112 results about "Physiological function" patented technology

The application relates to the technical field of data processing, and discloses an old person health state evaluation data processing system based on multi-modal data, which comprises a medical data integration module, an across-modal causal fusion processing module, a health state evolution modeling module, a backtracking evaluation report module and a decision output module. The medical data integration module acquires electronic medical record data and medical examination reports through a FHIR interface and extracts structured health indexes. The across-modal causal fusion processing module fuses monitoring data and medical texts through an image, a text and an image sandwich architecture. The health state evolution modeling module maps a health feature vector into three-dimensional state indexes of physiological functions, cognitive levels and motor abilities. The backtracking evaluation report module and the decision output module are used for backtracking evaluation and decision output. Through the image, the text and the image sandwich architecture, deep semantic fusion of multi-modal features is realized under the constraint of medical pathology rules, feature weight adaptive distribution is dynamically guided based on a medical causal graph, a high-dimensional fusion vector retaining key pathological information is generated, the semantic integration capability of health data is significantly improved, and the reliability of discrimination and decision is improved.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

The embodiment of the invention provides an intelligent cabin control method, device, equipment and program product, and the method comprises the steps: collecting the multi-modal data of a driver, and generating a cross-modal feature according to the multi-modal data; the multi-modal data comprises image data and physiological time sequence signal data, inputting the cross-modal features into a classification model, determining an output result of the classification model as a physiological state of the driver, the physiological state comprising a physiological function state and an emotional state, generating an intervention strategy according to the physiological state of the driver, and controlling the intelligent cabin according to the intervention strategy. By identifying the physiological state of the driver, the information most concerned by the driver at present is accurately judged, so that the intelligent cabin is accurately controlled.

This application relates to a device for detecting organ function and its control method, as well as a dietary management method and system, belonging to the technical field of medical device testing. The control method compares and analyzes changes in the microscopic features of the same area of ​​the tongue before and after eating, and calculates the corresponding metabolic index change rate, constructing a mapping relationship between the tongue's microscopic morphology and organ function, providing a basis for assessing internal physiological function through external characterization. Simultaneously, the dietary management method uses physiological responses before and after eating as real-time biofeedback signals to generate dynamically adjusted dietary management plans, forming a personalized health management closed loop of "monitoring-assessment-intervention-remonitoring," achieving precise adaptive adjustment of intervention strategies.

The invention relates to the technical field of biological medicine, and relates to a polypeptide in targeted combination with SOX2 protein and application thereof, the polypeptide has an amino acid sequence as shown in SEQ ID NO.1, or has at least 85%, 90%, 95% or more than 99% of sequence identity with the amino acid sequence; the polypeptide inhibits phase separation of SOX2, liquid drops formed by phase separation of SOX2 can be avoided, then the situation that the liquid drops wrap chemotherapeutic drugs, influence the curative effect of the chemotherapeutic drugs and cause tolerance of tumor cells to the chemotherapeutic drugs is avoided, and the polypeptide does not influence the transcription activation function of SOX2 serving as a transcription factor; the polypeptide can inhibit the phase separation of the SOX2, so that the regulation of normal physiological functions, such as high expression in organs such as eyes of a human body, of the SOX2 as a transcription factor is not influenced, and therefore, the polypeptide disclosed by the invention can reverse chemotherapy drug resistance of tumors such as squamous carcinoma by inhibiting the phase separation of the SOX2, can be used for adjuvant therapy of the tumors such as squamous carcinoma, and has no obvious toxic or side effect on each organ of an organism.

The invention discloses a treatment auxiliary device after obtaining of a transplanted donor lung, and belongs to the field of medical instruments, the treatment auxiliary device comprises an anastomat, the anastomat is provided with a handle, a forceps head and a shaft rod connecting the handle and the forceps head, and the forceps head comprises a nail abutting seat and a nail bin which can be meshed with each other to clamp tissue; the suction pipeline is provided with a suction end used for extending into an air pipe and a negative pressure connecting end used for being connected with a negative pressure source, and the suction pipeline comprises a first pipe section extending along the shaft rod; the air inflation pipeline is provided with an air injection end used for introducing air into the lung and an oxygen injection connecting end used for being connected with an air source, and the air inflation pipeline comprises a second pipe section extending along the shaft rod; the suction end and the air injection end are both arranged on the near side of the forceps head. By means of the arrangement, sputum suction, lung inflation and trachea clamping and closing operation can be completed after the donor lung is obtained and before transplantation, and therefore the physiological function and structural integrity of the donor lung are maintained.

The invention relates to a bemisia tabaci gene BtCOX8 and application thereof, and belongs to the field of biological control. The gene BtCOX8 highly expressed in the bemisia tabaci is screened, dsRNA is synthesized for the gene, the dsRNA is dripped on the body surface of nymphs of the bemisia tabaci, the nymphs are obviously shrunken and wizened, are in an obvious dehydration state and show the characteristics of growth resistance and serious physiological function disorder, and the results show that the BtCOX8 is a potential efficient RNAi lethal target. The dsRNA synthesized by the invention can be used for biological control of bemisia tabaci, is safe to encarsia formosa and orius minutus which are natural enemies of the bemisia tabaci, has the advantages of environmental friendliness and the like, and has a good application prospect.

The invention relates to the technical field of poultry breeding, and particularly discloses a staged efficient forced feeding method and feed for white ducks, and the forced feeding method comprises the following steps: selecting white ducks with the day age of 65 days and the initial weight of 3.6-4.2 kg as forced feeding objects; according to the method, the white ducks are subjected to continuous forced feeding for 27 days, the forced feeding period is divided into a first-stage adaptation period, a second-stage pressurization period and a third-stage sprint period, each stage lasts for 9 days, the three-stage forced feeding design accurately matches the natural law that the physiological function and the metabolic load of the white ducks in the forced feeding period are gradually increased, and the physiological function of the white ducks is improved. The stress impact caused by forced feeding of the traditional single high-energy feed is effectively avoided. Through rhythm control of early-stage low-load adaptation, middle-stage stable pressurization and later-stage efficient sprint, and in combination with the pineapple peel fermented bio-enzyme preparation added in the adaptation stage, the early-stage stress response, digestive system disease incidence and death rate of the ducks are remarkably reduced.

This invention belongs to the field of medical devices, specifically a combined internal fixator and fixation method for fixing joints with micro-motion. The combined internal fixator includes a first bone screw and a second bone screw. A movable connecting structure is provided between the connecting ends of the first and second bone screws. The movable connecting structure includes a groove and a shaft. The groove includes an insertion port and a mounting groove communicating with the insertion port. The mounting groove has a semi-circular cross-section. The shaft includes a semi-circular shaft adapted to the mounting groove, which is rotatably accommodated within the mounting groove, allowing the first and second bone screws to rotate relative to each other around a first radial axis. This invention, through a hook-groove sliding self-locking structure, achieves controllable micro-motion and integrated implantation for fixing joints with micro-motion. It has achieved significant technological advancements in preserving joint physiological function, simplifying surgical procedures, avoiding secondary surgeries, and reducing the incidence of complications. It has important clinical application value and is suitable for fixing joints with micro-motion.

Systems, methods, and computer code products monitor the behavior, health, and / or characteristics of an animal. In one implementation, the animal is positioned inside a waste container placed on a system that is adapted to determine, record and communicate over a network various animal health parameters. These parameters can be processed to determine trends, statistics and changes of animal physiological functions. The results can be used to access animal health conditions and issue warnings, alarms, messages, and other notifications to designated caretakers. These notifications may be displayed using various means such as computers and / or mobile devices. Data retrieval and review capability can provide improved understanding of an animal's health conditions and facilitate early illness detection.

The utility model discloses an electrically-driven multifunctional cardiopulmonary model, relates to the field of teaching models, and particularly aims to solve the problems that in the prior art, in the teaching process of an existing teaching double-lung model, only arteries and other structures and the distribution condition of lung segments can be determined, and the teaching efficiency is low. In order to solve the problems that in the prior art, in the prior art, the whole process of lung gas exchange, lung circulation and alveolar change cannot be further dynamically simulated, and the working process of the heart and the lung cannot be vividly restored, the utility model provides an electrically-driven multifunctional heart and lung model which is scientific and vivid, meets more teaching contents, enables a solid model to be dynamic, enables the lung physiological process to be visualized, and improves the teaching efficiency. The main physiological functions of the lung are simulated through various lights, the basic anatomical structure and the dynamic physiological process are combined, the lung anatomical structure and the physiological functions are comprehensively displayed, the discipline barrier is broken, learning and understanding of students are facilitated, and the higher teaching requirements at present are met.

This invention relates to an intraoperative nerve localization system for thoracic sympathectomy, belonging to the field of minimally invasive surgical assistance and medical information processing technology. During thoracoscopic surgery, this system identifies and analyzes candidate regions of the thoracic sympathetic nerve by acquiring intraoperative thoracoscopic images and patient physiological signals. It also verifies the sympathetic nerve properties of the target structure by combining the physiological functional responses induced by intraoperative nerve stimulation. Based on this, the system fuses and calculates the image structural information and functional response information to generate the localization reliability of the thoracic sympathetic nerve, providing the surgeon with localization references and safety prompts for thoracic sympathectomy. This system enables real-time, objective localization of the thoracic sympathetic nerve during surgery, reducing reliance on surgeon experience, lowering the risk of mis- or missed sympathectomy, and improving the safety and consistency of thoracic sympathectomy, thus possessing high clinical application value.

The invention discloses an information processing method and device for extracting anorectal pressure frequency domain characteristics, equipment and a medium, relates to the technical field of medical instruments, is applied to a computer device and is used for receiving original pressure information of various anorectal channels at different acquisition time points, and the original pressure information is acquired by an anorectal pressure measuring catheter; integrating the original pressure information of various anorectal channels under a target analysis time window to obtain a time domain pressure signal; performing short-time Fourier transform on the time domain pressure signals to obtain power spectral density of the pressure signals of various anorectal channels in the target analysis time window; and based on a target frequency band corresponding to the target analysis time window, extracting frequency domain features related to anorectal physiological functions from the power spectral density. And the frequency domain characteristics in anorectal pressure measurement are accurately extracted.

The present invention provides a plastic composition, comprising at least one plastic and at least one plasticizer. The plastic comprises polylactic acid, the plasticizer comprises an amide ester compound, and the amide ester compound has biodegradability. The weight percentage of the plastic in the plastic composition is 85% to 99.99%, and the weight percentage of the plasticizer in the plastic composition is 0.01% to 15%. Thus, the plastic composition of the present invention can reduce damage to the environment and ecology by the biodegradable polylactic acid and the plasticizer characteristics, and has excellent biodegradability and good plasticizing effect by the specific mixing ratio. Furthermore, by designing the plasticizer structure similar to the estrogen, the plasticizer can prevent affecting normal physiological functions.

This utility model relates to the field of orthopedic implant technology and discloses a prosthesis for defects after partial atlas resection. It aims to solve the problems of existing technologies, such as the lack of atlas prosthesis implants, long recovery times after autologous bone grafting, and the ineffective fixation of titanium mesh implants. This utility model includes a prosthesis that replaces the atlas, with bone screw holes to accommodate bone screw fixation contact points. The prosthesis includes an outer frame, which is a porous tubular or porous columnar structure. The cavity of the porous tubular structure is filled with autologous bone, allogeneic bone, or artificial bone. The upper and lower ends of the outer frame are provided with curved surfaces matching the facet joints of the occipital condyle and axis, and a support unit is provided within the outer frame. This utility model, combined with 3D printing technology, matches the shape of the corresponding segment and resection site, thereby replacing the resected segment, promoting the fusion of the atlantoaxial segment, and facilitating the restoration of the physiological function of the upper cervical spine.

The present application relates to the technical field of biomedical materials, in particular to a super-elastic hydrogel material, a super-elastic injectable scaffold and a preparation method and application thereof. The super-elastic hydrogel material is obtained by cross-linking a base material with an initiator; the base material comprises GelMA and PEGDA with a molecular weight of 2000-20000; the injectable scaffold comprises a three-dimensional structure scaffold composed of super-elastic material, which can restore the original shape after being compressed and injected. The present application utilizes the excellent mechanical properties and shape memory of super-elastic material to realize solid injection and restore the original shape after injection, thereby providing a new idea and approach for large-size injectable scaffolds. The scaffold of the present application can be used in the fields of tissue engineering and regenerative medicine, minimally invasive injection transplantation, artificial skin, myocardial patch, in-vitro engineered tissue model construction, tissue physiological function remodeling and pathological process mechanism research, mechanical regulation and stress regulation mechanism research, drug development and drug screening, etc.

The invention relates to a cell tissue culture device special for primary cells, and relates to the technical field of cell culture, the cell tissue culture device comprises an incubator, the interior of the incubator is divided into three independent culture chambers through partition plates, each culture chamber is internally provided with at least three culture dishes, and the cell tissue culture device further comprises a dynamic culture assembly, at least two culture rooms are provided with a dynamic culture assembly, the dynamic culture assembly is provided with a micro-channel structure capable of simulating blood vessels, the dynamic culture assembly, the electrophysiological stimulation piece and the traction force simulation piece are integrated to form the culture system capable of simulating various physiological conditions in the body, the dynamic culture assembly simulates a blood vessel microchannel to realize low-shear-force continuous perfusion; the electrophysiological stimulation piece simulates a neuroelectric signal; the traction force simulation part applies controllable mechanical traction force through a multi-caliber breather pipe, and the three parts have a synergistic effect, so that the physiological function expression and culture quality of the primary cells are improved.

The invention discloses a tuyere and a manufacturing method thereof.The tuyere is prepared from a high-temperature-resistant polymer base material, biological magnetic powder, graphene powder, metal powder, mineral substance powder and an auxiliary additive, and the manufacturing method comprises the following steps that S1, pretreatment is conducted; step S2, drying treatment; step S3, primary mixing; step S4, performing secondary mixing; s5, injection molding is carried out; s6, cooling, part taking and assembling are conducted; the manufactured tuyere is assembled on a hair dryer and connected with the hair dryer in a magnetic adsorption mode, after the hair dryer works and hot air passes through the tuyere, multi-band far infrared radiation of mineral materials and far infrared radiation of graphene form a superimposed effect, and heat energy and multi-broadband bands can be more effectively transmitted to a human body; in addition, graphene can form a weak biological electric field on the surface of the human body to stimulate cell activity, and negative ions released by mineral substances are in contact with the skin of the human body to regulate the physiological function of the human body.

This invention relates to the field of voiceprint recognition technology, specifically disclosing a federated learning personalized audio monitoring method and system that combines voiceprint recognition. The method includes: extracting feature offsets and marking physiological function deterioration based on these offsets to obtain suspected fatigue segments; establishing a dual-track isolation architecture for read / write isolation by constructing purified fatigue features; collecting speech features for signal-to-noise isolation, verifying identity through core identity deviation and attenuation span, and issuing a degraded monitoring status; triggering federated local fine-tuning under degraded monitoring, and extracting pure upload gradients through an orthogonal projection matrix; and resetting the model by sending gradients to the server for aggregation and issuing low-level instructions to destroy the temporary feature pool after detecting physiological reset. The system includes: a fatigue marking module, an architecture construction module, an identity verification module, a gradient purification module, and a model reset module. This invention is beneficial for improving data purity and identity verification security under fatigue monitoring conditions.

1. The name of the design product: table type semiconductor laser physiotherapy instrument. 2. The use of the design product: through high intensity laser irradiation of blood to trigger a series of biochemical reactions in the human body, through the two aspects of blood and static blood to improve and restore the physiological function of blood, and to relieve pain after operation. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and / or performing a neuromodulation procedure on a bladder is disclosed.

The application relates to a thymoma epithelial cell subpopulation with neuromuscular characteristics and application, and a thymoma epithelial cell subpopulation with neuromuscular characteristics is obtained through single clone dilution culture screening from a thymoma cell line Thy0517 of a patient with myasthenia gravis (MG) in combination, and a thymoma epithelial cell with neuromuscular characteristics in the cell subpopulation is named as Thymus_NMi; the cell subpopulation has synapse-like structures and neuromuscular adhesion characteristics, and efficiently expresses genes participating in neural cell adhesion and synapse connection, highly integrates neuromuscular double characteristics, and simulates key pathological characteristics of abnormal thymus-induced immune tolerance of MG patients in a molecular phenotype and physiological function, so that a cell model closest to a real clinical state is provided for exploring a myasthenia gravis occurrence mechanism.

This invention belongs to the field of biomedical and health care technology. Specifically, this invention relates to a composition of metabiotics and calcium salts and its application. Our unit unexpectedly discovered, through extensive research, that *Lactobacillus delbrueckii* subsp. bulgaricus Lb-87 (… Lactobacillus delbrueckii subsp. Bulgaricus Lb-87 (a metabiotic) can synergistically work with calcium salts to significantly improve the absorption rate of calcium ions in the body, thereby effectively promoting calcium utilization and maintaining normal physiological functions. This discovery provides a new technical path and solution for developing foods, pharmaceuticals, health foods, and dietary supplements with highly efficient calcium absorption-promoting functions and multiple effects.

This invention discloses the application of tannic acid in the preparation of drugs for treating the toxic side effects of vandetanib, belonging to the field of pharmaceutical technology. This invention provides a drug that can effectively treat the toxic side effects of vandetanib; tannic acid can effectively reverse the liver and heart damage caused by vandetanib, greatly expanding the clinical use of tannic acid. The effective dose of tannic acid in the drug provided by this invention does not affect the survival, physiological state, or liver and heart function of animals, demonstrating high safety and high clinical feasibility.

The present application relates to a kind of biomimetic lung surfactant carrier, which is prepared from total fat and simulation peptide, in the total fat, the mass ratio of dipalmitoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, dipalmitoyl phosphatidyl ethanolamine-polyethylene glycol 2000, cholesterol is 8-12:1:1:1;The lung surfactant simulation peptide is the simulation peptide of SP-B protein and / or the simulation peptide of SP-C protein.The biomimetic lung surfactant carrier has the advantages of high loading rate and high stability.The present application also relates to inhalation dosage form of drug for treating pulmonary arterial hypertension loaded by the biomimetic lung surfactant carrier, which makes the loaded drug obtain more uniform intra-pulmonary distribution, the inhalation drug is more close to natural lung surfactant in composition and physiological function, can delay the degradation of product, improve the utilization rate of drug, achieve good pulmonary arterial hypertension treatment effect.

The invention discloses a construction method of an in-vitro full-thickness skin model based on a dynamic skin chip, belongs to the technical field of biology, and particularly relates to the construction method of the in-vitro full-thickness skin model based on the dynamic skin chip. The construction method comprises the following steps: injecting a fibroblast suspension and a 3D epithelial cell culture medium into a dynamic skin chip for culturing, and constructing to obtain a corium layer; and inoculating keratinocytes above the corium layer for differentiation culture, and carrying out dynamic differentiation treatment to obtain the in-vitro full-thickness skin model. On the basis of the dynamic skin chip, a nutrient perfusion and metabolic waste removal approach is provided by simulating the structure and the function of an in-vivo blood circulation system, the complete in-vitro full-thickness skin model with the physiological function is constructed and formed, and the model can simulate the permeation process and the metabolic process of a medicine in the human skin, so that the in-vitro full-thickness skin model has a good application prospect. Therefore, an effective platform is provided for accurately evaluating the curative effect and the safety of the medicine.

Chronological age is an important predictor of morbidity and mortality, however it is unable to account for heterogeneity in the decline of physiological function and health with advancing age. Several attempts have been made to instead define a “biological age” using multiple physiological parameters in order to account for variation in the trajectory of human aging; however, these methods require technical expertise and are likely too time-intensive and costly to be implemented into clinical practice. Accordingly, a metabolomic signature of biological aging was developed that can predict changes in physiological function with the convenience of a blood sample. A weighted model of biological age was generated based on multiple clinical and physiological measures in a large group of healthy adults and was then applied to a cohort of healthy older adults who were tracked longitudinally over a 5-10 year timeframe. Plasma metabolomic signatures were identified that were associated with biological age, including some that could predict whether individuals would age at a faster or slower rate. These results not only have clinical implications by providing a simple blood-based assay of biological aging, but also provide insight into the molecular mechanisms underlying human healthspan.

The invention relates to the technical field of rehabilitation assessment, in particular to a cerebral apoplexy rehabilitation assessment method and system based on voice multi-task learning, and the method comprises the following steps: carrying out the psychological emotion recognition of assessment voice data, and obtaining a cerebral apoplexy rehabilitation subjective assessment task used for perceiving the subjective rehabilitation feeling of an assessment object; performing physiological function recognition on the evaluation voice data to obtain a cerebral apoplexy rehabilitation objective evaluation task for perceiving the objective rehabilitation state of the evaluation object; and performing weight adaptive combination on the stroke rehabilitation subjective evaluation task and the stroke rehabilitation objective evaluation task by using a multi-task learning mechanism to obtain a stroke rehabilitation evaluation model. According to the method, objective function states and subjective emotional feelings fed back from the voices of the patient can be taken into consideration during rehabilitation evaluation, pain and discomfort of the stroke patient can be perceived during functional evaluation, the individual accuracy of stroke rehabilitation evaluation is improved, and the user experience is enhanced.