The invention belongs to the technical field of chemical materials, and particularly relates to a preparation process of 2, 2, 4-trimethyl-1, 3-pentanediol di-n-
butyrate, which comprises the following steps: by adopting a specific acid catalyst, controlling the
molar ratio of 2, 2, 4-trimethyl-1, 3-pentanediol to n-
butyric acid to be (1: 2)-(1: 2.5), reacting at 120-170 DEG C for 5-10 hours, filtering, washing and
drying to obtain 2, 2, 4-trimethyl-1, 3-pentanediol di-n-
butyrate. The method comprises the steps of reaction in a reaction kettle, separation in a first rectifying
tower,
neutralization and extraction in an alkaline
tower, refining in a second rectifying
tower and the like. The process has the advantages of small catalyst dosage, strong selectivity,
reusability, unique rectification and
neutralization flow combination, reaction condition optimization, mild alkali liquor
neutralization and effective
waste treatment. According to the technology, the product purity reaches 98-99.5%, the conversion rate is 90-95%, and the technology has the advantages of being low in cost,
environmentally friendly, efficient and the like and is suitable for large-scale production.