53 results about "Triphenylphosphine" patented technology

The application discloses a green preparation method of a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative and application of the derivative in mitochondrial-targeted antioxidation, and relates to the following steps: taking hydroxytyrosol and saturated halogenated fatty acids with medium-chain length C8-C12 as raw materials, and synthesizing a medium-chain hydroxytyrosol lipoid compound through a low-field ultrasonic coupling immobilized lipase synergistic directional alcohol hydroxyl acylation reaction; and further synthesizing the lipoid compound through high-speed stirring reaction with a triphenylphosphine compound to obtain a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative. The derivative has the antioxidation effect of mitochondrial-targeted enrichment and active oxygen radical scavenging. The hydroxytyrosol derivative prepared by the application has the characteristics of green efficiency, directional bonding and simple operation. The acylation reaction of hydroxytyrosol does not need to involve flammable and explosive, easily oxidized and corrosive concentrated sulfuric acid and concentrated nitric acid, and the medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative has mitochondrial targeting, can be used as a potential mitochondrial nutritional supplement product, and has a wide application prospect in the health care functions of anti-aging, cardiovascular protection, diabetes prevention and the like.

This invention discloses a method for preparing 4-(trifluoromethylsulfinyl)pyrazole compounds, comprising: dissolving terminal alkyne in n-hexane under nitrogen atmosphere, adding anhydrous zinc chloride, and reacting trifluoromethylsulfinyl chloride to obtain α-trifluoromethylalkynyl sulfoxide; adding benzoyl chloride dropwise to a CH2Cl2 solution of phenylhydrazine and triethylamine under nitrogen atmosphere to obtain acylhydrazine; adding carbon tetrachloride to a suspension of acylhydrazine and triphenylphosphine in acetonitrile to obtain hydrazone chloride; and reacting α-trifluoromethylalkynyl sulfoxide, hydrazone chloride, potassium carbonate, and anhydrous ethanol at room temperature to obtain 4-(trifluoromethylsulfinyl)pyrazole compounds. This invention uses inexpensive and readily available raw materials, the entire reaction route is mild and simple to operate, does not require stringent reaction conditions, and most of the reaction process is carried out at room temperature. The product yield is high, and the prepared trifluoromethylalkynyl sulfoxide pyrazole structure has multiple derivatization sites, showing good application prospects.

This invention discloses a phenylnaphthic acid derivative and its application in phosphorescent information encryption. The preparation method involves using 3,5-bis(ethoxycarbonyl)phenylboronic acid and methyl 6-bromo-2-naphthylcarboxylate as raw materials, and then performing a Suzuki coupling reaction under tetra(triphenylphosphine)palladium(O) catalysis to obtain the intermediate ethyl 2-(3,5-bis(ethoxycarbonyl)phenyl)-6-naphthylcarboxylate. This intermediate is then subjected to alkaline hydrolysis and acidification to obtain the target product, 2-(3,5-dicarboxyphenyl)-6-naphthylcarboxylic acid. This phosphorescent material has a simple preparation method, lower cost compared to noble metal phosphorescence systems, a simple guest synthesis method with high yield, and exhibits significant and stable phosphorescence effects. Furthermore, precise emission color control of high-performance doped thin films is achieved through the triplet-to-singlet Förster fluorescence resonance energy transfer (TS-FRET) mechanism, establishing a multicolor long-lifetime emission system. In addition, the material has multi-color adjustable properties and excellent long afterglow emission performance, showing great application potential in cutting-edge application fields such as multi-dimensional information encryption and high-end anti-counterfeiting.

This utility model discloses a plug flow device for triphenylphosphine, relating to the field of chemical production equipment. It includes a first stirred tank, a first feeder located at the top of the first stirred tank, a second stirred tank connected to the first stirred tank with its inlet lower than the outlet of the first stirred tank, a second feeder located at the top of the second stirred tank, a third stirred tank connected to the second stirred tank with its inlet lower than the outlet of the second stirred tank, a fourth stirred tank connected to the third stirred tank with its inlet lower than the outlet of the third stirred tank, and a flow-suppressing structure located inside the second stirred tank to suppress the flow of liquid within it. This plug flow device for triphenylphosphine ensures a plug flow state for the material during the reaction process, improving the reaction efficiency.

The application discloses a preparation method and application of a hollow conjugated microporous polymer. It belongs to the field of photocatalytic organic synthesis and comprises the following steps: step S1, dispersing SiO2 nanosphere templates in a triethylamine solvent; step S2, adding 4,7-dibromo-2,1,3-benzothiadiazole, dichlorobistriphenylphosphine palladium and cuprous iodide; step S3, slowly adding a toluene solution of 1,3,5-triethynylbenzene; step S4, heating, stirring, washing, etching with a hydrofluoric acid solution, washing and drying to obtain the hollow conjugated microporous polymer. The hollow spherical structure of the hollow conjugated microporous polymer enhances light capture; high specific surface area and hierarchical pores promote mass transfer and active site exposure; the D-A type conjugated system constructed by BT units effectively narrows the band gap, expands the visible light response range and greatly improves the charge separation efficiency; and the all-organic composition makes the hollow conjugated microporous polymer environmentally friendly and relatively low in cost.

The present invention relates to a method for recovering and reusing a selective homogeneous hydrogenation catalyst. The present invention relates to a method for recovering a selective homogeneous hydrogenation catalyst from a second reaction resolution in which a synthesis of cyclododecene is completed after synthesizing the cyclododecene by selective hydrogenation of a first reaction solution containing cyclododecatriene, triphenylphosphine, formaldehyde, and ruthenium chloride, and the method includes: preparing the selective homogeneous hydrogenation catalyst from the triphenylphosphine, the formaldehyde, and the ruthenium chloride during the selective hydrogenation of the first reaction solution, and synthesizing the cyclododecene; mixing a solvent containing cyclododecanone with the first reaction solution; and recovering the selective homogeneous hydrogenation catalyst through evaporation separation from the second reaction solution in which the synthesis of the cyclododecene is completed.

The present invention relates to an improved process for preparing triphenylphosphine (TPP) by reacting triphenylphosphine oxide (TPPO) with a specific catalyst.

This invention discloses a apigenin-betaine compound and its preparation method. The compound uses apigenin (Api) as its core, with -O-(CH2) at the 7', 4', and / or 5-position hydroxyl groups. n -N + (CH3)2-CH2COO ‑ Fragment substitution (n=2~12, x=1~3) forms an internal salt-type zwitterionic structure. In preparation, apigenin is first reacted with bromool Br(CH2). n A mitsunobu reaction was performed on OH under triphenylphosphine / dialkyl azodicarbonate conditions to obtain mono / polysubstituted bromoalkoxylated apigenin; subsequently, nucleophilic substitution with N,N-dimethylglycine under alkaline conditions yielded the target product. This structure, possessing both a tunable alkyl chain and a betaine cation / anion pair, significantly enhances the solubility and hydration capacity of apigenin in aqueous / alcoholic media, strengthens its affinity and stability for biomembranes, thereby improving in vivo absorption and distribution and potentially maintaining its antioxidant and anti-inflammatory activities. The method is mild, with a wide solvent and temperature range, suitable for scale-up and formulation applications.

This invention discloses a semi-sandwich structured ruthenium triphenylphosphine dithiocarboxylic acid complex with a simple preparation process and its applications. The complex has the structure shown in Figure (I), with the central ruthenium and... η 5 - Coordination with cyclopentadiene, triphenylphosphine, and dithiocarboxylic acid derivatives, wherein the dithiocarboxylic acid ligands are selected from ethyl xanthic acid, isopropyl xanthic acid, ... N,N Diethyldithiocarbamic acid, morpholine dithiocarbamic acid, and carbazole dithiocarbamic acid. This invention employs a simple one-step method of room temperature preparation and recrystallization purification using a ruthenium precursor and dithiocarbamic acid ligand. This method offers advantages such as readily available raw materials, mild reaction conditions, simple post-processing, and high yield. In vitro tests show that the complexes exhibit excellent anti-proliferative activity against non-small cell lung cancer A549 cells, significantly superior to cisplatin. The complexes demonstrate activity by reducing mitochondrial membrane potential, inducing intracellular reactive oxygen species accumulation, and arresting the cell cycle (G1 phase), leading to late apoptosis in A549 cells.

This invention relates to the field of perovskite solar cell technology, and discloses a method for preparing a hole transport layer and a perovskite solar cell. The method utilizes spiro-OMeTAD as the hole transport layer, mixes ethyltriphenylphosphine bis(trifluoromethanesulfonyl)imide salt (ETPTFSI) in a CB solvent, forms a precursor solution through photopretreatment, and then forms the hole transport layer through a coating process. The method also explores the discovery of ethyltriphenylphosphine cation (ETP... + The lowest unoccupied molecular orbital (LUMO) energy level is similar to that of organic high conductivity layers (HTLs), and upon photoexcitation, it accepts an electron from the organic semiconductor and forms a neutral radical ETP. • ETP • The unpaired electrons in the chlorobenzene have high energy and can break the C-Cl bond in chlorobenzene. This reaction chain promotes the efficient doping of organic HTL by the solvent CB through CB. In addition, ETPTFSI has extremely low hygroscopicity and a large space size, which helps to improve moisture resistance and reduce the migration of iodide ions to the HTL / silver electrode, thereby significantly improving stability.

The present application relates to polymeric triphenylphosphine ruthenium trichloride and its preparation method and application in catalytic preparation of 2,2'-dipyridyl, and belongs to the technical field of fine chemical industry. The polymeric triphenylphosphine ruthenium trichloride obtained by copolymerization of triphenylphosphine ruthenium trichloride-benzene-dimethylol formaldehyde is used as a catalyst to catalyze the pyridine dehydrogenation coupling reaction in a fixed bed reactor at 100-180 DEG C and 0.1-2.0 MPa pressure, and 2,2'-dipyridyl can be prepared at a highest yield of 92%. Compared with the existing method for preparing 2,2'-dipyridyl, the present application provides a method for preparing 2,2'-dipyridyl at a high yield under mild reaction conditions.

The application discloses a photo-thermal dual-curing resin based on pyromellitic dianhydride and cinnamyl alcohol, which is composed of 4-6 parts of bio-based cinnamyl alcohol, 5-9 parts of hydroxyethyl methacrylate, 4-6 parts of pyromellitic dianhydride, 4-6.5 parts of bio-based epoxy soybean oil, 0.04-0.07 parts of a first catalyst, 0.07-0.09 parts of a polymerization inhibitor, 0.1-0.2 parts of a second catalyst and 0.4-0.7 parts of a photoinitiator in terms of weight parts; the first catalyst is at least one selected from 4-dimethylaminopyridine, p-toluenesulfonic acid, triethylamine and stannous octoate; and the second catalyst is triphenylphosphine. By introducing a rigid benzene ring structure (from PMDA) and multiple photosensitive groups (acrylate double bonds and cinnamyl double bonds), the application effectively solves the problems of low mechanical strength and poor thermal stability of a cured product of pure epoxy soybean oil-based resin. The obtained resin has excellent thermal performance, mechanical strength and high bio-based content.

The application discloses a kind of near-infrared two-area aggregation-induced emission nanoparticles to realize synergistic photodynamic-photothermal tumor treatment, belong to using aggregation-induced emission material for cancer treatment field.The preparation method of the photosensitive compound of near-infrared two-area aggregation-induced emission of the present application includes the following steps: compound 1, compound 2, tetra-triphenylphosphine palladium, potassium carbonate are mixed in the mixed solution of tetrahydrofuran and water, backflow reaction, obtain compound 3;Compound 3 and R2 are mixed in acetic anhydride, reaction, obtain the photosensitive compound of the near-infrared two-area aggregation-induced emission.The present application successfully prepares a kind of multifunctional photosensitizer by molecular design, which integrates NIR-II excitation, efficient I-type PDT, super high efficiency PTT and AIE characteristics, provides a kind of new technical scheme for solving the bottleneck of hypoxia in tumor treatment and realizing efficient synergistic treatment.

The application provides an organic-inorganic hybrid lead-based halide perovskite material and a preparation method and application thereof. The organic-inorganic hybrid lead-based halide perovskite material has a one-dimensional face-sharing perovskite structure or a quasi-one-dimensional face-sharing perovskite structure, and a chemical general formula of the organic-inorganic hybrid lead-based halide perovskite material is APbX3, A includes an alkyl-substituted triphenylphosphine cation, and X is at least one of halogen elements. The organic-inorganic hybrid lead-based halide perovskite material provided by the application has a one-dimensional or quasi-one-dimensional face-sharing perovskite structure under a specific component composition, can simultaneously realize material properties of no self-absorption and nanosecond-level ultrafast self-trapped exciton emission, has a large Stokes shift, breaks through the traditional STE ''slow decay'' fixed limit, has a high X-ray absorption capacity, has low detection limit and high spatial resolution, and is suitable for low-dose and high-resolution imaging.

This invention relates to a method for preparing trivalent phosphorus from triphenylphosphine sulfur, belonging to the field of organic synthesis technology. The invention applies this method to the conversion of phosphorus and sulfur compounds, using metallic iron powder as a reducing agent to achieve a high yield of triphenylphosphine sulfur by reduction at 100℃-135℃. In this invention, the catalyst for triphenylphosphine sulfur, ferric chloride, is only required in a small amount, for example, 1-5 mol%, to produce a high yield of triphenylphosphine. This invention overcomes the problem in existing technologies where the reduction of triphenylphosphine sulfur is limited by high reaction temperatures. The raw materials used in this invention are inexpensive and readily available, and it does not use expensive reagents such as silane or borane, resulting in a significant cost advantage and making it suitable for large-scale industrial applications.

The invention provides a composite catalyst and a method for chemical recovery of a polymethacrylate polymer, and belongs to the technical field of high polymer materials. The composite catalyst for chemical recovery of the polymethacrylate polymer comprises a trivalent iron salt, a quaternary ammonium salt chelating agent and a triphenylphosphino conjugated super-crosslinked polymer with a layered porous structure, the triphenylphosphino conjugated super-crosslinked polymer is prepared from triphenylphosphine and an aromatic monomer through a Friedel-Crafts alkylation reaction under the catalytic action of a Lewis acid catalyst.

The present invention describes the gold-catalyzed construction of geminocyano-substituted tricyclic [4.4.0.0] 1,5 The method for synthesizing the decane skeleton belongs to the field of organic synthesis technology. Compound 1 is added to an organic solvent, and the reaction is carried out at 25℃-80℃ for 3 hours in the presence of a gold catalyst and additives to obtain product compound 2. The gold catalyst is selected from triphenylphosphine monochloride, triphenylphosphine gold(I) 3-methylbenzotriazole salt, and triphenylphosphine gold(I) trifluoromethanesulfonate. The additive is selected from silver trifluoromethanesulfonate, silver fluoroantimonate, and silver bis(trifluoromethanesulfonylimide). The synthetic method described in this invention is simple to operate, low in cost, highly efficient, and widely applicable, possessing practical application value. Substrate 1 in this invention can be flexibly derivatized by adjusting the structure of its synthetic raw materials or through subsequent functionalization modifications, providing greater convenience for skeleton modification. This invention utilizes the properties of gold catalysts to achieve rapid and convenient synthesis of fused-ring skeletons containing three-membered rings that are difficult to synthesize under other conditions.

This invention relates to the field of pharmaceutical intermediate synthesis, specifically to a key intermediate of 3-hydroxymethylaziridine-1-carboxylic acid tert-butyl ester and its preparation method. The method includes the following steps: Ylide reagent is prepared based on the reaction of benzylchloromethyl ether and triphenylphosphine. Without post-treatment, it is directly reacted with compound II (1-diphenylmethylaziridine-3-one) under alkaline conditions to prepare the key intermediate compound III; compound III undergoes catalytic hydrogenation to prepare compound IV; compound IV reacts with di-tert-butyl dicarbonate to prepare 3-hydroxymethylaziridine-1-carboxylic acid tert-butyl ester (compound I), with a purity of up to 98.87% and an overall reaction yield of up to 72.36%. The preparation method proposed in this invention uses inexpensive and readily available raw materials, is simple to operate, has a high reaction yield, and is highly safe, making it suitable for the industrial production of the pharmaceutical intermediate 3-hydroxymethylaziridine-1-carboxylic acid tert-butyl ester.

This invention belongs to the field of electrode material technology, and discloses a Fe-N / P co-doped porous carbon, its preparation method, and its application in lithium-sulfur batteries. The porous carbon is obtained by pyrolyzing sodium citrate. The three-dimensional porous carbon framework and its hierarchical channels achieve Fe-N / P co-doping through electrostatic interactions. 3+ Spatial confinement and initial fixation; subsequently, glucose and Fe 3+ A chelation reaction occurs, forming dispersed organometallic units, effectively inhibiting the aggregation of iron species; finally, mild pyrolysis promotes the exchange of N / P and Fe elements in melamine (triphenylphosphine). 3+ By combining with a porous carbon matrix, a single-atom catalyst with a stable Fe-N-P-C coordination structure is constructed. The method of this invention balances high metal loading with large-scale production; the sulfur cathode material obtained by compositing the Fe-N / P co-doped porous carbon with sulfur exhibits excellent electrochemical performance in lithium-sulfur batteries.

The present application relates to the technical fields of nano-catalytic material preparation and heterogeneous catalysis, and particularly relates to a Pd5P2 / CNFs catalyst based on sulfide replacement phosphorization and a preparation method and application thereof.A mixed solution of palladium acetate and thiourea is adsorbed on carbon nanofibers; a palladium sulfide Pd4S / CNFs intermediate is generated in situ through hydrogen atmosphere heat treatment; triphenylphosphine is used as a phosphorus source to realize the replacement of sulfur by phosphorus through gas phase migration under low temperature conditions, and a topological phase change generates the Pd5P2 / CNFs catalyst.The present application uses sulfur atoms as anchoring agents to prevent metal aggregation, and as sacrificial templates to reduce the energy consumption of phosphorization, so that small-size, highly-dispersed palladium phosphide catalysts can be prepared under mild conditions.The present application solves the problem that palladium phosphide is usually prepared under high temperature conditions.The application of the present application to quinoline selective hydrogenation reactions exhibits excellent catalytic activity, selectivity and significant nitrogen poisoning resistance.

The application belongs to the technical field of catalyst preparation, and provides a high-loading cobalt monatomic transition metal-based composite catalyst, a preparation method thereof and oxygen reduction application. ZIF material of the application is converted into nitrogen-phosphorus co-doped porous carbon through pyrolysis reaction combined with triphenylphosphine, the porous carbon is used as a carrier, and monatomic cobalt, cobalt nanoparticles, molybdenum species (MoC) and cobalt species (Co9S8) generated by pyrolysis are limited in the porous carbon. The nitrogen-phosphorus co-doped porous carbon can improve the conductivity of the catalyst, and the existence of phosphorus and nitrogen elements provides a stable environment for metal monatomic atoms, so that the catalyst has high metal loading while maintaining the monatomic structure. At the same time, Co9S8 generated by cobalt sulfide increases the metallicity of the catalyst, further provides rich catalytic active sites for the catalyst, so that the catalyst exhibits excellent performance in the oxygen reduction reaction, and the half-wave potential can reach 0.94 V, which is 90 mV higher than that of the Pt / C-based catalyst.

The application belongs to the technical field of neuromorphic computing and artificial intelligence hardware, and discloses a high-linearity organic all-optical synapse thin film, a preparation method thereof, a synapse device and an optical dose sensing system. The thin film is formed by doping triphenylphosphine (TPP) as a host and N,N-dimethyl-1,1-binnaphthyl diamine (BINN) as a guest in a polymethyl methacrylate (PMMA) matrix, and then performing heat treatment to form a glassy blend thin film. Under the excitation of an ultraviolet light pulse, the light emission intensity of the thin film has a high-linearity growth relationship with the cumulative dose of the input light pulse, thereby forming a high-linearity organic all-optical synapse device. The application further provides an optical dose sensing system integrated with the device, which can linearly map the incident light dose to the light emission response of the device, and after photoelectric conversion and signal processing, realizes quantitative sensing and display of the optical dose. The application has excellent linearity, low energy consumption, simple preparation and high system integration.

This invention discloses a quinolinonylpropane sulfonate, its preparation method, and its application. The structural formula of the quinolinonylpropane sulfonate is shown in formula (III). The preparation method is as follows: using 4-methylquinoline and 1,3-propanesulfonic acid lactone as raw materials, a reaction is carried out to obtain product (I); using (4-(diphenylamino)phenyl)boronic acid and 7-bromobenzo[c][1,2,5]thiadiazole-4-carboxaldehyde as raw materials, a coupling reaction is carried out under potassium carbonate and nitrogen atmosphere catalyzed by tetrakis(triphenylphosphine)palladium to obtain product (II); using products (I) and (II) as raw materials, quinolinonylpropane sulfonate (III) is prepared. The quinolinonylpropane sulfonate of this invention exhibits antibacterial activity, especially against Streptococcus pneumoniae, and can be used as an antibacterial agent.

This invention relates to diphenyl ether compounds targeting Kaiso protein, their preparation methods, and applications. The molecular structure of the diphenyl ether compounds is shown in Formula I, where R is selected from any one of hydrogen atom, halogen, alkyl, hydroxyl, methoxy, ester, cyano, nitro, and 3,4-methylene. The preparation steps include: reacting isovandrin, copper acetate, and p-bromophenylboronic acid under alkaline conditions with dichloromethane as a solvent to obtain compound 1; reacting compound 1 with malonic acid and ammonium acetate under heating with ethanol as a solvent to obtain compound 2; dissolving compound 2 in ethanol as a solvent, adding sulfoxide dropwise at low temperature, and then reacting at room temperature to obtain compound 3; and reacting tetra(triphenyl)phosphine palladium, compound 3, and phenylboronic acid under alkaline conditions and a nitrogen atmosphere with water and 1,4-dioxane as solvents to obtain the target compound. The diphenyl ether compounds prepared by this invention exhibit excellent inhibitory activity against lung cancer cells.

This invention discloses a method for the electrochemical degradation of sulfur hexafluoride gas, belonging to the field of organic electrochemical technology. In this method, at room temperature, triphenylphosphine and sulfur hexafluoride degrade sulfur hexafluoride through an electrochemical reaction under the action of electrodes, an electrolyte, and a base. The positive electrode is zinc (Zn), the negative electrode is tin (Sn), the electrolyte is tetrabutylammonium tetrafluoroborate, and the base is triethylamine. The advantages are: the method uses mild conditions, readily available and inexpensive raw materials, and is simple to operate, making it highly valuable for application.

This invention belongs to the field of photosensitizer delivery and photodynamic therapy technology, and discloses a TPP-modified PAMAM-loaded CyI mitochondrial-targeting nanophotosensitive system, its preparation method, and its applications. This invention aims to solve the problems of poor water dispersibility, insufficient in vivo stability, low delivery efficiency, and lack of mitochondrial targeting ability of CyI during application. The nanophotosensitive system consists of G5 generation PAMAM dendritic macromolecules, triphenylphosphine-based mitochondrial-targeting groups (TPP), and the near-infrared photosensitizer CyI. The preparation method involves first coupling TPP with G5 generation PAMAM to obtain a modified carrier, then mixing and purifying it with CyI to obtain the target nanophotosensitive system. This system is beneficial for improving the stability and delivery efficiency of CyI and enhancing its enrichment ability in tumor mitochondria, showing promising application prospects in tumor near-infrared fluorescence imaging and photodynamic therapy.

This invention discloses a method for the synergistic catalytic carbonylation of furfuryl alcohol to FDCA using rhodium and iodide ligands, relating to the field of FDCA synthesis technology. Using rhodium dicarbonyl chloride dimer ([Rh(CO)₂Cl]₂) as the main catalyst, iodomethane (CH₃I) as the co-catalyst, and triphenylphosphine (PPh₃) as the ligand, the method achieves efficient carbonylation of furfuryl alcohol in an acetic acid-water mixed solvent at 180-200°C and 4-6 MPa carbon monoxide pressure. Through synergistic design of the catalytic system and optimization of process conditions, highly efficient conversion of furfuryl alcohol and highly selective generation to FDCA are achieved. The furfuryl alcohol conversion rate can reach over 95%, and the FDCA selectivity can reach over 93%, significantly superior to traditional rhodium catalytic systems, reducing the generation of byproducts and the burden of subsequent purification.

The present invention belongs to the technical fields of lipid peroxidation fluorescent probe design synthesis and visualization imaging. Provided are a lipid peroxidation detection probe based on a perylene imide-triphenylphosphine structure, a preparation method therefor and the use thereof. The structural formula of the lipid peroxidation detection probe is shown as formula (I). The lipid peroxidation detection probe is based on structural optimization of perylene imide-triphenylphosphine compound Liperfluo, thereby greatly improving the stability thereof. The present invention has good sensitivity and selectivity to a ferroptosis marker lipid hydroperoxides, involves simple pretreatment of test samples, can be used for detecting ferroptosis endogenously and exogenously caused by fibrosarcoma cells, and can be used for studying specific regulation mechanisms and biological functions for ferroptosis-related metabolic diseases. The detection probe is a solid powder, is easy to store and use, involves a simple synthesis method, has a high yield and a low cost, and has good prospects in market application.

The application discloses an ethyne hydrochlorination reaction catalyst, which is prepared by stirring nitrogen-containing precursors, phosphorus-containing precursors, copper sources and organic solvents uniformly, drying, high-temperature calcination and acid washing; the nitrogen-containing precursors are one or more of 1-butyl-3-methyl imidazole bromide, 1-butyl-3-methyl imidazole chloride, 2-methyl imidazole and pyridine; the phosphorus-containing precursors are one or more of phosphoric acid, triphenyl phosphine, tetraphenyl phosphonium bromide and tetraphenyl phosphonium chloride; and the copper source is copper chloride or copper nitrate. The catalyst obtained by the application has the advantages of high stability and high activity.