38 results about "Quercetin derivatives" patented technology

The invention discloses quercetin or quercetin derivative and platinum complexes and salts thereof in the filed of medicines. The chemical structural formula of the complexes is the formula (I) or formula (II). The invention also discloses methods for preparing the complexes and the salts thereof and uses of the complexes and the salts thereof in the preparation of drugs for treating cancers.

The invention relates to bola type quercetin derivatives and a preparation method thereof. A bola type amphiphilic molecule is formed by connecting two polar head groups by using a hydrophobic chain; and unique natures such as better stability and compatibility in a plasma membrane are given to the bola type amphiphilic molecule through the special structure. The bola type quercetin derivatives shown as general formulas I-V are developed by utilizing bola type characteristics to increase the water solubility and the bioavailability of the derivatives; meanwhile, proved by research results, compared with non-bola type quercetin lipid derivatives, the bola type quercetin derivatives are capable of better inhibiting the growth activity of tumor cells; the bola type quercetin derivatives are transformed into nanometer drugs through micromolecule self-assembly on the basis of the structure to improve the physicochemical property of compounds; the ability of targeting focal tissues is enhanced and the damage of the drugs to normal tissues and cells is reduced; and R and n in the general formulas are defined as the claim.

The invention discloses a quercetin derivative and a preparation method thereof, and belongs to the field of pharmaceutical synthesis. The invention aims to solve the problems of poor water solubility and low bioavailability of quercetin in the prior art, and provides a quercetin derivative Derivatives, the fat solubility of the obtained quercetin derivatives is far better than that of quercetin, and the bioavailability is greatly improved, which can be used for treating cardiovascular and cerebrovascular diseases, anti-cancer and anti-cancer. Another object of the present invention is to provide a method for synthesizing the quercetin derivative, using quercetin to protect the hydroxyl group, then performing a substitution reaction and a hydrogenation reaction to prepare the quercetin derivative, and obtaining a high-purity quercetin derivative, The present invention chemically modifies natural quercetin, and through the substitution reaction at the 5-OH hydroxyl position, it is beneficial to improve its water solubility and fat solubility, and improve its bioavailability. The method has simple principle, high product yield, and high product yield. 37%‑57%, purity 96%‑98%, R f = 0.2 to 0.5.

The invention discloses application of a compound (QB) shown in a formula I in preparation of medicines for prevention and / or treatment. The MTT experiment displays that the proliferation inhibition effects of the compound QB on the four tumor cells, such as human esophageal squamous carcinoma cell EC109, the human esophageal squamous carcinoma cell EC9706, the human gastric carcinoma cell SGC7901 and mouse melanoma cell B16-F10, are obviously superior to those of quercetin. The inhibition effect of (IC50=5.201mu g / mL) on the EC109 cells is equivalent to that of fluorouracil 5-FU(IC50=5.426mu g / mL), the toxic or side effect is relatively small, and the compound is a potential antitumor candidate compound.

A method for treating cancer with a combination of a chemotherapy agent and a composition that includes a quercetin, vitamin B3, and vitamin C. The quercetin can be quercetin aglycon or a quercetin derivative, and the composition can also include folic acid.