56 results about "Continuous reaction" patented technology

Provided is a synthesis method for azoxystrobin, comprising: in a water-oil system of an organic solvent and an aqueous solution of trimethylamine, a compound represented by formula I reacts with 2-cyanophenol to obtain azoxystrobin, wherein the molar ratio of the compound represented by formula I to trimethylamine is 1:(0.96-2). The synthesis method has high reaction efficiency, does not produce CO2, avoids the risks of entrainment and overflow, reduces the generation of side reactions and solid waste emissions and is environmentally friendly. In addition, the method does not require the use of solid sodium carbonate or potassium carbonate, and the material reaction system is an oil-water reaction system, so that the reaction efficiency is greatly improved, and the yield can also be maintained at 95% or more, thereby taking both the efficiency (timeliness) and the yield into account and easily achieving continuous reaction, and thus providing technical support for intelligent and unmanned production. Moreover, since trimethylamine can be recycled, the use of one raw material is reduced, and further there is no need for complicated treatment for mixed salts and waste water thereof, thereby significantly reducing the energy consumption.

The application relates to the technical field of agricultural analysis and detection, and discloses a multi-union type fertilizer synergist urease activity automatic detection and analysis system, which comprises a physical execution layer and an intelligent control layer. The physical execution layer is configured with a reaction generation module, a gas transmission and conditioning module and a detection and regeneration module which are connected in sequence in a gas path, is used for constructing a closed loop flow path and executing ammonia gas absorption and titration. The intelligent control layer controls the gas transmission and conditioning module to switch the gas path according to an adaptive time sequence, constructs an intermittent absorption environment, executes static titration and resets trace acid liquid under the condition of maintaining a bypass state, and simultaneously uses system lag parameters to perform dynamic deconvolution reconstruction on discrete titration data collected, so as to restore a continuous reaction rate curve. Through the combination of hardware time sequence control and algorithm correction, the application eliminates the influence of physical transmission delay on the signal phase, and improves the detection precision and efficiency of the dynamic change of urease activity.

This application discloses a process and apparatus for the continuous preparation of lithium difluorooxalate borate, relating to the field of lithium salt additive preparation technology. The process mainly includes a pretreatment step, a continuous reaction step, and a spray drying step. Specifically, it includes: preparing an oxalic acid solution and dehydrating the oxalic acid solution to obtain a dehydrated oxalic acid solution with a moisture content of less than 20 ppm; continuously pumping a lithium tetrafluoroborate solution, trimethylchlorosilane, and the dehydrated oxalic acid solution into a spiral pipe reactor for reaction to obtain a lithium difluorooxalate borate reaction solution; and spray drying the lithium difluorooxalate borate reaction solution to remove organic solvents, obtaining crude lithium difluorooxalate borate. This application precisely controls the moisture content in the raw materials, enabling large-scale continuous production and effectively avoiding the problems of caking and sticking to the walls during the drying process. It also solves the problems of corrosion caused by excessive moisture and low drying efficiency in the preparation of lithium difluorooxalate borate, thus improving production efficiency and product yield.

The present application relates to the technical field of low-carbon metallurgical CO2 reduction catalyst, and specifically discloses a single-atom Mo loaded titanium dioxide hollow sphere, a preparation method and application thereof. The present application inhibits CO from occupying the active center from the adsorption energy level through the electronic regulation of Mo sites, and at the same time, hinders CO from approaching the active center from the mass transfer level by using the hollow confinement structure of TiO2. The synergistic effect of the two significantly improves the stability and selectivity of the catalyst in a low-concentration CO2 atmosphere. Experiments show that in a simulated industrial low-concentration CO2 atmosphere (CO2 volume fraction 15%), the activity of the catalyst does not show obvious attenuation after 16 hours of continuous reaction, and the Mo sites do not show obvious CO poisoning and deactivation after the reaction, proving that the catalyst of the present application has broad application prospects and industrialization promotion value in the fields of CO2 resource utilization of industrial CO-containing exhaust gas and syngas purification.

This invention discloses a process and apparatus for the continuous fluorination preparation of 2,6-dichlorobenzonitrile under mild conditions. The apparatus includes sequentially connected units for 2,6-dichlorobenzonitrile preparation, raw material preparation, online dehydration, continuous metering feeding, continuous reaction, and post-treatment, with a supporting control system for precise parameter control. The process first involves the continuous preparation and purification of 2,6-dichlorobenzonitrile at 70–90℃ and 0.1–0.3 MPa. Then, a raw material solution and a fluorination suspension are prepared and deeply dehydrated. Subsequently, a continuous fluorination reaction is carried out at 80–150℃ and 0.1–1.0 MPa. Finally, the finished product is obtained through post-treatment. This invention achieves continuous production throughout the entire process, with mild reaction conditions, a solvent recovery rate ≥95%, a finished product purity ≥99.8%, high production efficiency, low cost, wide equipment adaptability, and easy industrialization.

The application discloses a kind of heavy metal wastewater continuous treatment methods rich in sulfate, belong to environmental management technical field.The method relies on adjusting tank, reaction tank, oxidation tank, sedimentation tank, transfer tank and filter press equipment, and uses calcium aluminate crystal lattice solidification method to treat wastewater: first, wastewater pH is adjusted to 7.0~8.0 by alkaline compound, then calcium source heavy metal removal agent A, oxidizing agent heavy metal removal agent B and aluminum source heavy metal removal agent C are added respectively, the pH of wastewater after reaction is controlled to 9.0~11.0, and the solid-liquid separation is carried out by filter pressing after 0.5h~1.5h continuous reaction.The method permanently fixes heavy metal ions in calcium aluminate crystal lattice through ion exchange, solves the problems of low efficiency, secondary pollution of sulfide and large amount of hazardous waste sludge in traditional chemical precipitation method, and realizes continuous and cooperative deep removal of sulfate and heavy metals.The filtrate meets the discharge standard, and the filter residue has no leaching toxicity, which can be used as foundation cushion and mine soil covering for secondary utilization.The method is efficient, low in cost, and suitable for industrial continuous treatment.

The application discloses a process method for preparing ethyl acetoacetate by crude ester circulation cooling, and belongs to the technical field of chemical industry. The method can dilute the heat generated in the reaction in time and effectively by performing crude ester circulation in the continuous reaction process, better solves the problem of heat accumulation in the reactor, and cannot dissipate heat in time, thereby causing the problem of rapid temperature rise, and avoids the "flying temperature" in the reaction process; the temperature in the reactor is stable without other complex and strict operation control, the operation is simple and feasible; the content of the crude product, the product quality and the yield are improved; the content of the crude methyl acetoacetate obtained by the method is 97.8-98.1%, the content of the finished product after rectification is 99.5-99.7%, and the product yield is 97.8-98.2%; the high-temperature resistance requirement of the pipeline equipment is reduced, and the safety hidden danger is reduced.

This invention provides an environmentally friendly method for preparing a carpacacininib intermediate, belonging to the field of pharmaceutical intermediate technology. The method discloses an oxidation reaction of N-Boc-4-hydroxypiperidine as the starting material, yielding compound 2 under the action of an oxidant and a buffer. Compound 2 is then reacted with a cyaniding reagent in the presence of ammonium carbonate via a Bucherer-Bergs reaction to obtain compound 3. Compound 3 undergoes hydrolysis in an alkaline system at 80–110°C to obtain compound 4. Compound 4 is then reacted with di-tert-butyl dicarbonate to perform a Boc protecting group reaction, yielding the carpacacininib intermediate. This invention provides a method suitable for green and environmentally friendly industrial production to obtain the carpacacininib intermediate. This method avoids the use of highly toxic substances and precious metal catalysts, and achieves continuous reaction, thereby improving reaction efficiency and stability and reducing the formation of by-products. The overall yield of the four-step reaction can reach over 70%, and the product purity can reach over 99.4%.

This invention belongs to the field of perfluoropentanone preparation technology, specifically relating to a continuous production process for perfluoropentanone. The continuous production process for perfluoropentanone includes the following steps: a fluorination catalyst is loaded into a reaction tube, purged with nitrogen, and a preheated mixture of hexafluoropropylene and trifluoroacetyl fluoride is introduced into the reaction tube for continuous reaction. Part of the reacted gas is condensed to obtain the target product, perfluoropentanone, while the other part is recycled back to the mixing and preheating stage. This continuous production process for perfluoropentanone uses hexafluoropropylene and trifluoroacetyl fluoride as raw materials, and employs a one-step gas-phase continuous flow method to rapidly synthesize perfluoropentanone under the action of a MgF2-based fluorination catalyst. No solvent is required, and the trifluoroacetyl fluoride raw material is a byproduct of the preparation of hexafluoropropylene oxide, making the raw materials readily available. The process route is simple, with high conversion rate and high selectivity, facilitating large-scale industrial production.

This utility model discloses a highly applicable continuous reaction overflow tank, comprising a set of multi-stage series reaction tanks (1), with adjacent reaction tanks (1) connected by an overflow pipe (2). Each reaction tank (1) is provided with a feed inlet (3) and a stirring device (4). The reaction tank (1) is also provided with a flow guiding device (5) that cooperates with the overflow port (11a). The flow guiding device (5) includes a flow guiding hood (51), which is closed at the upper end and open at the lower end. Inside the hood, a set of cross-arranged flow guiding plates (52) are provided from bottom to top, so that the inner cavity of the flow guiding hood (51) forms an S-shaped flow guiding channel (53). The advantages of this utility model are that it avoids the direct impact of the feed on the overflow port, offsets the damage of the overflow pipe to the flow field, satisfies the requirements of uniform material mixing and reaction, achieves continuous reaction, improves production efficiency and reaction effect, and reduces the content of valuable metal lithium ions in the waste residue.

The present application discloses a synthesis method for azoxystrobin, comprising a step of: reacting a compound of Formula I with 2-cyanophenol in a water-oil system of an organic solvent and an aqueous solution of trimethylamine to obtain azoxystrobin, wherein a molar ratio of the compound of Formula I to trimethylamine is 1:(0.96-2). The synthesis method of the present application has advantages of high reaction efficiency, no CO2 generation, avoidance of the risk of entrained overflow, reduced secondary reactions, reduced solid waste emissions, and environmental friendliness. Use of solid sodium carbonate or potassium carbonate is avoided and the material reaction system is an oil-water reaction system. The reaction efficiency is significantly improved and the yield can reach 95% or above. Both efficiency (timeliness) and yield can be taken into account, and continuous reactions can be realized easily, providing technical support for intelligent, unmanned production.

This invention relates to the field of chemical production technology, and particularly to a continuous recovery system for fluorinated silicon slag. The continuous reaction module, from front to back, includes a preliminary digestion device, a multi-stage reaction device, and a circulating sedimentation device. The preliminary digestion device is used to hydrothermally treat the fluorinated silicon slag with sodium carbonate to obtain a mixed solution. The multi-stage reaction device is located at the rear of the preliminary digestion device and has multiple overflow chambers, ultimately generating overflow liquid and sodium fluoride solid phase. The circulating sedimentation device is located at the rear of the multi-stage reaction device to receive the overflow liquid from the multi-stage reaction device. A filtration module is located at the slag outlets of both the multi-stage reaction device and the circulating sedimentation device to filter and separate the solid phases discharged from both devices. The continuous recovery system for fluorinated silicon slag provided by this invention converts fluorinated silicon slag into high-value-added silica and sodium fluoride products, achieving dual recovery of silicon and fluorine resources, and has significant industrial value.

This invention provides a one-step method for preparing 4-substituted indole. Using 2-methyl-3-nitroaniline as a raw material, acetic anhydride is slowly added after dissolving it in DMF solvent with low-temperature stirring. After the condensation reaction is completed, DMF-DMA and tetrahydropyrrole are directly added. A cyclization reaction is carried out in stages with controlled temperature, and methanol byproducts are evaporated. After cooling the reaction solution, ice water is added dropwise to crystallize and obtain a crude product. This crude product is then dissolved in 2-methyltetrahydrofuran, washed with hydrochloric acid, washed with water, washed with a saturated sodium bicarbonate aqueous solution, decolorized with activated carbon, concentrated, and recrystallized with acetonitrile to obtain high-purity 4-substituted indole. This invention employs a one-step continuous reaction, eliminating multiple purification steps such as intermediate separation, washing, and drying, significantly simplifying the process and shortening the production cycle. Compared with traditional processes, the yield is significantly improved, with fewer byproducts, lower energy consumption, and smaller emissions. The process is stable, reliable, simple, and safe to operate, suitable for industrial production, and meets the requirements of high-end pharmaceutical intermediates.

This utility model discloses a constant pressure conveying unit and a high-temperature, high-pressure continuous reaction system. The high-temperature, high-pressure continuous reaction system includes a continuous feeding unit, a premixing and preheating unit, a constant pressure conveying unit, a continuous micro-accumulation reaction unit, a heat exchange unit, and a product collection unit. The premixing and preheating unit receives raw materials and forms a mixed reaction mixture. The constant pressure conveying unit, heat exchange unit, and continuous micro-accumulation reaction unit are sequentially connected to form a first passage, where the constant pressure conveying unit transports the mixed reaction mixture to the heat exchange unit for heat exchange, and then into the continuous micro-accumulation reaction unit to generate a mixed reaction product. The continuous micro-accumulation reaction unit, heat exchange unit, and product collection unit are sequentially connected to form a second passage, where the heat exchange unit heats the mixed reaction product, and then the product collection unit collects the product. This reaction system operates in a completely closed system, supports continuous feeding and discharging, simplifies the process flow, improves production efficiency, and is suitable for various high-temperature, high-pressure continuous reactions.

This utility model discloses a shearing continuous reaction device, belonging to the technical field of chemical reaction equipment. The device includes a main reactor, which is divided into section A and section B along the material flow direction. Section A has inlet 1 and inlet 2 at its bottom and multiple star-shaped shearing components within it. Section B has inlet 3 and inlet 4 on its sidewall and multiple alternating cross-mixing structures within it. The main reactor has an outlet at its top. The space around the star-shaped shearing components is filled with a heat exchange medium. Temperature zones 1, 2, and 3 are respectively located on the outside of the main reactor corresponding to the lower part of section A and the upper part of section B. The design of filling the space around the star-shaped shearing components with a heat exchange medium solves the contradiction of "shearing structures encroaching on heat exchange space." Combined with the independent temperature control of temperature zones 1 in section A and 2 and 3 in section B, precise temperature matching can be achieved for different stages such as "dispersion preheating → high temperature of the main reaction → cooling of post-treatment."

This invention discloses a method for preparing high-purity nickel by carbonylation of nickel chloride, belonging to the field of carbonylation metallurgical technology. It solves the problem that existing carbonylation methods produce nickel pellets and nickel powders containing numerous impurities, making it impossible to produce high-purity nickel products. The method involves dissolving NiCl2 in water to form a solution, heating it, and adding 1%–3% analytical grade AlCl3 and H2O2. Ammonia is added to the mixed solution to adjust the pH. After continuous reaction, solid-liquid separation occurs in the solution. The ammonia mixture at the top is extracted for carbonylation, converting nickel chloride into nickel carbonyl gas, and then into liquid nickel carbonyl. The liquid nickel carbonyl is vaporized in a volatilizer, mixed with inert gas Ar, and then passed into a decomposer for nickel pellets or nickel powder to produce high-purity nickel. This invention is stable, reliable, and convenient. By optimizing the carbonylation method, it achieves the preparation of 99.999% (5N)Ni high-purity nickel. The mass production of multi-purpose high-purity nickel will provide a broad prospect for the high-quality development of new materials, with broad application prospects.

This invention relates to the field of low-carbon metallurgical CO2 reduction catalyst technology, specifically disclosing a single-atom Mo-supported hollow titanium dioxide sphere, its preparation method, and its applications. This invention inhibits CO from occupying the active center at the adsorption energy level through electronic regulation of the Mo sites, while simultaneously utilizing the hollow confinement structure of TiO2 to hinder CO from approaching the active center at the mass transfer level. The synergistic effect of these two methods significantly improves the stability and selectivity of the catalyst in a low-concentration CO2 atmosphere. Experiments show that in a simulated industrial low-concentration CO2 atmosphere (CO2 volume fraction 15%), the catalyst's activity did not significantly decrease after 16 hours of continuous reaction, and no obvious CO poisoning deactivation was observed at the Mo sites after the reaction. This demonstrates that the catalyst of this invention has broad application prospects and industrial promotion value in the fields of CO2 resource utilization from CO-containing industrial tail gas and syngas purification.

The utility model discloses a kind of continuous reaction devices, comprising: feeding assembly, the feeding assembly is transported to reaction component in material, the reaction component includes first reactor and second reactor in series, chlorination and oxidation reaction are carried out to material, from the second reactor output to desolventizing crystallization component;Through the desolventizing crystallization component and is separated by cyclic treatment, the desolventizing crystallization component is connected with recovery tank;Through design first reactor and second reactor, continuous reaction is carried out to material, the degree of back mixing of material in reaction process is reduced, side reaction in reaction greatly reduces, through continuous automation reaction, reaction time is shortened, and safety risk is small.

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.

The application relates to the field of organic synthesis, and discloses a continuous deuterium substitution preparation method of perdeuterated carbazole. The method comprises the following steps: taking carbazole and a deuterium source as raw materials, reacting under the catalysis of a solvent and a catalyst, collecting the flowing reaction liquid, cooling, and filtering, concentrating and recrystallizing to obtain perdeuterated carbazole. According to the method, perdeuterated carbazole is synthesized by hydrogen-deuterium exchange between carbazole and a deuterium source through continuous reaction catalyzed by a heavy metal chloride, the reaction condition is mild, the deuterium source is supplemented for multiple times in the reaction process to realize continuous deuterium substitution, and the conversion rate and the yield are greatly improved. The whole reaction system is carried out in an isolated environment, no other impurities enter the reaction system, the product is not polluted in the production process, the yield reaches more than 91%, the purity reaches more than 99.8%, and the deuterium substitution degree reaches more than 99%. The whole process does not need high temperature and high pressure conditions, and the operation is relatively simple, so that industrial large-scale production can be realized.

A system and method for preparing ultrafine powder by liquid phase continuous reaction, comprising: a fast mixer and an aeration reactor connected in sequence, the fast mixer comprising a feeding device and a rotating device, one end of the feeding device having an inlet for liquid phase material to be mixed, the other end extending into the mixing zone of the fast mixer, and a liquid distributor provided on the side of the feeding device, the liquid distributor facing the rotating device to deliver reaction solution, the rotating device being used to shear, rotate and cut the reaction solution to mix the reaction solution sufficiently and to carry out primary reaction to produce primary powder slurry; the reaction zone of the aeration reactor being provided with an aeration device, the aeration device generating a gas film rising from bottom to top to realize gas floating effect on the counter- contacting powder particles, so that the falling speed of the powder particles reaching the bottom of the aeration reactor is consistent with the speed of complete reaction, and continuous preparation is realized. The ultrafine powder has narrow particle size distribution and good dispersibility, the system is simple, practical and easy to use, and is suitable for industrial application under different process conditions.

The application discloses a chemical depolymerization method for preparing dioctyl terephthalate based on polyester waste materials in the technical field of polymer material chemical recycling and resource recycling, which takes polyester waste materials as raw materials, first carries out alcoholysis reaction with ethylene glycol in the presence of a catalyst, then adds isooctanol to carry out ester exchange reaction, and finally separates and purifies the final product to obtain dioctyl terephthalate. The core of the method is to use a brand-new multi-level pore palladium cerium modified zeolite catalyst, which is prepared by taking sodium type zeolite as a precursor, sequentially constructing a multi-level pore structure through acid treatment and surfactant assisted hydrothermal crystallization, then step by step loading cerium species, palladium and iron components, and high-temperature reduction. The catalyst has suitable acidity and magnetism, can efficiently catalyze the continuous reaction process of alcoholysis and ester exchange, and can be simply recovered and recycled by means of an external magnetic field after reaction. The process steps are simple, the raw materials used are all commercially available products except for the specially made catalyst, and high-value resource utilization of the polyester waste materials is realized.

The utility model discloses an overflow kettle type reactor, including reactor body, the inside vertical of reactor body is provided with the flow guide cylinder of two ends opening, and the flow guide cylinder divides the reactor body inside structure into the reaction zone in the flow guide cylinder and the overflow area outside the flow guide cylinder, the stirring paddle includes upper layer stirring paddle, middle layer stirring paddle and lower layer stirring paddle, and upper layer stirring paddle and middle layer stirring paddle are arranged in the inside reaction zone, and lower layer stirring paddle is arranged between the bottom of flow guide cylinder and reactor body, the utility model discloses through increasing the flow guide cylinder structure, sets up the reaction zone and overflow area, and separates the overflow port from the reaction zone, avoids the material that just joined in the kettle from directly flowing out the kettle body without being reacted fully, and moreover through setting up multilayer different function's stirring paddle, realizes the rapid mixing and conveying of material, can satisfy the solid -liquid heterogeneous phase reaction requirement of high solid content and high viscosity, significantly improves the reaction efficiency and effect, is applicable to solid -liquid heterogeneous phase continuous reaction.

A supported catalyst, its preparation method, and its application in the continuous fixed-bed production of pentanediol belong to the field of biomass catalytic conversion technology. The catalyst comprises 30-60% support and 40-70% active components supported on the support, wherein the support is zirconium oxide, and the active components are copper and cobalt in a mass ratio of 4:1 to 5:1. In the continuous fixed-bed production of pentanediol, using furfuryl alcohol as raw material, this catalyst is employed to carry out a hydrogenation reaction under a hydrogen atmosphere, achieving efficient and highly selective conversion of furfuryl alcohol to pentanediol. Furthermore, the catalyst exhibits excellent long-term stability, maintaining a conversion rate of approximately 90% and a pentanediol selectivity of approximately 75% after 230 hours of continuous reaction. This process is highly continuous, stable in operation, and environmentally friendly, suitable for large-scale industrial production, and solves the problems of complex processes and severe equipment corrosion in traditional pentanediol production methods.

The application provides a method for continuously preparing maleic acid diethyl ester in a microchannel, comprising the following steps: mixing maleic anhydride and anhydrous ethanol, and then feeding the mixture into a micro-mixer A for pre-reaction to obtain a mixed solution containing mono-ester; feeding the mono-ester mixed solution into a micro-reactor B for esterification reaction with a mixed solution of sulfuric acid / anhydrous ethanol; collecting the solution flowing out of the reactor, and then purifying, drying and vacuum distilling the solution to obtain maleic acid diethyl ester product. The preparation process utilizes the high heat and mass transfer of the microchannel reactor, realizes continuous reaction, effectively improves the product selectivity and product yield, and does not need a water-carrying agent in the reaction, and the energy consumption of synthesis is low.

This application relates to the technical field of organic synthesis, specifically disclosing a continuous flow microchannel synthesis method for o-hydroxybenzoic acid and its derivatives. The continuous flow microchannel synthesis method for o-hydroxybenzoic acid and its derivatives disclosed in this application employs an integrated microchannel reactor and includes the following steps: using phenol or its derivatives as raw materials, a phenolate reaction is carried out with an alkali metal hydroxide solution in a first microchannel to obtain intermediate 1; CO2 is introduced into intermediate 1, and a carboxylation reaction is carried out in a second microchannel to obtain intermediate 2; intermediate 2 is reacted with a dilute acid solution in a third microchannel to obtain a crude solution; the crude solution is carried into a fourth microchannel for crystallization to obtain the target crystalline form; and the target crystalline form is carried into a fifth microchannel for post-processing to obtain the target product. The synthesis method employed in this application, through continuous reaction, significantly improves the synthesis efficiency and allows for online control of the crystal form.

This invention discloses a method for the continuous preparation of formic acid using a green carbon source. The method involves adding a slurry of catalyst and water to a microchannel reactor, adjusting the flow rates of hydrogen and carbon dioxide (the green carbon source) according to the feed rate, and synthesizing formic acid after microchannel reaction. The microchannel reactor employs a multi-module structure, with the reaction plate consisting of three layers: the first and third layers are heat transfer layers, and the middle layer is the reaction layer, with multiple reaction modules connected in series. This invention can use various types of catalysts, exhibiting strong adaptability, and provides mild reaction conditions, achieving good reaction results. Compared to conventional reactors, the microchannel reactor allows for precise control of reaction conditions, and the larger heat exchange area significantly improves mass and heat transfer efficiency. The online continuous reaction of this invention breaks the intermittent operation mode of conventional reactors, reducing experimental errors caused by intermittent operation.