484 results about "Skin elasticity" patented technology

The invention belongs to the technical field of cosmetics, and discloses anti-aging recombinant collagen as well as a preparation method and application thereof. The amino acid sequence of the anti-aging recombinant collagen is as shown in SEQ ID NO.1, and the nucleotide sequence of the anti-aging recombinant collagen is as shown in SEQ ID NO.2. The recombinant collagen CaI1 is constructed and expressed by recombining the effective sequences of the I-type collagen, the III-type collagen and the XVII-type collagen, and the recombinant collagen CaI1 is free of cytotoxicity, free of hidden danger of endotoxin and good in safety. The skin care product added with the recombinant collagen CaI1 can promote skin collagen absorption, inhibit skin aging and improve skin elasticity, and has a good application prospect.

The invention discloses a scalp essence capable of controlling oil and removing dandruff and a preparation method thereof, and provides the scalp essence capable of controlling oil and removing dandruff. The formula consists of the following raw materials: water, saccharomycetes / rice fermentation product filtrate, butanediol, phenoxyethanol, caprylic acid / capric triglyceride, galactose yeast-like bacterium fermentation product filtrate, allantoin, a saccharomycetes / zinc fermentation product, nicotinamide, arginine, polysorbate-20, hydrogenated lecithin, acrylic acid (ester) / C10-30 and an alkanol acrylate cross-linked polymer. Hydrolyzed sodium hyaluronate and trace components. According to the oil-controlling and dandruff-removing scalp essence disclosed by the invention, through the synergistic interaction among the raw materials, the effects of replenishing water, preserving moisture, controlling oil and removing dandruff are increased, the effects of relieving, recovering oil-water balance, recovering skin elasticity and delaying senescence are also achieved, the effects of preventing hair loss and nourishing hair are also achieved, and meanwhile, the oil-controlling and dandruff-removing scalp essence has the advantage of being stable in storage.

The invention relates to the field of protein cosmetics, in particular to human albumin anti-aging essence and a preparation method thereof. The human albumin anti-aging essence is prepared from the following components in parts by mass: 20 to 45 parts of human albumin; 5-15 parts of a red ginseng extract; 2.5-10 parts of a vitis amurensis seed extract; 1.5 to 5 parts of a blueberry peel extract; 20 to 40 parts of a humectant; 0.2 to 1.6 parts of a thickening agent; 0.01 to 0.1 part of an excipient; and the balance of deionized water. The human albumin anti-aging essence can be used for skin aging resistance, has the effects of resisting free radicals, increasing skin elasticity and the like, has good biocompatibility and effectiveness, and has important significance on skin aging resistance and skin improvement.

The invention discloses a recombinant XVII type collagen engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering, and the recombinant XVII type collagen engineering bacterium is realized through three steps of designing and optimizing collagen, improving translation through codon optimization and selecting a vector for cloning. By optimizing the amino acid sequence and the codon, the expression efficiency and the stability of the recombinant XVII type collagen in engineering bacteria are improved. The optimization not only improves the production efficiency of the protein, but also reduces the production cost. The recombinant XVII type collagen has potential in the medical field, especially in the fields of skin repair, wound healing, aging resistance and the like. Meanwhile, in the fields of beauty and biological materials, collagen is widely applied to products such as masks and skin care products as a basic component, and can promote skin cell regeneration and enhance skin elasticity and repair capacity.

In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface. Improving the appearance of the skin surface can be at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and / or preventing acne, reducing a blemish, reducing an appearance of spider veins and / or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.

The invention relates to the technical field of biological medicine, in particular to recombinant III-type humanized collagen as well as a preparation method and application thereof. In one embodiment, the recombinant III type humanized collagen prepared by the invention has an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 4. The recombinant III-type humanized collagen prepared by the invention has good biological activity, can promote collagen synthesis related gene expression, promote skin fibroblast proliferation, increase the content of skin collagenous fibers and elastic fibers, and improve skin elasticity and compactness; in addition, the expression of osteogenesis related genes is promoted, and the proliferation of osteoblasts is promoted. The results show that the recombinant III-type humanized collagen prepared by the invention has an extremely wide application prospect in developing related medical and cosmetic products for delaying skin aging and promoting wound repair and bone tissue healing.

The invention belongs to the technical field of cosmetics, and discloses a wrinkle-removing and anti-aging composition containing recombinant collagen as well as a preparation method and application of the wrinkle-removing and anti-aging composition. The composition is prepared from the following components: 20.4 to 35.6 percent of glycerol, 1.1 to 3.5 percent of 1, 2-hexanediol, 8.2 to 15.4 percent of apple fruit cell culture extract, 1.6 to 3.2 percent of inositol, 0.2 to 1.0 percent of elastin, 0.1 to 1.7 percent of hydroxyproline, 0.1 to 1.0 percent of sodium polyglutamate, 0.1 to 1.0 percent of sodium hyaluronate, 0.01 to 0.1 percent of acetyl hexapeptide-8, 0.01 to 0.1 percent of fibronectin, 1.72 to 3.21 percent of soluble collagen and the balance of deionized water. The amino acid sequence of the soluble collagen is as shown in SEQ ID NO. 1. The skin care product prepared by adding the anti-wrinkle and anti-aging composition is good in safety and has the effects of resisting wrinkles, improving skin elasticity and resisting aging.

The invention provides an anti-wrinkle combined cyclic peptide and application thereof in cosmetics, the anti-wrinkle combined cyclic peptide comprises cyclic pentapeptide-4, cyclic tripeptide-5 and cyclic hexapeptide-9, the combined cyclic peptide has a remarkable synergistic effect in the aspects of promoting expression of collagen genes Collagen I, Collagen III and Collagen IV and inhibiting acetylcholine secretion, the skin elasticity and glossiness are remarkably improved, and the anti-wrinkle combined cyclic peptide has a good anti-wrinkle effect. The generation of wrinkles is inhibited, and good anti-aging and wrinkle-removing effects are achieved.

The invention provides a hydrolyzed extracellular matrix and a preparation method and application thereof, and relates to the technical field of biological materials.The hydrolyzed extracellular matrix prepared through the method comprises hydrolyzed collagen, hydrolyzed elastin, hydrolyzed fibronectin and hydrolyzed laminin, in the hydrolyzed extracellular matrix, the number of polypeptide molecules with the molecular weight of 500-3000 Daltons accounts for not less than 96%, a good transdermal absorption effect can be achieved, and the hydrolyzed extracellular matrix has a good effect of promoting cell growth and proliferation and also has good functions of resisting wrinkles and enhancing skin elasticity.

The invention relates to a composition with anti-wrinkle and firming effects and application thereof. The composition is prepared from a brassica juncea leaf extract, a swertia indica extract, a kangaroo claw extract, a tomato fruit extract and polydeoxyribonucleotide. According to the invention, it is creatively found that the Brachirita leaf extract, the swertia indica extract, the kangaroo claw extract, the tomato fruit extract and the polydeoxyribonucleotide have a synergistic effect in the aspects of improving wrinkle resistance and tightening of skin. The composition can significantly reduce the ratio of crow's feet and nasolabial folds, improves the skin elasticity, and has excellent anti-wrinkle and firming effects.

The present invention relates to a preparation method of a collagen filler for injection. Non-crosslinked collagen, crosslinked collagen, and biodegradable polymer microspheres are compounded and mixed in a certain proportion to achieve an immediate filling effect. The biodegradable polymer microspheres play a long-term role, and the amino acid components degraded from collagen in the early and middle stages can become nutrients that stimulate the production of collagen regeneration by polyester microspheres. In the present invention, the crosslinked collagen has a high yield and less water loss through a gradient irradiation crosslinking technique. The non-crosslinked collagen gel can provide a microenvironment for nutritional repair and a filling effect in the early stage, the crosslinked extracellular matrix can provide a repair microenvironment in the middle stage of filling, and the degradation of polyester microspheres in the later stage promotes collagen regeneration, enabling the skin to have a good microenvironment throughout the repair cycle and increasing skin elasticity.

The invention belongs to the technical field of cosmetics, and discloses skin-tightening and anti-wrinkle essence. The skin-tightening anti-wrinkle essence is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of acetyl hexapeptide-8, 2.0 to 3.0 percent of palmitoyl pentapeptide-4, 3.0 percent of hydroxypropyl tetrahydropyrantriol, 2.0 percent of lipidosome-coated vitamin C ethyl ether, 0.5 percent of resveratrol PLGA microspheres, 0.8 percent of ceramide NP, 1.2 percent of pachymaran, 5.0 percent of glyceryl polyether-26, 0.3 percent of sodium hyaluronate, 0.5 percent of p-hydroxyacetophenone and 1, 3-propanediol, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate and the balance of water. The 1, 2-hexanediol accounts for 0.6%, and the balance is deionized water. Multi-target anti-wrinkle, deep moisturizing and long-acting repairing are achieved by scientifically compounding active ingredients such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 and combining a lipidosome wrapping technology and a nano-microsphere slow release technology, the preparation process comprises the steps of lipidosome homogenization, nano-microsphere multiple emulsion method and low-temperature emulsification, the ingredient stability and transdermal efficiency are ensured, and the skin care effect is good. Experiments prove that the essence can significantly improve skin elasticity and reduce wrinkles, and has a significant anti-aging effect.

The invention provides a composition containing elastin peptide as well as a preparation method and application thereof, and relates to the technical field of food. The composition containing the elastin peptide is prepared from the following components in parts by weight: 5 to 10 parts of fish collagen peptide, 3 to 10 parts of tremella polysaccharide, 0.1 to 0.5 part of elastin peptide, 0.01 to 0.1 part of skipjack elastin peptide, 1 to 2 parts of hydrolyzed II-type collagen, 0.01 to 0.05 part of vitamin C, 1 to 5 parts of pomegranate concentrated powder, 1 to 5 parts of cranberry concentrated powder, 5 to 15 parts of lily powder and 1 to 3 parts of blueberry juice powder. The composition containing the elastin peptide is high in safety, and meanwhile, the effects of improving skin elasticity, improving skin moisture, delaying generation of wrinkles and resisting aging are achieved by remodeling internal skin tissues, increasing skin moisture, improving oxidation resistance and the like.

The invention relates to the technical field of foods and medicines, and discloses a composition of medicinal and edible food extracts for treating insomnia, which comprises the following components in percentage by weight: 8.92%-9.9% of gamma-aminobutyric acid (GABA), 2.97%-3.96% of phosphatidylserine, 29.7%-39.64% of spina date seed extract, 29.7%-39.64% of poria cocos extract, 0.59%-0.79% of tea leaf theanine extract and 5.95%-6.94% of fish collagen peptide. The mask comprises the following components in percentage by weight: 5.95%-6.94% of honey, 0.59%-0.79% of collagen tripeptide, 0.59%-0.79% of sodium hyaluronate, 0.59%-0.79% of rice bran oil powder, 0.59%-0.79% of haematococcus pluvialis, 0.59%-0.79% of acerola cherry extract, 0.01% of nicotinamide and 0.59%-0.79% of grape seed extract. The composition for treating insomnia based on the concept of homology of medicine and food not only overcomes the limitation of the existing therapy, but also has higher safety, wide adaptability and good user acceptability, and has positive significance for improving the life quality of insomnia people, improving the overall health level and improving the skin elasticity and luster.

The present invention relates to the fields of medicine and cosmetology, and discloses a cell active peptide composition that promotes the regeneration of multi-type collagen structural proteins, its preparation method, and its application in medicine and cosmetology. The composition uses raw materials such as tripeptide-10 citrulline, hexapeptide-9, hydrolyzed sodium hyaluronate, γ-aminobutyric acid, decarboxylated carnosine hydrochloride, acetyl tetrapeptide-3, acetyl tetrapeptide-11, palmitoyl dipeptide-7, and palmitoyl pentapeptide-4. The composition can promote the coordinated expression of skin type I, type III, type IV, type VII, type XVII collagen, fibronectin, elastin, and glycosaminoglycans; prevent collagen cross-linking, maintain triple helix structure, and inhibit collagen degradation. Applied to dermatology and cosmetology, it can accelerate the regeneration of structural proteins such as skin collagen, repair skin damage, reduce wrinkles such as crow's feet, tear groove lines, nasolabial folds, and under-eye lines, solve the skin aging problem caused by the loss of structural proteins such as collagen, and improve skin elasticity and firmness.

The invention provides a ginseng exosome anti-aging and anti-oxidation composition and a preparation method thereof, and relates to the field of nursing materials, the ginseng exosome anti-aging and anti-oxidation composition comprises Exo nano-vesicles, procyanidine and cationic liposome, the Exo nano-vesicles are derived from ginseng extracellular fluid, the procyanidine is derived from the cationic liposome, and the cationic liposome is derived from the procyanidine. The ginseng exosome anti-aging and anti-oxidation composition provided by the invention can effectively improve skin wrinkles, enhance skin elasticity, promote collagen synthesis, inhibit collagen degradation and inhibit elastin degradation through the combined action of the Exo nano-vesicles, Pro and cationic lipidosome; degradation of elastin can cause skin to lose resilience, formation of wrinkles is accelerated, and facial skin can be effectively improved and wrinkles can be reduced by promoting synthesis of collagen and inhibiting degradation of elastin.

The invention relates to the technical field of cosmetics, in particular to an inula flower extract, a preparation method thereof and a cosmetic composition. The invention relates to an inula flower extract for reducing skin texture (smoothing skin), resisting wrinkles, enriching apple muscle, lifting mandibular line, reducing pore depth and improving skin elasticity, the extract comprises an aqueous extract of inula flower and / or an organic solvent extract, and the volume fraction of the organic solvent is 0.01%-100%. The inula flower extract disclosed by the invention is rich in phenolic acid, flavone, polysaccharide and sesquiterpenoids, and has the effects of reducing the skin texture degree (smoothing the skin), resisting wrinkles, enriching apple muscles, lifting the mandibular line, reducing the pore depth and improving the skin elasticity.

The invention discloses application of a glucosyl modified quercetin derivative and a composition containing the glucosyl modified quercetin derivative. Specifically, the invention discloses an application of glucosyl modified quercetin as an anti-skin photoaging agent. According to the application disclosed by the invention, glucosyl modified quercetin, especially glucosyl modified isoquercitrin, has a remarkable effect in the aspect of resisting skin photoaging; cosmetics prepared from glucosyl modified quercetin have good anti-aging ability, and can significantly improve percutaneous water loss, skin elasticity and skin roughness.

The invention discloses an anti-aging composition and a preparation method thereof, and belongs to the technical field of cosmetics, the anti-aging composition provided by the invention is prepared from the following components in parts by mass: 0.001-0.01 part of freeze-dried powder of secretin of porcine umbilical cord mesenchymal stem cells, 15-20 parts of argania spinosa leaf extract, 10-13 parts of eucheuma gelatinae extract and 1-3 parts of northeast stichopus japonicus adventitious root extract. The anti-aging composition provided by the invention has the effects of resisting aging and improving the migration rate of skin cells, and the whole anti-aging composition is mild and non-irritant; when the anti-aging composition is applied to cosmetics, the anti-aging composition can effectively resist aging, lighten wrinkles, improve skin elasticity and increase the water content of cuticles. In addition, the composition provided by the invention is natural in component source, simple in preparation method and suitable for actual production.

The invention discloses a skin anti-wrinkle whitening composition containing ginkgetin and a preparation method of the skin anti-wrinkle whitening composition. The composition takes ginkgo biflavone as a main active component, has the characteristics of safety and effectiveness, can remarkably improve skin elasticity and reduce wrinkles, and has the effect of whitening skin.

The present invention provides an anti-wrinkle and firming composition containing collagen and its application in cosmetics, the composition comprises the following components in parts by weight: 20-40 parts by weight of posiin, 0.5-2.5 parts by weight of pterostilbene, 0.5-2.5 parts by weight of soluble collagen, 0.5-2.5 parts by weight of ergothioneine, 0.02-0.1 parts by weight of palmitoyl tripeptide-5 and an appropriate amount of solvent component. After posiin, pterostilbene, soluble collagen, ergothioneine and palmitoyl tripeptide-5 are matched and coordinated with each other, a very thin film layer can be formed on the surface of the skin, thereby making the skin plump and wrinkles stretched, achieving control of sebaceous gland secretion to reduce oil discharge, locking collagen, and keeping the skin fresh, and finally improving the elasticity of the skin and reducing skin wrinkles.

The invention relates to an anti-aging composition for strengthening a skin supporting network and application thereof, and the anti-aging composition comprises the following components: a golden camellia flower extract, a saffron crocus extract, camellia seed oil, tranexamic acid and epigallocatechin gallate glucoside, the weight ratio of the golden camellia flower extract to the saffron crocus extract to the camellia seed oil to the tranexamic acid to the epigallocatechin gallate glucoside is (0.1 to 5) to (0.01 to 5) to (0.1 to 10) to (0.01 to 2) to (0.001 to 0.1). The composition provided by the invention can synergistically strengthen a skin support network and comprehensively improve skin elasticity and compactness by promoting growth of two core structural proteins and three macromolecular adhesives of skin, and is mild, non-irritant and suitable for people with sensitive skin.

The scar removing cream is prepared from the following raw materials in percentage by weight: 30 to 80 percent of silica gel component, 5 to 30 percent of solvent, 0.1 to 10 percent of emulsifying agent, 1 to 5 percent of thickening agent, 0.01 to 10 percent of extract / synergistic component, 0.1 to 20 percent of medicament component, 1 to 50 percent of moisturizing component, 0.01 to 0.1 percent of growth factor, 0.1 to 2 percent of other component, 0.01 to 0.5 percent of preservative and 0.1 to 2 percent of pH (Potential of Hydrogen) regulator. The traditional Chinese medicine composition has the effects of improving skin repair, whitening and diminishing inflammation, accelerates skin elasticity recovery and reduces scars.

The invention relates to the technical field of daily chemicals, in particular to a composition containing lucid ganoderma and application of the composition. The composition is prepared from honey, glycerol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl glycol, an angelica sinensis extract and a ganoderma sinensis extract. The composition provided by the invention contains a plurality of plant components, so that the skin state with oil outside and dry inside can be synergistically improved in a multi-effect manner; the composition can balance the homeostasis, improve fine wrinkles, enhance skin elasticity and reproduce full skin, has the effects of tightening, resisting wrinkles, moisturizing and the like, and can improve wrinkles, improve pachulosis and make the skin tight and tender.

The invention relates to an anti-aging composition and application thereof. The anti-aging composition is prepared from the following raw materials: dendrobium officinale, camellia japonica and polygonatum kingianum. Dendrobium officinale, camellia japonica and polygonatum kingianum cooperate with one another to achieve a synergistic effect, secretion of type I collagen (COL-1) can be promoted, secretion of matrix metalloproteinase-1 (MMP-1) can be inhibited, and decomposition of collagen in extracellular matrixes can be slowed down. The anti-aging composition can increase skin elasticity, improve the skin barrier function, reduce the percutaneous water loss rate and delay skin aging.

The invention provides a method and system for evaluating facial skin aging, and the method comprises the steps: obtaining visible light, ultraviolet reflection and near-infrared spectrum images through multispectral imaging, and extracting skin texture, color spots and capillary network parameters through preprocessing; constructing a three-dimensional facial skin model, and measuring skin elasticity parameters in combination with a mechanical sensor; and inputting the parameters into a deep learning aging evaluation model, outputting a comprehensive evaluation report containing the physiological age of the skin, the elasticity grade and the regional aging difference index, and providing personalized aging protection suggestions. According to the method, multi-modal data and a deep learning technology are fused, multi-dimensional quantitative evaluation is realized, the method has the characteristics of high precision, objectivity and individuation, a powerful tool is provided for skin health management, and the method has a wide application prospect.

The invention provides recombinant humanized elastin with an effect of improving endogenous skin aging and application of the recombinant humanized elastin, and belongs to the technical field of crossing of dermatology and biological materials. The recombinant humanized elastin is based on a human elastin core function sequence, recombinant optimization and efficient expression are carried out by adopting a synthetic biological strategy, and excellent stability and biological activity are shown. The recombinant humanized elastin can be used for constructing a skin repair dressing, and synergistically improves endogenous aging characteristics such as skin elasticity reduction, collagen loss and high oxidative stress by remodeling an extracellular matrix network structure. Animal experiments prove that a product based on the recombinant humanized elastin has good tissue repair capacity, biocompatibility and antioxidant activity, and can be widely applied to functional skin care products and medical cosmetic preparations.

The invention relates to a composition for promoting collagen generation based on sophora flower powder as well as a preparation method and application of the composition, and belongs to the technical field of sophora flower extracts. A preparation method of the sophora flower powder extract comprises the following steps: taking sophora flower powder, adding water, boiling, cooling, adding a carbon source and aspergillus oryzae CICC 2066, fermenting, sterilizing, filtering, concentrating and freeze-drying to obtain the sophora flower powder extract. The sophora flower powder extract can be applied to food, can also be applied to cosmetics, and can effectively promote the generation of collagen and improve the skin elasticity and tightening effect.

The invention discloses preparation and application of a whitening and repairing composition containing temperature-sensitive oxidized resveratrol hydrogel, and relates to the technical field of cosmetics. The composition comprises the following components in parts by weight: 1-5 parts of temperature-sensitive oxidized resveratrol hydrogel, 4-6 parts of a peucedanum praeruptorum dunn extract, 1-3 parts of a willowleaf swallowwort rhizome extract and 0.1-0.5 part of a tephrosia rubescens seed extract. The combination of the peucedanum praeruptorum dunn extract, the cynanchum wilfordii extract, the tephros glauca seed extract and the oxyresveratrol finds that the composition has a synergistic interaction effect, and the composition formed by the components through specific compatibility has the effects of whitening, repairing and improving skin elasticity. The oxidized resveratrol is wrapped by the temperature-sensitive hydrogel, so that the oxidized resveratrol is kept in a gel state at an epidermal cuticle layer, and after the oxidized resveratrol permeates into a skin basal layer, the oxidized resveratrol can be released at the skin basal layer, acts on melanocytes more effectively, inhibits tyrosinase and further affects generation of melanin.

The invention provides a skin care composition containing stem cell extract as well as a preparation method and application of the skin care composition, and belongs to the technical field of cosmetics. The method comprises the following steps: mixing and culturing the extracted urine-derived stem cells and pilose antler stem cells in a DMEM culture medium added with epidermal growth factors, cholera toxin, penicillin, streptomycin, transferrin, IL-2 and IL-15, then separating a culture solution to obtain mixed exosomes, mixed stem cells and extracellular matrixes, preparing the mixed stem cells into stem cell lipidosome, and preparing the stem cell lipidosome. Embedding the stem cell extract and the mixed exosome into titanium dioxide / silicon dioxide microspheres, adding into an extracellular matrix, and uniformly dispersing to obtain the skin care composition containing the stem cell extract. The skin care composition containing the stem cell extract prepared by the invention can obviously prolong the preservation period of stem cells and exosomes and improve the repair and improvement of the stem cells and the exosomes on skin, and the prepared composition has better effects of resisting aging, whitening, promoting skin elasticity, resisting wrinkles and the like, and has a wide application prospect.