10 results about "Intervertebral disk" patented technology

The description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable spacer includes a main body, a first endplate, a second endplate, a driving member, a plurality of pins, and an actuation member. The expandable spacer is configured to transition from a first configuration to a second configuration by various structures (e.g., steps, faceted surfaces, curved surfaces, multi-faceted portions) defined on the first endplate, the second endplate, and the driving member.

This invention discloses an injectable hydrogel loaded with 4-octyl itaconic acid, its preparation method, and its applications, belonging to the field of biomedical materials technology. The injectable hydrogel is formed by enzymatic cross-linking of a hyaluronic acid-tyramine complex to create a three-dimensional network, with 4-octyl itaconic acid encapsulated within this network structure. This invention allows for precise implantation of the hydrogel into the intervertebral disc lesion via minimally invasive injection, achieving local high-concentration drug accumulation. The three-dimensional network of the hydrogel serves as a drug reservoir, enabling continuous and controllable release of 4-OI, prolonging the drug's duration of action and achieving long-term therapeutic effects. Simultaneously, the loaded 4-OI specifically activates the Nrf2 / GPX4 antioxidant pathway in nucleus pulposus cells, mechanistically antagonizing ferroptosis and matrix degradation, thus achieving a dual function of mechanical support and biological therapy. It exhibits good biocompatibility and solves the problems of difficult targeted drug delivery, short-lived efficacy, and lack of disease-modifying effects in existing treatments for intervertebral disc degeneration.

The invention discloses an induction culture medium for inducing fibroblasts to transdifferentiate into nucleus pulposus cells and application of the induction culture medium, and belongs to the technical field of cytobiology and regenerative medicine. The induction culture medium comprises a basic culture medium and an induction composition, can be used for realizing 2D / 3D transdifferentiation of fibroblasts into nucleus pulposus cells, and meets the requirements of different application scenes. Meanwhile, the invention further provides an amplification culture medium, a technical system for forming a 3D (three-dimensional) organoid through amplification of the amplification culture medium is provided, and the method has important significance in promoting cell therapy of the intervertebral disc degenerative change.

The application discloses a device for removing loose disc nucleus pulposus fragments under a spinal minimally invasive surgery endoscope and belongs to the technical field of spinal minimally invasive surgery instruments. The device comprises a handle, a first fixing frame is fixedly connected to the inside center of the handle, a suction pipe assembly is rotatably connected to the inner wall of the first fixing frame, a removing mechanism is installed at the inside center of the suction pipe assembly, and a driving mechanism is installed in the handle. The removing mechanism can not only suck out the disc nucleus pulposus fragments, but also cut the nucleus pulposus fragments with flocculent tissue involvement through a cutting cylinder, so that the nucleus pulposus fragments are cut off from the disc, and finally, the nucleus pulposus fragments are also sucked out. The device can remove multiple nucleus pulposus fragments at one time, and the surgeon does not need to pick up the fragments one by one, so that the surgery efficiency is improved. Meanwhile, the device can also suck out the nucleus pulposus fragments in the corners of the disc, so that the surgery effect is improved.

The present invention provides a nanoparticle with which it is possible, safely, efficiently, and stably over a long period of time, to introduce siRNA used for RNA interference into an intervertebral disk cell. This nanoparticle is used for prevention or treatment of intervertebral disk degeneration, and has a biodegradable hydrogel and a ribonucleic acid molecule that is retained by a particle of the biodegradable hydrogel and that selectively inhibits an activity of a mammalian target of rapamycin (mTOR) complex.

The invention discloses a functional exosome as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The exosome highly expresses miR-124-3p and miR-10a-5p, and the miR-124-3p can inhibit degradation of an extracellular matrix and promote remodeling of the extracellular matrix by inhibiting signal molecules such as ROCK1 and the like; and the latter can inhibit a proinflammatory factor receptor (IL6R) in a targeted manner so as to inhibit local inflammation. According to the dual synergistic effect of matrix remodeling and anti-inflammatory regulation, accurate intervention is carried out on core pathological links (matrix degradation and inflammation) of intervertebral disc degeneration, and the treatment effect which is difficult to achieve by a single therapy is achieved. According to the exosome, Syntenin-1 and IL-1RA are taken as dual molecular targets for screening functional exosome subgroups, and the specific exosome subgroups with dual functional potentials of'tissue repair 'and'immune regulation' are accurately screened from a complex exosome group derived from fibroblasts through a double-antibody immunoaffinity method.

The application discloses application of a viscoelastic biomaterial in the technical field of biological medicine, and aims to solve the problem of the influence mechanism of viscoelasticity on the metabolic state and pathway of nucleus pulposus cells in the prior art. The application comprises application of a viscoelastic double-network hydrogel of the viscoelastic biomaterial as a drug for promoting tissue repair and application of the viscoelastic biomaterial as a therapeutic drug for intervertebral disc degeneration; the application is suitable for development of a tissue repair drug, and a tissue repair drug is prepared from the viscoelastic biomaterial, so that a new route is provided for development of a tissue repair preparation.

The present invention relates to the technical field of biomedicine. The present invention aims to provide a use of Mn3O4 nanoparticles in alleviating intervertebral disc degeneration, trimanganese tetroxide nanoparticles Mn3O4 NPs are added as nanozymes to interventional drugs for treating intervertebral disc degeneration. The present invention uses Mn3O4 nanoparticles as nano-active catalytic enzymes, which have multi-enzyme catalytic activities similar to superoxide dismutase, catalase, and glutathione peroxidase, and can effectively scavenge reactive oxygen species (ROS) and control ECM metabolism, significantly reducing cell apoptosis, delaying cell senescence, inhibiting inflammation, and enhancing autophagy, thereby promoting annulus fibrosus AF repair in the treatment of intervertebral disc degeneration. Mn3O4 nanoparticles have good biocompatibility, and metabolites thereof can be used in other physiological processes, producing no toxic side effects in the in vivo circulation. Furthermore said nanoparticles perform stably in adverse microenvironments of low oxygen and low pH in intervertebral discs, and have in vivo stability that other active catalytic enzymes do not possess.

The present disclosure describes an intervertebral implant having a laterovertically-expanding shell operable for a reversible expansion from a collapsed state into an expanded state, the laterovertically-expanding shell having one or more connectors, and a pair of lateral extension elements that function to laterally expand the footprint of the implant within an intervertebal disc space.

The invention discloses injectable bioactive matrix hydrogel with an anti-angiogenesis and anti-neurogenesis microenvironment and application of the injectable bioactive matrix hydrogel. The injectable bioactive matrix hydrogel is prepared from bevacizumab, a concentrated growth factor and methacrylic acid chondroitin sulfate. The hydrogel prepared by the invention not only shows excellent injectability and biocompatibility, but also can inhibit pathological vascularization and neurogenesis, polarize macrophages to promote regeneration of M2 phenotype so as to relieve inflammation, and directly enhance deposition of cartilage specific ECM components (such as type II collagen and aggregation proteoglycan). By utilizing the coordinated multi-mechanism strategy, the comprehensive structure and function repair of the degenerated intervertebral disc is realized.