12 results about "Cyclohexylamine" patented technology

The application discloses a preparation method of enciferstat bulk drug and belongs to the field of drug synthesis. 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (SM) is used as a raw material, and the raw material is reacted with cyclohexylamine under alkaline conditions, and the reaction is washed with water, dried, and concentrated to obtain an intermediate I; the intermediate I is reacted with urea under pressurized heating conditions to prepare an enciferstat drug molecule, the two-step yield is more than 67%, and the purity is more than 99%, the method has a simple operation process, the product is easy to purify, the yield is high, the product purity is high, and a new method for preparing enciferstat bulk drug is provided.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

The invention discloses oxidized paraffin and antirust wax and a preparation method thereof, and relates to the field of paraffin. The antirust wax comprises oxidized paraffin, an emulsifier, an antirust agent and water, and the emulsifier is at least one of sorbitan monooleate, lauryl sodium sulfate and fatty alcohol-polyoxyethylene ether; the antirust agent is at least one of cyclohexylamine stearate, alkenyl succinic acid and alpha-mercaptobenzothiazole; the oxidized paraffin is loaded with a Mn metal element through a carrier. The catalyst loaded with the active component Mn is added in the preparation process of the oxidized paraffin, the acid value and the soap value of the oxidized paraffin are effectively increased, the oxidized paraffin interacts with the specific emulsifier and the antirust agent, the emulsifier does not affect the anti-oxidation protection function of functional components, and meanwhile, the antirust agent and the oxidized paraffin cooperate with each other to achieve the anti-corrosion effect in a synergistic mode; and the antirust capability of metal in a humid and hot environment and an acid-base environment is improved, and the application prospect is expanded.

This invention discloses a phosphorus-free composite polyamine boiler water treatment agent, its preparation method, and its application, belonging to the fields of chemical and water treatment technology. The water treatment agent is made from the following raw materials in parts by weight: 9-15 parts diethylenetriamine, 1-6 parts N-9-octadecene-1,3-propanediamine, 18-20 parts tannin, 1-6 parts cyclohexylamine, 10-24 parts polycarboxylic acid, and 30-60 parts deionized water. In preparation, the polycarboxylic acid is dissolved in deionized water, and N-9-octadecene-1,3-propanediamine, cyclohexylamine, diethylenetriamine, and tannin are added sequentially. After stirring at room temperature, the mixture is allowed to stand. The water treatment agent of this invention is phosphorus-free and has the functions of scale inhibition, corrosion inhibition, passivation, pre-filming, deoxygenation, desiliconization, scale dispersion and online removal of steam turbine salt deposits. It has a scale inhibition rate of ≥98%, a corrosion inhibition rate of ≤0.025mm / a and a deoxygenation efficiency of ≥97%. It can be adapted to high-pressure, subcritical and supercritical power plant boilers, is easy to prepare and suitable for industrial application.

This invention discloses a cyclohexylaminosilane coupling agent production apparatus and its production process, belonging to the field of coupling agent production technology. The cyclohexylaminosilane coupling agent production apparatus of this invention includes a synthesis kettle, a centrifuge, and a distillation column. The inlet of the synthesis kettle is equipped with a metering tank, the outlet of the synthesis kettle is connected to the centrifuge, the outlet of the centrifuge is connected to a crude product storage tank, and the output end of the crude product storage tank is equipped with a distillation column. This invention solves the problem that existing reaction devices cannot achieve reflux. The cyclohexylaminosilane coupling agent production apparatus and its production process proposed in this invention are equipped with a continuously processing synthesis kettle, centrifuge, and distillation column, facilitating the synthesis, separation, and distillation of the cyclohexylaminosilane coupling agent. A stirring reflux assembly is installed in the synthesis kettle, and a drive motor drives a rotating shaft to rotate. The spiral blades follow the rotating shaft, pushing the liquid in the limiting cylinder upwards to form reflux.

The invention provides a compound containing quinazoline and cyclohexylamine as well as a preparation method and application of the compound. According to the invention, quinazoline compounds and cyclohexylamine are spliced and modified to synthesize a series of novel-structure derivatives formed by combining quinazoline rings and cyclohexylamine, and release of inflammatory factors can be inhibited to achieve the purpose of treatment.

The invention relates to the technical field of sponge processing, in particular to zero-hardness sponge and a preparation method thereof.The zero-hardness sponge is prepared from, by weight, polyester polyol A, polyester polyol B, polyether polyol, diisocyanate, methoxypolyethylene glycol, glycerin, a nonionic surfactant, a catalyst and N, N-dimethylformamide. According to the formula, polyester polyol A, polyester polyol B, polyether polyol, polyethylene glycol monomethyl ether and other components are added into a reaction kettle, the reaction kettle is made of polyether polyol A, polyether polyol B, N, N-dimethyl cyclohexylamine, polyoxyethylene fatty amide, an antioxidant, an anti-ultraviolet agent, a chain extender, a modifier and water, the modifier is composed of polyether modified polydimethylsiloxane, ethylhexyl palmitate, chitosan and a glacial acetic acid solution, and in the formula, polyester polyol A, polyester polyol B, polyether polyol, polyethylene glycol monomethyl ether and other components are added into the reaction kettle. On the premise that the rebound resilience is not reduced, the hardness of the sponge is reduced to a new level, the requirements of underwear and other application scenarios for extreme softness are met, meanwhile, the sponge can still quickly restore to the original shape after being pressed for a long time, and the attractiveness and wearing comfort of the clothes are kept.

The application discloses a molecular sieve, a preparation method of a hydrogen type molecular sieve catalyst and application of the hydrogen type molecular sieve catalyst in a cyclohexene hydration reaction, and comprises the following steps: mixing raw materials containing a silicon source, an aluminum source, an alkali source, cyclohexylamine and water, and performing dynamic crystallization to obtain a ZSM-5 / ZSM-11 co-crystallization molecular sieve. Compared with a traditional tetrabutylammonium bromide and 1,6-hexanediamine template system, the catalyst prepared from the molecular sieve synthesized by using the system has higher cyclohexene conversion rate in the cyclohexene hydration reaction.

An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.

The present application belongs to the technical field of rubber vulcanization accelerator production, and relates to a method for preparing vulcanization accelerator CBS by catalytic oxidation. A catalyst, MBT and distilled water are mixed in a reaction kettle and fully stirred, cyclohexylamine is added, and M-cyclohexylamine salt is generated by stirring and beating. Hydrogen peroxide solution is added dropwise, and the end point of the oxidation reaction is detected by using an indicator. The reaction kettle system is naturally cooled to room temperature, solid-liquid separation is performed, water washing is performed until neutral, the obtained wet product is placed in an oven for drying, and the finished product CBS is obtained after drying. The present application only uses hydrogen peroxide as an oxidizing agent, and the yield of the accelerator CBS is almost equivalent to the yield of CBS by using sodium hypochlorite as an oxidizing agent in the current industry (or the yield of CBS by using a mixed oxidation method). The present application has the potential for large-scale industrial production. The whole operation process is relatively simple, the conditions are mild, and the process belongs to an environment-friendly type, which is beneficial to large-scale industrialization.