29 results about "Intervertebral disk" patented technology

The invention discloses an osteoporosis detection system based on nuclear magnetic resonance, and relates to the technical field of intelligent detection, the osteoporosis detection system comprises a pre-operation module, an image processing module, an analysis module and a precision module, an image segmentation model is trained to obtain an intervertebral disc image, the preprocessed image is segmented to obtain a region-of-interest image, and the region-of-interest image is obtained; and judging a first osteoporosis level of the region of interest, inputting the region of interest image to the expert platform to obtain a second osteoporosis level, and executing a second operation. Through cooperative work of the pre-operation module, the image processing module, the analysis module and the precision module, the detection precision and efficiency are improved, through the image segmentation model and the analysis module, more comprehensive osteoporosis evaluation is provided, an expert platform is introduced, the accuracy and reliability of a detection result are ensured, and the detection efficiency is improved. The MRI technology is used for osteoporosis detection, radiation exposure is avoided, and the method is a non-invasive and safe detection method.

The invention relates to the technical field of medical instruments, and discloses a UBE surgery fibrous ring suturing device and a knotting-free suturing method.The UBE surgery fibrous ring suturing device comprises a first suturing instrument, a second suturing instrument, a third suturing instrument and a surgical suture line; each of the first stitching instrument, the second stitching instrument and the third stitching instrument comprises a first stitching instrument shell, a second stitching instrument shell, a push rod assembly and a needle cylinder; the first stitching instrument shell and the second stitching instrument shell are connected in an interference fit mode through the connecting pins and the connecting holes. The lower portion of the push rod assembly is arranged in the needle cylinder and can move freely, the upper portion of the push rod assembly is connected with the second stitching instrument shell through a gear and a rack to move up and down, and left-right movement of the push rod assembly is limited through a sliding way on the first stitching instrument shell. Through the cooperation of the surgical suture line and the stop strip, a fixed structure is formed under intervertebral disc fibrous ring tissue, in-vitro knotting is not needed, the suture line keeps stable through the interaction of the stop strip and the coil after vertically penetrating the tissue, and postoperative complications are reduced while it is ensured that suturing is firm.

The description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable spacer includes a main body, a first endplate, a second endplate, a driving member, a plurality of pins, and an actuation member. The expandable spacer is configured to transition from a first configuration to a second configuration by various structures (e.g., steps, faceted surfaces, curved surfaces, multi-faceted portions) defined on the first endplate, the second endplate, and the driving member.

This invention discloses an injectable hydrogel loaded with 4-octyl itaconic acid, its preparation method, and its applications, belonging to the field of biomedical materials technology. The injectable hydrogel is formed by enzymatic cross-linking of a hyaluronic acid-tyramine complex to create a three-dimensional network, with 4-octyl itaconic acid encapsulated within this network structure. This invention allows for precise implantation of the hydrogel into the intervertebral disc lesion via minimally invasive injection, achieving local high-concentration drug accumulation. The three-dimensional network of the hydrogel serves as a drug reservoir, enabling continuous and controllable release of 4-OI, prolonging the drug's duration of action and achieving long-term therapeutic effects. Simultaneously, the loaded 4-OI specifically activates the Nrf2 / GPX4 antioxidant pathway in nucleus pulposus cells, mechanistically antagonizing ferroptosis and matrix degradation, thus achieving a dual function of mechanical support and biological therapy. It exhibits good biocompatibility and solves the problems of difficult targeted drug delivery, short-lived efficacy, and lack of disease-modifying effects in existing treatments for intervertebral disc degeneration.

The invention discloses an induction culture medium for inducing fibroblasts to transdifferentiate into nucleus pulposus cells and application of the induction culture medium, and belongs to the technical field of cytobiology and regenerative medicine. The induction culture medium comprises a basic culture medium and an induction composition, can be used for realizing 2D / 3D transdifferentiation of fibroblasts into nucleus pulposus cells, and meets the requirements of different application scenes. Meanwhile, the invention further provides an amplification culture medium, a technical system for forming a 3D (three-dimensional) organoid through amplification of the amplification culture medium is provided, and the method has important significance in promoting cell therapy of the intervertebral disc degenerative change.

The technical description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable intervertebral spacer includes a main body, a first endplate, a second endplate, a driving member, and an actuation member. The expandable intervertebral spacer is transitions from a first configuration to a second configuration by structural interfacing between steps defined on the first endplate, the second endplate, and the driving member. Steps include a surface that lies on a plane disposed at a non-parallel angle to the longitudinal axis of the intervertebral spacer.

The present disclosure describes an intervertebral implant having a laterovertically-expanding shell operable for a reversible expansion from a collapsed state into an expanded state, the laterovertically-expanding shell having one or more connectors, and a pair of lateral extension elements that function to laterally expand the footprint of the implant within an intervertebral disc space.

The technical description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable intervertebral spacer includes a main body, a first endplate, a second endplate, a driving member, and an actuation member. The expandable intervertebral spacer is transitions from a first configuration to a second configuration by structural interfacing between steps defined on the first endplate, the second endplate, and the driving member. Steps include a surface that lies on a plane disposed at a non-parallel angle to the longitudinal axis of the intervertebral spacer.

The application discloses a device for removing loose disc nucleus pulposus fragments under a spinal minimally invasive surgery endoscope and belongs to the technical field of spinal minimally invasive surgery instruments. The device comprises a handle, a first fixing frame is fixedly connected to the inside center of the handle, a suction pipe assembly is rotatably connected to the inner wall of the first fixing frame, a removing mechanism is installed at the inside center of the suction pipe assembly, and a driving mechanism is installed in the handle. The removing mechanism can not only suck out the disc nucleus pulposus fragments, but also cut the nucleus pulposus fragments with flocculent tissue involvement through a cutting cylinder, so that the nucleus pulposus fragments are cut off from the disc, and finally, the nucleus pulposus fragments are also sucked out. The device can remove multiple nucleus pulposus fragments at one time, and the surgeon does not need to pick up the fragments one by one, so that the surgery efficiency is improved. Meanwhile, the device can also suck out the nucleus pulposus fragments in the corners of the disc, so that the surgery effect is improved.

The invention belongs to the technical field of biological medicine, particularly relates to application of a reagent related to expression of glutaminase 1, and provides application of a reagent for detecting the expression quantity of GLS1 in preparation of a diagnostic product for intervertebral disc degeneration due to the fact that the expression level of GLS1 protein is found to be remarkably reduced in degenerated nucleus pulposus tissue. According to the present invention, the GLS1 regulates and controls the iron ion homeostasis by promoting the expression of cysteine desulfatase so as to antagonize ferroptosis and senescence of nucleus pulposus cells and further delay the degenerative change of the intervertebral disc, such that the GLS1 is adopted as the treatment target, and the GLS1 is overexpressed by using the overexpression reagent provided by the invention so as to achieve the intervertebral disc degeneration regulation and control effect of the GLS1; therefore, the invention provides application of a reagent for overexpressing GLS1 in preparation of a product for treating intervertebral disc degeneration.

A method for damaged viable disc regeneration has the steps of identifying the damaged viable disc and inserting a cannula via Kambin's Triangle to an edge of an outer annulus of the disc; introducing a trocar into the cannula and penetrating the trocar into a central region of nucleus pulposus; removing a tissue biopsy sample from the nucleus pulposus for pathology and removing additional degenerative tissue from the central region to create a void or space; withdrawing the trocar from the cannula and inserting a needle into the cannula to the void or space; and injecting a regenerative disc material through the needle into the void or space to repair the damaged disc.

The present disclosure relates to hydrogels and their use for repairing or supplementing body tissue. The hydrogels are capable of safe injection into patients through fine gauge needles and are suitable for repairing, supplementing, or replacing the nucleus pulposus of an intervertebral disc. Methods of manufacturing and methods of using the hydrogels of the present disclosure to repair or replace tissues are also disclosed.

The present invention provides a nanoparticle with which it is possible, safely, efficiently, and stably over a long period of time, to introduce siRNA used for RNA interference into an intervertebral disk cell. This nanoparticle is used for prevention or treatment of intervertebral disk degeneration, and has a biodegradable hydrogel and a ribonucleic acid molecule that is retained by a particle of the biodegradable hydrogel and that selectively inhibits an activity of a mammalian target of rapamycin (mTOR) complex.

The application discloses an in-vitro bionic mechanical testing system and method for spinal skeletal muscle, and particularly relates to the field of mechanical testing, and comprises a bionic module, a finite element modeling module, a multi-axis mechanical loading module, an iterative calculation module and a correction module; the application is modularized, comprises a vertebral body unit, a disc simulation assembly and a skeletal muscle simulation unit, each assembly is customized according to the anatomical characteristics of the human body, a three-dimensional model is generated by using the finite element modeling module, multi-directional mechanical loads are applied, and response data are collected; experimental data are input into the finite element model for iterative calculation, so that the stress distribution, the strain field and the kinematic deviation are compared; if the error exceeds a preset threshold, the model parameters and the physical parameters are corrected until the experimental and simulation results converge; finally, the failure mechanism of the spinal skeletal muscle under complex loads is predicted based on the optimized finite element model, and the risks of fracture, bone fracture, nucleus pulposus protrusion and muscle strain are evaluated.

The present invention discloses a lumbar disc herniation degeneration assessment method and system based on CT images, the method comprising: according to lumbar CT image data, projecting the image data of the three-dimensional lumbar disc region to a multi-view plane to generate a local feature map containing the local structure of the lumbar disc and a global feature map containing the macroscopic structure of the lumbar disc; extracting the structural features of the lumbar disc annulus, nucleus pulposus and protrusion from the local feature maps and global feature maps of different view angles to reconstruct the anatomical structure of the lumbar disc in three-dimensional space to obtain a geometric deformation model of the lumbar disc; according to the geometric deformation model, constructing a multi-level assessment model of lumbar disc degeneration, wherein the multi-level assessment model is trained by a deep learning network to perform feature classification and quantitative scoring to assess the protrusion degeneration level. By using the embodiments of the present invention, the degeneration state of the lumbar disc can be comprehensively and accurately analyzed through the combination of three-dimensional reconstruction and deep learning technology.

The present invention discloses an osteoporosis detection system based on nuclear magnetic resonance, which relates to the technical field of intelligent detection. It includes a pre-operation module, an image processing module, an analysis module, and an accurate module. Train an image segmentation model to obtain intervertebral disc images, segment the preprocessed images to obtain region-of-interest images, judge the first osteoporosis grade of the region-of-interest, input the region-of-interest images to the expert platform to obtain the second osteoporosis grade, and perform the second operation. Through the collaborative work of the pre-operation module, the image processing module, the analysis module, and the accurate module, the present invention improves the accuracy and efficiency of detection. Through the image segmentation model and the analysis module, a more comprehensive osteoporosis assessment is provided. By introducing the expert platform, the accuracy and reliability of the detection results are ensured. Using MRI technology for osteoporosis detection avoids radiation exposure and is a non-invasive and safe detection method.

The invention provides an intervertebral disc fibrous ring repairing device, and belongs to the technical field of medical instruments. A round head wire and a mesh; the rivet wire clamping handle is located on the surface of the rivet handle; the rivet is fixedly connected with one side end of the rivet handle; the rivet head is arranged on one side of the rivet; the rivet head hole is formed in the circumferential surface of the rivet head; through the matched design of the rivet and the rivet head, it is ensured that the mesh is accurately anchored to the edge of a vertebral end plate during implantation, displacement or looseness is avoided, the mesh is made of a PET material, biocompatibility and mechanical strength are achieved, fiber ring damage can be effectively closed, and nucleus pulposus is prevented from protruding again. The mesh is uniformly stressed through linkage fixation of the four-corner flat round-head lines and the round-head lines, local stress concentration is avoided, meanwhile, a doctor can accurately control the implantation depth through the scale line design of the rivet handle, and operation errors are reduced.

The invention discloses a functional exosome as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The exosome highly expresses miR-124-3p and miR-10a-5p, and the miR-124-3p can inhibit degradation of an extracellular matrix and promote remodeling of the extracellular matrix by inhibiting signal molecules such as ROCK1 and the like; and the latter can inhibit a proinflammatory factor receptor (IL6R) in a targeted manner so as to inhibit local inflammation. According to the dual synergistic effect of matrix remodeling and anti-inflammatory regulation, accurate intervention is carried out on core pathological links (matrix degradation and inflammation) of intervertebral disc degeneration, and the treatment effect which is difficult to achieve by a single therapy is achieved. According to the exosome, Syntenin-1 and IL-1RA are taken as dual molecular targets for screening functional exosome subgroups, and the specific exosome subgroups with dual functional potentials of'tissue repair 'and'immune regulation' are accurately screened from a complex exosome group derived from fibroblasts through a double-antibody immunoaffinity method.

The invention discloses application of YAP protein in preparation of a product for preventing and treating intervertebral disc nucleus pulposus cell aging. The YAP protein is selected from an amino acid sequence as shown in SEQ ID NO: 1. Experiments prove that the aging of the nucleus pulposus cells can be effectively inhibited by overexpressing the YAP in the aged nucleus pulposus cells, and the discovery provides a new thought for the treatment of the intervertebral disc degeneration. More importantly, the invention provides a strategy of inhibiting mitochondrial division by overexpression of YAP for the first time to inhibit aging of nucleus pulposus cells. The innovative viewpoint not only is fully proved through experiments, but also shows a very high application value. By regulating and controlling the expression level of YAP, a brand new and effective treatment method is expected to be provided for intervertebral disc degeneration patients, so that the pain of the intervertebral disc degeneration patients is relieved, and the life quality of the intervertebral disc degeneration patients is improved. In addition, the discovery may also provide new enlightenment and reference for treatment of other diseases related to cell aging.

The application discloses application of a viscoelastic biomaterial in the technical field of biological medicine, and aims to solve the problem of the influence mechanism of viscoelasticity on the metabolic state and pathway of nucleus pulposus cells in the prior art. The application comprises application of a viscoelastic double-network hydrogel of the viscoelastic biomaterial as a drug for promoting tissue repair and application of the viscoelastic biomaterial as a therapeutic drug for intervertebral disc degeneration; the application is suitable for development of a tissue repair drug, and a tissue repair drug is prepared from the viscoelastic biomaterial, so that a new route is provided for development of a tissue repair preparation.

A method of using a tissue retraction and neuromonitoring system includes: penetrating spinal disc tissue of a patient with an initial dilator, inserting at least one dilator over the initial dilator, and inserting a tissue retractor over the at least one dilator. The tissue retractor is configured for performing neuromonitoring. The initial dilator is non-cannulated and is configured for performing neuromonitoring. The at least one dilator is configured for performing neuromonitoring, is cannulated, and creates an operative corridor to a surgical site.

The present disclosure relates to an expandable interbody that includes superior and inferior shells enclosing a control mechanism that includes interlocking proximal and distal cages as well as an adjustment screw that longitudinally translates the distal cage relative to the proximal cage and thereby expands interbody by pushing apart the distal ends of the superior and inferior shells.

A patient positioning system for positioning a patient in preparation for an anterior cervical spinal procedure includes a base section, an upper body support attachable to a superior portion of the base section and a lower body support attachable to an inferior portion of the base section. The upper body support is configured to support the head and upper torso of the patient in a manner that aids in opening cervical spine disk space. The lower body support is configured to comfortably lift and support the legs of the patient. A traction strap assembly is attachable to the base section and configured to extend from the base section up around the shoulders of the patient and along the anterior side of the patient to a lower terminal end to enable intermittent traction of the patient's shoulders.

The present invention relates to the technical field of biomedicine. The present invention aims to provide a use of Mn3O4 nanoparticles in alleviating intervertebral disc degeneration, trimanganese tetroxide nanoparticles Mn3O4 NPs are added as nanozymes to interventional drugs for treating intervertebral disc degeneration. The present invention uses Mn3O4 nanoparticles as nano-active catalytic enzymes, which have multi-enzyme catalytic activities similar to superoxide dismutase, catalase, and glutathione peroxidase, and can effectively scavenge reactive oxygen species (ROS) and control ECM metabolism, significantly reducing cell apoptosis, delaying cell senescence, inhibiting inflammation, and enhancing autophagy, thereby promoting annulus fibrosus AF repair in the treatment of intervertebral disc degeneration. Mn3O4 nanoparticles have good biocompatibility, and metabolites thereof can be used in other physiological processes, producing no toxic side effects in the in vivo circulation. Furthermore said nanoparticles perform stably in adverse microenvironments of low oxygen and low pH in intervertebral discs, and have in vivo stability that other active catalytic enzymes do not possess.

The functional gel microspheres are provided by taking the angle of tissue engineering biomechanics as a starting point, the functional gel microspheres comprise GM (at) mTG porous microspheres and JTG, synthetic tiger bone powder JTG with anti-inflammatory and anti-oxidation characteristics is utilized, multifunctional methacrylic acid gelatin GelMA microspheres are developed, and the JTG is locally delivered to be used for IVDD treatment. In vitro, the functional microspheres not only improve the release kinetics of JTG, but also effectively inhibit the inflammatory response and oxidative stress of lipopolysaccharide-induced nucleus pulposus NP cells, and promote cell proliferation. In vivo, by adjusting the biomechanical matrix rigidity of the functionalized microspheres, the functions of promoting secretion of extracellular matrix ECM, relieving inflammatory response, maintaining the water content of NP and the height of the intervertebral disc, maintaining the complete intervertebral disc tissue structure and the like are achieved, and finally regeneration of IVD is promoted.

The present disclosure describes an intervertebral implant having a laterovertically-expanding shell operable for a reversible expansion from a collapsed state into an expanded state, the laterovertically-expanding shell having one or more connectors, and a pair of lateral extension elements that function to laterally expand the footprint of the implant within an intervertebal disc space.

The invention discloses injectable bioactive matrix hydrogel with an anti-angiogenesis and anti-neurogenesis microenvironment and application of the injectable bioactive matrix hydrogel. The injectable bioactive matrix hydrogel is prepared from bevacizumab, a concentrated growth factor and methacrylic acid chondroitin sulfate. The hydrogel prepared by the invention not only shows excellent injectability and biocompatibility, but also can inhibit pathological vascularization and neurogenesis, polarize macrophages to promote regeneration of M2 phenotype so as to relieve inflammation, and directly enhance deposition of cartilage specific ECM components (such as type II collagen and aggregation proteoglycan). By utilizing the coordinated multi-mechanism strategy, the comprehensive structure and function repair of the degenerated intervertebral disc is realized.

The purpose of the present invention is to use MMP as an active ingredient in a treatment agent for a disease caused by intervertebral disk degeneration even when the subject is a human.　The present invention provides a treatment agent for a disease caused by intervertebral disk degeneration. The treatment agent comprises MMP as an active ingredient, and the dose of the MMP per administration is 100-700 μg.

The utility model relates to the technical field of clinical medicine of traditional Chinese medicine, in particular to an arrowhead needle which comprises a needle head and a needle body, the needle head is arranged at one end of the needle body, the needle head is in a spoon shape with two symmetrical sides, an opening portion of the spoon shape is a cambered surface inclining downwards, and the bottom of the needle head is a spherical curved surface. The spoon needle can act on intervertebral disc tissues deeply buried in a skin layer, a muscle layer and a fascia layer through the spoon-shaped design symmetrical on the two sides of the needle head, the specific position, size and direction of nucleus pulposus protrusion can be accurately positioned according to the touch transmitted by the contact of the needle head, and during operation, the protruded nucleus pulposus and surrounding annulus fibrosus are firstly positioned; the protruding nucleus pulposus tissue is fixed through a spoon shape on one side, and then force is slowly applied to push the nucleus pulposus tissue into the deep intervertebral disc along the rupture space of the annulus fibrosus; the spoon-shaped part on the other side is used for driving the fibrous ring to be stored inwards together and winding and wrapping the fibrous ring on the nucleus pulposus again, and the nucleus pulposus can be stored in place generally through multiple times of adjustment.