63 results about "Itaconic acid" patented technology

The application belongs to the technical field of oil exploitation, and particularly relates to a temporary plugging agent for fracturing acidification and a preparation method thereof. The preparation method is as follows: in a reactor, itaconic acid, p-styrene sulfonic acid, 2-allyloxy methyl-2-hydroxymethyl propane-1,3-diol, vinyl pyridine, pentaerythritol diacrylate, buffer salt and deionized water are sequentially added, stirring is conducted, the pH value is adjusted, and all raw materials are completely dissolved; an initiator is added from a high-position dropping tank, the reaction is automatically heated, the reaction is kept, a reducing agent is added, the reaction is terminated, the pH value is adjusted, and a temporary plugging agent solution is obtained; the temporary plugging agent solution is dried and granulated to obtain the product temporary plugging agent. The preparation method has the characteristics of simple synthesis process and no by-products; the temporary plugging agent has the advantages of large water absorption, large plugging strength, high breakthrough pressure, self-degradation and designable degradation time.

The present application relates to the technical fields of high polymer material and ultraviolet (UV) curing coating, and particularly relates to an epoxy acrylate / itaconic acid derivative composite photocuring coating composition, a preparation method thereof, a photocuring coating layer and application.The photocuring coating composition comprises the following components in parts by mass: an epoxy acrylate / itaconic acid derivative composite photocuring resin: 40-80 parts; an active diluent: 20-60 parts; and a photoinitiator: 1-8 parts.The present application provides a bio-based monomer IG with high crosslinking activity, a green catalyst-free and solvent-free preparation method of the bio-based monomer IG, and an innovative petroleum-based / bio-based resin composite strategy and a coating composition thereof, so that the mechanical strength of the petroleum-based EA is efficiently enhanced, and meanwhile, the mechanical properties of the composite system still maintain a high level after the active diluent is added, the application range of the EA is expanded, and the petroleum-based resin is modified to be green and high-performance.

This invention belongs to the field of polymer protective materials technology, and discloses a nitrile glove modified with bio-based itaconic acid ester rubber latex and compounded with an antibacterial agent, as well as its preparation method. The glove uses carboxylated nitrile butadiene latex as the matrix, introduces a bio-based itaconic acid ester rubber latex pretreated with a silane coupling agent as a reactive interfacial compatibility component, and uses nano-silver-zinc composite particles and reactive quaternized chitosan to form an immobilized composite antibacterial phase. The glove is prepared through blending, impregnation molding, surface immobilization treatment, gradient vulcanization, and post-treatment. The resulting glove possesses excellent flexibility, low-temperature embrittlement resistance, oil resistance, and long-lasting antibacterial properties, and the antibacterial components are not easily migrated or detached, making it suitable for food processing, medical auxiliary protection, and low-temperature operations.

This invention relates to the field of metal protection and lubrication materials, and discloses a silent, vibration-damping, film-forming, long-lasting rust-preventive oil for bearings and its preparation method. The rust-preventive oil comprises a base oil, a dynamic borate ester-organosilicon-tungsten bridging synergistic modifier, itaconic acid hydrazine, a dimer ester, calcium petroleum sulfonate, polyisobutylene, a phosphate extreme pressure agent, and an antioxidant. The dynamic borate ester-organosilicon-tungsten bridging synergistic modifier forms a reversible dynamic covalent network of borate esters with phenylboronic acid through a diol-based compound, and then undergoes a confined sol-gel polymerization reaction with vinyltriethoxysilane to form silicon-oxygen segments. These segments are then coordinated and bridged by tungstate and diol groups to construct a three-dimensional coupled structure. The rust-preventive oil of this invention has advantages such as high film density, strong adhesion, good vibration damping and noise reduction effect, and strong rust prevention durability, making it suitable for the storage and operational protection of high-end bearings.

This invention discloses an environmentally friendly bio-based reinforcing compound and its preparation method. The compound, by weight, comprises: 100 parts EPDM rubber, 15-25 parts modified epoxidized soybean oil, 40-60 parts silane-modified rice husk ash silica, 2-2.5 parts peroxide, 1.5-2.5 parts crosslinking agent, and 5-7 parts additives. The modified epoxidized soybean oil is prepared by reacting epoxidized soybean oil with N-(2-hydroxyethyl)itaconic acid monoamide, followed by a reaction with a bio-based quaternary ammonium salt. This invention uses bio-based materials to replace traditional petroleum-based materials, resulting in excellent environmental performance. The introduction of modified epoxidized soybean oil significantly improves the compatibility and dispersibility of the bio-based reinforcing material with the rubber matrix, giving the compound excellent tensile strength, elongation at break, damping properties, antibacterial properties, and fatigue resistance. It can be widely used in automotive seals, shock absorbers, and other fields.

An aqueous compound and a fabric, the aqueous compound being a radical reaction product of an esterified itaconic acid and an unsaturated organic acid or an unsaturated organic alcohol, wherein the esterified itaconic acid is an esterification reaction product of itaconic acid and a linear dihydric alcohol of the formula 4‑12 wherein the unsaturated organic acid is a C n H 2n‑x (COOH) x wherein n is 2 to 8 and x is 1 to 3, and wherein the unsaturated organic alcohol is a C m H 2m‑y (OH) y wherein m is 3 to 8 and y is 1 to 3.

Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

A hydrophilic compound is formed by reacting an esterified itaconic acid with an unsaturated organic acid or an unsaturated organic alcohol through a free radical reaction. The esterified itaconic acid is formed by reacting an itaconic acid with a C4-12 linear diol through an esterification reaction. The unsaturated organic acid is CnH2n-x(COOH)x, wherein n is an integer of 2 to 8, and x is an integer of 1 to 3. The unsaturated organic alcohol is CmH2m-y(OH)y, wherein m is an integer of 3 to 8, and y is an integer of 1 to 3.

This invention discloses a high-strength carbon fiber modified plastic and its preparation method. By weight, it comprises the following raw materials: 90-100 parts polypropylene, 8-12 parts modified carbon fiber, 3-5 parts maleic anhydride-grafted polypropylene, 2-4 parts toughening agent, 0.7-1.1 parts antioxidant, and 0.5-0.8 parts lubricant. This high-strength carbon fiber modified plastic achieves its goal by subjecting the carbon fiber surface to specific multi-step modification, sequentially introducing an aminosilane coupling layer, a gallic acid amide bond linking layer, and an itaconic acid active double bond functional layer. This forms an inside-out covalently bonded interface system, transforming the simple physical contact between the carbon fiber and the polypropylene matrix into a chemical bond. Furthermore, by combining maleic anhydride-grafted polypropylene as an interface compatibilizer and ethylene-octene copolymer as a toughening agent, the formulation design ensures both high strength and material toughness, resulting in a high-strength carbon fiber modified polypropylene composite material with balanced mechanical properties.

The present invention relates to a novel metabolic pathway for producing itaconic acid and a recombinant microorganism, for producing itaconic acid, into which the metabolic pathway is introduced. It has been confirmed that the recombinant microorganism, for producing itaconic acid, into which the novel itaconic acid metabolic pathway is introduced, according to the present invention, significantly increases the production and yield of itaconic acid. In addition, as the recombinant microorganism for producing itaconic acid of the present invention uses an intermediate material of glycolysis rather than an intermediate material of the TCA cycle, the recombinant microorganism can further increase the production yield of itaconic acid through further improvement. Accordingly, the novel metabolic pathway for producing itaconic acid and the recombinant microorganism into which the metabolic pathway is introduced can increase the economic feasibility of itaconic acid, and thus can be variously used in industrial fields for synthetic resins, latexes, food additives, and the like in which itaconic acid is utilized.

This invention discloses an environmentally friendly biodegradable plastic packaging material and its preparation method, belonging to the technical field of polymer biodegradable packaging materials. It aims to solve the problems of poor compatibility, low melt strength, and slow degradation of existing polylactic acid (PLA) blends. This invention uses PLA as a matrix, introduces a furanyl dicarboxylic acid-pentanediol-itaconic acid copolyester containing side-chain double bonds as a functionalized flexible component, and adds thiol-modified epoxidized soybean oil as a reactive compatibilizer. Chemical linkages between different polymer chains are achieved through reactive extrusion, constructing a cross-linked network structure of thioether bonds. The resulting packaging material maintains good mechanical properties while exhibiting excellent gas barrier properties and biodegradability.

This invention provides an itaconic acid-producing strain, its construction method, and its application. E.coli W3110, as the chassis strain, upregulated the gltA, acnA, ACS, and gatA genes, knocked out the aceA and Pta genes, downregulated the transcription level of the icd gene using the BBa_J23115 promoter, and carried the high-copy plasmid PET-28a-WAL. The plasmid was used with the T7 promoter to overexpress a gene derived from... Aspergillus terreus The strain constructed using the CAD1 gene exhibits excellent itaconic acid synthesis capabilities and stable performance. It can efficiently and stably synthesize itaconic acid de novo using glucose as a carbon source through fermentation, with low production costs and high acid production efficiency, thus achieving efficient itaconic acid production and showing excellent prospects for industrial applications.

Disclosed are methods for treating an autoimmune and / or an inflammatory disease, disorder, or condition, including a skin disease, disorder, or condition comprising orally administering a prodrug of itaconate, 4-methyl itaconate, or 1-methyl itaconate to a subject in need of treatment thereof.

This invention relates to a method for preparing a self-healing polyurethane flexible strain sensor. The self-healing polyurethane flexible strain sensor possesses self-healing capabilities because the polyurethane elastomer network contains a large number of polar groups and dynamic disulfide bonds, which can form strong hydrogen bonds with the polar groups on modified carbon nanotubes, creating a high-density hydrogen bond network. Simultaneously, the modified carbon nanotubes exhibit good compatibility with the polyurethane elastomer, and the itaconic acid and polylactic acid segments possess good biocompatibility. This results in a flexible strain sensor with wide strain detection capabilities and controllable degradation capabilities, and it can also be used to monitor human health and movement, demonstrating great potential in the fields of health monitoring and smart wearable devices.

This invention proposes a method for preparing a neutrophil membrane-like biomimetic nanoplatform, characterized by the following steps: Step 1: Synthesizing a 4-octyl itaconic acid-retinol prodrug (OR); Step 2: Preparing ORNPs; Step 3: Extracting dHL-60 cell membranes; Step 4: Assembling M@ORNPs to obtain core-shell structured M@ORNPs nanoparticles with a hydration kinetic diameter of approximately 108.2 nm, which constitute the biomimetic nanoplatform. The biomimetic nanoplatform possesses active chemotaxis and immune escape properties, enabling precise delivery of 4-octyl itaconic acid-retinol in sepsis-associated acute lung injury.

The application discloses a kind of phosphorus-free scale inhibiting dispersants and preparation method thereof.In one aspect, the application provides a kind of phosphorus-free scale inhibiting dispersants, and the mass fraction ratio of each component of the phosphorus-free scale inhibiting dispersants includes: modified polyaspartic acid-acrylic acid-EDTA copolymer 24~28 parts, itaconic acid-styrene sulfonic acid copolymer 60~64 parts, zinc sulfate 2~3 parts.In another aspect, the application provides the preparation method of the above-mentioned phosphorus-free scale inhibiting dispersant, including the following steps: S1, preparation modified polyaspartic acid-acrylic acid-EDTA copolymer;S2, preparation itaconic acid-styrene sulfonic acid copolymer;S3, according to formula amount weighing each component, after being mixed sufficiently, phosphorus-free scale inhibiting dispersant is prepared.The high temperature stability of the application is better, and the scale inhibiting effect of calcium, magnesium, barium and other ions is all more excellent.

This invention discloses a high-acid-value reactive polycarboxylate and high-carboxyl fiber synergistic composition for electrostatic base paper and its application in surface sizing, belonging to the field of papermaking chemicals and paper surface sizing technology. The composition comprises water, dry solids components, and auxiliary agents. The dry solids components contain an effective component of a high-carboxyl copolymer obtained by free radical polymerization of aqueous solution. This effective component contains at least structural units derived from acrylic acid, maleic acid or maleic anhydride, and itaconic acid, and can form high-acid-value reactive polycarboxylate branches or water-soluble carboxyl copolymer branches for electrostatic base paper surface sizing. When this composition is compounded with surface starch and used in uncoated printing paper and electrostatic base paper, it helps reduce lint, dust, paper dust, and machine contamination, while also considering surface strength, water absorption, electrical stability, and repulping adaptability.

This invention relates to the technical field of tobacco leaf preservation, and particularly to a tobacco humectant, its preparation method, and its application. The tobacco humectant is formed by a eutectic reaction of a hydrogen bond donor and a hydrogen bond acceptor. The hydrogen bond acceptor includes at least one selected from betaine, urea, diammonium hydrogen phosphate, ammonium chloride, and ammonium acetate. The hydrogen bond donor includes at least one selected from sodium phytate, tartaric acid, itaconic acid, potassium lactate, and D-glucopyranose. This invention, by forming a eutectic solvent system and constructing a stable hydrogen bond network, enables the prepared tobacco humectant to possess excellent dual functions of hygroscopic absorption and water retention. When sprayed onto reconstituted tobacco leaves, it solves the problems of rapid moisture release and easy drying of reconstituted tobacco leaves, significantly improving their water-holding capacity. Simultaneously, through precise selection of hydrogen bond donors and acceptors, it further reduces the impact on the user's smoking experience.

This invention discloses an injectable hydrogel loaded with 4-octyl itaconic acid, its preparation method, and its applications, belonging to the field of biomedical materials technology. The injectable hydrogel is formed by enzymatic cross-linking of a hyaluronic acid-tyramine complex to create a three-dimensional network, with 4-octyl itaconic acid encapsulated within this network structure. This invention allows for precise implantation of the hydrogel into the intervertebral disc lesion via minimally invasive injection, achieving local high-concentration drug accumulation. The three-dimensional network of the hydrogel serves as a drug reservoir, enabling continuous and controllable release of 4-OI, prolonging the drug's duration of action and achieving long-term therapeutic effects. Simultaneously, the loaded 4-OI specifically activates the Nrf2 / GPX4 antioxidant pathway in nucleus pulposus cells, mechanistically antagonizing ferroptosis and matrix degradation, thus achieving a dual function of mechanical support and biological therapy. It exhibits good biocompatibility and solves the problems of difficult targeted drug delivery, short-lived efficacy, and lack of disease-modifying effects in existing treatments for intervertebral disc degeneration.

This invention provides a halogen-free no-clean flux and its preparation method, belonging to the field of flux technology. The method includes the following steps: Step S1: L-histidine and itaconic acid are compounded and reacted, then concentrated under reduced pressure, dried, pulverized, and sieved to obtain a histidine-itaconic acid composite activator; Step S2: Polyvinyl butyral is added to a mixed solvent of isopropanol, anhydrous ethanol, and dipropylene glycol methyl ether for wetting, dispersion, and dissolution, followed by the addition of hydrogenated rosin and triethyl citrate to obtain a resin-based solution; Step S3: The histidine-itaconic acid composite activator is added to a mixed system of deionized water, isopropanol, and anhydrous ethanol to obtain an activator solution; Step S4: The activator solution is slowly added to the resin-based solution, defoamed, filtered, and cured to obtain a halogen-free no-clean flux. This invention achieves the goals of good soldering activity, controllable residue, high system uniformity, and good storage stability in halogen-free no-clean flux.

This invention belongs to the field of compatibilizer technology, and relates to a bio-based polylactic acid (PLA) compatibilizer, its preparation method, and a fully bio-based PLA composite material. This invention discloses a bio-based PLA compatibilizer and its preparation method. This invention also discloses a fully bio-based PLA composite material, the raw materials of which include PLA, plant powder and / or plant fiber, and a bio-based PLA compatibilizer. This invention uses a self-synthesized bio-based itaconic acid diglycidyl ester as a grafting monomer as the bio-based source for grafting with PLA. The resulting bio-based PLA compatibilizer exhibits excellent compatibility; furthermore, using the bio-based PLA compatibilizer to prepare a fully bio-based PLA composite material can improve the interfacial compatibility and mechanical properties of the PLA composite material.

This invention relates to the field of pipe materials and discloses a flame-retardant chlorinated polyvinyl chloride (PVC) cable protection pipe and its preparation method. The cable protection pipe comprises: chlorinated polyvinyl chloride, modified polyvinyl chloride, modified multi-walled carbon nanotubes, and additives. The modified polyvinyl chloride is prepared by grafting a sulfur-containing benzimidazole-based cashew phenol plasticizer onto polyvinyl chloride. The sulfur-containing benzimidazole-based cashew phenol plasticizer is prepared by reacting aldehyde-based cashew phenol with 2-aminobenzimidazole, followed by ring-opening with glycidol, and then reacting sequentially with methyl mercaptopropionate, mercaptopropionic acid, and dimethyl itaconic acid. The modified multi-walled carbon nanotubes are prepared by grafting a polymer of phosphorus-containing acrylate monomers prepared by reacting DOPO, formaldehyde, and acryloyl chloride, maleic anhydride, and butyl acrylate onto the surface of aminated multi-walled carbon nanotubes. The pipe material prepared by this invention has good mechanical properties, thermo-oxidative stability, photo-oxidative stability, heat resistance, and flame-retardant properties.

This invention relates to the field of biodegradable polymer materials technology, specifically to a method for preparing bio-based biodegradable polyester, which is obtained by esterification and polycondensation reaction of bio-based diacid, bio-based diol, bio-based catalyst and antioxidant; the bio-based diacid is bio-fermented succinic acid, or a mixture of succinic acid and itaconic acid in a molar ratio of 8:2; the bio-based diol is a mixture of 1,3-propanediol and isosorbide, or a mixture of 1,3-propanediol, isosorbide and 1,4-butanediol in a molar ratio of 4:3:3; the bio-based catalyst is a guanidine carboxylate zinc complex or a zinc glutamate complex; this invention uses a fully bio-based raw material system to construct biodegradable polyester, with all raw materials derived from bio-fermentation and natural biomass conversion, realizing the renewability and environmental friendliness of the material from the source, which is in line with the development trend of green materials.

The application discloses a kind of polypropylene / bamboo fiber / poly (methyl acrylate-co-itaconic acid) composite material and preparation method thereof, belong to polymer composite material technical field.The composite material includes by weight fraction: polypropylene 40~80 parts, modified bamboo fiber 15~50 parts, poly (methyl acrylate-co-itaconic acid) nano particle with core-shell structure 2~15 parts, antioxidant 0.1~1 parts, lubricant 0.5~3 parts.The core layer of the nano particle is crosslinked acrylate flexible polymer, shell is poly (methyl acrylate-co-itaconic acid) copolymer, weight average molecular weight 30,000~200,000 g / mol, itaconic acid unit mole content 2%~20%.The modified bamboo fiber is pretreated by alkali treatment and silane coupling agent, and the nano particle is coated on the surface of modified bamboo fiber by pre-coating process before being melt-blended with polypropylene.The application is synergized by core-shell structure design and fiber pre-coating process, and forms the synergistic effect of "chemical bonding+physical toughening" in interface area, overcomes the technical bottleneck of traditional compatilizer "enhancing must reduce toughness", realizes the synergistic promotion of mechanical property, thermal stability and green attribute.

The application discloses a mycotoxin attenuant for improving mitochondrial function and application, and has the following components: 10-20 parts by weight of L-malic acid, 3-5 parts by weight of alpha-ketoglutaric acid (salt), 15-25 parts by weight of itaconic acid and 1-3 parts by weight of 5-norwongenin. In mycotoxin contaminated feed, the addition of L-malic acid, alpha-ketoglutaric acid (salt), itaconic acid or 5-norwongenin alone cannot improve mitochondrial function or relieve mycotoxin toxicity. Compared with the combination of any one of the four components, the complete addition of the four components can significantly enhance mitochondrial oxidative phosphorylation, weaken glycolysis, obviously improve mitochondrial energy metabolism, effectively relieve mycotoxin-induced mitochondrial damage in the intestines and liver of livestock and poultry, and thus improve the production performance and health status of livestock and poultry. The application can significantly reduce the toxic effect of mycotoxin on livestock and poultry through the synergistic effect of the components.

This invention discloses a two-system composite water-reducing agent containing polycarboxylate for concrete and its preparation method, belonging to the field of building material admixture processing technology. The two-system composite water-reducing agent for concrete includes component A and component B; component A is a passivating agent for acidic soil; component B is a polycarboxylate water-reducing agent mother liquor with a pH of 7-7.5; the amount of component A is 5%-10% of the mass of component B; component A includes a boric acid-modified MXene / chitosan, a sodium alginate-coated ammonium-modified polyacrylic acid polymer composite, an organotin catalyst, or an organic base catalyst; wherein the sodium alginate in the sodium alginate-coated ammonium-modified polyacrylic acid polymer composite is isocyanate cross-linked modified sodium alginate; component B includes a polymer prepared using isopentenyl alcohol polyoxyethylene ether, isomeric ester, acrylic acid, and itaconic acid as monomers, and alkylamide betaine. This application is applicable to concrete systems containing acidic soil.

The application discloses a slow-release biochar-based compound fertilizer and a production process thereof, and belongs to the technical field of biochar-based fertilizers.The compound fertilizer comprises, in terms of weight parts, modified biochar 30-45 parts, inorganic nutrient raw material 50-65 parts, composite cross-linking binder 4-10 parts and chelated trace elements 1-3 parts;the production process comprises, in sequence, biochar micropore cleaning and activation, free radical oxidation modification, surface grafting polymerization, vacuum impregnation loading and cross-linking embedding granulation;the application increases oxygen-containing functional groups on the surface of biochar and constructs hierarchical pore structures through an oxalic acid-assisted catalytic free radical oxidation system and a maleic anhydride-itaconic acid double monomer grafting technology;through modification of biochar and in combination with a vacuum loading process, nutrients are locked inside the hierarchical pores, and then, a moisture-responsive binder coating is supplemented, so that double synergistic slow release of nutrients is realized, the problems of loose nutrient loading, easy loss and short slow-release period of existing carbon-based fertilizers are solved, and the application is especially suitable for saline-alkali soil improvement and dry farming.