151 results about "Bifunctional" patented technology

The invention provides a bifunctional nano-enzyme SERS (Surface Enhanced Raman Scattering) detection platform for ultrasensitively detecting mi RNA (Ribonucleic Acid) related to cerebral infarction and a preparation method, and relates to the technical field of biomedical engineering. The preparation method comprises the following steps: synthesizing gold nanorods (AuNRs) by using a seed growth method, and growing Pt on the surface of a product to prepare gold platinum nanorods (Au (at) Pt NRs); the preparation method comprises the following steps: synthesizing gold nano hexagonal plates (AuNHs) by using a seed growth method, and preparing an AuNHs array through oil-water interface self-assembly; and modifying an aptamer complementary chain (H1) on the Au (at) Pt NRs obtained in the step (1) through an Au-S bond. And combining the assembled AuNHs array with a nucleic acid aptamer (cDNA) corresponding to mi R-106a-5p to functionalize the assembled AuNHs array in the step (2), so as to construct an SERS (Surface Enhanced Raman Scattering) detection platform. The target mi R-106a-5p can be specifically combined with cDNA, so that Au (at) Pt NRs carrying H1 are separated from the surface of an AuNHs array, TMB oxidation is reduced, and SERS signals are remarkably reduced. And according to SERS signal intensity, substituting the SERS signal intensity into a linear regression equation to realize quantitative detection of mi RNA.

This invention relates to a method for synthesizing iron-cobalt alloy-doped carbon nanofibers for electrocatalysis using zinc oxide etching, belonging to the technical field of electrode materials and catalysts. The preparation method includes the following steps: 1) mixing DMF (dimethylformamide), PMDA (pyromellitic dianhydride), and ODA (4,4-diaminodiphenyl ether) in a certain proportion to prepare a PAA (polyamic acid) spinning solution; 2) preparing PAA nanofibers from the PAA spinning solution using an electrostatic melt-blowing device; 3) imidizing the PAA nanofibers using a programmed temperature rise method to obtain PI nanofibers; 4) impregnating the PI nanofibers in a salt solution; 5) carbonizing the impregnated PI nanofibers with a large number of metal ions on their surface in an inert atmosphere using a certain temperature rise program to obtain iron-cobalt alloy-doped carbon nanofibers. The iron-cobalt alloy-doped carbon nanofibers prepared by this method exhibit excellent performance as an ORR / OER bifunctional electrocatalyst and have wide applications.

The invention belongs to the technical field of chemical pharmacy, and particularly relates to a preparation method and application of an impurity of a beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound. According to the impurity preparation method of the beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound, acetylation of amino is successfully realized by using acetylation reagents such as acetyl chloride and alkali accelerators such as N, N-diisopropylethylamine, then debenzylation is performed through hydrogenation reaction, and the compound shown in the formula I is successfully prepared. Then, through liquid chromatography purification, a high-purity compound as shown in the formula I is obtained, and the raw material medicine as shown in JKN2304 can meet the requirements of reference substances in the research and development process; the technical problem that in the prior art, an impurity synthesis process of a beta 2 adrenal gland receptor agonist and M receptor antagonist bifunctional active compound is lacked is solved.

Polymerizable, radiation-curable compositions are provided and comprise (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and / or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and / or visible range or a photoinitiator system for the UV and / or visible range. The compositions are usable for producing, via a rapid prototyping, manufacturing, or tooling process, dental prosthetic parts, orthopaedic instruments, or dental pre-forms that have a flexural strength of greater than or equal to 75 MPa, a modulus of elasticity of greater than or equal to 2600 MPa, and / or a water absorption of less than 45 [μg / mm3].

The invention relates to the technical field of coatings, in particular to a high-efficiency photocuring monomer based on bio-based star-shaped polyester polyol and a preparation method of the high-efficiency photocuring monomer based on bio-based star-shaped polyester polyol. Castor oil derived trimethylolpropane is used as a core, adipic acid and epoxidized soybean oleic acid are introduced through a condensation polymerization reaction to form star-shaped structure polyol; an acrylate group is introduced into a polyol molecule through a glycidyl methacrylate ring-opening reaction, and an epoxy group in the epoxidized soybean oleic acid is retained; through unique molecular structure design, reasonable component selection and innovative process optimization, multiple technical breakthroughs are realized. The bio-based branching design has remarkable effects in the aspects of cost reduction and environmental protection; the reaction activity and the curing performance of the material are greatly improved through the synergistic effect of bifunctional groups; and the problem of environmental pollution in the traditional process is solved by green process integration. The invention provides a high-performance and environment-friendly novel photocuring monomer for the field of photocuring materials.

The application discloses a bifunctional HMGR mutant, which is obtained by replacing aspartic acid at the 154th amino acid of the amino acid sequence of natural HMGR with other amino acids. The application also discloses a nucleotide sequence and an amino acid sequence. The application further discloses a preparation method and application of the bifunctional HMGR mutant. The HMGR mutant of the application has high activity to both NADP(H) and NAD(H) substrates, and has significantly improved catalytic activity in a certain pH range.

The invention provides a novel bifunctional material and a preparation method and application thereof, and relates to the technical field of catalyst preparation, the bifunctional material has the following general formula: A-M / CaO-S, wherein A is an active component, M is an auxiliary agent metal, and S is a bifunctional material carrier; a is selected from at least one of Rh, Ru and Ni; m is selected from at least one of La, Ce, K and Na. According to the invention, the problems of tedious steps, low carbon efficiency, low energy efficiency and poor technical economy due to mutual independence of carbon dioxide trapping and chemical utilization processes are solved, and the technical effects of efficiently trapping carbon dioxide, catalyzing the reaction of carbon dioxide and methane in situ and successfully generating synthesis gas (H2 and CO) are achieved; and a solid scientific support is provided for economical efficiency and resource utilization of carbon dioxide.

The invention discloses a catalyst for photocatalytic coupling of CO2 reduction and HMF oxidation as well as a preparation method and application of the catalyst. The preparation method comprises the following steps: dissolving a noble metal precursor in a titanium dioxide dispersion liquid, and then adding a reducing agent for reaction; the catalyst for photocatalytic coupling of CO2 reduction and HMF oxidation is obtained. The Au-coated TiO2 Schottky heterojunction bifunctional photocatalyst prepared by the invention has the effects of simultaneously reducing CO2 and oxidizing HMF, electrons and holes are fully utilized, the CO precipitation efficiency can reach 17.6 [mu] mol g <-1 > h <-1 >, the yield of HMFCA reaches 34.6%, and the selectivity exceeds 95.0%. Visible light is used as energy to drive reaction, and energy consumption and environmental pollution are reduced. In addition, energy fuel and high-added-value chemicals can be synchronously produced, good environmental and economic benefits are achieved, harmful by-products are not generated in the whole photocatalysis process, and the principle of green chemistry is met.

Embodiments of the disclosure relate to methods of selectively depositing a metal after use of a flowable polymer to protect a substrate surface within a feature. A first metal layer is deposited by physical vapor deposition (PVD). The semiconductor substrate surface is exposed to one or more monomers to form a flowable and flexible polymer film on the first metal layer within the at least one feature. The flowable polymer film forms on the first metal layer on the bottom. The one or more monomers are selected from one or more of amines with bi-functional groups, aldehydes with bi-functional groups, cyanates with bi-functional groups, ketones with bi-functional groups, and alcohols with bi-functional groups. At least a portion of the first metal layer is selectively removed from the top surface and the at least one sidewall. The flowable polymer film is removed.

This invention provides a thiourea-tertiary amine bifunctional chitosan microsphere and its preparation method, belonging to the field of adsorption material technology. Through a stepwise functionalization and sequential crosslinking method, thiourea groups are first introduced onto the chitosan microspheres, followed by the introduction of tertiary amine groups and secondary crosslinking, successfully preparing chitosan microspheres possessing both thiourea and tertiary amine bifunctional groups. The thiourea and tertiary amine groups in the microspheres of this invention exhibit a synergistic adsorption effect on noble metal chloride anions, significantly improving the selective adsorption capacity and adsorption rate for noble metals such as palladium, platinum, and rhodium. Simultaneously, the dense three-dimensional network structure constructed through stepwise crosslinking greatly enhances the chemical stability and mechanical strength of the microspheres under strongly acidic environments, extending their service life. This preparation method is simple, mild, and environmentally friendly. The prepared adsorbent is particularly suitable for the efficient and selective recovery of noble metals from complex acidic wastewater or electronic waste leachates.

The invention discloses an oxygen-doped carbon nanofiber bifunctional electrocatalytic oxidation film and a preparation method and application thereof. The atomic ratio of nitrogen atoms to oxygen atoms in the oxygen-doped carbon nanofiber bifunctional electrocatalytic oxidation film is 11: (6-15). The catalytic performance of the electrocatalytic oxidation film can be improved by controlling the atomic ratio of nitrogen atoms to oxygen atoms in the oxygen-doped carbon nanofiber bifunctional electrocatalytic oxidation film, and then the catalytic efficiency of the electrocatalytic oxidation film is improved.

The invention provides a preparation method of a novel chiral thiourea / phosphine bifunctional organic catalyst with a cis-cyclic 1, 2-phosphinamine skeleton and application of the novel chiral thiourea / phosphine bifunctional organic catalyst in an asymmetric catalytic reaction. The chiral organic catalyst is prepared by taking cis chiral 2-(diphenylphosphine)-1, 2, 3, 4-tetrahydro-1-naphthylamine and an isothiocyanate compound as raw materials through a one-step reaction under a mild condition. The chiral thiourea / phosphine bifunctional organic catalyst is simple to prepare and stable in property, and shows excellent catalytic activity and stereoselectivity in an asymmetric hydrosilylation reaction of o-amido benzophenone.

The invention relates to the technical field of industrial wastewater denitrification, in particular to an industrial wastewater deep denitrification method based on a graphene adsorption material, which comprises the following steps: introducing industrial wastewater containing total nitrogen into an adsorption reaction unit; ammonia nitrogen and nitrate nitrogen in the wastewater are removed by adjusting the empty bed contact time; when the adsorption material is saturated, the particles are regenerated, and regenerated liquid is collected for nitrogen resource utilization. According to the core-shell type dual-functional graphene adsorption particle, rich amino functional groups on a PEI chain of the core of the core-shell type dual-functional graphene adsorption particle can efficiently and specifically adsorb and remove ammonia nitrogen through the ion exchange effect, the shell of the core-shell type dual-functional graphene adsorption particle is composed of magnesium-aluminum hydrotalcite growing in situ, exchangeable anions between hydrotalcite laminates can be subjected to ion exchange with nitrate nitrogen, and therefore the ammonia nitrogen can be removed through the core-shell type dual-functional graphene adsorption particle. Selective adsorption of nitrate nitrogen is realized; the synchronous deep removal of ammonia nitrogen and nitrate nitrogen in industrial wastewater is realized, the treatment efficiency is greatly improved, and the process flow is simplified.

The invention discloses a double-function (p) ppGpp synthetase or hydrolase mutant, a biological material and application of the double-function (p) ppGpp synthetase or hydrolase mutant to preparation of L-threonine, and belongs to the technical field of gene engineering. The technical problem to be solved by the invention is how to improve the yield of L-threonine. Relative to a wild type, the bifunctional (p) ppGpp synthetase or hydrolase mutant comprises one or more of the following mutations: K1) mutation of 174th amino acid of SEQ ID NO: 2 into cysteine, K2) mutation of 529th amino acid of SEQ ID NO: 2 into phenylalanine, and K3) insertion of histidine and aspartic acid between 84th amino acid and 85th amino acid of SEQ ID NO: 2. The bifunctional (p) ppGpp synthetase or hydrolase mutant provided by the invention can be used for improving the yield of L-threonine of Escherichia coli.

The invention belongs to the field of chemistry and environmental technology, and relates to a preparation method of amidoximated COFs material with adsorption and detection of uranyl bifunctional. The present invention uses 3,4-diaminobenzonitrile and 2-hydroxy-1,3,5-benzenetricarboxaldehyde as raw materials, and obtains cyanated COFs material after reaction; The cyanated COFs material is subjected to amidoximation modification to obtain amidoximated COFs material with adsorption and detection of uranyl bifunctional. The amidoximated COFs material with adsorption and detection of uranyl bifunctional prepared by post-modification has high adsorption selectivity and faster adsorption kinetics (5.11mg / g / min) for uranyl, has unique and excellent adsorption performance for hexavalent uranium, is easy to recover and recycle, and is environmentally friendly.

Acylated benzene sulfonated compounds with dual functionality can have the following structure:wherein each R is independently hydrogen or a C1 to C11 alkyl, each X is independently an alkali metal ion, an alkaline earth metal ion, and / or a quaternary ammonium cation, n is 1 to 3, and m is 1 to 2, with the proviso that when m is 2, the —OC(O)R groups are not located in an ortho configuration at positions 1 and 2 of the benzene ring. Cleaning compositions including the acylated benzene sulfonated compound are also disclosed.

The invention relates to a difunctional gastrodia elata glycosyl transferase GaUGT015 gene and application thereof in preparation of gastrodin and arbutin, and belongs to the technical field of biology. The nucleotide sequence of the difunctional glycosyl transferase GaUGT015 gene of the gastrodia elata is shown as SEQ ID NO.1, and the total length of the sequence is 1407 bp; the amino acid sequence of the encoded protein is as shown in SEQ ID NO.2, and 469 amino acid residues are encoded. The gastrodia elata bifunctional glycosyl transferase GaUGT015 gene disclosed by the invention can be used as a biosynthesis regulation gene of gastrodin and arbutin, is applied to preparation of gastrodin and arbutin, and is remarkable in application prospect and easy to popularize and apply.

The invention provides a difunctional electrocatalyst prepared by using Joule heat and a preparation method and application thereof, and belongs to the technical field of new energy materials. The preparation method comprises the following steps: synthesizing an organic framework compound by adopting dimethyl imidazole, zinc nitrate and transition metal salt of cobalt (Co), then pyrolyzing to prepare a cobalt-nitrogen-doped carbon material with oxygen reduction (ORR) activity, mixing the cobalt-nitrogen-doped carbon material with a nickel compound and an iron compound respectively, and preparing the cobalt-nitrogen-doped carbon material. Nickel and iron compounds are reduced into alloy nanoparticles in an extremely short time by using Joule heat, and the alloy nanoparticles are directly loaded on the surface of a cobalt-nitrogen-doped carbon material to obtain a high-performance dual-function (ORR and OER) electrocatalyst which can be used as a cathode catalyst to be applied to a metal-air battery.

This invention discloses a three-dimensional hierarchical NiCo2S4@NiMo3S4 / CT bifunctional electrocatalyst, its preparation method, and its applications, belonging to the field of electrocatalytic materials technology in new energy technologies. This invention employs a combination of a two-stage hydrothermal method and an annealing method. A two-dimensional NiCo2O4 / CT precursor is grown on carbon cloth as a conductive substrate. After sulfidation, a framework NiCo2S4 nanotube array is obtained. A second hydrothermal method is then used to grow NiMo3S4 nanosheets on the NiCo2S4 / CT nanotubes. The ultrathin NiMo3S4 nanosheets provide more catalytic reaction sites, allowing the NiMo3S4 nanosheets to cover the surface of the NiCo2S4 nanotube array, thus forming a unique three-dimensional hierarchical NiCo2S4@NiMo3S4 / CT heterostructure bifunctional electrocatalyst. The three-dimensional hierarchical NiCo2S4@NiMo3S4 material obtained by this invention exhibits excellent catalytic performance, cycle stability, active sites, and a large specific surface area. The preparation method of this invention is simple, constructs a special interface, forms a rich defect and phase transition coupled electronic structure, and obtains a bimetallic sulfide with a heterostructure, which improves the electron transport rate and enhances the electrical properties of transition metal sulfides.

The invention discloses a preparation method and application of an acid-base bifunctional magnesium-aluminum bimetallic oxide catalyst, and relates to the technical field of biomass catalytic conversion and heterogeneous catalytic materials.The preparation method comprises the steps that firstly, magnesium nitrate hexahydrate and aluminum nitrate nonahydrate are dissolved into a metal salt mixed solution; dropwise adding a sodium hydroxide aqueous solution into the metal salt mixed solution to obtain a turbid solution; heating and crystallizing in a water bath, transferring into a reaction kettle, and putting into a drying oven for hydrothermal crystallization. The method comprises the following steps: synthesizing a hydrotalcite-like precursor through a coprecipitation-hydrothermal coupling method, and carrying out high-temperature roasting to obtain the acid-base bifunctional composite metal oxide. The acid-base bifunctional composite metal oxide has the beneficial effects that the acid-base bifunctional composite metal oxide has a layered structure and a high specific surface area and is suitable for a biomass pyrolysis-catalytic reforming process, an alkaline site of the acid-base bifunctional composite metal oxide promotes a deoxidation reaction, an acidic site of the acid-base bifunctional composite metal oxide promotes an aromatization reaction, and the acid-base bifunctional composite metal oxide can effectively regulate and control the composition of biomass pyrolysis volatile components; the content of oxygen-containing compounds is obviously reduced, and the selectivity of monocyclic aromatic hydrocarbon is improved.

The invention belongs to the field of high polymer materials, and relates to a high-performance layer structure PVC door curtain and a preparation method thereof. According to the door curtain, modified polyvinyl chloride resin is used as a matrix, and a polar gradient layered structure is formed by molecular chains through fluorine-silicon bifunctional group synergistic grafting modification; meanwhile, small organic molecule 2-vinyl-4-hydroxyacetophenone is introduced as a reinforcing agent, and a stable network is formed between layers through pi-pi accumulation and hydrogen-bond interaction. The door curtain is prepared from modified polyvinyl chloride resin, 2-vinyl-4-hydroxyacetophenone, epoxidized soybean oil, dioctyl phthalate and an auxiliary agent through blending granulation and three-layer co-extrusion molding. The structure effectively improves the interfacial compatibility and molecular arrangement uniformity, so that the material has high transparency, excellent flexibility and strong interface bonding force at the same time. The light transmittance of the prepared door curtain reaches 93% or above, the door curtain still keeps flexibility at 40 DEG C, the peel strength is high, the ultraviolet aging resistance is remarkably superior to that of a traditional PVC product, and the comprehensive performance is excellent.

The invention relates to a composition which can be fixed by actinic radiation and cured by heat, the composition comprising: (A) an at least bifunctional, passivated, and solid isocyanate; (B) an isocyanate-reactive component which comprises at least one liquid hybrid compound (B1) which, in addition to at least one isocyanate-reactive group, contains at least one radically curable group, the hybrid compound (B1) having a molar mass of at least 400 g / mol; and (C) an initiator system for radical polymerisation, which comprises a first initiator (C1) and a second initiator (C2), the first initiator (C1) being a radical photoinitiator and the second initiator (C2) being a radical initiator for heat curing. The invention also relates to a method for bonding, casting and / or coating substrates, and to a use of a curable composition.

The present invention relates to the technical field of pollutant treatment, in particular to an amine-fluorine bifunctional hydrogel adsorbent, and preparation and use thereof. The present invention provides a preparation method of an amine-fluorine bifunctional hydrogel adsorbent, which comprises the following steps: uniformly mixing a fluorine-containing alkene monomer, a quaternary ammonium salt alkene monomer, a traditional Chinese medicine residue cellulose dispersion liquid, N,N′-methylene bisacrylamide and ammonium persulfate, and sequentially carrying out heating reaction, deionized water swelling and drying to obtain the amine-fluorine bifunctional hydrogel adsorbent. According to the present invention, the quaternary ammonium salt alkene monomer is introduced as a hydrophilic monomer, and the fluorine-containing alkene monomer is introduced as a hydrophobic monomer, so that the amine-fluorine bifunctional hydrogel adsorbent has a hydrophilic amine and hydrophobic fluorine dual-network interpenetrating porous structure, and the structure enhances water transmission and the mass transfer rate of a per- nd polyfluoroalkyl substance.

The invention discloses a method for preparing 2, 5-furandicarboxylic acid under mild conditions, which comprises the following steps: in a water phase system, by taking bifunctional furan aldol as a raw material, a nitroxide free radical compound and nitrate as catalysts and bromine-containing inorganic salt as a promoter, oxidizing the bifunctional furan aldol under the action of an oxidizing agent to obtain the 2, 5-furandicarboxylic acid. And 2, 5-furandicarboxylic acid is obtained. The method is mild in reaction condition, can realize high conversion rate and high yield at room temperature, and has the advantages of low energy consumption and safe process; the used solvent is a water phase, no organic solvent is needed, and the method has the advantages of being green, environmentally friendly, low in price, high in safety, non-toxic and the like. The method avoids the adverse factors of organic solvent and high temperature in the conventional oxidation preparation process of the FDCA, and is a new process for preparing the FDCA.

The invention discloses a gold nano array sensor and a method for efficiently and rapidly identifying the multielement form of phosphorus in wastewater, the gold nano array sensor comprises four groups of functionalized gold nano particle probe units, and the functionalized gold nano particle probe units are composed of nanogold probes modified by four surface modifiers, the first unit is a nanogold probe modified by amino / sulfydryl bifunctional molecules, the second unit is a nanogold probe modified by rare earth metal ions, the third unit is a nanogold probe modified by a quaternary ammonium salt type surfactant, and the fourth unit is a nanogold probe modified by a quaternary phosphonium salt type surfactant. The gold nano array sensor disclosed by the invention is based on multi-wavelength detection, and realizes rapid identification and quantitative detection of different phosphorus forms in wastewater through qualitative and quantitative analysis of multi-dimensional data. The method does not need a complex pretreatment process, has the advantages of short detection time, simplicity and convenience in operation, high sensitivity, strong anti-interference capability and the like, and provides an innovative thought for the distinguishing and concentration detection combined analysis of phosphorus species in industrial wastewater.

The invention relates to the technical field of coatings, and particularly discloses wear-resistant organic silicon modified acrylate resin for a coating and a preparation process of the wear-resistant organic silicon modified acrylate resin. The preparation process comprises the following steps: carrying out supramolecular anchoring and dynamic covalent cross-linking reaction on AD / carboxyl dual-functionalized nano composite particles and organosilicone modified acrylate resin containing beta-cyclodextrin and hydrazino to obtain the acrylate resin. According to the preparation method, the problem of compatibility between organic silicon and acrylate resin is solved through chemical copolymerization, the problems of interface separation, void defects and the like caused by polarity difference between a nano material and resin are solved through dual-mechanism crosslinking, and the prepared organic silicon modified acrylate resin has good wear resistance.

The invention discloses a bifunctional molecular group structure for photoresist. The bifunctional molecular group structure comprises a linker, PAG molecules and PDQ molecules. And the linker contains a carbon-oxygen chemical bond or a carbon-nitrogen chemical bond. PAG molecules and PDQ molecules are synthesized on each linker at the same time, wherein the number of the PAG molecules and the number of the PDQ molecules are in proportion, and the total number of the PAG molecules and the PDQ molecules is three or more. And PAG molecules are synthesized on the linker through a carbon-oxygen chemical bond. PDQ molecules are synthesized on the linker through a carbon-nitrogen chemical bond. The invention also discloses a synthesis method of the bifunctional molecular group structure for the photoresist. The invention also discloses a use method of the photoresist adopting the bifunctional molecular group structure. According to the invention, the proportion of PAG molecules to PDQ molecules can be set, so that the uniformity of PAG and PDQ in the photoresist can be ensured, the uniformity and roughness of the line width of the photoresist can be ensured, and different requirements of users on the contrast ratio and light sensitivity of chemical amplification glue can be met at the same time.

The invention discloses a high-wear-resistance Co-W composite coating electrolyte based on bifunctional particles as well as a preparation method and an electro-deposition method thereof, and relates to the technical field of material surface engineering. The electrolyte takes water as a solvent, and the mass percent of solutes in an electrolyte system is as follows: 3.59 to 8.07 percent of cobalt sulfate, 6.4 to 14.4 percent of sodium tungstate, 7.69 to 17.3 percent of a complexing agent, 1.92 to 4.32 percent of sodium chloride, 2.56 to 5.76 percent of a buffering agent, 2.56 to 5.76 percent of silicon carbide, 0.07 to 0.15 percent of carbon powder and 0.01 to 0.03 percent of a surfactant. And based on the electrolyte, the high-wear-resistance Co-W composite coating is prepared by adopting an electro-deposition method. By means of the supporting effect of the Co-W alloy matrix and the synergistic interaction of the silicon carbide and carbon powder dual-function particles, the comprehensive performance of the coating is remarkably improved, the whole process is convenient, fast and efficient, and the surface protection requirements of all industrial parts are met.

The invention discloses 1, 3-bifunctional isobutyramide pyridinium salt, a preparation method and application of the 1, 3-bifunctional isobutyramide pyridinium salt in antiviral drugs, and belongs to the field of drug synthesis. The preparation method comprises the following steps: under the protection of argon, by taking (3-(2-fluorophenyl)-2, 2-dimethyl propionyl) (pyridine-2-yl) amide as a raw material and dichloroethane as a solvent, adding palladium acetate, iodobenzene diacetate, water and acetic acid, and reacting to obtain 1, 3-hydroxyl / acetoxy pyridinium salt; the preparation method comprises the following steps: by taking N-(3-((2-(2-fluoro-4-phenylbiphenyl-3-yl)-2-methylpropionyl) oxy)-2, 2-dimethyl propionyl) pyridinium as a raw material and toluene as a solvent, adding palladium acetate, 4, 5-diazafluorene-9-one, iodobenzene diacetate, potassium carbonate and acetic anhydride, and reacting to obtain the 1, 3-diacetoxypyridinium salt. The synthesis process of the 1, 3-bifunctional isobutyramide pyridinium salt is simple and convenient, and the reaction conditions are mild; meanwhile, the pyridinium salt has good anti-enterovirus activity and is expected to become a medicine for effectively treating EV-A71 infection.

The application discloses a transition metal doped alkali base bifunctional CO2 adsorbent, a preparation method and application thereof, and comprises an alkali base bifunctional material and a transition metal. The preparation comprises the following steps: weighing transition metal, Ni, Na and Zr sources, dissolving the transition metal, Ni, Na and Zr sources in deionized water, stirring to form a uniform solution, weighing a precipitant, dissolving the precipitant in deionized water, adding the mixed system into the precipitant after complete dissolution, stirring and precipitating the mixed system in a constant-temperature water bath, drying the precipitate, calcining the obtained solid powder, and grinding the calcined solid powder into powder to obtain the transition metal doped alkali base bifunctional CO2 adsorbent. The preparation method of the transition metal doped alkali base bifunctional CO2 adsorbent material is simple, the transition metal is doped into Ni-Na2ZrO3 by using a coprecipitation method, the formation of in-situ pores and channels is promoted, the exposure area of active sites of the adsorbent is increased, the formation of lattice defects in the crystal cell is promoted, the surface energy of the crystal face of the material is changed from the dimension of solid physics, and the CO2 adsorption capacity and cycle stability are improved.