laying peak season, improve color of the eggshells and the laying rate by 8 to 20 percent, and increase weight of eggs.
Owner:邹振可

Multicellular metabolic models and methods

The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) a constraint set for said plurality of reactions for said first, second and third data structures, and (e) commands for determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells. The first, second and third data structures also can include a plurality of data structures. Additionally provided is a method for predicting a physiological function of a multicellular organism. The method includes: (a) providing a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) providing a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) providing a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) providing a constraint set for said plurality of reactions for said first, second and third data structures; (e) providing an objective function, and (f) determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells.
Owner:GENOMATICA INC
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