168 results about "Pyrone" patented technology

The present invention provides the synthesis and application of a group of multiple stimulus-responsive aggregation-induced emission enhancement probes, belonging to the field of aggregation-induced emission materials. Through a simple three-step method, a D-π-A type molecular skeleton is constructed in the molecule, and a group of pyranone-type aggregation-induced emission enhancement probes are synthesized. This group of probes can undergo non-interfering changes in fluorescence color or intensity under multiple stimuli such as solvents, pressure, humidity, and pH. On the one hand, it makes up for the relatively single variety of AIE template molecules; on the other hand, it breaks through the technical barrier of single response of aggregation-induced emission probes, realizing the possibility that the same molecule can simultaneously respond non-interferingly to multiple external stimuli. The preparation method of this probe is simple, with high yield and sensitive and rapid fluorescence response, and is suitable for various application needs.

The invention relates to a fluorescent array sensor, in particular to a difunctional fluorescent array sensor containing a modified high-molecular polymer, a preparation method of the difunctional fluorescent array sensor and application of the difunctional fluorescent array sensor in bacterial detection and fermentation carbohydrate detection. The array sensor comprises at least two different fluorescent sensing units, each fluorescent sensing unit is a PN-coumarin dye compound formed by covalent interaction of PN and coumarin dye, PN is a nitrophenylboronic acid modified high-molecular polymer PEI, the coumarin dye is 6, 7-diphenyl-1, 3, 4-triazole-3-carboxylic acid, and the coumarin dye is a coumarin dye compound. The compound is selected from the group consisting of 2, 7-dihydroxy-2H-benzopyran-2-one ES or 4-methylesculetin MS. The compound fluorescent array sensor disclosed by the invention can simultaneously realize distinguishing detection of thirteen types of bacteria related to IBS and fourteen FODMAPs, and has the advantages of high sensitivity, short detection time, low cost, good repeatability, high accuracy, no need of professional technicians and the like.

Disclosed herein are improved synthetic pathways for the preparation of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo [4, 5-c] pyridine-2 (3H)-one (toltinib). Also disclosed herein are novel compounds for use in the synthesis of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo [4, 5-c] pyridine-2 (3H)-one.

The invention relates to a dimer non-fullerene acceptor molecule based on a pyrone-ring lock structure, preparation of the dimer non-fullerene acceptor molecule and application of the dimer non-fullerene acceptor molecule as an acceptor photovoltaic material, and belongs to the technical field of organic solar cell materials. An A-D-A '-D-A type dimer non-fullerene acceptor molecule is designed and synthesized based on a pyrone structure, A is an electron withdrawing unit, D is an electron donating unit, and A' is an electron withdrawing unit based on the pyrone structure. The dimer molecule has a structural general formula I shown in the specification. Wherein EG is selected from conjugated groups with electron withdrawing capability, Ar is selected from conjugated groups with electron donating capability, and X is selected from hydrogen atoms or halogen. The dimer acceptor molecule shows a small dihedral angle, which is beneficial to accumulation between molecules, so that the material has high carrier mobility. The dimer acceptor molecule with the pyrone structure shows obviously improved stability under illumination and attack of a nucleophilic reagent, and the organic solar cell device shows good photoelectric conversion efficiency.

The present invention relates to a process for preparing N-hydroxypyridone compounds (I) from pyrone compounds using a phase transfer catalyst. # imgabs0 #

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter and may exhibit a carbon dioxide capacity of at least 11.0 weight percent at 30° C. and 760 mmHg. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

The invention belongs to the technical field of biomedical materials, and particularly relates to a preparation method and application of collagen-chitosan composite microspheres with high biocompatibility, the collagen-chitosan composite microspheres are prepared through an emulsification cross-linking method, and the particle size is 30-50 microns; the collagen-chitosan composite microsphere disclosed by the invention has the advantages that the injectability and the degradability are good; the collagen-chitosan composite microsphere implant has high biocompatibility and biological activity, and can be used for promoting the proliferation, adhesion and migration of fibroblasts (HFF-1); the collagen-chitosan composite microspheres can effectively repair photoaging skin, improve skin elasticity and remarkably promote regeneration of collagen; the collagen-chitosan composite microspheres disclosed by the invention are mild in preparation condition, high in efficiency and short in time; the collagen-chitosan composite microsphere prepared by the method can be used in the fields of dermatology, tissue engineering and the like, and has a wide application prospect.

The invention relates to an isopentenyl-alpha-pyrone dimer Hyperumonates D-F as well as a preparation method and application thereof, and belongs to the field of medical chemistry, the isopentenyl-alpha-pyrone dimer Hyperumonates D-F is obtained by extracting and separating from leaves and branches of Hypericum monogynum for the first time, and the structural formula of the isopentenyl-alpha-pyrone dimer Hyperumonates D-F is D-F. The invention further discloses a preparation method of the isopentenyl-alpha-pyrone dimer Hyperumonates D-F. The isopentenyl-alpha-pyrone dimer Hypericumonates D-F has the advantages that the compounds D-E have remarkable inhibition effects on generation of NO in mouse microglial cells (BV-2 cells) induced by lipopolysaccharide (LPS), the activity of the compounds D-E is higher than that of positive medicine minocycline, and the compounds D-E have application potentials in the field of neuroinflammation medicines, and the invention also relates to a pharmaceutical composition which comprises the isopentenyl-alpha-pyrone dimer Hypericumonates D-F and can be used for preparing medicines for treating neuroinflammation. And pharmaceutically acceptable auxiliary materials, wherein the pharmaceutical composition has the effect of resisting neuroinflammation.

The present invention relates to the technical field of radioactive gas adsorbents, and in particular to a modification method for increasing the adsorption capacity of activated carbon for radon gas. The present invention performs fluorination modification on the activated carbon by pre-reacting the activated carbon in an F2 / N2 mixed gas atmosphere with an F2 volume concentration of 5%, and then reacting in an F2 / N2 mixed gas atmosphere with an F2 volume concentration of 8-15%, so as to increase the adsorption capacity of the activated carbon for radon gas. The present invention provides a modification method for increasing the adsorption capacity of activated carbon for radon gas, and increases the adsorption capacity of activated carbon for radon gas by fluorination modification of the activated carbon. The method of the present invention overcomes the problems in the prior art that the micropore adjustment technology is not highly controllable, the preparation method is complicated, and the selective adsorption capacity of radon gas is limited.

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A1) a compound having two or more nitrogen atoms to which a hydroxyalkyl group is bonded and (B) a 4-pyrone-based compound represented by General Formula (1) below. A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A2) a polyglycerol and (B) a 4-pyrone-based compound represented by General Formula (1) below.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The present invention provides a preparation method of benzopyrone. The preparation method includes: step S1, using trifluoronitrobenzene as the first raw material, performing ortho-substitution reaction with nitromethane to obtain 1,2-difluoro-4-nitro-3-nitromethylenebenzene, and performing para-substitution reaction with alkoxide to obtain a first intermediate; step S2, subjecting the first intermediate to a Nef reaction, converting the nitromethyl group to a carboxyl group to obtain a second intermediate; step S3, subjecting the second intermediate to a reduction reaction, an oxidation reaction, and a denitrogenation rearrangement reaction to convert the nitro group to an aldehyde hydrazine to obtain an aldehyde hydrazine intermediate; step S4, under the action of a catalyst, subjecting the aldehyde hydrazine intermediate to a nucleophilic addition reaction with the second raw material to generate a secondary alcohol intermediate, and subjecting the secondary alcohol intermediate to a ring-closing reaction to obtain a target product. The above-mentioned method for preparing benzopyrone has a wide range of raw material sources, relatively mild reaction conditions, and a high overall reaction yield.

The invention discloses an olefin polymerization catalyst component, an olefin polymerization catalyst and application of the olefin polymerization catalyst component, the olefin polymerization catalyst component comprises Mg, Ti, halogen, at least one internal electron donor a compound and at least one internal electron donor b compound, and the internal electron donor a compound is selected from 2, 4, 6-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1 the internal electron donor b compound is selected from a Lewis base compound, and the internal electron donor b compound is selected from a Lewis base compound; the olefin polymerization catalyst containing the catalyst component can be used for preparing polyolefin with high melt flow rate.

Formulations comprised of pyrone and a mixture of at least one cationic surfactant, such as for preservation of personal care compositions, are disclosed. Articles comprising the formulations are further disclosed.

The application relates to a pyrone-based chelating resin, a preparation method thereof and a method for removing impurities. The main chain skeleton of the pyrone-based chelating resin is a styrene-based adsorption resin, and at least one pyrone functional group is branched on the side chain. The multi-oxygen structure of the pyrone functional group and the nitrogen atom on the main chain skeleton can produce strong coordination with aluminum ions, and a stable six-membered ring chelate is formed through a chelation reaction, thereby showing excellent selective aluminum removal performance. Meanwhile, the pyrone functional group has acid-base properties, can undergo ion exchange reaction or physical adsorption with organic matters, and thus can effectively remove TOC in a water environment. Therefore, by using the pyrone-based chelating resin provided in the application, the aluminum ions and TOC in a rare earth solution can be efficiently removed through the synergistic cooperation of the multi-oxygen coordination effect and the selective ion exchange capacity, and the loss rate of the rare earth ions is obviously reduced.

The application belongs to the field of compound synthesis, and discloses a kind of compound containing seven-membered lactam and pyrone skeleton and its construction and application, and the chemical structure is shown in the following, wherein R1 is selected from any one of hydrogen, alkyl, halogen;R2 is selected from any one of alkyl, aryl;R3 is selected from any one of hydrogen, phenyl.The seven-membered lactam and pyrone skeleton has good drug activity, and can be used for preparing antitumor drugs.The application also discloses a construction method of the seven-membered lactam and pyrone skeleton.The construction method of the seven-membered lactam and pyrone skeleton has the advantages that raw materials and catalysts are cheap and easy to obtain, operation is simple and convenient, and the universality of substrates is wide.

The invention belongs to the field of medical chemistry, and relates to a benzopyrone compound, a benzopyrone composition and application of the benzopyrone compound and the benzopyrone composition in preparation of a medicine for treating hyperuricemia. The chemical structure is as shown in formula I; in the formula, R1 is fluorine or hydrogen; r2 is fluorine or hydrogen; r3 is hydrogen, nitryl or tertiary butyl; r4 is hydrogen, fluorine or trifluoromethyl; and R1, R2, R3 and R4 are not hydrogen at the same time. The benzopyrone compound provided by the invention has good inhibitory activity on XOD, and can reduce the level of uric acid, thereby being beneficial to treatment of hyperuricemia.

The application relates to the technical field of synthetic chemistry, and provides a preparation method of alpha-pyrone-polyketone, which comprises the following steps: coupling reaction of compound 3 and compound 2 to obtain compound 26; secondary alcohol group of the compound 26 is removed to obtain compound 27; the compound 27 is removed from a protection group to obtain the alpha-pyrone-polyketone shown in compound 1; wherein the structural formula of the compound is as follows: the preparation method of the alpha-pyrone-polyketone provided in the application is based on the instability of the bis-bisolefin, and is constructed by using an alkenyl tin intermediate and an alkenyl iodine intermediate through a coupling reaction, so that the operation is simple, the yield of each step is high, and the method can be widely popularized and applied.

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, and the additive includes (A) a 4-pyrone-based compound represented by General Formula (1) below, and (B1) a compound of which a 1 mM aqueous solution has a pH of 3.7 or more or (B2) a cyclic compound having at least one functional group selected from the group consisting of a carboxy group, a carboxylate group, an amino group, and a hydroxy group. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, and the additive includes a compound having two or more nitrogen atoms to which a hydroxyalkyl group is bonded.[in the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The invention discloses a preparation method of a porphyrin-based conjugated polymer with a mesoporous structure as well as a product and application of the porphyrin-based conjugated polymer. A silica gel solution, pyrrole and 1, 4-terephthalaldehyde are adopted as starting raw materials, hydrochloric acid is adopted as a medium, and the porphyrin-based conjugated polymer (mPCPs) with the mesoporous structure is prepared through the technological processes of mixing, stirring and heat treatment by means of a mesoporous template and a solvothermal synthesis technology. The polymer has high specific surface area and optimized mass transfer characteristic, obviously enhances the anchoring performance of iodine-chlorine molecules, and shows excellent synergistic stability in the electron conversion process in the field of electrochemistry. The preparation method is simple and adjustable, the preparation cost is low, and large-scale production can be realized.

This invention discloses a compound with antiepileptic activity, its preparation method, and its uses. The compound's structural formula is shown in Figure I. The preparation method involves fermenting actinomycetes to obtain pyranone ferments, then extracting the ferments with ethyl acetate to obtain a crude extract. This crude extract is then purified by normal-phase silica gel column chromatography, reversed-phase medium-pressure column chromatography, and reversed-phase semi-preparative high-performance liquid chromatography. This pyranone compound has potential applications as an antiepileptic inhibitor. Its advantage lies in its antiepileptic activity, suggesting its potential for developing drugs for the prevention and treatment of epilepsy.

The present invention discloses an indole-2-one derivative, an antibody-drug conjugate thereof and an application thereof. The compound of formula I disclosed in the present invention has an anti-tumor effect, and the present invention discloses an antibody-drug conjugate containing the compound, which can achieve tumor enrichment, eliminate or reduce the toxic and side effects caused by the indole-2-one derivative acting on non-disease tissues, and improve the therapeutic effect.

The present invention relates to the technical field of steel core aluminum stranded wire, and proposes a steel core aluminum stranded wire and a preparation method thereof, comprising a steel core, an aluminum stranded wire, and an anti-corrosion coating coated on the surface of the steel core and the aluminum stranded wire. The present invention sprays an anti-corrosion coating on the surface of the steel core and the aluminum stranded wire to form an anti-corrosion layer, which not only has excellent corrosion resistance and weather resistance, but also maintains the original mechanical properties and electrical properties of the steel core aluminum stranded wire. The hyperbranched polymer and modified filler added to the anti-corrosion coating work synergistically to improve the anti-corrosion performance of the coating. The hyperbranched polymer also acts as a curing agent and improves the mechanical properties of the coating at the same time. The modified filler is based on MXene nanosheets, and polypyrrole and functional monomers are loaded on its surface and between layers, and the synergistic effect improves the anti-corrosion performance of the coating.

The present disclosure relates generally to antimicrobial compositions, specifically antimicrobial synergistic combinations of ingredients derived from natural sources, and more specifically to compositions of at least one 4-pyrone derivative and one or more plant extracts.

The present invention discloses an olefin polymerization catalyst component, an olefin polymerization catalyst and applications thereof, the olefin polymerization catalyst component comprises Mg, Ti, halogen, at least one internal electron donor a compound and at least one internal electron donor b compound, and the internal electron donor a compound is selected from 2, 3, 4, 5, 6-tetramethyl-1, 3-pentanediol in a general formula (I). The compound A is 2, 6-dimethoxycarbonyl substituent-4-pyrone, and the internal electron donor b is selected from a Lewis alkali compound. According to the catalyst component disclosed by the invention, after the 2, 6-dimethoxycarbonyl substituent-4-pyrone is adopted as an internal electron donor and compounded with the Lewis alkali compound, the activity can be remarkably improved, polypropylene obtained by the catalyst is high in isotacticity, and high-isotacticity polyolefin can still be obtained even if an external electron donor is not added.

The invention provides a method for catalytically synthesizing 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol is prepared by catalyzing (3 + 3) cyclization reaction. The synthesis method provided by the invention is simple in reaction raw material synthesis, low in rare earth salt price, easy in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis, organic materials and the like.

The intermediate (3) is obtained by addition under alkaline condition, and then ring closure under acidic condition to synthesize 2-perfluoroalkyl-4H-pyrane-4-ketone derivative (4). The addition reaction is carried out by using perfluoroalkyl acyl chloride, so that the yield of the addition reaction is effectively improved; efficient ring closure is realized at room temperature through a trifluoroacetic acid / ethanol system; high-temperature conditions and easily-made-poisoning reagents are avoided, and the method has an industrial application prospect.

The invention belongs to the technical field of medicinal chemistry and agricultural biology, and particularly relates to a preparation method of pyrone natural products and application of the pyrone natural products in preparation of agricultural antifungal drugs. According to the invention, two novel pyrone natural products are separated from the plant endophytic fungus Diaporthe kyushuensis ZMU-48-1 for the first time, and the two novel pyrone natural products can be obtained. The two compounds have the advantages that the obvious inhibition activity on the valsa mali Miyabe amp (G. Yamada) can be realized by the two compounds, and the two compounds can be used for inhibiting the valsa mali Miyabe amp (G. Yamada). Compared with traditional chemical synthetic fungicides, the compound has the outstanding advantages of novel structure, strong targeting property, environmental friendliness, slow resistance development and the like, has a good prospect in the field of research and development of agricultural antifungal drugs, is particularly suitable for green control of plant fungal diseases, and has important scientific research value and application value.