22 results about "Cyclohexylamine" patented technology

The application discloses a preparation method of enciferstat bulk drug and belongs to the field of drug synthesis. 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (SM) is used as a raw material, and the raw material is reacted with cyclohexylamine under alkaline conditions, and the reaction is washed with water, dried, and concentrated to obtain an intermediate I; the intermediate I is reacted with urea under pressurized heating conditions to prepare an enciferstat drug molecule, the two-step yield is more than 67%, and the purity is more than 99%, the method has a simple operation process, the product is easy to purify, the yield is high, the product purity is high, and a new method for preparing enciferstat bulk drug is provided.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

The invention discloses oxidized paraffin and antirust wax and a preparation method thereof, and relates to the field of paraffin. The antirust wax comprises oxidized paraffin, an emulsifier, an antirust agent and water, and the emulsifier is at least one of sorbitan monooleate, lauryl sodium sulfate and fatty alcohol-polyoxyethylene ether; the antirust agent is at least one of cyclohexylamine stearate, alkenyl succinic acid and alpha-mercaptobenzothiazole; the oxidized paraffin is loaded with a Mn metal element through a carrier. The catalyst loaded with the active component Mn is added in the preparation process of the oxidized paraffin, the acid value and the soap value of the oxidized paraffin are effectively increased, the oxidized paraffin interacts with the specific emulsifier and the antirust agent, the emulsifier does not affect the anti-oxidation protection function of functional components, and meanwhile, the antirust agent and the oxidized paraffin cooperate with each other to achieve the anti-corrosion effect in a synergistic mode; and the antirust capability of metal in a humid and hot environment and an acid-base environment is improved, and the application prospect is expanded.

This invention discloses a phosphorus-free composite polyamine boiler water treatment agent, its preparation method, and its application, belonging to the fields of chemical and water treatment technology. The water treatment agent is made from the following raw materials in parts by weight: 9-15 parts diethylenetriamine, 1-6 parts N-9-octadecene-1,3-propanediamine, 18-20 parts tannin, 1-6 parts cyclohexylamine, 10-24 parts polycarboxylic acid, and 30-60 parts deionized water. In preparation, the polycarboxylic acid is dissolved in deionized water, and N-9-octadecene-1,3-propanediamine, cyclohexylamine, diethylenetriamine, and tannin are added sequentially. After stirring at room temperature, the mixture is allowed to stand. The water treatment agent of this invention is phosphorus-free and has the functions of scale inhibition, corrosion inhibition, passivation, pre-filming, deoxygenation, desiliconization, scale dispersion and online removal of steam turbine salt deposits. It has a scale inhibition rate of ≥98%, a corrosion inhibition rate of ≤0.025mm / a and a deoxygenation efficiency of ≥97%. It can be adapted to high-pressure, subcritical and supercritical power plant boilers, is easy to prepare and suitable for industrial application.

The invention discloses a thermal insulation material construction method for a ship body, and relates to the technical field of ship body construction, the construction method comprises the following steps: base material surface treatment, primer coating, thermal insulation material installation, flame retardant layer construction and surface treatment; the thermal insulation material is prepared from the following components in parts by weight: 100 to 120 parts of polyether polyol, 110 to 130 parts of diphenylmethane diisocyanate, 8 to 22 parts of modified filler, 5 to 9 parts of petroleum ether, 2 to 6 parts of glycerol, 0.2 to 1 part of dibutyltin dilaurate, 0.5 to 1.5 parts of dimethyl cyclohexylamine and 0.8 to 1.2 parts of pentaerythritol, the thermal insulation material disclosed by the invention integrates excellent thermal insulation performance and excellent flame retardant property, can show excellent dimensional stability and durability in severe environments such as high temperature, high humidity and vibration of ships, and provides a safe and reliable comprehensive thermal insulation solution for the ships.

This invention discloses a cyclohexylaminosilane coupling agent production apparatus and its production process, belonging to the field of coupling agent production technology. The cyclohexylaminosilane coupling agent production apparatus of this invention includes a synthesis kettle, a centrifuge, and a distillation column. The inlet of the synthesis kettle is equipped with a metering tank, the outlet of the synthesis kettle is connected to the centrifuge, the outlet of the centrifuge is connected to a crude product storage tank, and the output end of the crude product storage tank is equipped with a distillation column. This invention solves the problem that existing reaction devices cannot achieve reflux. The cyclohexylaminosilane coupling agent production apparatus and its production process proposed in this invention are equipped with a continuously processing synthesis kettle, centrifuge, and distillation column, facilitating the synthesis, separation, and distillation of the cyclohexylaminosilane coupling agent. A stirring reflux assembly is installed in the synthesis kettle, and a drive motor drives a rotating shaft to rotate. The spiral blades follow the rotating shaft, pushing the liquid in the limiting cylinder upwards to form reflux.

The invention provides a compound containing quinazoline and cyclohexylamine as well as a preparation method and application of the compound. According to the invention, quinazoline compounds and cyclohexylamine are spliced and modified to synthesize a series of novel-structure derivatives formed by combining quinazoline rings and cyclohexylamine, and release of inflammatory factors can be inhibited to achieve the purpose of treatment.

The invention provides odor-free low-amine-odor environment-friendly floor paint and a preparation method thereof.The environment-friendly floor paint comprises a component A and a component B. The component A comprises, by weight, 32%-40% of 128 epoxy resin, 7%-20% of 692 epoxy reactive diluent benzyl glycidyl ether, 6%-10% of benzyl alcohol, 10%-20% of inorganic color paste and 20%-40% of porous mineral powder; the component B is prepared from 46 to 60 percent of trimethyl cyclohexylamine, 10 to 25 percent of nonyl phenol substitute, 10 to 20 percent of benzyl alcohol, 6 to 10 percent of K54 epoxy accelerator and 1 to 2 percent of natural plant essence. The environment-friendly floor paint prepared by the invention has the effects of removing odor and deodorizing, and has a good decomposition and removal effect on stink such as amine odor.

The invention relates to the technical field of sponge processing, in particular to zero-hardness sponge and a preparation method thereof.The zero-hardness sponge is prepared from, by weight, polyester polyol A, polyester polyol B, polyether polyol, diisocyanate, methoxypolyethylene glycol, glycerin, a nonionic surfactant, a catalyst and N, N-dimethylformamide. According to the formula, polyester polyol A, polyester polyol B, polyether polyol, polyethylene glycol monomethyl ether and other components are added into a reaction kettle, the reaction kettle is made of polyether polyol A, polyether polyol B, N, N-dimethyl cyclohexylamine, polyoxyethylene fatty amide, an antioxidant, an anti-ultraviolet agent, a chain extender, a modifier and water, the modifier is composed of polyether modified polydimethylsiloxane, ethylhexyl palmitate, chitosan and a glacial acetic acid solution, and in the formula, polyester polyol A, polyester polyol B, polyether polyol, polyethylene glycol monomethyl ether and other components are added into the reaction kettle. On the premise that the rebound resilience is not reduced, the hardness of the sponge is reduced to a new level, the requirements of underwear and other application scenarios for extreme softness are met, meanwhile, the sponge can still quickly restore to the original shape after being pressed for a long time, and the attractiveness and wearing comfort of the clothes are kept.

The application discloses a molecular sieve, a preparation method of a hydrogen type molecular sieve catalyst and application of the hydrogen type molecular sieve catalyst in a cyclohexene hydration reaction, and comprises the following steps: mixing raw materials containing a silicon source, an aluminum source, an alkali source, cyclohexylamine and water, and performing dynamic crystallization to obtain a ZSM-5 / ZSM-11 co-crystallization molecular sieve. Compared with a traditional tetrabutylammonium bromide and 1,6-hexanediamine template system, the catalyst prepared from the molecular sieve synthesized by using the system has higher cyclohexene conversion rate in the cyclohexene hydration reaction.

An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.

The invention relates to the technical field of water treatment, in particular to a polyamine boiler water treatment agent and a preparation method thereof. The preparation method comprises the following steps: firstly, dissolving N-oleyl-1, 3-propylene diamine in cyclohexylamine, and then adding water to obtain the polyamine boiler water treatment agent. The agent provided by the invention takes the film-forming amine (N-oleyl-1, 3-propylene diamine) and the neutralizing amine (cyclohexylamine) as main components, is simple to prepare and harmless to the environment, can effectively relieve metal corrosion of a boiler steam-water system, and is an efficient and environment-friendly boiler water treatment agent suitable for middle and high pressure boilers.

The present invention relates to a pharmaceutical composition comprising a novel terephthalate-cyclohexylamine-based polymer compound for photodynamic therapy for glioblastoma, wherein the polymer compound can specifically fluorescently label glioblastoma, and generates reactive oxygen species in glioblastoma so as to reduce the size of tumor cells such that an anticancer effect is exhibited, and thus the present invention can be effectively used in related industries.

The invention discloses a preparation method of an ensafenetine raw material medicine, and belongs to the field of medicine synthesis. The preparation method comprises the following steps: by taking 9, 10-dimethoxy-2-(2, 4, 6-trimethyl phenyl imino)-3, 4, 6, 7-tetrahydro-2H-pyrimido [6, 1-a] isoquinoline-4-ketone (SM) as a raw material, reacting with cycloethylamine under an alkaline condition, and washing, drying and concentrating the reaction to obtain an intermediate I; under the conditions of pressurization and heating, the intermediate I reacts with urea to prepare the ensafenetine drug molecule, the two-step yield is 67% or above, the purity is 99% or above, the method is simple in operation process, the product is easy to purify, the yield is high, the product purity is high, and a new method is provided for preparation of an ensafenetine raw material medicine.

The present application belongs to the technical field of rubber vulcanization accelerator production, and relates to a method for preparing vulcanization accelerator CBS by catalytic oxidation. A catalyst, MBT and distilled water are mixed in a reaction kettle and fully stirred, cyclohexylamine is added, and M-cyclohexylamine salt is generated by stirring and beating. Hydrogen peroxide solution is added dropwise, and the end point of the oxidation reaction is detected by using an indicator. The reaction kettle system is naturally cooled to room temperature, solid-liquid separation is performed, water washing is performed until neutral, the obtained wet product is placed in an oven for drying, and the finished product CBS is obtained after drying. The present application only uses hydrogen peroxide as an oxidizing agent, and the yield of the accelerator CBS is almost equivalent to the yield of CBS by using sodium hypochlorite as an oxidizing agent in the current industry (or the yield of CBS by using a mixed oxidation method). The present application has the potential for large-scale industrial production. The whole operation process is relatively simple, the conditions are mild, and the process belongs to an environment-friendly type, which is beneficial to large-scale industrialization.

The invention discloses a reusable high-temperature viscosity-reducing adhesive tape and a preparation method thereof, and belongs to the technical field of adhesive tapes, and the preparation method comprises the following steps: firstly, mixing 1, 10-decanediol diacrylate, acrylic acid, glyceryl methacrylate, an initiator and acetone, and carrying out polymerization reaction in a nitrogen environment to obtain a pretreated mixture; secondly, polydipentaerythritol pentaacrylate, N, N-bis (2, 3-epoxypropyl) cyclohexylamine and an initiator are added, and a post-treatment mixture is formed; then adding pentaerythritol tri (3-aziridinyl) propionate as a cross-linking agent, and stirring to obtain a high-temperature viscosity reducer; and finally, coating the PP film with a high-temperature viscosity reducer, coating the other surface with the high-temperature viscosity reducer to form a grid pattern, curing in an oven, and covering with a release film to obtain a final product. Compared with the prior art, the adhesive tape has good viscosity at normal temperature, the viscosity is reduced at high temperature, and the adhesive tape is easy to strip, can be repeatedly used and is suitable for various industrial applications, the production efficiency is effectively improved, and the cost is reduced.

The invention provides a high-edge-covering cathode epoxy modified electrophoretic coating and a preparation method thereof, and belongs to the technical field of electrophoretic coatings. The invention discloses a high-edge-covering cathode epoxy modified electrophoretic coating which comprises epoxy resin emulsion and color paste. The epoxy resin emulsion comprises polyether amine modified epoxy resin, a curing agent, organic acid, an alcohol ether additive, a shrinkage-proof agent and deionized water. The color paste is prepared from polyurethane modified acrylic resin, carbon black, kaolin, an anti-rust pigment, N, N-dimethyl cyclohexylamine, propylene glycol phenyl ether and the balance of deionized water; the invention also provides a preparation method of the cathode epoxy modified electrophoretic coating. The bath solution of the electrophoretic coating provided by the invention is good in stability, so that the coating efficiently permeates into complex structures such as an inner cavity, a welding seam and an edge of a workpiece under the action of an electric field, 100% dead-corner-free coating is realized, and the problem of coverage blind areas of a traditional spraying process is solved; the coating film is flat and smooth, has strong adhesive force, and also has excellent corrosion resistance, aging resistance and high corner corrosion resistance.

The invention discloses polyimide, a preparation method thereof and polyester electronic glue. Polymeric monomers of the polyimide comprise a dianhydride monomer and a diamine monomer, the dianhydride monomer is selected from one or more of 4, 4 '-(4, 4'-isopropyl diphenoxy) bis (phthalic anhydride), 3, 3 ', 4, 4'-benzophenone tetracarboxylic dianhydride, 4, 4 '-oxydiphthalic anhydride and 2, 3, 3', 4 '-biphenyl tetracarboxylic dianhydride, and the diamine monomer is selected from one or more of 4, 4'-(4, 4 '-isopropyl diphenoxy) bis (phthalic anhydride), 3, 3', 4, 4 '-benzophenone tetracarboxylic dianhydride and 2, 3, 3', 4 '-biphenyl tetracarboxylic dianhydride. The diamine monomer is selected from one or more of dapsone, 1, 3-bis (4 '-aminophenoxy) benzene, 2, 2'-bis [4-(4-aminophenoxy) phenyl] propane, 4, 4 '-bis (3-aminophenoxy) diphenyl sulfone, 1, 3-cyclohexanedimethylamine, 4, 4'-diaminodiphenyl ether, dimer diamine and trimer diamine. The polyimide disclosed by the invention can be used for modifying polyester or an epoxy system, and the flame retardant property and the adhesion stripping force can be greatly improved. And the coating process is volatilized at a lower temperature, and the solvent boiling point of the system is low, so that the requirements of the existing process can be met.

The utility model provides rectification equipment for cyclohexylamine rectification. The rectifying equipment comprises a rectifying tower with a cylindrical barrel structure, the rectifying tower is divided into a pre-fractionation section, a rectifying section, a stripping section and a middle discharging section, and a vertical partition plate is arranged in the tower to separate the pre-fractionation section from the middle discharging section. By utilizing the rectification equipment, the quantity of equipment can be reduced, the process flow is simplified, the device investment is reduced, the consumption of raw materials and energy in production is reduced, the production cost is reduced, and the carbon emission of a production device is reduced.

The invention relates to the technical field of polyurethane materials, in particular to a light polyurethane shoe material for sports shoes and a preparation process thereof, and the light polyurethane shoe material comprises the following components: 40-60 parts by weight of polyether polyol, 20-40 parts by weight of hexamethylene diisocyanate, 20-40 parts by weight of N, N-dimethylformamide, 1-5 parts by weight of a coupling agent, 1-5 parts by weight of an antioxidant, 1-5 parts The invention relates to a flame-retardant and flame-retardant material which is prepared from the following components in parts by weight: 0.5-1.5 parts of N, N-dimethyl cyclohexylamine, 5-15 parts of modified p-toluenesulfonhydrazide microcapsules, 1-3 parts of a nucleating agent, 0.5-2 parts of zinc dialkyl dithiophosphate, 0.5-2 parts of phenyl salicylate and 0.5-2 parts of polyoxyethylene sorbitan monooleate. The aryl halide can improve the thermal decomposition temperature of p-toluenesulfonyl hydrazide, so that the p-toluenesulfonyl hydrazide is not easy to decompose in advance under a high-temperature processing condition, and the foaming process can be accurately controlled. Due to the fact that the fatty acid can reduce the surface tension of the system, gas can form tiny bubble nucleuses in the system more easily, the number of bubble nucleation sites is increased, a more fine and uniform bubble structure can be generated, and the buffering performance and the overall quality of the shoe material are improved.