53 results about "Pyrone" patented technology

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A1) a compound having two or more nitrogen atoms to which a hydroxyalkyl group is bonded and (B) a 4-pyrone-based compound represented by General Formula (1) below. A polishing liquid containing: abrasive grains; an additive; and water, in which the additive includes (A2) a polyglycerol and (B) a 4-pyrone-based compound represented by General Formula (1) below.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The application belongs to the field of compound synthesis, and discloses a kind of compound containing seven-membered lactam and pyrone skeleton and its construction and application, and the chemical structure is shown in the following, wherein R1 is selected from any one of hydrogen, alkyl, halogen;R2 is selected from any one of alkyl, aryl;R3 is selected from any one of hydrogen, phenyl.The seven-membered lactam and pyrone skeleton has good drug activity, and can be used for preparing antitumor drugs.The application also discloses a construction method of the seven-membered lactam and pyrone skeleton.The construction method of the seven-membered lactam and pyrone skeleton has the advantages that raw materials and catalysts are cheap and easy to obtain, operation is simple and convenient, and the universality of substrates is wide.

The invention belongs to the field of medical chemistry, and relates to a benzopyrone compound, a benzopyrone composition and application of the benzopyrone compound and the benzopyrone composition in preparation of a medicine for treating hyperuricemia. The chemical structure is as shown in formula I; in the formula, R1 is fluorine or hydrogen; r2 is fluorine or hydrogen; r3 is hydrogen, nitryl or tertiary butyl; r4 is hydrogen, fluorine or trifluoromethyl; and R1, R2, R3 and R4 are not hydrogen at the same time. The benzopyrone compound provided by the invention has good inhibitory activity on XOD, and can reduce the level of uric acid, thereby being beneficial to treatment of hyperuricemia.

The invention provides a method for catalytically synthesizing 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the 7-amino-3-oxabicyclo [3.3. 1] nonyl-6-ene-1-ol is prepared by catalyzing (3 + 3) cyclization reaction. The synthesis method provided by the invention is simple in reaction raw material synthesis, low in rare earth salt price, easy in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis, organic materials and the like.

The invention belongs to the technical field of medicinal chemistry and agricultural biology, and particularly relates to a preparation method of pyrone natural products and application of the pyrone natural products in preparation of agricultural antifungal drugs. According to the invention, two novel pyrone natural products are separated from the plant endophytic fungus Diaporthe kyushuensis ZMU-48-1 for the first time, and the two novel pyrone natural products can be obtained. The two compounds have the advantages that the obvious inhibition activity on the valsa mali Miyabe amp (G. Yamada) can be realized by the two compounds, and the two compounds can be used for inhibiting the valsa mali Miyabe amp (G. Yamada). Compared with traditional chemical synthetic fungicides, the compound has the outstanding advantages of novel structure, strong targeting property, environmental friendliness, slow resistance development and the like, has a good prospect in the field of research and development of agricultural antifungal drugs, is particularly suitable for green control of plant fungal diseases, and has important scientific research value and application value.

The application provides a catalyst component for olefin polymerization, a catalyst and application thereof; the composition of the catalyst component comprises: Mg, Ti, halogen, 2,6-dicarboxylate-4-pyrone internal electron donor and Lewis base internal electron donor; wherein the 2,6-dicarboxylate-4-pyrone internal electron donor has a structure shown in formula I: the catalyst component and the catalyst have high catalytic activity, and the polypropylene obtained by catalytic polymerization has high bulk density and high isotacticity; for propylene polymerization, when the Al / Ti ratio is reduced, a polymer with low ash content can be obtained.

The present invention provides a pyranone compound represented by formula (I). The pyranone compound has excellent anti-inflammatory activity and cholinesterase inhibitory activity, features a high blood-brain barrier penetration potential and good safety, and can ameliorate cognitive impairment related to Alzheimer's disease, reduce glial cell activation, decrease Aβ deposition and alleviate neuroinflammation.

The invention provides a method for catalytically synthesizing 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol by using rare earth, which comprises the following steps of: adding a catalyst and a catalyst, according to the preparation method of the 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol, rare earth trifluoromethanesulfonate is taken as a catalyst, 6-alkoxy-2, 6-dihydropyran-3-ketone and enamine compounds are taken as raw materials, and the preparation of the 7-oxa-2-azabicyclo [3.3. 1] nonyl-3-ene-1-ol is realized. The method is simple in reaction raw material synthesis, simple in experimental operation and suitable for large-scale preparation. The obtained compound can be applied to the fields of organic synthesis, drug synthesis and the like.

The invention belongs to the technical field of medicinal chemistry and agricultural biology, and particularly relates to a pyrone natural product with antifungal activity and a preparation method and application thereof. According to the invention, a novel pyrone natural product is separated from the plant endophytic fungus Diamorpha kushuensis ZMU-48-1 for the first time, and the novel pyrone natural product can be obtained. According to the present invention, the compound has significant inhibitory activity on colletotrichum musae (Colletotrichum gloeosporioides) and colletotrichum gloeosporioides (Colletotrichum gloeosporioides), and can be used for the preparation of the compound, such that the compound has significant inhibitory activity on colletotrichum musae (Colletotrichum gloeosporioides), compared with traditional chemical synthetic fungicides, the compound has the outstanding advantages of novel structure, strong targeting property, environmental friendliness, slow resistance development and the like, has a good prospect in the field of research and development of agricultural antifungal drugs, is particularly suitable for green control of plant fungal diseases, and has important scientific research value and application value.

The present invention relates to a mixture, blend or combination, comprising at two, preferably at least three, chosen from the following compounds: (A) a pyrone derivative, (B) a tropolone derivative, (C) a phenylpropanoid, (D) a monoterpene or monoterpenoid, (E) an aromatic acid or salt, (F) a dipeptide, and (G) an alkanediol, and its use as chelating mixture.

The application discloses an olefin polymerization catalyst component, an olefin polymerization catalyst and application thereof. The olefin polymerization catalyst component comprises Mg, Ti, halogen, at least one internal electron donor a compound and at least one internal electron donor b compound. The internal electron donor a compound is selected from 2,6-dimethoxycarbonyl substituent-4-pyrone in a general formula (I), and the internal electron donor b compound is selected from a Lewis base compound. The catalyst component of the application can significantly improve the activity after being compounded with the Lewis base compound by taking 2,6-dimethoxycarbonyl substituent-4-pyrone as the internal electron donor. The catalyst can obtain high isotacticity of polypropylene, and even when no external electron donor is added, high isotacticity of polyolefin can still be obtained.

The present application belongs to the field of pharmaceutical chemistry and agricultural biotechnology, and particularly relates to a preparation method of pyrone natural products and use thereof in preparing agricultural antifungal drugs. Diaporthe kyushuensis Two novel pyrone natural products are isolated from ZMU-48-1 for the first time. Valsa mali The two compounds exhibit significant inhibitory activity on Valsa mali (Miyabe & G.Yamada). Compared with traditional chemical synthetic fungicides, the compounds have the advantages of novel structure, strong targeting, environmental friendliness, slow resistance development, and good prospects in the field of agricultural antifungal drug research and development, and are particularly suitable for green control of plant fungal diseases, and have important scientific research value and application value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a novel method for synthesizing brexpiprazole. 4-piperazinyl benzothiophene and 4-bromobutyraldehyde are used as starting materials, a brominated intermediate compound with high activity is prepared through a reductive amination reaction, the brominated intermediate compound and 7-hydroxy-2H-benzopyran-2-ketone are subjected to a substitution reaction to prepare the target product burepidazole, and the product obtained through the process has high yield and purity and is suitable for industrial production.

The invention discloses a catalyst for synthesis of a macloxvir intermediate and a preparation method of the intermediate, and belongs to the technical field of pharmaceutical chemical synthesis. The catalyst is an HZSM-5 spherical molecular sieve supported iron / tungsten-based catalyst; under the combined action with sodium hypochlorite, methyl in 3-(benzyloxy)-2-methyl-4H-pyran-4-one can be oxidized into carboxyl with high selectivity, so that a target carboxylic acid structure is efficiently constructed. The preparation method of the intermediate comprises the following steps: synchronously pumping a mixed solution of a sodium hydroxide aqueous solution of maltol and acetonitrile and a benzyl chloride solution into a first microchannel reactor for a benzylation reaction to obtain a 3-(benzyloxy)-2-methyl-4H-pyran-4-one solution; then pumping the 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid solution and a sodium hypochlorite solution into a second micro-channel reactor for oxidation reaction to generate a 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid solution; and finally, separating out the product through an acidification process, and filtering and recrystallizing to obtain the macarovir intermediate with the purity of 99.9%.

A herbicidal composition including ethyl [3-[2-chloro-4-fluoro-5-(1-methyl-6-trifluoromethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate and a herbicide selected from the group consisting of bicyclopyrone, mesotrione, tembotrione, isoxaflutole, pyrasulfotole, topramezone, and tolpyralate. A weight ratio of ethyl [3-[2-chloro-4-fluoro-5-(1-methyl-6-trifluoromethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate to the herbicide is from 1:1 to 1:42.

The application discloses an olefin polymerization catalyst component, an olefin polymerization catalyst and application thereof, and the olefin polymerization catalyst component comprises Mg, Ti, halogen, at least one internal electron donor a compound and at least one internal electron donor b compound, wherein the internal electron donor a compound is selected from 2,6-dimethoxy substituent-4-pyrone compounds in a general formula (I), and the internal electron donor b compound is selected from Lewis base compounds; the olefin polymerization catalyst comprising the catalyst component can prepare high-melt-flow-rate polyolefins.

This invention provides a method for producing silica nanocapsules without using reagents that are difficult to handle. [Solution] The present invention provides a method for producing silica nanocapsules containing a water-soluble compound, comprising hydrolyzing and dehydrating a silicon alkoxide in an aqueous solution containing a water-soluble compound to produce silica, wherein the water-soluble compound has a pyranone ring and a hydroxyl group. Furthermore, the present invention provides a method for producing porous silica nanocapsules, further comprising dispersing the water-soluble compound-encapsulated silica nanocapsules obtained by the above method in water or an aqueous solution to elute the water-soluble compound from the water-soluble compound-encapsulated silica nanocapsules.

The present disclosure relates to the technical field of drug synthesis, and particularly relates to a Hispidin derivative, and a preparation method and use thereof. The Hispidin derivative has a structure of formula (I):The present disclosure employs 4-hydroxy-6-methyl-2-pyrone and 3,4-dihydroxybenzaldehyde as starting raw materials to synthesize a series of compounds with styrylpyrone as a backbone. The preparation method provided by the present disclosure has simple steps, is easy to operate, has good feasibility, has the potential for large-scale industrial application, and has a broad market prospect. The present disclosure further provides use of the preparation method described above and the resulting Hispidin derivative in preparation of a lipid-lowering drug. The aryl compound provided by the present disclosure has a good lipid-lowering therapeutic effect and can be used for preparing a lipid-lowering drug, thus having good social benefits.

The invention discloses composite nanoparticles loaded with fusarium solani dsRNA (double-stranded ribonucleic acid) and 1, 2-benzopyrone, which are prepared by the following steps: mixing aminated mesoporous silica with a fusarium solani dsRNA solution, and incubating at room temperature to obtain aminated mesoporous silica-dsRNA nanoparticles; then mixing the aminated mesoporous silica with a 1, 2-benzopyrone solution, and incubating at room temperature to obtain aminated mesoporous silica 1, 2-benzopyrone nanoparticles; finally, mixing the aminated mesoporous silica-dsRNA nano-particle solution with the aminated mesoporous silica 1, 2-benzopyrone nano-particle solution at room temperature, so as to obtain a composite nano-particle solution; according to the composite nano-particles, the stability of dsRNA and 1, 2-benzopyrone in an adverse environment is improved, meanwhile, the inhibition effect on root rot is enhanced, and the composite nano-particles have important application value in prevention and treatment of panax notoginseng root rot and promotion of panax notoginseng growth.

The invention discloses a high-thermal-stability PBAT resin composition and a preparation method thereof, and belongs to the technical field of degradable plastics. The high-thermal-stability PBAT resin composition is prepared from the following raw materials in parts by mass: 60 to 80 parts of PBAT resin, 10 to 20 parts of high-heat-resistance heterocyclic esterification derivatives, 5 to 15 parts of filler and 1 to 5 parts of auxiliaries, the high-heat-resistance heterocyclic esterification derivative is prepared by carrying out sulfydryl-double bond click reaction on a high-heat-resistance heterocyclic ester and 1, 6-hexanedithiol. The high-heat-resistance heterocyclic esterification derivative contains a heterocyclic structure and an ester group, the heterocyclic structure can effectively inhibit thermal motion of a molecular chain segment and has better biodegradability compared with a benzene ring, unsaturated double bonds on pyrone at two ends are utilized to perform sulfydryl-double bond click to introduce sulfydryl, so that the high-heat-resistance heterocyclic esterification derivative is crosslinked with PBAT resin, and the high-heat-resistance heterocyclic esterification derivative is prepared. The thermal stability and the mechanical property of the PBAT resin composition are effectively improved.

The invention relates to compounds and methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, Type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder including by modulating biological processes by the inhibition of cell cycle checkpoint targets CDKs, and / or PI3 kinase, and / or bromodomain protein binding to substrates, comprising the administration of a compound(s) of Formula 1-V1 (or pharmaceutically acceptable salts thereof) as defined herein.

The application discloses a solid catalyst component for olefin polymerization, an olefin polymerization catalyst and application thereof. The solid catalyst component for olefin polymerization comprises Mg, Ti, halogen, an internal electron donor a compound and an internal electron donor b compound. The internal electron donor a compound is selected from substituted 2,6-diformate-4-pyrone compounds of general formula (I), and the internal electron donor b compound is selected from tetrahydro-ortho-substituted phenyl compounds of general formula (II). The solid catalyst component of the application uses substituted 2,6-diformate-4-pyrone compounds as internal electron donors of polyolefin catalysts. After being compounded with tetrahydro-ortho-substituted phenyl compounds, the solid catalyst component has high polymerization activity, high polymer melt index and good hydrogen regulation sensitivity.

The invention relates to the technical field of chemical synthesis, and particularly provides a C-6 axially chiral 2-pyrone compound as well as a preparation method and application thereof. The structural formula of the C-6 axial chiral 2-pyrone compound provided by the invention is as shown in the following formula 3. The C-6 axially chiral biaryl 2-pyrone compound provided by the invention can be directly used as a high-efficiency catalyst to be applied to an asymmetric catalytic reaction, shows excellent catalytic performance and has relatively high application value, and the preparation method is simple and convenient to operate, low in energy consumption and green and environment-friendly. 3.

This invention discloses a method for preparing pyranone derivatives containing a thioester structure, comprising the following steps: reacting a nickel catalyst, a ligand, manganese, molybdenum carbonyl, a base, a 5-iodo-2H-pyranone derivative, and a sulfonyl chloride compound at 90–110 °C for 12–20 hours. After the reaction is complete, post-treatment yields the pyranone derivative containing the thioester structure. This preparation method uses a sulfonyl chloride compound as a sulfur source, and molybdenum carbonyl as both a carbonyl source and a reducing agent. It is simple to operate, uses readily available and inexpensive starting materials, has a wide tolerance range for substrate functional groups, and exhibits high reaction efficiency. Various pyranone derivatives containing thioester structures can be synthesized according to actual needs, simplifying the operation and broadening the applicability of this method.

The present invention provides a genetically modified plant or plant cell comprising a nucleic acid encoding one or more heterologous enzymes operably linked a promoter, wherein one or more heterologous enzymes synthesizes 2-pyrone-4,6-dicarboxylic acid (PDC).

This invention provides a vinylpyranone compound, which exhibits excellent antioxidant activity, anti-inflammatory activity, and Aβ inhibition. 1‑42 Aggregation activity and inhibition of cholinesterase activity.

The present invention relates to a mixture, blend or combination, comprising at two, preferably at least three, chosen from the following compounds: (A) a pyrone derivative, (B) a tropolone derivative, (C) a phenylpropanoid, (D) a monoterpene or monoterpenoid, (E) an aromatic acid or salt, (F) a dipeptide, and (G) an alkanediol, and its use as chelating mixture.

The invention relates to application of alpha-pyrone compounds in preparation of antithrombotic drugs, and belongs to the technical field of biological medicines. The alpha-pyrone compound separated from deep-sea fungus fermentation liquor is applied to the field of prevention and treatment of thrombotic diseases for the first time. After detection, it is found that the compounds 6-((2S, 3S)-2, 3-dihydroxy-2-butyl)-3-methyl-2H-pyran-2-one and 6-ethyl-4-methoxy-3-methyl-2H-pyran-2-one can significantly increase the red blood volume of zebra fish and relieve tail thrombus, and have the ability to resist thrombus, and the compounds 6-((2S, 3S)-2, 3-dihydroxy-2-butyl)-3-methyl-2H-pyran-2-one and 6-ethyl-4-methoxy-3-methyl-2H-pyran-2-one have the ability to resist thrombus; further detection shows that the 6-ethyl-4-methoxy-3-methyl-2H-pyran-2-one can improve the blood flow velocity of a thrombus area and inhibit platelet aggregation, and is low in action concentration, so that the 6-ethyl-4-methoxy-3-methyl-2H-pyran-2-one is small in toxic and side effects, has the potential of developing novel antithrombotic drugs, health-care foods and functional foods, and is wide in market application prospect.

The present invention relates to a mixture, blend or combination, comprising at least two, preferably at least three, chosen from the following compounds: (A) a pyrone derivative, preferably a 3-hydroxy-4-pyrone, (B) a tropolone derivative, (C) a phenylpropanoid, (D) a mono- or sesquiterpene, or mono- or sesquiterpenoid, (E) an aromatic acid or salt, and (F) an alkanediol, and its use as antimicrobial mixture, blend or combination.