471 results about "Cyclohexylamine" patented technology

A method for synthesizing MCM-22 molecular screen, which possesses MWW topological structure, employing silicon, aluminium, alkali, mould agent and deionized water as reacting raw material, blooming under the temperature of 135-185 Deg C for some time, hydrothermal synthesizing the needed molecular screen; the invention is characterized by using diamin liquid mixture (BA) as mould agent to prepare molecular screen, one (SDAI) is hexamethylene amine (HMI), another (SDA2) is any one of the followings: cyclohexylamine (CHA)or buta (BuA) or isopropyl amine (IPA).

The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds

are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

The invention provides a method for preparing an MCM-49 molecular sieve containing rare earth. The molecular sieve comprises the following raw materials: an aluminum source, a base source, a silicon source, hexamethylene imine, cyclohexane, deionized water and salts of the rare earth, wherein the molar ratios of the raw materials comprise: SiO2:Al2O3 is 12-50, OH:SiO2 is 0.05-0.7, (HMI+CHA):SiO2 is 0.08-1.2, H2O:SiO2 is 10-70, and Re2O3:Al2O3 is 0.01- 0.5. The method comprises the following steps: putting the raw materials into a synthesizing kettle according to the ratios, and sealing the kettle; raising programming temperature to a crystallization temperature of between 135 and 180 DEG C; and then crystallizing and cooling the raw materials in self-generated pressure; and obtaining the MCM-49 molecular sieve containing the rare earth after a crystallized product is subjected to filtering, washing and drying. The method can improve the stability of a molecular sieve catalyst by introducing the rare earth into the molecular sieve in synthesizing, and obviously reduce the synthesizing cost by replacing partial or most of the hexamethylene imine by the cyclohexane in organic amine; meanwhile, the preparation method has the characteristics of good repeatability and high degree of crystallinity of the product.

An o-chloroaniline production method takes o-nitrochlorobenzene as raw material and is characterized in that the o-nitrochlorobenzene is dissolved in alcohol solvent in the presence of catalyst and additive and reacted with hydrogen at 10-120 DEG C and under 0.3-4.0 MPa; the reaction process is continuous reaction; after the completion of the reaction, the o-chloroaniline is obtained through treatment, wherein, the catalyst can be selected from one of the following: Ni/Al2O3, Raney Ni, Pt/C and Pd/C; while the additive can be selected from one, or two, or three of the following compounds: cyclohexylamine, ethylenediamine, ethanolamine, diethanolamine, triethanolamine, pyridine, liquid ammonia, ammonium bicarbonate, ammonium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, potassium carbonate, potassium hydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate and sodium dihydrogen phosphate; the dosage of the catalyst takes up 0.05% to 20% of the mass of the o-nitrochlorobenzene; the dosage of the additive takes up 0. 5% to 20% of the mass of the o-nitrochlorobenzene; the alcohol can be methanol or ethanol; the dosage of alcohol takes up 30% to 150% of the dosage of the o-nitrochlorobenzene; the continuous reaction is realized through 1 to 6 tank reactors which are connected in series.

The invention discloses a method for synthesizing cyclohexylamine with aniline by means of gas-phase catalytic hydrogenation, which includes the steps: 1) mixing fresh hydrogen with circulating hydrogen; 2) mixing mixed hydrogen with the aniline according to the molar ratio of 15:1-19:1 in an aniline evaporator to enable vaporization of the aniline; 3) carrying out a hydrogenation reaction of vaporized mixed gas in a fixed bed hydrogenation reactor prefilled with cobalt-ruthenium catalyst or nickel-ruthenium catalyst at the reaction temperature of 165-179 DEG C and under the reaction pressureof 0.2-0.3MPa; and 4) materials which are subjected to the hydrogenation reaction enter a separator by means of heat exchange, condensation and cooling, performing gas separation to obtain crude cyclohexylamine, and then rectifying so that a cyclohexylamine product is prepared. By the aid of the method, production cost is effectively reduced, product yield is increased, and the service life of the catalyst is prolonged.

The invention discloses a tanshinoneIderivant and application in pharmacy, which is characterized by the following: the derivant constitutional formula is showed in the right chart: when R1 represents -Ar, R2,R3 represents hydrogen or alkyl with one to eight carbon atoms, cycloalkyl, aromatic nucleus or heterocyclic radical; or R2-N-R3 represents nitrogen saturation aza with nitrogen, imidazoline and its derivant, glyoxaline and its derivant, diethylenediamine and its derivant, piperidine and its derivant, morpholine and its derivant; when R1 represents -H, R2, R3 represents hydrogen and alkyl with three to eight carbon atoms, cycloalkyl, aromatic nucleus; or R2-N-R3 represents cyclohexylamine, imidazoline and its derivant, glyoxaline and its derivant, diethylenediamine derivant, piperidine derivant, morpholine derivant. The derivant can apply for preparing clinical preparation.

The invention discloses a production technology of N, N'-dicyclo hexylcar bodiimide, which comprises the following steps: generating dicyclohexyl sulfourea and sodium sulfide with cyclohexylamine and carbon bisulphide; generating N, N'-dicyclo hexylcar bodiimide by oxygenizing dicyclohexyl sulfourea twice with sodium hypochlorite and removing hydrogen sulfide. The invention is characterized by the following: adding the accelerant when dicyclohexyl sulfourea is oxygenized by sodium hypochlorite; applying triethyl benzyl ammonium chloride(TEBA)or carbowax as the accelerant; adding sodium sulfide which is generated in the first step reaction in order to removing sulfur by reacting with sulfur in the organic phase after oxygenizing twice. The invention guarantees the sufficient oxidation reaction, which reduces the production cost, and improves the product quality.

The invention relates to a synthetic method of antibiotic cefoxitin. 7-ACA is taken as a starting material and firstly reacts with thiopheneacetyl chloride, cephalothin acid is obtained by separation; the cephalothin acid is not purified, and the methoxylation is directly carried out on the cephalothin acid to obtain an intermediate A which introduces methoxy on the position of 7, the intermediate A obtains 7-alpha-methoxy cephalothin cyclohexylamine salt under the action of cyclohexylamine; the 7-alpha-methoxy cephalothin cyclohexylamine salt reacts with benzathine diacetate under the catalysation of solid alkaloid to obtain 7-alpha-methoxy-3-deacetoxy cephalothin benzathine salt; and the carbamylation is carried out under the action of chlorosulfonyl isocyanate to obtain the cefoxitin. The synthetic method has the advantages that compared with the prior art, the synthetic method simplifies the operation process, has high product yield, reduces the production cycle, eliminates the discharge of waste water containing organic solvent and reduces the production cost. The product quality is stable, and the synthetic method is applicable to the large-scale industrial production.

The invention discloses grease specially used for a heavy-load open-type gear and a preparation method. The grease of the invention comprises the following raw materials by weight percentage: 1-2% of MDI (diphenylmethane-4,4'-diisocyanate), 0.2-1% of octadecylamine, 0.5-2% of cyclohexylamine, 35-50% of base oil A, 30-45% of base oil B, 0.5-1.0% of anti-oxidant A, 1.5-3.0% of anti-oxidant B, 0.5% of antirust agent, 0.5-1.5% of extreme pressure antiwear additive A, 4-8% of extreme pressure antiwear additive B, 2-5% of oiliness agent A, 0.1-0.3% of oiliness agent B, 10-15% of adhesive compound and 4-8% of solid lubricant. Various raw materials are stirred and mixed under certain sequence according to different temperature while preparing, the grease of the present invention has ultra-strong extreme pressure and antiwear property, and excellent adhesiveness, anticorrosion and antirust performance, good anti-oxidizability and water resistance performance and spray characteristic, and has good adaptability with routine seal elements. The grease has no heavy metal lead or a volatile solvent, and belongs to the energy saving and environment-friendly product.

The invention discloses a production method of bromhexine hydrochloride, which uses a multi-function reaction kettle with a special kettle bottom valve as the reaction vessel, uses a special filter as the purifier, uses 2-nitrobenzyl bromide and N-methyl cyclohexylamine as the starting materials, enables the product generated by the reaction under the condition of normal temperature and pressure to the react with hydrazine hydrate under the catalysis of Raney's nickel, and produces the bromhexine hydrochloride by brominating substitution reaction, chlorine hydride salification reaction, purification and drying. Compared with the disclosed production process of bromhexine hydrochloride and the bromhexine hydrochloride produced by the current synthesis device, the production method of the invention has the advantages of less reaction steps, moderate reaction condition, convenient purification and simple operation; the used special device has the advantages of good heat insulation, oxidation resistance, air tightness and environmental protection effects and thorough reaction; and the reaction device has the advantages of simple structure, convenient operation, easy disassembly/assembly and cleaning, high filter efficiency, reaction quality and yield, and stable product quality.

The invention belongs to a method for treating wastewater of a rubber vulcanization accelerator N-cyclohexyl-2-benzothiazole sulfonamide (CZ). The method comprises: returning 30%-40% of generated wastewater into a CZ synthesis reaction vessel for indiscriminate application, subjecting the rest part to vacuum distillation, recovering cyclohexylamine; precipitating organic components dissolved in cyclohexylamine, filtering the recovered mother liquid, and putting the precipitated organic matter into the synthesis reaction vessel for continuous reaction, and leading the filtrate to multiple-effect evaporation so as to obtain a sodium chloride saturated solution, conducting concentration so as to obtain a supersaturated solution of sodium chloride, and carrying out centrifugation, thus obtaining sodium chloride; returning part of the evaporated water to the device for reuse, and leaving the left part to biochemical treatment. In order to make the raw material M completely reacted during production, excess cyclohexylamine is added, so that a great amount of cyclohexylamine is contained in the wastewater. By adopting a mother liquid indiscriminate application technology, the mother liquid can be recycled, the primary utilization rate of cyclohexylamine can be enhanced, simultaneously the mother liquid treatment cost can be reduced, and the CZ yield can be improved. After mother liquid indiscriminate application, the CZ product has no abnormal change in appearance, and no obvious change in melting point as well as ash content.

The invention discloses a thermal test solution for an engine, which consists of the following components in weight percent: 70-80 percent of ethylene glycol, 0.1-5.0 percent of aliphatic monocarbocylic, 1.0-5.0 percent of straight-chain aliphatic dicarboxylic acid, 0.1-1.0 percent of triazine skeleton tricarboxylic acid, 0.1-4.5 percent of aromatic acid, 0.1-1.0 percent of composite inhibitor, 0.1-0.5 percent of hydrolytic polymaleic anhydride, 0.2-4.0 percent of alkenyl amines, 0.2-2.0 percent of cyclohexylamine carbonate, 0.001-0.2 percent of antifoaming agent and the balance of deionized water. The invention can inhibit and prevent the corrosion during the thermal test process of the engine, has a unique gaseous phase corrosion inhibition technology, can be used for preventing the corrosion generated by potential corrosion which is formed by the contacting of the residual liquid and the air during the placing process after the thermal test of the engine, and has both a fully organic acid type engine coolant corrosion inhibition technology and a gaseous phase corrosion inhibition technology as well as good stability.

The invention relates to a gas phase antirust coating, the components of the combination account according to parts by weight, and the scope is as follows: 8 to 25 parts of acrylate modified alkyd resin, 5 to 20 parts of 2402 phenolic resin, 0 to 15 parts of petroleum sulfonate barium, 0 to 25 parts of oxidized malthenes magnesium soap, 0 to 5 parts of dodecatylene base succinic acid imidazoline, 0 to 6 parts of sebacic acid morpholine, 0 to 6 parts of octanoic acid two cyclohexylamines, 0 to 6 parts of octanoic acid tributyl amine, 0 to 6 parts of capric acid tributyl amine, 0 to 15 parts of benzoic acid monoethanolamine, 0.1 to 1.0 part of drier, 0 to 5 parts of thixotropic agent, 1 to 5 parts of dibutyl phthalate, 0 to 5 parts of black paste, and the rest of xylene/200 model solvent (1:1). The gas phase antirust coating of the invention has the advantages of fast table-drying speed, long antirust time, high rigidity, high brightness, good temperature resistance, etc., and can satisfy the requirements of the automatic pipeline production and long time open storage antirust need of oil steel pipes and other large pipes or profiles.

The invention provides a method for preparing a micro-emulsified procetane. The method comprises the following steps of: selecting the following components in percentage by weight: 60% of oleic acid, 10% of naphthenic acid, 6% of ethanolamine, 2% of triethanolamine, 7% of cyclohexylamine, 3% of n-butyl alcohol, 3% of isopropanol, 2% of Span-80, 0.5% of Span-20, 0.5% of polyethylene glycol, 2% of alkylphenol polyoxyethylene ether OP4, 0.5% of alkylphenol polyoxyethylene ether OP10 and 3.5% of conditioning agent; agitating the mixture at room temperature and normal pressure for 40-60 minutes toprepare the micro-emulsified procetane. By using the method provided by the invention, the physicochemical performance and use effects of the emulsified fuel gas are improved and energy is saved by more than 30%; the exhaust gas purification rate is more than 30-60%, the cost is reduced by more than 15-20% and the dynamic performance and the oil consumption of the micro-emulsified procetane have little difference from those of pure diesel oil.

The invention relates to concentrated emulsified diesel fuel and a preparation method thereof, wherein the concentrated emulsified diesel fuel is long in shelf life and low in cost and is prepared by the following raw materials by weight parts: 50-80 of diesel, 0.5-1 of cyclohexylamine, 0.5-2 of ethanolamine, 0.03-0.08 of water and hydrazine, 8-17 of oleic acid or fatty acid, 0.01-0.08 of ferrocene, 0.1-1 of isooctyl nitrate or amyl nitrate, 5-10 of ethanol, 4-15 of solvent oil and 10-30 of water. The concentrated emulsified diesel fuel is long in service life which is 6 years, has no emulsion breaking, is good in stability, can be used directly, also can be used by being mixed with national-standard diesel in any proportion, and further has the advantages of being simple in production process, easy to control, low in sulphur content and good in flowability, and the quality of the diesel is free of influence caused by secondary water adding.

The invention provides a preparation method of a ZSM-35 molecular sieve. The preparation method comprises the following steps of: firstly, with cyclohexane as a reaction medium and a template agent, adding a precursor compound of aluminum, a precursor compound of silicon, an alkali source, water and a homogeneous molecular sieve crystal seed with ZSM-35 into the cyclohexane by violent stirring to obtain a precursor mixer of the molecular sieve; crystallizing the precursor mixer prepared in the first step at the reaction temperature of 130-220DEG C for 10-240 hours; and thirdly, cooling the mixture crystallized in the second step to room temperature and filtering to obtain solid and carrying out vacuum drying on the obtained solid to obtain the ZSM-35 molecular sieve. According to the preparation method disclosed by the invention, after the synthesis is finished, the cyclohexane can be directly separated and recycled; and meanwhile, the washing of the molecular sieve is avoided and no waste water generates in the reaction. The preparation method is an environment-friendly production process for the molecular sieve.

The invention discloses a novel synthesis method of N, N'-dicyclohexylcarbo-diimide. The novel synthesis method comprises the steps of adding water and cyclohexylamine, starting to stir; dropwise adding carbon disulfide, controlling temperature and pressure, and filtering after cooling to obtain N, N'-dicyclohyxylthiourea; after mixing N, N'-dicyclohyxylthiourea and an adjuvant, adding the mixture into a sodium hypochlorite solution, separating the liquid by heating, adding an organic phase into a hot sodium sulfide solution, separating the liquid while heating, extracting the organic phase, washing the organic phase twice by using a hot sodium hydroxide solution to obtain a crude product, wherein each washing time is 15 minutes; and rectifying to obtain a finished product, namely N, N'-dicyclohexylcarbo-diimide. By using the synthesis method, no organic solvents are used, and the dangers that the organic solvents are flammable and combustible are eliminated; the solvent does not need to be evaporated before N, N'-dicyclohexylcarbo-diimide is rectified, so that the energy waste, the cost and the product loss are reduced, and no solvent residues are left; the novel synthesis method is wide in application range; and the yield and purity of N, N'-dicyclohexylcarbo-diimide are increased, the yield is not lower than 93.5%, and the purity is not lower than 99.3%.

The corrosion inhibitor for industrial boiler steam condensating water system includes alkyl amine with 12-18 carbon atoms or epoxy alkyl amine, Tween-60, Span-60, morpholine, cyclohexylamine and/or ammonia, and water. The corrosion inhibitor is emulsified liquid, and has functions of filming and neutralizing, reasonable steam-liquid distribution ratio, lower consumption, concentration indication, corrosion inhibiting efficiency over 98 %, obvious energy saving function and simple use, and may be used widely in various industrial boiler steam condensating water systems.

The invention relates to a tail gas refining method, and in particular relates to a method for preparing refined hydrogen through deamination in tail gas generated by preparation of cyclohexylamine and dicyclohexylamine through aniline hydrogenation, belonging to the technical field of chemical engineering. The method comprises the following steps: allowing tail gas discharged by a cyclohexylamine device and a dicyclohexylamine device to enter an ammonia absorption tower by virtue of a Roche hydrogen compressor and a degreaser, wherein most of ammonia is absorbed by water to be converted into ammonia water to be output from the tower bottom in the tower, and the gas output from the tower top is water-containing hydrogen; allowing the water-containing hydrogen to pass through a water segregator, a fiber filter and a water adsorption tower so as to further remove water vapor, thereby obtaining the refined hydrogen. The concentration of the refined hydrogen can be 98.0-99.8 percent, the material and energy consumption is reduced, and the aims of energy conservation and emission reduction are achieved. The refined hydrogen can serve as recycling gas to be used for an aniline hydrogenation reaction, and gas phase zero emission is realized.

The invention provides a synthetic process of hexazinone. The synthetic process comprises the steps of: by taking ethanol, lime nitrogen, cyclohexylamine, dimethylamine, dimethyl sulfate, sodium methoxide and phosgene as main active ingredients, generating a series of chemical reactions in solvent, and carrying out desolventizing and concentration, crystallizing and separating and drying to obtain a finished hexazinone product. According to the synthetic process, the solvent extraction can be omitted, the reaction procedures can be reduced, the efficiency can be improved, the energy consumption can be saved by 10%, and the conversion rate can also be improved by 5%; while the amount of waste water can be greatly decreased, dimethylamine can be recycled, and the quality of solvent can be guaranteed; a great amount of water can be saved, therefore, the production cost can be greatly lowered.

The process of preparing cocrystallized molecular sieve of ZSM-35 accounting for 0-100 wt% and MCM-22 adopts the mixture of hexamethylene imine and cyclohexylamine as template agent. Compound of silicon and aluminum, hydroxide of alkali metal, hexamethylene imine, cyclohexylamine and deionized water as materials are crystallized at 90-200 deg.c for some period and reacted completely to synthesize the molecular sieve hydrothermally. The synthesized molecular sieve is catalyst used widely in the catalytic reaction of converting hydrocarbons, such as hydrocarbon isomerization and aromatization, etc.

The invention discloses a polyurea floor coating and preparation and application methods thereof as well as carbamide resin. The carbamide resin is polyaspartic acid ester carbamide resin; the polyaspartic acid ester carbamide resin is prepared by reacting diethyl maleate and 3,3-dimethyl-4,4-methylenebis(cyclohexylamine) as raw materials at 60-80 DEG C for 70-74 DEG C, with the weight ratio of the diethyl maleate to the 3,3-dimethyl-4,4-methylenebis(cyclohexylamine) is 1.0 to (1.55-1.60). The polyaspartic acid ester carbamide resin can stably exist at a room temperature; the polyaspartic acid ester carbamide resin is taken as a base component; and packing, an assistant and the like are added, so as to prepare the polyurea floor coating disclosed by the invention. The polyurea floor coating and an HDI curing agent are mixed to use at a certain ratio, so that the polyurea floor coating has the advantages of good abrasive resistance, ageing resistance, waterproofness, controllable elasticity and high-strength shock resistance.

The invention relates to the field of fine chemical product production, in particular to a method for preparing a rubber vulcanization accelerator CBS by using a microchannel reactor. In the method for preparing the rubber vulcanization accelerator CBS by using the microchannel reactor, the microchannel reactor consisting of a micro mixer and a micro reactor which are connected together is included. The method is characterized by comprising the following steps: dissolving an accelerator M into excessive cyclohexylamine to form a solution, introducing cyclohexylamine together with an oxidant into a micro mixer for mixing, and feeding into the micro reactor for an oxidation reaction; and after the reaction is completed, performing suction filtration, washing filter cakes with water, and drying, thereby obtaining the rubber vulcanization accelerator CBS. As the microchannel reactor is adopted to prepare the rubber vulcanization accelerator CBS, the reaction time and the reaction temperature can be precisely controlled, the reaction time can be shortened, the reaction conversion rate can be increased, high throughput can be achieved, the product quality can be stable, production can be enlarged, high security can be achieved, and defects of a conventional reaction kettle can be effectively overcome.