245 results about "Physiological function" patented technology

The invention relates to the technical field of data processing, and discloses an old people health state assessment data processing system based on multi-modal data, and the system comprises a medical data integration module which obtains electronic medical record data and a medical examination report through an FHIR interface, and extracts a structured health index; the cross-modal causal fusion processing module is used for fusing the monitoring data and the medical text through an image, text and image interlayer architecture; the health state evolution modeling module is used for mapping the health feature vectors into physiological function, cognitive level and athletic ability three-dimensional state indexes; an evaluation report backtracking module; and a decision output module. Through an image, text and image interlayer architecture, deep semantic fusion of multi-modal features is realized under the constraint of medical pathology rules, feature weight adaptive distribution is dynamically guided based on a medical causal atlas, a high-dimensional fusion vector retaining key pathology information is generated, the semantic integration ability of health data is remarkably improved, and the health data fusion efficiency is improved. And the reliability of discrimination and decision making is improved.

The utility model provides a tracheal stent structure and an artificial trachea. The tracheal stent structure comprises a main body, the main body comprises a plurality of supporting units which are linearly arranged at intervals; each supporting unit is of a C-shaped structure with an opening, a connecting unit is arranged between every two adjacent supporting units, and each connecting unit is of a structure with a hole. According to the tracheal stent assembly, the bionic tubular structure similar to the tracheal structure of the human body is formed by arranging the structure, so that the contraction and expansion functions can be achieved in the breathing process, and the physiological function requirements are met.

The invention relates to the technical field of bioactive peptides, in particular to a novel multifunctional collagen-like tripeptide and application thereof, an amino acid sequence contains multiple combinations, X can be selected from multiple components, 3-methoxy-4-hydroxyphenylalanine and the like are added, and the novel multifunctional collagen-like tripeptide can interact with specific proteins, activate related pathways and play multiple physiological functions and is applied to multiple fields. The collagen-like tripeptide has obvious advantages, innovates component expansion functions, improves the preparation method, improves the efficiency, reduces the cost, is matched with other components in the fields of beauty, health care and medicine, enhances the efficacy, realizes targeted delivery, and brings a new opportunity to related industries.

The application relates to the technical field of data processing, and discloses an old person health state evaluation data processing system based on multi-modal data, which comprises a medical data integration module, an across-modal causal fusion processing module, a health state evolution modeling module, a backtracking evaluation report module and a decision output module. The medical data integration module acquires electronic medical record data and medical examination reports through a FHIR interface and extracts structured health indexes. The across-modal causal fusion processing module fuses monitoring data and medical texts through an image, a text and an image sandwich architecture. The health state evolution modeling module maps a health feature vector into three-dimensional state indexes of physiological functions, cognitive levels and motor abilities. The backtracking evaluation report module and the decision output module are used for backtracking evaluation and decision output. Through the image, the text and the image sandwich architecture, deep semantic fusion of multi-modal features is realized under the constraint of medical pathology rules, feature weight adaptive distribution is dynamically guided based on a medical causal graph, a high-dimensional fusion vector retaining key pathological information is generated, the semantic integration capability of health data is significantly improved, and the reliability of discrimination and decision is improved.

The invention belongs to the technical field of biomedicine, and relates to a method for constructing a mouse embryo-derived hypothalamic organ model and application, the invention proposes that a mouse embryo is used for constructing a hypothalamic organ for the first time, and the mouse embryo has a definite development time sequence and genetic operability; the naturally retained vascular endothelial cells and multilineage precursor cells provide unique advantages for constructing a three-dimensional organ containing multiple nucleuses such as a preoptic region, a paraventricular nucleus, an arcuate nucleus and a supraoptic nucleus, and the model not only breaks through the nucleus coverage limitation of the existing iPSCs organ, but also can be used for constructing the three-dimensional organ containing multiple nucleuses such as the preoptic region, the paraventricular nucleus, the arcuate nucleus, the supraoptic nucleus and the like by reconstructing a nerve-blood vessel unit. High-fidelity simulation of complex physiological functions of the hypothalamus is realized, and an irreplaceable technical platform is provided for mechanism analysis of neuroendocrine diseases and high-throughput screening of drugs.

The invention relates to the technical field of biology, and particularly provides an endometrial organ culture method. By optimizing the endometrial organoid differentiation culture system, compared with an existing culture mode, the optimized culture system is easy to operate, the organoid with more complete physiological functions can be prepared without co-culture with stromal cells, continuous culture can be conducted for at least one year or above, and the obtained organoid is complete in secretion function and free of secondary pollution. The phenotype of cilia cells is more obvious.

The invention relates to the technical field of medical information analysis, in particular to a thoracic surgery postoperative complication assessment method and system based on multi-dimensional analysis, and the method comprises the following steps: S1, obtaining a postoperative multi-dimensional monitoring data set; s2, performing standardized preprocessing on the multi-dimensional monitoring data set to generate standardized monitoring data; s3, classifying and integrating the standardized monitoring data into physiological function data, drainage feature data and motion perception data according to data types; s4, chest dynamic pressure change analysis is carried out, and pressure gradient change parameters are calculated; s5, obtaining an abnormal metabolite ratio index; and S6, generating a complication risk assessment report. According to the method, through standardized integration and weighted analysis of the multi-dimensional postoperative monitoring data, accurate quantitative evaluation and graded output of the thoracic surgery postoperative complication risk are realized, and the reliability of early warning and the timeliness of clinical intervention are improved.

The invention discloses a chest wall defect three-dimensional reconstruction and personalized repair material design system, and relates to the technical field of intelligent medical aided design. Comprising a data acquisition module used for acquiring and preprocessing multi-modal data of the chest wall of a patient; the partition module is used for dividing the defect area into different functional partitions by coupling and analyzing stress and blood flow data and setting a threshold value; the dynamic optimization module is used for mapping the breathing time sequence to a three-dimensional space and dynamically correcting the partition boundary according to the stress change in the breathing cycle; the interface matching module is used for carrying out parameterization design on a host bone interface according to the bone mineral density data; and the optimization design module is used for carrying out topological structure and pore distribution dual optimization on the repair material based on the dynamic partition and the interface parameters, and finally, the output module generates design data capable of directly driving manufacturing. Precise matching of the repairing material and the physiological anatomical structure and the dynamic physiological function of the patient is achieved.

The invention relates to the technical field of digital cell models, in particular to a construction method and system of a digital cell model and a storage medium. The method comprises the following steps: acquiring target cell data, extracting a target cell structure, and performing molecular physiological function analysis in combination with the cell structure and the data to obtain molecular physiological function data of cells; performing cell molecule metabolism network analysis to obtain cell molecule metabolism network data, and constructing a digital cell model; through the model, the reaction of the cells under the environmental pressure can be simulated, the attenuation of the physiological state of the cells can be estimated, and then the gene defects of the cells can be analyzed; according to the cell gene defect, adjusting the target cell data to obtain cell gene adjustment data; according to the method, the cell model is constructed, so that the dynamic change analysis of the cells is more accurate.

The present invention relates to a method and system for analysing audio (eg. music) tracks. A predictive model of the neuro-physiological functioning and response to sounds by one or more of the human lower cortical, limbic and subcortical regions in the brain is described. Sounds are analysed so that appropriate sounds can be selected and played to a listener in order to stimulate and / or manipulate neuro-physiological arousal in that listener. The method and system are particularly applicable to applications harnessing a biofeedback resource.

The invention provides a motor neuron and myotubular cell co-culture method and model and application thereof. The motor neuron and myotubular cell co-culture method comprises the steps that motor neuron is cultured to form a neural network, and a motor neuron culture layer with the formed neural network is obtained; culturing myoblasts, inducing differentiation to form fine myotube cells, adding a mitosis inhibitor, and digesting and separating to obtain the fine myotube cells; and inoculating fine myotubular cells to the motor neuron culture layer with the formed neural network, and co-culturing. The co-culture method disclosed by the invention overcomes the limitation of a traditional nerve cell and muscle cell co-culture method, and has the advantages of simplicity, convenience, high efficiency, stability and the like. The method not only provides an effective experimental tool for related basic research of neuromuscular joint formation, physiological functions and the like, but also has wide application prospects in the fields of neuromuscular disease research, drug screening, toxicological research, gene therapy and the like.

The invention discloses application of miRNA in diagnosis, prediction and treatment of bile duct cancer, and relates to the technical field of biological pharmacy. Specifically, the invention provides a reagent for promoting miR-26 expression or exerting physiological functions, and / or a simulation compound with the same physiological functions as miR-26, and an application method of the reagent in preparation of drugs for treating bile duct cancer, and provides a possibility for treating bile duct cancer and guiding research, development and screening of related drugs. The invention also provides a product for diagnosing and / or predicting the biliary duct cancer of a subject, and the expression level of miR-26 can be detected by using the product, so that the risk of the subject suffering from the biliary duct cancer can be predicted, and the severity of the biliary duct cancer can be diagnosed; and a possibility is provided for diagnosing the bile duct cancer.

The invention relates to medicine and is intended for the multimodal treatment of child patients with congenital cleft lip and palate. A method for the stepped multimodal treatment of children with cleft lip and palate involves carrying out multimodal treatment in a number of steps. At the age of 1-3 months, primary cheilorhinoplasty is performed; at the age of 6-8 months, the cleft in the soft palate is repaired; the congenital defect in the hard palate is repaired at the age of up to 12 months; and the results of the multimodal surgical treatment are assessed at the age of 2-3 years. The method makes it possible to fully restore a child's physiological functions, achieve aesthetically pleasing contours of the upper lip and nose and allow age-appropriate speech development.

The invention relates to a method for regulating and controlling the phase separation capacity of protein and application thereof. The method comprises the following steps: mixing a first protein element and a second protein element to obtain a mixture; detecting the phase separation capacity of the mixture; wherein the first protein element comprises an IDR structural domain of the scaffold protein, and the second protein element comprises a self-assembly structural domain of the scaffold protein or the IDR structural domain of the scaffold protein. According to the method, the IDR structural domain of the scaffold protein is used as the first protein element, the self-assembly structural domain of the scaffold protein or the IDR structural domain of the scaffold protein is used as the second protein element, and the first protein element and the second protein element interact with each other, so that the phase separation strength of the protein elements can be accurately regulated and controlled; and physical or chemical factor intervention is not needed, so that the compatibility between the regulation process and the normal physiological function of the cell is ensured. The method for regulating and controlling the phase separation capacity of the protein has relatively high controllability and biocompatibility.

Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The embodiment of the invention provides an intelligent cabin control method, device, equipment and program product, and the method comprises the steps: collecting the multi-modal data of a driver, and generating a cross-modal feature according to the multi-modal data; the multi-modal data comprises image data and physiological time sequence signal data, inputting the cross-modal features into a classification model, determining an output result of the classification model as a physiological state of the driver, the physiological state comprising a physiological function state and an emotional state, generating an intervention strategy according to the physiological state of the driver, and controlling the intelligent cabin according to the intervention strategy. By identifying the physiological state of the driver, the information most concerned by the driver at present is accurately judged, so that the intelligent cabin is accurately controlled.

The utility model relates to the technical field of ancient and famous tree protection, and discloses an ancient and famous tree hole filling and repairing structure which comprises a repairing frame, an adjusting frame is arranged on one side of the repairing frame, groove cavities are formed in the repairing frame and the adjusting frame, and movable wheels are arranged in the groove cavities; the movable mechanism is located on the opposite side of the repairing frame and the adjusting frame, the movable mechanism comprises an inserting assembly, a control assembly and a positioning assembly, the inserting assembly is located on the opposite side of the repairing frame and the adjusting frame, and the control assembly is located on one side of the inserting assembly; through the arrangement of the movable mechanism, tree holes in different positions in the same circumference of an ancient tree can be repaired, frequent dismounting and mounting are not needed, the situation that the tree holes continuously exist is avoided, the repairing efficiency of the device is improved, the flexibility of the device is improved, and meanwhile the problems that in an existing device, tree holes in different positions are difficult to repair, and the repairing efficiency is poor are solved. The normal physiological functions of the trees are affected.

This application relates to a device for detecting organ function and its control method, as well as a dietary management method and system, belonging to the technical field of medical device testing. The control method compares and analyzes changes in the microscopic features of the same area of ​​the tongue before and after eating, and calculates the corresponding metabolic index change rate, constructing a mapping relationship between the tongue's microscopic morphology and organ function, providing a basis for assessing internal physiological function through external characterization. Simultaneously, the dietary management method uses physiological responses before and after eating as real-time biofeedback signals to generate dynamically adjusted dietary management plans, forming a personalized health management closed loop of "monitoring-assessment-intervention-remonitoring," achieving precise adaptive adjustment of intervention strategies.

The invention relates to the technical field of biological medicine, and relates to a polypeptide in targeted combination with SOX2 protein and application thereof, the polypeptide has an amino acid sequence as shown in SEQ ID NO.1, or has at least 85%, 90%, 95% or more than 99% of sequence identity with the amino acid sequence; the polypeptide inhibits phase separation of SOX2, liquid drops formed by phase separation of SOX2 can be avoided, then the situation that the liquid drops wrap chemotherapeutic drugs, influence the curative effect of the chemotherapeutic drugs and cause tolerance of tumor cells to the chemotherapeutic drugs is avoided, and the polypeptide does not influence the transcription activation function of SOX2 serving as a transcription factor; the polypeptide can inhibit the phase separation of the SOX2, so that the regulation of normal physiological functions, such as high expression in organs such as eyes of a human body, of the SOX2 as a transcription factor is not influenced, and therefore, the polypeptide disclosed by the invention can reverse chemotherapy drug resistance of tumors such as squamous carcinoma by inhibiting the phase separation of the SOX2, can be used for adjuvant therapy of the tumors such as squamous carcinoma, and has no obvious toxic or side effect on each organ of an organism.

The utility model relates to the technical field of breeding, and particularly discloses a breeding environment adjusting device which comprises a breeding room body, a gauze element and a cover plate, a ventilation opening is formed in the top of the breeding room body, a sliding groove is formed in one side of the inner wall of the ventilation opening, and a connecting block is slidably connected into the sliding groove; by arranging the cover plate, the gauze elements, the guide grooves, the guide assemblies and the sliding assemblies, the sliding assemblies can drive the cover plate to slide so as to drive the gauze elements to move, the guide assemblies guide sliding of the cover plate, lighting can be conveniently conducted in the breeding house body, and the breeding house is convenient to use. Meanwhile, when reverse operation is carried out, the cover plate can be closed, the heat preservation performance of the breeding room body is improved, and the situation that the livestock suffers from diseases due to the fact that the body temperature of the livestock is reduced due to insufficient heat preservation is reduced is reduced.

The nerve monitoring device comprises an interface box, a monitor and a tested body, the interface box is connected with the monitor, the interface box is connected with a recording electrode, a grounding subcutaneous needle, a stimulation loop subcutaneous needle and a stimulation probe, a trachea cannula is arranged on the recording electrode, and the stimulation probe is arranged on the grounding subcutaneous needle. The recording electrode, the grounding subcutaneous needle, the stimulation loop subcutaneous needle and the stimulation probe are all arranged on a tested body. According to the nerve monitoring device with the telescopic electrode, nerve walking can be effectively positioned and recognized, nerve point physiological function feedback can be provided in real time in an operation, potential risk or high-risk operation of nerve injury can be warned in advance, the safety and thoroughness of the operation are improved, the nerve monitoring electrode can be stretched out and drawn back, the nerve monitoring device is suitable for patients of different body types, and the operation efficiency is improved. In addition, the electrode probe can be retracted for protection, infection is not prone to being caused, and nerve monitoring data can be conveniently collected, transmitted, processed, analyzed and stored.

To provide a biomimetic system that mimics the human proximal tubule, which is a high-performance in vitro model that can reproduce the physiological functions of the human proximal tubule in vitro and can be used as an evaluation tool in drug discovery.SOLUTION: The present invention provides a proximal tubule biomimetic system comprising a microfluidic device and LTL-positive cells derived from pluripotent stem cells contained within the microfluidic device. The microfluidic device has (A) a device body, (B) a first chamber provided in the device body, (C) a second chamber provided in the device body, and (D) a porous membrane positioned between the first chamber and the second chamber, separating the first chamber from the second chamber. The LTL-positive cells are contained within the first chamber and adhere to a first surface of the porous membrane facing the first chamber. The first surface of the porous membrane is coated with an extracellular matrix.SELECTED DRAWING: None

The utility model belongs to the technical field of magnetic field generation, and discloses a dynamic magnetic field generator which comprises an upper shell and a lower shell, an installation piece is arranged in the lower shell, a columnar magnet is placed on the installation piece, a control assembly and a coil are arranged in the lower shell, the coil is wound on the outer side of the installation piece, and the columnar magnet is placed on the control assembly. And the control assembly is electrically connected with the coil. Through the arrangement of the control assembly, the internal control assembly controls the power supply to output pulse current to the coil to drive the column-type magnet in use, a continuously changing dynamic magnetic field is formed, and when the magnetic therapy is used, the physiological function of a human body can be improved, pain can be relieved, the immunity can be improved, and the rehabilitation of the human body can be promoted; and the structure is simple, novel and unique.

The invention discloses a treatment auxiliary device after obtaining of a transplanted donor lung, and belongs to the field of medical instruments, the treatment auxiliary device comprises an anastomat, the anastomat is provided with a handle, a forceps head and a shaft rod connecting the handle and the forceps head, and the forceps head comprises a nail abutting seat and a nail bin which can be meshed with each other to clamp tissue; the suction pipeline is provided with a suction end used for extending into an air pipe and a negative pressure connecting end used for being connected with a negative pressure source, and the suction pipeline comprises a first pipe section extending along the shaft rod; the air inflation pipeline is provided with an air injection end used for introducing air into the lung and an oxygen injection connecting end used for being connected with an air source, and the air inflation pipeline comprises a second pipe section extending along the shaft rod; the suction end and the air injection end are both arranged on the near side of the forceps head. By means of the arrangement, sputum suction, lung inflation and trachea clamping and closing operation can be completed after the donor lung is obtained and before transplantation, and therefore the physiological function and structural integrity of the donor lung are maintained.

The invention discloses an integrated guide control method for a prostate dilation catheter, relates to the technical field of medical treatment, solves the problem of highly integrating two core links of'guide 'and'control' in an operation, and realizes simplification of operation, accuracy of positioning and controllability of mechanical parameters, so that the treatment effect is ensured, and the operation cost is reduced. According to the technical scheme, the method is characterized by comprising the following steps that firstly, preoperative measurement and planning are carried out; 2, a catheter is placed in and initially positioned; 3, integrated guiding and accurate anchoring are carried out; the prostate dilation device has the advantages that the prostate dilation operation is successfully converted from a complex technology which highly depends on experience and equipment to an advanced treatment mode which is standardized, quantitative, minimally invasive and excellent in function protection through unique integrated guide and control design, and revolutionary improvement is brought to multiple dimensions of curative effect, safety, function and efficiency.

The invention relates to a bemisia tabaci gene BtCOX8 and application thereof, and belongs to the field of biological control. The gene BtCOX8 highly expressed in the bemisia tabaci is screened, dsRNA is synthesized for the gene, the dsRNA is dripped on the body surface of nymphs of the bemisia tabaci, the nymphs are obviously shrunken and wizened, are in an obvious dehydration state and show the characteristics of growth resistance and serious physiological function disorder, and the results show that the BtCOX8 is a potential efficient RNAi lethal target. The dsRNA synthesized by the invention can be used for biological control of bemisia tabaci, is safe to encarsia formosa and orius minutus which are natural enemies of the bemisia tabaci, has the advantages of environmental friendliness and the like, and has a good application prospect.

The invention relates to the technical field of poultry breeding, and particularly discloses a staged efficient forced feeding method and feed for white ducks, and the forced feeding method comprises the following steps: selecting white ducks with the day age of 65 days and the initial weight of 3.6-4.2 kg as forced feeding objects; according to the method, the white ducks are subjected to continuous forced feeding for 27 days, the forced feeding period is divided into a first-stage adaptation period, a second-stage pressurization period and a third-stage sprint period, each stage lasts for 9 days, the three-stage forced feeding design accurately matches the natural law that the physiological function and the metabolic load of the white ducks in the forced feeding period are gradually increased, and the physiological function of the white ducks is improved. The stress impact caused by forced feeding of the traditional single high-energy feed is effectively avoided. Through rhythm control of early-stage low-load adaptation, middle-stage stable pressurization and later-stage efficient sprint, and in combination with the pineapple peel fermented bio-enzyme preparation added in the adaptation stage, the early-stage stress response, digestive system disease incidence and death rate of the ducks are remarkably reduced.