351 results about "Glucoside" patented technology

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention discloses a radix astragali, rhizoma polygonati and ligustrum lucidum ait traditional Chinese medicine preparation for treating myelosuppression as well as a preparation method and a detection method thereof. The preparation is prepared from 50-150 parts of radix astragali, 50-150 parts of wine-processed rhizoma polygonati, 25-75 parts of wine-processed ligustrum lucidum ait, 50-150 parts of blanched rhizoma drynariae, 50-150 parts of radix trichosanthis and 25-75 parts of herba epimedii. The optimal extraction process and refining process are screened out based on effective components and pharmacological activity through a large number of tests, and the optimal preparation process of the Shuanghuangliangwhitening oral liquid and other traditional Chinese medicine preparations is obtained through stability investigation and verification. According to the invention, a thin layer chromatography is adopted, the four medicinal materials of astragalus membranaceus, glossy privet fruit, rhizoma drynariae and herba epimedii are respectively subjected to thin layer chromatography research, and methodology research shows that the method is stable and feasible. The invention establishes a content determination method for astragaloside, calycosin-7-glucoside, specnuezhenide and icariin, establishes a quality standard, and has important significance for ensuring the clinical curative effect and safety of astragaloside, calycosin-7-glucoside, specnuezhenide and icariin.

The invention provides a fingerprint spectrum and multi-component content determination method of a calamus-far nerve calming mixture, and relates to the field of quality control of traditional Chinese medicines. 31 common peaks are calibrated by establishing a fingerprint spectrum, and 24 common peaks can clearly belong to polygala tenuifolia. Meanwhile, synchronous content determination of seven components including chlorogenic acid, caffeic acid, ferulic acid, liquiritin, 2, 3, 5, 4 '-tetrahydroxy stilbene-2-O-beta-D-glucoside, 3, 6'-dimustard acyl sucrose and rosmarinic acid is realized. The method is good in precision, high in repeatability and stable and reliable in result, the medicine quality can be comprehensively and accurately reflected and controlled, and powerful support is provided for guaranteeing the safety and effectiveness of the calamus-far Ningmind mixture.

The invention relates to the technical field of biology, in particular to a phloretin-O-monoglucoside glycosyl transferase protein DoUGT019 in dendrobium officinale as well as an encoding gene and application thereof, and discloses a phloretin-O-monoglucoside glycosyl transferase protein with an amino acid sequence as shown in SEQ ID NO: 1, which can be used for preparing a glycosyl transferase protein with an amino acid sequence as shown in SEQ ID NO: 1 in the presence of a UDP-glucose donor. The method has the advantages that the method is simple and convenient to operate and can catalyze O-glycosylation of phloretin A ring 2 '-OH, 4'-OH and B ring 4-OH, three high-value monoglucosides, namely phlorizin, trilobatin and phloretin-4-O-glucoside, are synchronously generated, multi-product synthesis can be realized without synergy of various enzymes, the process is greatly simplified, and the use cost of enzyme preparations is reduced. Meanwhile, discovery of the protein reveals a unique phloretin glycosylation metabolic pathway of dendrobium plants, and a cloning and functional verification system of the protein can also be used as a general technical template for research of similar glycosyltransferase to promote technical iteration and theoretical development in the field of glycosylation biosynthesis.

The application discloses a chemical synthesis method of hydroxytyrosol glucoside. The method uses hydroxytyrosol as a starting material, and acetyl protection, glycosylation, hydrolysis and other steps are performed to prepare the hydroxytyrosol glucoside. The synthesis method of the hydroxytyrosol glucoside has the characteristics of low cost, simple process and industrialization.

The invention provides application of linariin-6-O-glucoside in preparation of a product for preventing and treating osteoporosis, and relates to the field of biological medicine. According to the invention, dyeing experiments of alkaline phosphatase, alizarin red and tartaric acid resistant acid phosphatase prove that the sesaminin-6-O-glucoside has affinity for FPPS receptors, has the capability of promoting bone marrow mesenchymal stem cells to form bone cells, is superior to that of bisphosphate, and can inhibit the generation of osteoclasts; microCT (micro computed tomography) detection results show that the sesaminin-6-O-glucoside has the effect of relieving the osteoporosis and can promote the formation of bone trabecula. According to the application disclosed by the invention, it is proved for the first time that the sesaminin-6-O-glucoside has the effect of resisting osteoclast formation, and meanwhile, the sesaminin-6-O-glucoside also has a better osteogenesis effect, so that a basis is provided for developing the sesaminin-6-O-glucoside as a potential medicine for treating osteoporosis.

Surfactant and cleaning compositions for cleaning of food and beverage processing equipment and milking systems. The surfactant composition includes a hydrocarbon surfactant selected from alkyl glucosides, alkyl poly glucosides and amphoteric-based sultaine surfactants, or combinations thereof, and a fluorosurfactant.

The invention belongs to the technical field of biomedicine, and relates to a novel application of 3-O-methyl chrysotoxin, in particular to an application of 3-O-methyl chrysotoxin in preparation of a medicine for treating xerophthalmia. The core of the 3-O-methyl chrysotoxin disclosed by the invention is that the 3-O-methyl chrysotoxin effectively relieves corneal epithelial cell injury induced by hyperosmosis and inhibits oxidative stress and proinflammatory factor release by activating an EGFR (Epidermal Growth Factor Receptor) signal channel. In-vitro and in-vivo experiments prove that the composition can remarkably enhance cell activity, reduce apoptosis and active oxygen accumulation and repair the steady state of a tear film. The compound is applied to preparation of xerophthalmia drugs and has important clinical value.

The invention belongs to the technical field of biological medicines, and provides a method for synthesizing testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside through two-step enzymatic coupling. Mainly relates to an intermediate compound testosterone 17-O-beta-D-glucosyl-(1-> 4)-beta-D-glucoside for synthesizing the molecule, mutant amino acid and nucleotide sequences of glycosyl transferase OsSGT2 for synthesizing the intermediate, and synthesis application. In addition, the invention also provides an application of the testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside in liver protection.

The invention relates to the technical field of artificial design of enzymes, in particular to an artificial intelligence design and expression system construction method and system for lysosomal membrane protein type N-acetyltransferase with 11 transmembrane regions, and the method comprises the following steps: collecting reaction rate information of an enzyme and a substrate, associating a structure model with rate parameters, and comparing three-dimensional difference of residues, according to the method, by collecting the reaction rate correlation structure conformation, dynamic recognition of the key conformation state is achieved, the accuracy of three-dimensional space difference analysis is improved, host expression optimization factors are fused in the construction process, and the construction efficiency is improved. According to the method, the expression efficiency is improved, conformation function screening and structural stability parallel evaluation are carried out, the screening accuracy of efficient catalysis and stable expression is enhanced, three links of recognition, screening and construction are broken through, the target enzyme obtaining efficiency and expression quality are improved, and enzyme engineering is promoted to be developed towards high-throughput systematization.

The invention relates to the cosmetic and non-therapeutic use of a composition consisting essentially of a compound of formula I below: (I) or its enantiomers, isomers or diastereoisomers, or a mixture thereof, or a salt or a solvate thereof, wherein R1 and R2, independently of each other, are a C3-C6 sugar, a uronic acid, or a glucoside, for bleaching or whitening the skin and skin appendages of a healthy individual.

The application discloses a high-efficiency absorption whitening and freckle-removing skin care product and a preparation process thereof, and belongs to the technical field of cosmetics. The high-efficiency absorption whitening and freckle-removing skin care product contains the following components in terms of weight parts: 0.1-5 parts of a whitening compound (I), 5-10 parts of cocoyl glucoside, 0.5-1 part of menthol, 5-10 parts of phospholipid, 0.5-1 part of EDTA, 0.1-1 part of hyaluronic acid and 150-200 parts of deionized water. The whitening and freckle-removing skin care product has good antioxidant and tyrosinase enzyme activity inhibiting effects, and can realize the effects of whitening and freckle removal.

The invention provides immobilized cyclodextrin glucosyltransferase as well as a preparation method and application thereof and a preparation method of ascorbic acid glucoside, and belongs to the technical field of enzymes, the technical field of biological catalysis and the technical field of preparation of chemical raw material medicines. The preparation method of the immobilized cyclodextrin glucosyltransferase comprises the following steps: activating a carrier; mixing the activated carrier with a solution containing cyclodextrin glucosyltransferase, stirring, carrying out solid-liquid separation, and washing to obtain an immobilized enzyme; and mixing the obtained immobilized enzyme with a polyethylene glycol-polyethyleneimine copolymer solution, stirring, carrying out solid-liquid separation, and washing to obtain the immobilized cyclodextrin glucosyltransferase. The immobilized cyclodextrin glucosyltransferase prepared by the preparation method is high in catalytic activity and good in use stability, and when the immobilized cyclodextrin glucosyltransferase is applied to catalytic synthesis of ascorbic acid glucoside, high-content and high-yield ascorbic acid glucoside can be obtained.

The invention discloses an antioxidant composition based on pH response type microcapsules as well as a preparation method and application of the antioxidant composition. Wherein the antioxidant composition contains ferulic acid, L-ascorbic acid-2-glucoside and tocopheryl acetate, and the mass ratio of the ferulic acid to the L-ascorbic acid-2-glucoside to the tocopheryl acetate is 1 to (3 to 5) to (5 to 10). A composition of ferulic acid, L-ascorbic acid-2-glucoside and tocopheryl acetate in a specific ratio is used as a core material, and a chitosan-sodium alginate compound is used as a wall material. The microcapsule can effectively protect the stability of antioxidant active ingredients in the storage period, and can specifically respond to a weak acidic pH environment of skin to release active matters so as to realize intelligent delivery. Components of the core material have a synergistic anti-oxidation effect, so that the final effect of the product is remarkably improved. The cosmetic composition containing the microcapsules has the advantages of being high in stability, remarkable in effect, good in skin feeling and the like.

The present invention relates to compositions and methods for manufacturing an adjuvant comprising an aminoalkyl glucosaminide phosphate compound or glucopyranosyl lipid adjuvant using a microfluidic device and to related aspects.

The application belongs to the technical field of daily chemicals, and particularly relates to an alkyl glucoside derivative and a preparation method thereof. The alkyl glucoside derivative provided by the application is prepared by chemically modifying the activity of a hydroxyl group on a glucoside sugar unit, specifically by first cross-linking through a cross-linking agent and then introducing an anionic sulfonic acid group. The alkyl glucoside derivative modified by sulfonation in the application has a significantly increased molecular weight, can not only reduce the transdermal penetration rate and the residual amount of a surfactant on the skin, but also help to form larger micelles, reduce the irritability of the surfactant to the skin, has higher mildness, and is suitable for formulating products with higher mildness requirements. In addition, the preparation method of the alkyl glucoside derivative provided by the application also has the advantages of high yield (the yield is more than 93%), simple operation, and high repeatability, and is conducive to the popularization and application of the alkyl glucoside derivative preparation process.

The invention discloses a telmisartan glucoside derivative, a microbial conversion preparation method thereof and application of the telmisartan glucoside derivative in preparation of a medicine for preventing or treating osteoporosis. The telmisartan glucoside derivative is characterized in that a telmisartan propyl side chain is connected with a glucosyl group. According to the invention, a microbial conversion technology is utilized, telmisartan is taken as a substrate, and glucosyl is introduced into a telmisartan propyl side chain in a regioselective manner, so that the telmisartan glucoside derivative with a novel structure is obtained. Experiments on the osteoblast proliferation promoting activity and the postmenopausal osteoporosis resisting effect of the telmisartan glucoside derivative by using an in-vitro osteoblast model and an ovariectomized induced osteoporosis mouse model prove that the telmisartan glucoside derivative has relatively good osteoblast proliferation promoting activity and postmenopausal osteoporosis resisting activity; the compound can be used as an active component of a medicine for treating osteoporosis, and has wide application.

The application belongs to the technical field of medicine production, and particularly relates to a preparation method and application of five deuterium-substituted glucose. The method comprises deuterium substitution of D-methyl glucoside, and demethylation of the deuterium-substituted D-methyl glucoside to obtain a target product, namely [2,3,4,6,6'-d5]-D-glucose. The preparation method of the five deuterium-substituted glucose is simple in process route, convenient to operate, mild in experimental conditions, and the synthesized five deuterium-substituted glucose is successfully applied to the description of glycolysis metabolism in a brain glioma model, which is helpful to the clinical conversion application of metabolic imaging technology.

The present application provides a kind of microalgae source glycerol glucoside preparation and its preparation method and application, belong to medical technical field.The crude extract solution is obtained by low-osmotic extraction liquid extraction to salt stress algal mud, impurity is removed by filtration, and phycocyanin concentrated solution and glycerol glucoside containing permeate are obtained by membrane filtration separation, glycerol glucoside containing permeate is concentrated, bleaching and desalting, drying, and microalgae source glycerol glucoside is prepared, is mixed uniformly with gypenoside and bisabolol, and the mixture is prepared, after being embedded with oleic acid modified cholesterol and phospholipid to prepare modified liposome, mixed with chitosan solution and reacted, centrifuged, and the supernatant is discarded, and the solid is washed and dried to prepare microalgae source glycerol glucoside preparation.The present application realizes the technical effects of microalgae resource green low-carbon high-value utilization, product efficient purification, multi-target point synergistic anti-inflammatory and high transdermal absorption retention, and provides a kind of safe and effective, long-term use natural source new choice for treating atopic dermatitis externally.

The invention relates to a method for extracting roselle anthocyanin through enzymolysis-ultrasonic assistance, a product and application of the product. The method comprises the following steps: degreasing roselle powder, and performing enzymolysis for 24 hours by using cellulase and pectinase (20U / g respectively) under the conditions that the pH is 5.0 and the temperature is 40 DEG C; an acetone-hydrochloric acid mixed solution (the volume fraction of hydrochloric acid is 36%) with the liquid-material ratio being 10: 1 serves as an extracting agent, and ultrasonic extraction is conducted for 34 minutes at the temperature of 58 DEG C and the power of 160 W; and finally, centrifuging, extracting with ethyl acetate, and purifying to obtain an anthocyanin product. According to the method, the extraction rate reaches 3.087 mg / g, the main component of the product is cyanidin-3-glucoside, the antioxidant and antibacterial activity is remarkable, the scavenging rates of DPPH, ABTS and hydroxyl radicals are 86.26%, 81.34% and 93.75% respectively under the concentration of 3.0 mg / mL, and the scavenging rates are superior to those of vitamin C with the same concentration; under the concentration of 11mg / mL, the compound has an obvious inhibition effect on escherichia coli and staphylococcus aureus. The process is efficient and mild, the product activity is excellent, and the method is suitable for development and application of natural antioxidants and antibacterial agents.

This primary battery comprises a positive electrode containing 2,5-dimethoxy-1,4-benzoquinone, a negative electrode, and an electrolyte disposed between the positive electrode and the negative electrode. The electrolyte contains a C18-22 alkyl glucoside.

The invention relates to the technical field of biological detection, and discloses a reagent and a kit for treating a biological sample and application of the reagent and the kit. The reagent comprises a buffer solution and a nonionic surfactant, wherein the nonionic surfactant is prepared from ethyl phenyl polyethylene glycol and decyl glucoside. When the reagent provided by the invention is used for treating a biological sample, especially a biological sample with relatively high impurity content, the adverse effect of impurities on the adsorption of pathogens by magnetic beads can be effectively reduced.

The invention belongs to the technical field of agricultural product production, and particularly relates to an astragalus membranaceus planting method based on farmyard manure. The planting method comprises the following steps: S1, soil improvement; s2, seed selection and seedling raising; s3, transplanting the seedlings; s4, field management; s5, harvesting and processing. The soil is directionally improved by applying fermented farmyard manure per mu, and the organic planting of astragalus membranaceus is realized in cooperation with standardized planting, management and processing flows. Astragalus mongholicus planted through the method is free of pesticide residues, the content of effective components such as astragaloside and calycosin-7-glucoside far exceeds the national standard, the extract content is remarkably higher than that of common astragalus mongholicus, the soil quality is continuously optimized, the yield is stable, the problems that in traditional astragalus mongholicus planting, pesticide residues exceed the standard, soil is hardened, effective components are insufficient, and the yield is low are solved, and the method is suitable for large-scale popularization and application. The method is suitable for large-scale popularization and application.

The present application relates to a kind of anti-aging composition for promoting intercellular communication of skin cell and its application, the composition includes the following components: camellia japonica flower extract, bacillus fermentation product, european linden extract and safflower glucoside, the weight ratio of the camellia japonica flower extract, bacillus fermentation product, european linden extract and safflower glucoside is (1-10):(1-8):(1-6):(0.1-1).The anti-aging composition of the present application can promote the activity of skin communication cell, strengthen intercellular communication and interaction, fully exert the function of cell biology, achieve the effect of anti-aging;And inhibit the damage of cortisol to skin barrier, achieve the effect of repair and emotional stress relief, synergistic effect between components, can achieve the best wrinkle, firming, smoothing and repair effect.

The invention discloses a moisturizing and repairing type hand sanitizer, and relates to the technical field of daily chemical products. The moisturizing and repairing type hand sanitizer is prepared from the following components in percentage by mass: 11 to 15 percent of a surfactant, 0.6 to 1.0 percent of an antibacterial composition, 4.1 to 5.7 percent of a moisturizing and skin moistening composition and 0.25 to 0.5 percent of an auxiliary agent, the surfactant is prepared from a plurality of materials selected from coco-glucoside, decyl glucoside and potassium cocoyl glutamate; the antibacterial composition is prepared from multiple of tea tree essential oil, polylysine hydrochloride and chitosan; the moisturizing and skin moistening composition is prepared from multiple of panthenol, shea butter, sodium hyaluronate and a honeysuckle flower extract; the auxiliary agent comprises xanthan gum and / or citric acid. The moisturizing and repairing type hand sanitizer provided by the invention realizes multiple advantages of naturalness, mildness, skin care, health and the like through a compound design of multiple systems of surface activity, antibiosis, moisturizing and skin moistening and the like.

The invention belongs to the technical field of preparation of isomaltooligosacharide, and particularly relates to a high-panose material as well as a preparation method and application thereof. According to the catalytic characteristics of the glucoside transferase, raw materials with specific components are selected, and product guidance is realized by controlling the reaction process. When the maltose content in the raw materials is higher (more than or equal to 80%), the reaction preferentially generates the panose, and meanwhile, the generation of other components such as isomaltose or pantetraose is inhibited, so that the high-purity panose is obtained, the utilization rate of the raw materials is continuously improved, and the reaction time is shortened. In addition, the preparation method provided by the invention overcomes the problems of wide component distribution, low water activity and easy moisture absorption of the isomaltooligosacharide.

The application belongs to the technical field of daily chemicals, and particularly relates to a high-temperature and mild alkyl glucoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the application is obtained by using the hydroxyl activity on the glucose unit of glucoside to perform chemical modification, and specifically, the alkyl glucoside is first subjected to intramolecular cross-linking by using 1,3-dichloro-2-propanol, and then subjected to anionization modification by using 3-chloro-2-hydroxypropanesulfonate sodium. The alkyl glucoside sulfonate prepared by the application has the advantages of mildness, low irritation, strong hard water resistance, good foaming performance, low skin penetration and small residual amount, can effectively solve the defects of strong penetration, strong deproteinization and delipidation, great damage to skin barrier and weak thickening effect of alkyl glucoside in personal cleaning products, and is very suitable for being widely used and popularized in daily chemicals.

The invention discloses a water-soluble luteoloside derivative obtained by fermenting a probiotic composition as well as a preparation method and application of the water-soluble luteoloside derivative. The water-soluble luteoloside derivative is luteolin-3 '-alpha-7-beta-di-O-D-glucoside. The luteolin-3 '-alpha-7-beta-di-O-D-glucoside has the advantage that the luteolin-3'-alpha-7-beta-di-O-D-glucoside has

The invention belongs to the technical field of food attractants, and particularly relates to a dichocrocis punctiferalis food attractant. The invention relates to a food attractant. The food attractant is prepared from alpha-pinene oxide, methyl glucoside caprylate and leaf acetate according to the mass ratio of 1: (1-3): (1-5). According to the food attractant for dichocrocis punctiferalis disclosed by the invention, the specific components alpha-pinene oxide, methyl glucoside caprylate and leaf acetate are combined and proportioned, and the alpha-pinene oxide, the methyl glucoside caprylate and the leaf acetate respectively play roles in three links of smell attraction, nutritional requirements and host recognition, and are mutually promoted and complemented and synergistic, so that the attraction, attraction and gathering effects of the food attractant on dichocrocis punctiferalis adults are improved; the trapping and killing effect can be greatly optimized, powerful support is provided for green and efficient prevention and control of dichocrocis punctiferalis, agricultural production loss can be reduced, and the quality of agricultural products and agricultural ecological safety are guaranteed.

The invention relates to the field of cosmetics, in particular to a vegetable wax sunscreen synergistic composition which is composed of vegetable wax and an emulsifier. The mass ratio of the vegetable wax to the emulsifier is (0.1-1.5): (0.1-2.9); the vegetable wax is one or a combination of two of candelilla wax and synthetic candelilla wax; the emulsifying agent is one or a combination of more of stearyl alcohol polyether-21, C12-20 alkyl glucoside and PEG (Polyethylene Glycol)-100 stearate; according to the plant wax sunscreen synergistic composition provided by the invention, the specific plant wax and the emulsifier are compounded, and the synergistic effect between the plant wax and the emulsifier is utilized, so that the plant wax sunscreen synergistic composition is applied to a sunscreen product, and the sunscreen effect of the sunscreen product can be effectively improved; meanwhile, the invention further discloses application of the plant wax sunscreen synergistic composition and cosmetics containing the plant wax sunscreen synergistic composition.