347 results about "Bifunctional" patented technology

Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

A photocatalytic / thermocatalytic coating includes an inner layer of metal / titanium dioxide or metal oxide / titanium dioxide that is applied on a honeycomb and an outer layer of titanium dioxide or metal oxide doped titanium dioxide applied on the inner layer. The inner layer of can be gold / titanium dioxide, platinum / titanium dioxide, or manganese oxide / titanium dioxide. The outer layer of titanium dioxide or metal oxide doped titanium dioxide oxides volatile organic compounds to carbon dioxide, water, and other substances. As the outer layer is thin and porous, the contaminants in the air can diffuse through the outer layer and adsorb onto the inner layer. When photons of the ultraviolet light are absorbed by the coating, reactive hydroxyl radicals are formed that oxidize the contaminant to produce water, carbon dioxide, and other substances.

The invention relates to coating material compositions for, for example, metallic, mineral substrates or for substrates of wood, paper and plastics, which comprise yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters which are very largely free of benzene and formaldehyde, as a result of which the adhesion of these coating material compositions is improved even under critical ambient conditions, and to a preparation process and use of said compositions. More specifically, the invention relates to coating material compositions, substantially including 1, yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters which are very largely free of benzene and formaldehyde; 2, at least one other adhesive; 3, at least one accessory ingredient and / or additive; 4, at least one colorant and / or stuffing. The yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters are composed by the following components: I. acid components, made up of A) at least one alpha, beta-unsaturated dicarboxilic acid, and B) at least one linear and / or branch fatty group and / or alicyclic and / or aromatic bifunctional and / or polyfunctional carboxyl acid, which is not provided with alpha, beta-unsaturated part; II. alcohol components, made up of C) bis(hydroxymethyl)tricyclo compounds and D) at least one bifunctional and / or polyfunctional alcohol, wherein, based on the polyesters, the content of benzene is lower than 10mg / kg and the content of formaldehyde is lower than 10mg / kg, the molecular weight distribution polydispersity of the polyesters is 1.3-4.5, the content of tricyclodecane(mono- / di-)aldehyde in the bis(hydroxymethyl)tricyclo compound C) is lower than 2 weight percent; mono(hydroxymethyl)tricyclo [5.2.1.0<2,6>] decane in the compound C) is lower than 10 weight percent, and the content of chromium, nickel, copper, cadmium and plumbum in the compound C) is lower than 2mg / kg.

The invention discloses a bifunctional micro-encapsulation phase-change energy storage material with a photo-catalysis property and a preparation method thereof. A core material of the bifunctional micro-encapsulation phase-change energy storage material is a phase-change material such as high-grade aliphatic alkane, alcohol, acid, acid ester and the like, and a wall material of the bifunctional micro-encapsulation phase-change energy storage material is crystalline titanium dioxide or element-doped crystalline titanium dioxide with the photo-catalysis property. The preparation method comprises the steps of mixing and stirring 2.0-3.4wt.% of surfactant, 79.0-80.0wt.% of solvent, 6.0-10.0wt.% of phase-change energy storage material and 4.5-8.5wt.% of titanium source in percentage by weight to form a stable emulsion; adding mixed liquid of the solvent and water to initiate reaction; then adding 0.0-3.0wt% of crystallization induction additive in percentage by weight to obtain the micro-encapsulation phase-change energy storage material of a crystalline titanium dioxide coated organic phase-change material. The micro-encapsulation phase-change energy storage material of an element-doped crystalline titanium dioxide coated organic phase-change material can be obtained by adding a product into a metal solution or non-metal solution while stirring.

Provided are previously uncharacterised markers of cancers, for example colorectal cancers, and uses of these as diagnostic and prognostic markers of cancers, and in particular colorectal cancers. The markers are SEQ ID NO: 1—hnRNP-K; SEQ ID NO:2—HMG-1; SEQ ID NO:3—proteasome subunit alpha type 1; SEQ ID NO:4—bifunctional purine biosynthesis protein; SEQ ID NO:5—ST11; SEQ ID NO:6—annex in IV; SEQ ID NO:7—60 kDa heat shock protein; SEQ ID NO:8—T complex protein 1 beta subunit; SEQ ID NO:9—T complex protein 1 epsilon subunit; SEQ ID NO: 10—mortalin; and SEQ ID NO: 11—TER-ATPase. The invention further provides related methods and materials for the use of the markers in therapeutic intervention in colorectal and other cancers e.g. to specifically target neoplastic cells without causing significant toxicity in healthy tissues, and to provide methods for the evaluation of the ability of candidate therapeutic compounds to modulate the biological activity of cancerous cells from the colon, rectum and other tissues.

The invention relates to bifunctional stapled or stitched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stitched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stitched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stitched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stitched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.

The invention relates to carboxylic acid polymer which is an admixture of concrete which can control the slump loss of the concrete. Hydroxyl bifunctional polyether esterifies with bifunctional maleic or the acid anhydride of maleic to produce crosslinked large monomer, and copolymerizes with allylic alcohol ether and bifunctional small monomer to produce certain molecular weight polymer. The water-reducing agent can incessantly release small molecular weight water-reducing agent during the hydration of the cement, thereby the goal of continuously restraining slump loss is achieved.

This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds are covalently linked by a biologically labile bond. This invention also relates to methods of making such compounds. The invention also relates to methods of using such bifunctional compounds in the prevention or treatment of diseases or conditions that are affected or can be assisted by altering the integrity or rearrangement of the cytoskeleton. Particularly, this invention relates to methods of treating ophthalmic diseases such as disorders in which intraocular pressure is elevated, for example primary open-angle glaucoma, using the bifunctional compounds.

The invention discloses a polymer dispersed liquid crystal material and a method for preparing liquid crystal thin films from the same, which belongs to the technical field of liquid crystal application. Thin films prepared can be widely applied in liquid crystal display, intelligent glass and other related fields. A polymer dispersed liquid crystal composition comprises 20 to 80 parts by weight of polymer monomer, 1 to 10 parts by weight of photoinitiator, 20 to 70 parts by weight of oligomer and 0.1 to 10 parts by weight of polymerization inhibitor, wherein the oligomer is at least one of epoxy acrylate oligomer, urethane acrylate oligomer, polyester acrylate oligomer, polyether acrylate oligomer and unsaturated polyester oligomer, and the polymer monomer is at least one of monofunctional-group (methyl) acrylate monomer, bifunctional-group (methyl) acrylate monomer and high-functional-group acrylate monomer with three or more functional groups. A PDLC thin film prepared from the mixture provided by the invention has high contrast, low driving voltage and good stability.

The invention discloses a four-color fluorescence labeling reversible terminal and a use thereof in DNA (Deoxyribonucleic Acid) sequencing. The structural formula of the reversible terminal is as shown in a formula (I) in the specification, wherein R1 is triphosphate; R2 is H or OH; the basic group is U, C, A, G or derivatives thereof; the connecting unit is a bifunctional compound which is breakable under a mild condition; the fluorescence group is one selected from a combination of BODIPY, fluorescein, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, squarene dye and an energy transferring dye, and derivatives thereof. The reversible terminal provided by the invention can be used for DNA single-molecule sequencing; simultaneously, raw materials required by the synthesis of the reversible terminal provided by the invention are simple and easy to get and the synthesis process of the reversible terminal is completely involved with conventional chemical reactions, so that the four-color fluorescence labeling reversible terminal can be popularized and utilized to a large scale; biological evaluation results indicate that the reversible terminal is capable of completely meeting the biochemical reaction requirements of high-flux sequencing and has a good practical prospect.

A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.

A bifunctional LED headlamp for a vehicle is disclosed, wherein at least one of a shield, a lens, a reflector, and an LED are movable to facilitate use of the headlamp in both a low beam mode and a high beam mode.

The invention relates to the technical field of polymer material, in particular to a free spraying weather resistant anti-friction PA / PMMA alloy and a preparation method thereof. The invention discloses a free spraying weather resistant anti-friction PA / PMMA alloy which includes amide-type polymer and acrylic esters polymer, and is characterized in that the total weight is taken as standard, and the PA / PMMA alloy also comprises 1-10% of compatilizer, wherein, the compatilizer is styrene and acrylonitrile quadripolymer containing epoxide group and alkyl acrylic ester bifunctional monomer or styrene tertiary polymer containing methacrylic acid and maleic anhydride bifunctional monomer. The invention also discloses the preparation method of the PA / PMMA alloy. The PA / PMMA alloy is superior to PA / ABS alloy on the characteristics of free spraying, weather resisting property and friction resistance, so as to be a potential environment protective and energy-saving alternate material in the field of inside and outside decorative parts of automobile.

Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.

A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.

The invention provides an acid-base bifunctional metal organic skeletal catalyst and a preparation method and an application thereof. The preparation steps are as follows: zirconium salt and 2-aminaterephthalic acid are dissolved in weakly acidic solution, and the obtained mixed solution is uniformly dispersed under an ultrasonic condition, and reacts in water bath; after reaction, the product is filtered, collected and washed; after the washed product is immersed in low-boiling point solvent, filtration is carried out, vacuum drying is then carried out, and thereby a UiO-66-NH2 material is obtained; trichloromethane solution which contains 1,3-propane sultone is prepared, added with the prepared UiO-66-NH2 material and heated in water bath to react, and the prepared solid product is then centrifugally separated and washed by using Soxhlet extraction; the obtained solid material is put into a vacuum drying oven, and thereby the acid-base bifunctional metal organic skeletal catalyst is obtained. The process of preparing the product is simple, the preparation cost is low, the acid-base bifunctional metal organic skeletal catalyst is used in the preparation of 5-hydroxymethylfurfural by one-step catalysis of dextrose, the reaction progress is accelerated, and the reaction process is simplified.

The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and / or prokinetic agents.

The invention discloses a nonmetallic bifunctional oxygen catalyst based on ZIF-8 and double-doped with phosphorus and sulfur, and a preparation method and an application thereof. A nonmetal carbon porous nano-compound is prepared through calcination in an inert atmosphere with ZIF-8 as a template, sodium phytate as a phosphorus source and 1-dodecanethiol as a sulfur source, the porous skeleton structure of ZIF makes the carbon material obtained after calcination inherit the porous structure, and metal Zn is sublimated and removed due to the low boiling point, so the carbon material uniformlyco-doped with phosphorus and sulfur is obtained. The obtained catalyst has a high specific surface area and a high conductivity, and has good oxygen reduction and oxygen evolution electrocatalytic activity in an alkaline medium, because the porous carbon material catalyst effectively increases the specific surface area and the conductivity; and the phosphorus and sulfur partially replace C-C sp<2>hybrid orbital to form C-P and C-S links, so active sites are increased, the conduction of electrons is benefited, the electrocatalytic performance of the material is greatly improved, and the material has potential application values in the field of energy conversion and storage.

The invention provides an antibiotic and heavy metal removed meso-porous silicon based bifunctional adsorbing material and a preparation method thereof. The adsorbing material contains a functional group-amino and Fe (III). The method comprises the following steps: uniformly mixing a mesoporous molecular sieve with a methylbenzene solution in protective atmosphere after drying the mesoporous molecular sieve, adding a silane coupling agent into the mixed solution, mixing and stirring in the protective atmosphere, filtering, cleaning, drying, adding into an Fe (III)-containing alcoholic solution, stirring, filtering, cleaning and drying to obtain the meso-porous silicon based bifunctional adsorbing material. The prepared adsorbing material contains different functional groups, can specifically adsorb specific pollutants, can remove the antibiotics and heavy metals in a water body under the complexing action of the amino and the heavy metal and the complexing action of the Fe (III) and the antibiotics, and the removal cost can be reduced; and besides, the preparation method is simple and the conditions can be controlled easily.

The invention relates to a class of novel bifunctional benzoyl formic acid hydroxy ketone ester compounds and photoinitiators containing the compounds. The general formula I and II of the compounds are shown in the specification, wherein n is 0-90, R1 and R2 are selected from hydrogen, alkane or aryl groups with C1-C12 straight chains or branched chains and cyclic structures containing C5-C12 carbocycles, Ar is selected from phenyl rings or substituted phenyl rings wherein the substituent is one or more R, OR and halogen atom, and R is selected from alkyl, phenyl ring or benzyl with C1-C12 straight chains or branched chains. The compounds are suitable as photoinitiators of olefinic unsaturated compounds or mixtures containing the compounds for photopolymerization. The compounds can also be used with combination of another photoinitiator and / or other additives.

Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.

The invention discloses a magnetic fluorescent bifunctional nano biological probe and a preparation method thereof. The invention is characterized by preparing magnetic fluorescent bifunctional nanoparticles which can be used a nano biological probe, wherein each nanoparticle is in a core-shell spherical structure, and the nanoparticles are prepared from hydrophobic superparamagnetic nanoparticles as the core layer and a fluorescent amphipathic polymer as the shell layer by a nano emulsion process. After entering cells, the composite magnetic fluorescent nanoparticles can be used for imaging analysis on the cells respectively by a fluorescence process and a magnetic resonance imaging process. The magnetic fluorescent nano probe disclosed by the invention has high sensitivity and stability, greatly enhances the sensitivity and accuracy of cell imaging, reduces the emergence of false positive and false negative in cell diagnosis and analysis, and can be well used for diagnosing various diseases, such as tumor cells, cancer cells and the like.

The invention relates to a novel kind of pyrrolopyridone bifunctional molecule and its pharmaceutically acceptable salt, hydrate and prodrug and a pharmaceutical composition using the compounds as active ingredients, and application in the preparation of these compounds and their pharmaceutical composition and in the treatment or prevention of tumors, inflammation, diseases related immunity, etc.The bifunctional molecule involved in the invention is a proteolytic targeting chimera (PROTAC). A small molecule inhibitor of BET protein and a Von Hippel-Lindau (VHL) protein ligand in E3 ubiquitinligase complex are linked by a connecting arm to obtain the bifunctional molecule. The obtained compound can selectively induce the degradation of BET protein, and has significant anti-tumor effect.

The invention discloses a method for preparing silicone rubber / polyamide thermoplastic vulcanized rubber by virtue of reactive compatibilization. According to the method, the raw materials (parts by weight) are as follows: 100 parts of silicone rubber, 20-90 parts of polyamide, 1-20 parts of a self-made solubilizer, 0.5-2 parts of an antioxidant, 1-5 parts of a vulcanizing agent and 0.5-2 parts of a polymerization inhibitor, wherein the self-made solubilizer is epoxidized silicone rubber obtained by epoxidation reaction of peroxy acid and vinyl-terminated silicone rubber. The method comprises the steps of carrying out shearing blending on the silicone rubber, polyamide, the self-made solubilizer and the antioxidant at 170-260 DEG C to obtain a mixture, uniformly mixing the mixture with the vulcanizing agent and the polymerization inhibitor at the room temperature, and finally carrying out high-temperature high-speed dynamic vulcanizing, so as to obtain the silicone rubber / polyamide thermoplastic vulcanized rubber. The thermoplastic vulcanized rubber has the characteristics of fine microcosmic phase state structure, excellent physical and mechanical properties, excellent high temperature resistance and oil resistance and the like and can be applied to automotive fuel rubber pipes, conveying belts, cable insulation layers, tool handles and the like.

Novel bifunctional peptides useful in the treatment and / or diagnosis of EAE or MS. The peptides have a first peptide portion derived from an epitope of myelin proteolipid protein, myelin oligodendrocyte glycoprotein, or oligodendrocyte-specific peptide and a second peptide portion derived from CD11a (LFA-1 alpha subunit), CD18 (LFA-1 beta subunit), CD154 (CD40L), Fas-Ligand, or CTLA4. The carboxy and / or amino termini of the bifunctional peptides may be modified.

The invention relates to reactively compatibilized butyl rubber / polyamide TPV (thermoplastic vulcanzate) and a preparation method thereof. The butyl rubber, a bifunctional compound and a radical initiator are mixed at a high temperature, bifunctional compound graft-modified butyl rubber is prepared and taken as a compatibilizer, and the butyl rubber / polyamide TPV with excellent physical and mechanical properties, air tightness, hardness and the like is prepared with rubber and plastic premixing and dynamic vulcanization technologies.

The invention provides a process for producing a modified conjugated diene based polymer which attains favorable interaction between a rubber component and carbon black and / or silica, thereby improving dispersibility of the fillers, and which exhibits excellent properties such as heat-buildup-suppressing performance, fracture characteristics, and wear resistance; a modified conjugated diene based polymer produced through the process; a rubber composition containing the diene polymer; and a tire produced from the rubber composition and exhibiting the above properties. The process for producing a modified conjugated diene based polymer includes a step (a) of reacting a silicon compound with a conjugated diene based polymer having an active end so that the reaction takes place at the active end, the silicon compound having a protected primary amino group in the molecule thereof and a bi-functional silicon atom to which a hydrocarbyloxy group and a reactive group are bonded, to thereby modify the active end, and a step (b) of performing condensation reaction which involves the compound having a bi-functional silicon atom, in the presence of a titanium compound serving as a titanium-based condensation-accelerating agent.