This invention provides a topical composition comprising, by total weight of the composition: 1) 0.5-5% esflurprofen or a pharmaceutically acceptable salt thereof; 2) 1-10% an accelerator; and 3) 0.5-5% peppermint oil; wherein the accelerator is selected from one or more of clomiphene,
isopropyl myristate, tributyl acetylacetonate,
diethyl phthalate,
propylene carbonate,
glyceryl triacetate, hexyl laurate, and
isopropyl palmitate. The composition provided by this invention exhibits good release and
permeation properties, and the topical patch possesses good application properties, good adhesion, and is easy to peel off, maintaining stability during long-term storage.