294 results about "Physiological function" patented technology

A device and algorithm for controlling an autonomic function in an individual. A controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. For instance, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.

The invention relates to the technical field of data processing, and discloses an old people health state assessment data processing system based on multi-modal data, and the system comprises a medical data integration module which obtains electronic medical record data and a medical examination report through an FHIR interface, and extracts a structured health index; the cross-modal causal fusion processing module is used for fusing the monitoring data and the medical text through an image, text and image interlayer architecture; the health state evolution modeling module is used for mapping the health feature vectors into physiological function, cognitive level and athletic ability three-dimensional state indexes; an evaluation report backtracking module; and a decision output module. Through an image, text and image interlayer architecture, deep semantic fusion of multi-modal features is realized under the constraint of medical pathology rules, feature weight adaptive distribution is dynamically guided based on a medical causal atlas, a high-dimensional fusion vector retaining key pathology information is generated, the semantic integration ability of health data is remarkably improved, and the health data fusion efficiency is improved. And the reliability of discrimination and decision making is improved.

The invention provides a neuromuscular multi-element coupled organoid micro-fluidic chip, a device and a method. Relates to the technical field of organoid micro-fluidic chips. A first culture chamber, a second culture chamber and a third culture chamber are arranged in a culture layer of the chip; the first culture room is used for culturing nerve cells; the second culture room is used for culturing muscle cells; a microfluidic channel for communicating the first culture chamber with the second culture chamber is arranged between the first culture chamber and the second culture chamber; the third culture room is arranged on the micro-fluidic channel and is used for culturing a neuromuscular joint formed by convergence of axons of nerve cells and muscle cells; a microelectrode array plate is arranged in the circuit layer and is used for performing electrical stimulation and electrophysiological function detection on neuromuscular cells. Through the chip, co-culture of in-vitro nerves and muscle organs can be realized, a complex interaction relationship in a neuromuscular system can be accurately simulated, and the chip can also be used for constructing various neuromuscular related disease models.

The utility model provides a tracheal stent structure and an artificial trachea. The tracheal stent structure comprises a main body, the main body comprises a plurality of supporting units which are linearly arranged at intervals; each supporting unit is of a C-shaped structure with an opening, a connecting unit is arranged between every two adjacent supporting units, and each connecting unit is of a structure with a hole. According to the tracheal stent assembly, the bionic tubular structure similar to the tracheal structure of the human body is formed by arranging the structure, so that the contraction and expansion functions can be achieved in the breathing process, and the physiological function requirements are met.

The invention relates to the technical field of bioactive peptides, in particular to a novel multifunctional collagen-like tripeptide and application thereof, an amino acid sequence contains multiple combinations, X can be selected from multiple components, 3-methoxy-4-hydroxyphenylalanine and the like are added, and the novel multifunctional collagen-like tripeptide can interact with specific proteins, activate related pathways and play multiple physiological functions and is applied to multiple fields. The collagen-like tripeptide has obvious advantages, innovates component expansion functions, improves the preparation method, improves the efficiency, reduces the cost, is matched with other components in the fields of beauty, health care and medicine, enhances the efficacy, realizes targeted delivery, and brings a new opportunity to related industries.

An implant and an implant system. The implant is used for being implanted into a target part in a living body. The implant comprises a stent (100). The stent (100) is used for being provided at the target part to ameliorate physiological functions of the living body, the stent (100) comprises a cylindrical main body (110) made of a metal material, an opening (130) is provided on the peripheral surface of the cylindrical main body (110), and the opening (130) extends over at least a portion of the length of the cylindrical main body (110). The implant facilitates smooth transmission of wireless signals.

The invention relates to the technical field of artificial intelligence, and discloses a chronic disease patient-based home nursing auxiliary system. According to the system, physiological data of a chronic disease patient are collected through a remote health monitoring and diagnosis module, physiological function indexes of the chronic disease patient and body health indexes of the chronic disease patient are calculated to judge the abnormal body condition of the chronic disease patient, and health abnormal signals are sent out; a medicine taking reminding message is sent to a chronic disease patient through the smart home device and the smart phone terminal, health data, living habits, personal preferences and character characteristics of the chronic disease patient are recorded, and the risk prediction and intervention module analyzes the recorded data to predict the health risk faced by the patient in the future, so that the health risk of the patient in the future is predicted. And the intelligent nursing plan module performs intervention in advance and generates a health intervention signal, performs data analysis by applying an artificial intelligence algorithm according to the signal, and generates a personalized nursing plan meeting psychological and emotional requirements of the chronic disease patient.

The application relates to the technical field of data processing, and discloses an old person health state evaluation data processing system based on multi-modal data, which comprises a medical data integration module, an across-modal causal fusion processing module, a health state evolution modeling module, a backtracking evaluation report module and a decision output module. The medical data integration module acquires electronic medical record data and medical examination reports through a FHIR interface and extracts structured health indexes. The across-modal causal fusion processing module fuses monitoring data and medical texts through an image, a text and an image sandwich architecture. The health state evolution modeling module maps a health feature vector into three-dimensional state indexes of physiological functions, cognitive levels and motor abilities. The backtracking evaluation report module and the decision output module are used for backtracking evaluation and decision output. Through the image, the text and the image sandwich architecture, deep semantic fusion of multi-modal features is realized under the constraint of medical pathology rules, feature weight adaptive distribution is dynamically guided based on a medical causal graph, a high-dimensional fusion vector retaining key pathological information is generated, the semantic integration capability of health data is significantly improved, and the reliability of discrimination and decision is improved.

The invention discloses a tissue engineering integrated trachea regeneration construction method based on a frame structure scaffold and application. A multi-tissue-structure integrated gas pipe is constructed based on a 3D printing bioelastomer frame structure support, and the complex structure and physiological functions of a natural gas pipe are highly simulated. The preparation method comprises the following steps: firstly, by utilizing the characteristic that temperature-sensitive hydrogel Pluronic F-127 becomes semi-solid gel at 37 DEG C and is liquefied at a low temperature of 4 DEG C, and by adopting a strategy that the temperature-sensitive hydrogel is sacrificed after occupying, the patterned distribution of chondrocytes and fibroblasts on a two-dimensional plane is realized; secondly, simulating a three-dimensional tubular trachea structure through a 2D-3D (two-dimensional to three-dimensional) rolling assembly strategy, and realizing the ordered regeneration of C-shaped cartilage ring / O-shaped fiber ring alternate distribution and axial strip-shaped fiber bundle triple structures under the skin of the nude mouse. And finally, successfully extracting the airway mucosa epithelium, separating and amplifying enough airway basal cells in vitro, and loading the airway basal cells to the inner wall of the regenerated trachea by utilizing the photo-crosslinking hydrogel, thereby realizing the function simulation of the airway epithelium and enhancing the physiological functionality.

The invention belongs to the technical field of biomedicine, and relates to a method for constructing a mouse embryo-derived hypothalamic organ model and application, the invention proposes that a mouse embryo is used for constructing a hypothalamic organ for the first time, and the mouse embryo has a definite development time sequence and genetic operability; the naturally retained vascular endothelial cells and multilineage precursor cells provide unique advantages for constructing a three-dimensional organ containing multiple nucleuses such as a preoptic region, a paraventricular nucleus, an arcuate nucleus and a supraoptic nucleus, and the model not only breaks through the nucleus coverage limitation of the existing iPSCs organ, but also can be used for constructing the three-dimensional organ containing multiple nucleuses such as the preoptic region, the paraventricular nucleus, the arcuate nucleus, the supraoptic nucleus and the like by reconstructing a nerve-blood vessel unit. High-fidelity simulation of complex physiological functions of the hypothalamus is realized, and an irreplaceable technical platform is provided for mechanism analysis of neuroendocrine diseases and high-throughput screening of drugs.

The invention relates to the technical field of biology, and particularly provides an endometrial organ culture method. By optimizing the endometrial organoid differentiation culture system, compared with an existing culture mode, the optimized culture system is easy to operate, the organoid with more complete physiological functions can be prepared without co-culture with stromal cells, continuous culture can be conducted for at least one year or above, and the obtained organoid is complete in secretion function and free of secondary pollution. The phenotype of cilia cells is more obvious.

The invention relates to the technical field of medical information analysis, in particular to a thoracic surgery postoperative complication assessment method and system based on multi-dimensional analysis, and the method comprises the following steps: S1, obtaining a postoperative multi-dimensional monitoring data set; s2, performing standardized preprocessing on the multi-dimensional monitoring data set to generate standardized monitoring data; s3, classifying and integrating the standardized monitoring data into physiological function data, drainage feature data and motion perception data according to data types; s4, chest dynamic pressure change analysis is carried out, and pressure gradient change parameters are calculated; s5, obtaining an abnormal metabolite ratio index; and S6, generating a complication risk assessment report. According to the method, through standardized integration and weighted analysis of the multi-dimensional postoperative monitoring data, accurate quantitative evaluation and graded output of the thoracic surgery postoperative complication risk are realized, and the reliability of early warning and the timeliness of clinical intervention are improved.

The invention discloses a chest wall defect three-dimensional reconstruction and personalized repair material design system, and relates to the technical field of intelligent medical aided design. Comprising a data acquisition module used for acquiring and preprocessing multi-modal data of the chest wall of a patient; the partition module is used for dividing the defect area into different functional partitions by coupling and analyzing stress and blood flow data and setting a threshold value; the dynamic optimization module is used for mapping the breathing time sequence to a three-dimensional space and dynamically correcting the partition boundary according to the stress change in the breathing cycle; the interface matching module is used for carrying out parameterization design on a host bone interface according to the bone mineral density data; and the optimization design module is used for carrying out topological structure and pore distribution dual optimization on the repair material based on the dynamic partition and the interface parameters, and finally, the output module generates design data capable of directly driving manufacturing. Precise matching of the repairing material and the physiological anatomical structure and the dynamic physiological function of the patient is achieved.

The invention discloses a goat milk bioactive polypeptide with antioxidation and angiotensin converting enzyme inhibition activity, and preparation and application thereof, and belongs to the field of biological polypeptides, and a preparation method and application thereof. In-vitro tests prove that the polypeptide has an excellent antioxidant effect, can remarkably reduce blood pressure and is beneficial to prevention and treatment of cardiovascular diseases, the interaction mechanism of the polypeptide and ACE is defined by using a molecular docking technology, scientific basis and targets are provided for research and development of new drugs, and the polypeptide has potential physiological functions such as antioxidant activity and ACE inhibitory activity and has a broad application prospect. The method is suitable for functional food and medicine development and has a wide application prospect.

The invention relates to the technical field of digital cell models, in particular to a construction method and system of a digital cell model and a storage medium. The method comprises the following steps: acquiring target cell data, extracting a target cell structure, and performing molecular physiological function analysis in combination with the cell structure and the data to obtain molecular physiological function data of cells; performing cell molecule metabolism network analysis to obtain cell molecule metabolism network data, and constructing a digital cell model; through the model, the reaction of the cells under the environmental pressure can be simulated, the attenuation of the physiological state of the cells can be estimated, and then the gene defects of the cells can be analyzed; according to the cell gene defect, adjusting the target cell data to obtain cell gene adjustment data; according to the method, the cell model is constructed, so that the dynamic change analysis of the cells is more accurate.

The present invention relates to a method and system for analysing audio (eg. music) tracks. A predictive model of the neuro-physiological functioning and response to sounds by one or more of the human lower cortical, limbic and subcortical regions in the brain is described. Sounds are analysed so that appropriate sounds can be selected and played to a listener in order to stimulate and / or manipulate neuro-physiological arousal in that listener. The method and system are particularly applicable to applications harnessing a biofeedback resource.

The invention discloses an ear-nose-throat patient postoperative rehabilitation nursing strategy optimization method based on big data, and relates to the technical field of data analysis, and the method comprises the following steps: collecting various original data of an ear-nose-throat operation patient, including preoperative, intraoperative and postoperative whole-process data, integrating the collected data, and forming a rehabilitation nursing data set; and traversing data of the rehabilitation nursing data set, and performing feature extraction. According to the big-data-based postoperative rehabilitation nursing strategy optimization method for the ear-nose-throat patient, personalized requirements of postoperative rehabilitation of the ear-nose-throat patient are accurately matched through big data analysis, a rehabilitation nursing plan is customized for the patient by utilizing a rehabilitation nursing risk assessment result and combining physiological function scores, wound healing states and physiological state change data of the patient, and the patient can be effectively protected. The rehabilitation training device can provide targeted rehabilitation training according to specific conditions of a patient, can more effectively promote rehabilitation of the patient, reduces complications, and improves rehabilitation efficiency and quality.

The invention provides a motor neuron and myotubular cell co-culture method and model and application thereof. The motor neuron and myotubular cell co-culture method comprises the steps that motor neuron is cultured to form a neural network, and a motor neuron culture layer with the formed neural network is obtained; culturing myoblasts, inducing differentiation to form fine myotube cells, adding a mitosis inhibitor, and digesting and separating to obtain the fine myotube cells; and inoculating fine myotubular cells to the motor neuron culture layer with the formed neural network, and co-culturing. The co-culture method disclosed by the invention overcomes the limitation of a traditional nerve cell and muscle cell co-culture method, and has the advantages of simplicity, convenience, high efficiency, stability and the like. The method not only provides an effective experimental tool for related basic research of neuromuscular joint formation, physiological functions and the like, but also has wide application prospects in the fields of neuromuscular disease research, drug screening, toxicological research, gene therapy and the like.

The invention discloses application of miRNA in diagnosis, prediction and treatment of bile duct cancer, and relates to the technical field of biological pharmacy. Specifically, the invention provides a reagent for promoting miR-26 expression or exerting physiological functions, and / or a simulation compound with the same physiological functions as miR-26, and an application method of the reagent in preparation of drugs for treating bile duct cancer, and provides a possibility for treating bile duct cancer and guiding research, development and screening of related drugs. The invention also provides a product for diagnosing and / or predicting the biliary duct cancer of a subject, and the expression level of miR-26 can be detected by using the product, so that the risk of the subject suffering from the biliary duct cancer can be predicted, and the severity of the biliary duct cancer can be diagnosed; and a possibility is provided for diagnosing the bile duct cancer.

The invention relates to an ergonomic back pillow, a leg support and a systemic ergonomic sleep support system. The ergonomic back pillow is composed of a transverse head and upper cervical vertebra supporting pillow for supporting the neutral position of the spine pelvis, a longitudinal lower cervical vertebra and chest supporting pillow and a transverse waist supporting pillow, and the longitudinal central axis of the longitudinal lower cervical vertebra and chest supporting pillow is aligned with the longitudinal central axis of the transverse head and upper cervical vertebra supporting pillow and the longitudinal central axis of the transverse waist supporting pillow. The left side vacancy and the right side vacancy are defined by the longitudinal symmetrical assembly and the longitudinal symmetrical assembly. The ergonomic leg support is composed of a transverse lower part for lifting a leg, a longitudinal left upper wing and a longitudinal right upper wing which are used for fixing the leg when the user lies on the side to sleep, and a gap which is surrounded by the longitudinal left upper wing and the longitudinal right upper wing and is used for placing the hip and the upper part of the thigh. The whole-body ergonomic sleep support system formed by combining the two parts provides equipment which has high practicability and is beneficial to keeping the neutral position calibration or correction of the whole musculoskeletal and promoting related sleep physiological functions.

The invention relates to medicine and is intended for the multimodal treatment of child patients with congenital cleft lip and palate. A method for the stepped multimodal treatment of children with cleft lip and palate involves carrying out multimodal treatment in a number of steps. At the age of 1-3 months, primary cheilorhinoplasty is performed; at the age of 6-8 months, the cleft in the soft palate is repaired; the congenital defect in the hard palate is repaired at the age of up to 12 months; and the results of the multimodal surgical treatment are assessed at the age of 2-3 years. The method makes it possible to fully restore a child's physiological functions, achieve aesthetically pleasing contours of the upper lip and nose and allow age-appropriate speech development.

The invention relates to a method for regulating and controlling the phase separation capacity of protein and application thereof. The method comprises the following steps: mixing a first protein element and a second protein element to obtain a mixture; detecting the phase separation capacity of the mixture; wherein the first protein element comprises an IDR structural domain of the scaffold protein, and the second protein element comprises a self-assembly structural domain of the scaffold protein or the IDR structural domain of the scaffold protein. According to the method, the IDR structural domain of the scaffold protein is used as the first protein element, the self-assembly structural domain of the scaffold protein or the IDR structural domain of the scaffold protein is used as the second protein element, and the first protein element and the second protein element interact with each other, so that the phase separation strength of the protein elements can be accurately regulated and controlled; and physical or chemical factor intervention is not needed, so that the compatibility between the regulation process and the normal physiological function of the cell is ensured. The method for regulating and controlling the phase separation capacity of the protein has relatively high controllability and biocompatibility.

The invention discloses an SD rat neuropathic pain model dorsal root ganglion cell extraction method, and relates to the technical field of dorsal root ganglion cell extraction. In order to facilitate further research of physiological functions of dorsal root ganglion cells in in-vitro cells; comprising the following steps: selecting an SD (Sprague Dawley) rat as an experimental animal, carrying out sciatic nerve branch selective ligation (SNI), ligating tibial nerves and common peroneal nerves in sciatic nerves, keeping the completeness of the peroneal nerves, and observing the touch sensitivity change of the outer side area of the rat claw after the operation to verify that the model is successfully constructed. According to the method, the extraction efficiency of the dorsal root ganglion cells is effectively improved through the cell treatment steps such as surgical operation under the sterile condition, reasonable use of digestive enzymes and centrifugation and resuspension, so that the experiment time and cost are saved, the smooth proceeding of subsequent experiments is ensured, and the neuropathic pain model is established, so that the development of the neuropathic pain model is promoted. And a basis is provided for subsequent extraction and research of the dorsal root ganglion cells.

As a common complication, hydrothorax and ascites are poor in prognosis in a clinical intervention mode mainly based on symptomatic treatment. Under the guidance of a new theory of'inflammation-cancer 'transformation, the invention discloses a traditional Chinese medicine composition for preventing and treating hydrothorax and ascites and a preparation method for oral administration and external application. The composition comprises the following traditional Chinese medicinal materials in parts by mass: 3-20 parts of codonopsis pilosula, 3-20 parts of raw bighead atractylodes rhizome, 3-18 parts of cassia twig, 3-18 parts of radices trichosanthis, 3-12 parts of pseudo-ginseng, 3-15 parts of Chinese lobelia, 3-15 parts of bistort rhizome, 3-15 parts of euphorbia helioscopia and 3-15 parts of semen lepidii. The traditional Chinese medicine composition disclosed by the invention has the effects of strengthening the body resistance, dispersing blood stasis, detoxifying, clearing damp, inducing diuresis and diminishing swelling, and has good effects on preventing and treating inflammatory hydrothorax and ascites and malignant hydrothorax and ascites as well as dyspnea, chest pain, cough, anorexia, abdominal pain, abdominal distension, weakness, night sweat and the like caused by the inflammatory hydrothorax and ascites and the malignant hydrothorax and ascites. The preparation method comprises decoction, granules, pills, capsules and powder. The traditional Chinese medicine composition is helpful for promoting absorption and discharge of hydrothorax and ascites, diminishing inflammation and resisting cancer, adjusting and recovering physiological functions of internal organs, and improving life quality of patients.

Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The primary culture method of the porcine ovary granular cells comprises the following steps: step 1, taking a fresh porcine ovary, quickly putting the porcine ovary into a Hank's balanced salt solution preheated at 38 DEG C for transportation, repeatedly washing the ovary with the Hank's balanced salt solution to remove blood and impurities, and then extracting follicular fluid with a 5ml syringe under a sterile condition; according to the method, the granular cells can be effectively separated and cultured from the porcine ovary, and the porcine ovary granular cells with higher purity and better activity can be obtained, so that the subsequent cell biology experiment research, such as gene transfection, protein expression analysis and the like, is facilitated; a cell model is provided for researching the physiological functions (such as hormone secretion and follicle development regulation and control) of the porcine ovarian granular cells, the operation is relatively simple, the cost is relatively low, and the used reagents and instruments are common in a cell culture laboratory and are convenient to popularize and apply.

The embodiment of the invention provides an intelligent cabin control method, device, equipment and program product, and the method comprises the steps: collecting the multi-modal data of a driver, and generating a cross-modal feature according to the multi-modal data; the multi-modal data comprises image data and physiological time sequence signal data, inputting the cross-modal features into a classification model, determining an output result of the classification model as a physiological state of the driver, the physiological state comprising a physiological function state and an emotional state, generating an intervention strategy according to the physiological state of the driver, and controlling the intelligent cabin according to the intervention strategy. By identifying the physiological state of the driver, the information most concerned by the driver at present is accurately judged, so that the intelligent cabin is accurately controlled.