5 results about "Intervertebral disk" patented technology

This invention discloses an injectable hydrogel loaded with 4-octyl itaconic acid, its preparation method, and its applications, belonging to the field of biomedical materials technology. The injectable hydrogel is formed by enzymatic cross-linking of a hyaluronic acid-tyramine complex to create a three-dimensional network, with 4-octyl itaconic acid encapsulated within this network structure. This invention allows for precise implantation of the hydrogel into the intervertebral disc lesion via minimally invasive injection, achieving local high-concentration drug accumulation. The three-dimensional network of the hydrogel serves as a drug reservoir, enabling continuous and controllable release of 4-OI, prolonging the drug's duration of action and achieving long-term therapeutic effects. Simultaneously, the loaded 4-OI specifically activates the Nrf2 / GPX4 antioxidant pathway in nucleus pulposus cells, mechanistically antagonizing ferroptosis and matrix degradation, thus achieving a dual function of mechanical support and biological therapy. It exhibits good biocompatibility and solves the problems of difficult targeted drug delivery, short-lived efficacy, and lack of disease-modifying effects in existing treatments for intervertebral disc degeneration.

The application discloses a device for removing loose disc nucleus pulposus fragments under a spinal minimally invasive surgery endoscope and belongs to the technical field of spinal minimally invasive surgery instruments. The device comprises a handle, a first fixing frame is fixedly connected to the inside center of the handle, a suction pipe assembly is rotatably connected to the inner wall of the first fixing frame, a removing mechanism is installed at the inside center of the suction pipe assembly, and a driving mechanism is installed in the handle. The removing mechanism can not only suck out the disc nucleus pulposus fragments, but also cut the nucleus pulposus fragments with flocculent tissue involvement through a cutting cylinder, so that the nucleus pulposus fragments are cut off from the disc, and finally, the nucleus pulposus fragments are also sucked out. The device can remove multiple nucleus pulposus fragments at one time, and the surgeon does not need to pick up the fragments one by one, so that the surgery efficiency is improved. Meanwhile, the device can also suck out the nucleus pulposus fragments in the corners of the disc, so that the surgery effect is improved.

The application discloses application of a viscoelastic biomaterial in the technical field of biological medicine, and aims to solve the problem of the influence mechanism of viscoelasticity on the metabolic state and pathway of nucleus pulposus cells in the prior art. The application comprises application of a viscoelastic double-network hydrogel of the viscoelastic biomaterial as a drug for promoting tissue repair and application of the viscoelastic biomaterial as a therapeutic drug for intervertebral disc degeneration; the application is suitable for development of a tissue repair drug, and a tissue repair drug is prepared from the viscoelastic biomaterial, so that a new route is provided for development of a tissue repair preparation.

The present invention relates to the technical field of biomedicine. The present invention aims to provide a use of Mn3O4 nanoparticles in alleviating intervertebral disc degeneration, trimanganese tetroxide nanoparticles Mn3O4 NPs are added as nanozymes to interventional drugs for treating intervertebral disc degeneration. The present invention uses Mn3O4 nanoparticles as nano-active catalytic enzymes, which have multi-enzyme catalytic activities similar to superoxide dismutase, catalase, and glutathione peroxidase, and can effectively scavenge reactive oxygen species (ROS) and control ECM metabolism, significantly reducing cell apoptosis, delaying cell senescence, inhibiting inflammation, and enhancing autophagy, thereby promoting annulus fibrosus AF repair in the treatment of intervertebral disc degeneration. Mn3O4 nanoparticles have good biocompatibility, and metabolites thereof can be used in other physiological processes, producing no toxic side effects in the in vivo circulation. Furthermore said nanoparticles perform stably in adverse microenvironments of low oxygen and low pH in intervertebral discs, and have in vivo stability that other active catalytic enzymes do not possess.

The present disclosure describes an intervertebral implant having a laterovertically-expanding shell operable for a reversible expansion from a collapsed state into an expanded state, the laterovertically-expanding shell having one or more connectors, and a pair of lateral extension elements that function to laterally expand the footprint of the implant within an intervertebal disc space.