95 results about "Pyrone" patented technology

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter and may exhibit a carbon dioxide capacity of at least 11.0 weight percent at 30° C. and 760 mmHg. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A1) a compound having two or more nitrogen atoms to which a hydroxyalkyl group is bonded and (B) a 4-pyrone-based compound represented by General Formula (1) below. A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A2) a polyglycerol and (B) a 4-pyrone-based compound represented by General Formula (1) below.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The application relates to a pyrone-based chelating resin, a preparation method thereof and a method for removing impurities. The main chain skeleton of the pyrone-based chelating resin is a styrene-based adsorption resin, and at least one pyrone functional group is branched on the side chain. The multi-oxygen structure of the pyrone functional group and the nitrogen atom on the main chain skeleton can produce strong coordination with aluminum ions, and a stable six-membered ring chelate is formed through a chelation reaction, thereby showing excellent selective aluminum removal performance. Meanwhile, the pyrone functional group has acid-base properties, can undergo ion exchange reaction or physical adsorption with organic matters, and thus can effectively remove TOC in a water environment. Therefore, by using the pyrone-based chelating resin provided in the application, the aluminum ions and TOC in a rare earth solution can be efficiently removed through the synergistic cooperation of the multi-oxygen coordination effect and the selective ion exchange capacity, and the loss rate of the rare earth ions is obviously reduced.

The application belongs to the field of compound synthesis, and discloses a kind of compound containing seven-membered lactam and pyrone skeleton and its construction and application, and the chemical structure is shown in the following, wherein R1 is selected from any one of hydrogen, alkyl, halogen;R2 is selected from any one of alkyl, aryl;R3 is selected from any one of hydrogen, phenyl.The seven-membered lactam and pyrone skeleton has good drug activity, and can be used for preparing antitumor drugs.The application also discloses a construction method of the seven-membered lactam and pyrone skeleton.The construction method of the seven-membered lactam and pyrone skeleton has the advantages that raw materials and catalysts are cheap and easy to obtain, operation is simple and convenient, and the universality of substrates is wide.

The invention belongs to the field of medical chemistry, and relates to a benzopyrone compound, a benzopyrone composition and application of the benzopyrone compound and the benzopyrone composition in preparation of a medicine for treating hyperuricemia. The chemical structure is as shown in formula I; in the formula, R1 is fluorine or hydrogen; r2 is fluorine or hydrogen; r3 is hydrogen, nitryl or tertiary butyl; r4 is hydrogen, fluorine or trifluoromethyl; and R1, R2, R3 and R4 are not hydrogen at the same time. The benzopyrone compound provided by the invention has good inhibitory activity on XOD, and can reduce the level of uric acid, thereby being beneficial to treatment of hyperuricemia.

The application relates to the technical field of synthetic chemistry, and provides a preparation method of alpha-pyrone-polyketone, which comprises the following steps: coupling reaction of compound 3 and compound 2 to obtain compound 26; secondary alcohol group of the compound 26 is removed to obtain compound 27; the compound 27 is removed from a protection group to obtain the alpha-pyrone-polyketone shown in compound 1; wherein the structural formula of the compound is as follows: the preparation method of the alpha-pyrone-polyketone provided in the application is based on the instability of the bis-bisolefin, and is constructed by using an alkenyl tin intermediate and an alkenyl iodine intermediate through a coupling reaction, so that the operation is simple, the yield of each step is high, and the method can be widely popularized and applied.

This invention discloses a compound with antiepileptic activity, its preparation method, and its uses. The compound's structural formula is shown in Figure I. The preparation method involves fermenting actinomycetes to obtain pyranone ferments, then extracting the ferments with ethyl acetate to obtain a crude extract. This crude extract is then purified by normal-phase silica gel column chromatography, reversed-phase medium-pressure column chromatography, and reversed-phase semi-preparative high-performance liquid chromatography. This pyranone compound has potential applications as an antiepileptic inhibitor. Its advantage lies in its antiepileptic activity, suggesting its potential for developing drugs for the prevention and treatment of epilepsy.

The invention provides a method for catalytically synthesizing 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol is prepared by catalyzing (3 + 3) cyclization reaction. The synthesis method provided by the invention is simple in reaction raw material synthesis, low in rare earth salt price, easy in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis, organic materials and the like.

The intermediate (3) is obtained by addition under alkaline condition, and then ring closure under acidic condition to synthesize 2-perfluoroalkyl-4H-pyrane-4-ketone derivative (4). The addition reaction is carried out by using perfluoroalkyl acyl chloride, so that the yield of the addition reaction is effectively improved; efficient ring closure is realized at room temperature through a trifluoroacetic acid / ethanol system; high-temperature conditions and easily-made-poisoning reagents are avoided, and the method has an industrial application prospect.

The invention belongs to the technical field of medicinal chemistry and agricultural biology, and particularly relates to a preparation method of pyrone natural products and application of the pyrone natural products in preparation of agricultural antifungal drugs. According to the invention, two novel pyrone natural products are separated from the plant endophytic fungus Diaporthe kyushuensis ZMU-48-1 for the first time, and the two novel pyrone natural products can be obtained. The two compounds have the advantages that the obvious inhibition activity on the valsa mali Miyabe amp (G. Yamada) can be realized by the two compounds, and the two compounds can be used for inhibiting the valsa mali Miyabe amp (G. Yamada). Compared with traditional chemical synthetic fungicides, the compound has the outstanding advantages of novel structure, strong targeting property, environmental friendliness, slow resistance development and the like, has a good prospect in the field of research and development of agricultural antifungal drugs, is particularly suitable for green control of plant fungal diseases, and has important scientific research value and application value.

The application provides a catalyst component for olefin polymerization, a catalyst and application thereof; the composition of the catalyst component comprises: Mg, Ti, halogen, 2,6-dicarboxylate-4-pyrone internal electron donor and Lewis base internal electron donor; wherein the 2,6-dicarboxylate-4-pyrone internal electron donor has a structure shown in formula I: the catalyst component and the catalyst have high catalytic activity, and the polypropylene obtained by catalytic polymerization has high bulk density and high isotacticity; for propylene polymerization, when the Al / Ti ratio is reduced, a polymer with low ash content can be obtained.

The present invention provides a pyranone compound represented by formula (I). The pyranone compound has excellent anti-inflammatory activity and cholinesterase inhibitory activity, features a high blood-brain barrier penetration potential and good safety, and can ameliorate cognitive impairment related to Alzheimer's disease, reduce glial cell activation, decrease Aβ deposition and alleviate neuroinflammation.

The invention provides a method for catalytically synthesizing 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method of the 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the preparation of the 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol is realized. The method is simple in reaction raw material synthesis, simple in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis and the like.

The invention belongs to the technical field of medicinal chemistry and agricultural biology, and particularly relates to a pyrone natural product with antifungal activity and a preparation method and application thereof. According to the invention, a novel pyrone natural product is separated from the plant endophytic fungus Diamorpha kushuensis ZMU-48-1 for the first time, and the novel pyrone natural product can be obtained. According to the present invention, the compound has significant inhibitory activity on colletotrichum musae (Colletotrichum gloeosporioides) and colletotrichum gloeosporioides (Colletotrichum gloeosporioides), and can be used for the preparation of the compound, such that the compound has significant inhibitory activity on colletotrichum musae (Colletotrichum gloeosporioides), compared with traditional chemical synthetic fungicides, the compound has the outstanding advantages of novel structure, strong targeting property, environmental friendliness, slow resistance development and the like, has a good prospect in the field of research and development of agricultural antifungal drugs, is particularly suitable for green control of plant fungal diseases, and has important scientific research value and application value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to an efficient synthesis method of brexpiprazole. The invention provides a novel preparation method of bupreprazole, which comprises the following steps: by taking 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine as a starting material, carrying out substitution reaction on the 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine and 7-hydroxy-2H-benzopyran-2-ketone to prepare an intermediate 7-(4-(4-(benzo [b] thiophene-4-yl) piperazin-1-yl) butoxy)-2H-benzopyran-2-ketone; according to the present invention, with the process, the use of the noble metal catalyst and the generation of the related dimer and the heterotopic substitution impurity can be effectively avoided, and the product obtained through the process has characteristics of high yield and high purity, and is suitable for industrial production.

The invention discloses a synthesis method of 6-pentyl-2H-pyran-2-ketone, which comprises the following steps: step 1, reacting n-hexanoic acid or n-hexanoyl chloride with a malonate compound to obtain a compound a; step 2, carrying out carbonyl ketal protection reaction on the compound a to obtain a compound b; 3, the compound b is subjected to a reduction reaction, and a compound c is obtained; 4, the compound c is subjected to an oxidation reaction, and a compound d is obtained; 5, the compound d is subjected to a Wittig reaction, and a compound e is obtained; step 6, hydrolyzing the compound e, and removing a protecting group to obtain a compound f; and step 7, carrying out cyclization on the compound f, so as to obtain the 6-amyl-2H-pyran-2-one. According to the method, n-hexanoic acid (or n-hexanoyl chloride) serves as a starting raw material, 6PP is prepared through decarboxylation, ketal protection, reduction, oxidation, wittig reaction, hydrolysis deprotection and cyclization, the raw materials are cheap and easy to obtain, reaction conditions are mild, and the method is environmentally friendly and suitable for industrial production.

The invention belongs to the field of organic electroluminescent materials, and in particular relates to a pyrone type iridium phosphorescent complex as well as a preparation method and application thereof, the pyrone type iridium phosphorescent complex takes (ppy) 2Ir2Cl2 (ppy) 2 as a dimer, 3-hydroxy-2-methyl-gamma-pyrone, 2-ethyl-3-hydroxy-4-pyrone, 5-hydroxy-2-hydroxymethyl-1, 3, 4-triazole-1, 3, 5-triazole-1, 3, 5-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3- 3, 4-pyrone is used as an auxiliary ligand, and three pyrone type iridium phosphorescent complexes are obtained under simple operation steps and mild reaction conditions. Maltol, ethyl maltol and kojic acid which are selected as pyrone auxiliary ligands are all food additives and are easy to purchase and low in price, the cost of the organic electroluminescent material can be greatly reduced, and industrial conversion is effectively achieved.

The present invention relates to a mixture, blend or combination, comprising at two, preferably at least three, chosen from the following compounds: (A) a pyrone derivative, (B) a tropolone derivative, (C) a phenylpropanoid, (D) a monoterpene or monoterpenoid, (E) an aromatic acid or salt, (F) a dipeptide, and (G) an alkanediol, and its use as chelating mixture.

The application discloses an olefin polymerization catalyst component, an olefin polymerization catalyst and application thereof. The olefin polymerization catalyst component comprises Mg, Ti, halogen, at least one internal electron donor a compound and at least one internal electron donor b compound. The internal electron donor a compound is selected from 2,6-dimethoxycarbonyl substituent-4-pyrone in a general formula (I), and the internal electron donor b compound is selected from a Lewis base compound. The catalyst component of the application can significantly improve the activity after being compounded with the Lewis base compound by taking 2,6-dimethoxycarbonyl substituent-4-pyrone as the internal electron donor. The catalyst can obtain high isotacticity of polypropylene, and even when no external electron donor is added, high isotacticity of polyolefin can still be obtained.

Disclosed are methods of repelling one or more arthropod by treating an object or area with a composition comprising an arthropod repelling effective amount of massoia essential oil, one or more massoia essential oil component (e.g., massoia lactone), and / or analog(s) thereof (e.g., α-amyl-pyrone). Also disclosed are arthropod repellent systems with an applicator for applying an arthropod repelling effective amount of the composition to an object or area. In some embodiments, the applicator comprises a substrate impregnated with the composition and from which the composition evaporates. In some embodiments, the applicator further comprises a heating element operative to apply heat to the substrate. Further disclosed are methods of controlling one or more arthropod by contacting an arthropod or its environment with an insecticide composition comprising an arthropod killing effective amount of massoia essential oil, one or more massoia essential oil components, and / or analog(s) thereof.

The present application belongs to the field of pharmaceutical chemistry and agricultural biotechnology, and particularly relates to a preparation method of pyrone natural products and use thereof in preparing agricultural antifungal drugs. Diaporthe kyushuensis Two novel pyrone natural products are isolated from ZMU-48-1 for the first time. Valsa mali The two compounds exhibit significant inhibitory activity on Valsa mali (Miyabe & G.Yamada). Compared with traditional chemical synthetic fungicides, the compounds have the advantages of novel structure, strong targeting, environmental friendliness, slow resistance development, and good prospects in the field of agricultural antifungal drug research and development, and are particularly suitable for green control of plant fungal diseases, and have important scientific research value and application value.

The present application relates to the technical field of biological medicine, in particular to a pyrone compound, a preparation method and application thereof. The novel pyrone compound has a structure of formula 1, is separated into secondary metabolites of fungi Curvularia sp. ZYX-Z-4, and is found to have herbicidal effect through biological activity test evaluation. The pyrone compound has the advantages of low toxicity, high selectivity, target specificity and ecological friendliness when applied to herbicides. The herbicidal effect of the compound is evaluated by using model plants Arabidopsis thaliana. The results show that the pyrone compound has good inhibitory effect on the growth of Arabidopsis thaliana roots, can cause damage to root cytoplasmic membrane, and can cause root cell death. The pyrone compound can significantly inhibit the root length and fresh weight of three weeds, and further provides relevant theories and experimental basis for the development of biological herbicides.

This invention provides a vinylpyranone compound, which has excellent anti-inflammatory and antioxidant activities.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a novel method for synthesizing brexpiprazole. 4-piperazinyl benzothiophene and 4-bromobutyraldehyde are used as starting materials, a brominated intermediate compound with high activity is prepared through a reductive amination reaction, the brominated intermediate compound and 7-hydroxy-2H-benzopyran-2-ketone are subjected to a substitution reaction to prepare the target product burepidazole, and the product obtained through the process has high yield and purity and is suitable for industrial production.

The invention discloses a catalyst for synthesis of a macloxvir intermediate and a preparation method of the intermediate, and belongs to the technical field of pharmaceutical chemical synthesis. The catalyst is an HZSM-5 spherical molecular sieve supported iron / tungsten-based catalyst; under the combined action with sodium hypochlorite, methyl in 3-(benzyloxy)-2-methyl-4H-pyran-4-one can be oxidized into carboxyl with high selectivity, so that a target carboxylic acid structure is efficiently constructed. The preparation method of the intermediate comprises the following steps: synchronously pumping a mixed solution of a sodium hydroxide aqueous solution of maltol and acetonitrile and a benzyl chloride solution into a first microchannel reactor for a benzylation reaction to obtain a 3-(benzyloxy)-2-methyl-4H-pyran-4-one solution; then pumping the 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid solution and a sodium hypochlorite solution into a second micro-channel reactor for oxidation reaction to generate a 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid solution; and finally, separating out the product through an acidification process, and filtering and recrystallizing to obtain the macarovir intermediate with the purity of 99.9%.

The present invention discloses a method for stabilizing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP). The method involves contacting DDMP with at least one tertiary amine compound having the structural formula: #imgabs0#, wherein R1 is a methyl group, an ethyl group, or a phenyl group; and R2 is a phenyl group or hydrogen. The present invention provides a method for stabilizing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. DDMP is almost completely degraded after 180 days of storage. However, after adding the tertiary amine compound, degradation is only 8% at most within 180 days. This method successfully addresses the issues of DDMP's poor stability, easy deterioration and damage, and its unsuitability for use as a sweet and fragrant raw material.

A herbicidal composition including ethyl [3-[2-chloro-4-fluoro-5-(1-methyl-6-trifluoromethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate and a herbicide selected from the group consisting of bicyclopyrone, mesotrione, tembotrione, isoxaflutole, pyrasulfotole, topramezone, and tolpyralate. A weight ratio of ethyl [3-[2-chloro-4-fluoro-5-(1-methyl-6-trifluoromethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate to the herbicide is from 1:1 to 1:42.